{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T14:43:24Z","timestamp":1759589004788,"version":"build-2065373602"},"reference-count":49,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["20080441340"],"award-info":[{"award-number":["20080441340"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010041","name":"Tianjin Science and Technology Committee","doi-asserted-by":"publisher","award":["033609811","08JCYBJC06900"],"award-info":[{"award-number":["033609811","08JCYBJC06900"]}],"id":[{"id":"10.13039\/501100010041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81041071"],"award-info":[{"award-number":["81041071"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1016\/j.mce.2011.01.018","type":"journal-article","created":{"date-parts":[[2011,2,2]],"date-time":"2011-02-02T04:45:14Z","timestamp":1296621914000},"page":"43-51","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["LC, a novel estrone\u2013rhein hybrid compound, concurrently stimulates osteoprotegerin and inhibits receptor activator of NF-\u03baB ligand (RANKL) and interleukin-6 production by human osteoblastic cells"],"prefix":"10.1016","volume":"337","author":[{"given":"Yue","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling Zhi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Liang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya Qin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei Jia","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2011.01.018_bib0005","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1007\/s002239900104","article-title":"Effect of 17\u03b2-estradiol-bisphosphonate conjugates, potential bone-seeking estrogen pro-drugs, on 17\u03b2-estradiol serum kinetics and bone mass in rats","volume":"59","author":"Bauss","year":"1996","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.mce.2011.01.018_bib0010","doi-asserted-by":"crossref","first-page":"R71","DOI":"10.1186\/ar2444","article-title":"Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation\/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodeling","volume":"10","author":"Boileau","year":"2008","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.mce.2011.01.018_bib0015","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/S0026-895X(24)12119-0","article-title":"Differential response of estrogen receptors alpha and beta to SP500263, a novel potent selective estrogen receptor modulator","volume":"61","author":"Brady","year":"2002","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.mce.2011.01.018_bib0020","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1152\/physrev.2001.81.1.419","article-title":"Sex steroids and bone","volume":"81","author":"Compston","year":"2001","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.mce.2011.01.018_bib0025","first-page":"1154","article-title":"Determination of rhein in mouse bone by HPLC","volume":"17","author":"Cui","year":"2008","journal-title":"Chin. J. New Drugs"},{"key":"10.1016\/j.mce.2011.01.018_bib0030","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1359\/jbmr.2002.17.3.394","article-title":"Exposure of KS483 cells to estrogen enhances osteogenesis and inhibits adipogenesis","volume":"17","author":"Dang","year":"2002","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.mce.2011.01.018_bib0035","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1056\/NEJM199803123381107","article-title":"Treatment of postmenopausal osteoporosis","volume":"338","author":"Eastell","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mce.2011.01.018_bib0040","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2165\/00002512-200724050-00002","article-title":"Selective estrogen receptor modulators for postmenopausal osteoporosis: current state of development","volume":"24","author":"Gennari","year":"2007","journal-title":"Drugs Aging"},{"key":"10.1016\/j.mce.2011.01.018_bib0045","doi-asserted-by":"crossref","first-page":"4768","DOI":"10.1210\/endo.141.12.7840","article-title":"The expression of osteoprotegerin and RANK ligand and the support of osteoclast formation by stromal-osteoblast lineage cells is developmentally regulated","volume":"141","author":"Gori","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2011.01.018_bib0050","doi-asserted-by":"crossref","first-page":"4367","DOI":"10.1210\/endo.140.9.7131","article-title":"Estrogen stimulates gene expression and protein production of osteoprotegerin in human osteoblastic cells","volume":"140","author":"Hofbauer","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2011.01.018_bib0055","first-page":"309","article-title":"The roles of endoplasmic reticulum stress and Ca2+ on rhein-induced apoptosis in A-549 human lung cancer cells","volume":"29","author":"Hsia","year":"2009","journal-title":"Anticancer Res."},{"key":"10.1016\/j.mce.2011.01.018_bib0060","first-page":"379","article-title":"The role of Ca+2 on rhein-induced apoptosis in human cervical cancer Ca Ski cells","volume":"27","author":"Ip","year":"2007","journal-title":"Anticancer Res."},{"key":"10.1016\/j.mce.2011.01.018_bib0065","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/jbmr.5650110208","article-title":"Estrogen inhibits interleukin-6 production and gene expression in a human osteoblastic cell line with high levels of estrogen receptors","volume":"11","author":"Kassem","year":"1996","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.mce.2011.01.018_bib0070","doi-asserted-by":"crossref","first-page":"5050","DOI":"10.1210\/endo.142.12.8536","article-title":"The OPG\/RANKL\/RANK system","volume":"142","author":"Khosla","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2011.01.018_bib0075","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1590\/S0004-27302010000200016","article-title":"SERMs in the prevention and treatment of postmenopausal osteoporosis: an update","volume":"54","author":"Kulak J\u00fanior","year":"2010","journal-title":"Arq. Bras. Endocrinol. Metabol."},{"key":"10.1016\/j.mce.2011.01.018_bib0080","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0092-8674(00)81569-X","article-title":"Osteoprotegerin (OPG) ligand is a cytokine that regulates osteoclast differentiation and activation","volume":"93","author":"Lacey","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.mce.2011.01.018_bib0085","first-page":"309","article-title":"Rhein induced apoptosis through the endoplasmic reticulum stress, caspase- and mitochondria-dependent pathways in SCC-4 human tongue squamous cancer cells","volume":"23","author":"Lai","year":"2009","journal-title":"In Vivo"},{"key":"10.1016\/j.mce.2011.01.018_bib0090","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1073\/pnas.97.4.1566","article-title":"RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism","volume":"97","author":"Li","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mce.2011.01.018_bib0095","first-page":"6","article-title":"Synthesis and pharmacological activities of a series of estrogen\u2013rhein hybrid compounds","volume":"38","author":"Li","year":"2007","journal-title":"J. China Pharm. Univ."},{"key":"10.1016\/j.mce.2011.01.018_bib0100","unstructured":"Li, L.Z., Cui, Y., Zhang, Y.L., Cui, Y., 2004. Preparative methods of radix anthraquinone derivatives and active components of these derivatives-based drug combination. Chinese Patent ZL10094131.7."},{"key":"10.1016\/j.mce.2011.01.018_bib0105","first-page":"3313","article-title":"Rhein induces apoptosis through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death pathway in human nasopharyngeal carcinoma cells","volume":"27","author":"Lin","year":"2007","journal-title":"Anticancer Res."},{"key":"10.1016\/j.mce.2011.01.018_bib0110","first-page":"1099","article-title":"Rhein lysinate induces apoptosis in breast cancer SK-Br-3 cells by inhibiting HER-2 signal pathway","volume":"43","author":"Lin","year":"2008","journal-title":"Yao Xue Xue Bao"},{"key":"10.1016\/j.mce.2011.01.018_bib0115","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1097\/CAD.0b013e3283182913","article-title":"Rhein lysinate suppresses the growth of breast cancer cells and potentiates the inhibitory effect of taxol in athymic mice","volume":"20","author":"Lin","year":"2009","journal-title":"Anticancer Drugs"},{"key":"10.1016\/j.mce.2011.01.018_bib0120","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1142\/S0192415X09007417","article-title":"Rhein lysinate suppresses the growth of tumor cells and increases the anti-tumor activity of taxol in mice","volume":"37","author":"Lin","year":"2009","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.mce.2011.01.018_bib0125","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1081\/ERC-120025041","article-title":"Effects of estriol on the proliferation and differentiation of human osteoblastic MG-63 cells","volume":"29","author":"Luo","year":"2003","journal-title":"Endocr. Res."},{"key":"10.1016\/j.mce.2011.01.018_bib0130","doi-asserted-by":"crossref","first-page":"63S","DOI":"10.1016\/8756-3282(95)00180-L","article-title":"Role of cytokines in bone resorption","volume":"17","author":"Manolagas","year":"1995","journal-title":"Bone"},{"key":"10.1016\/j.mce.2011.01.018_bib0135","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1210\/rp.57.1.385","article-title":"Sex steroids and bone","volume":"57","author":"Manolagas","year":"2002","journal-title":"Recent Prog. Horm. Res."},{"key":"10.1016\/j.mce.2011.01.018_bib0140","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.bmcl.2008.12.051","article-title":"Bone selective effect of an estradiol conjugate with a novel tetracycline-derived bone-targeting agent","volume":"19","author":"Neale","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.mce.2011.01.018_bib0145","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/S0960-894X(01)80365-6","article-title":"Synthesis of \u03b2-estradiol-3-benzoate-17-(succinyl-12A-tetracycline): a potential bone-seeking estrogen","volume":"4","author":"Orme","year":"1994","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.mce.2011.01.018_bib0150","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1210\/endo.142.6.8220","article-title":"17\u03b2-estradiol stimulates expression of osteoprotegerin by a mouse stromal cell line, ST-2, via estrogen receptor-\u03b1","volume":"142","author":"Saika","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2011.01.018_bib0155","first-page":"447S","article-title":"Breast cancer endocrine resistance: how growth factor signaling and estrogen receptor coregulators modulate response","volume":"9","author":"Schiff","year":"2003","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.mce.2011.01.018_bib0160","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1182\/blood-2002-09-2684","article-title":"RANK ligand and osteoprotegerin in myeloma bone disease","volume":"101","author":"Sezer","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.mce.2011.01.018_bib0165","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1142\/S0192415X08006259","article-title":"Rhein induces apoptosis and cell cycle arrest in human hepatocellular carcinoma BEL-7402 cells","volume":"36","author":"Shi","year":"2008","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.mce.2011.01.018_bib0170","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0092-8674(00)80209-3","article-title":"Osteoprotegerin: a novel secreted protein involved in the regulation of bone density","volume":"89","author":"Simonet","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.mce.2011.01.018_bib0175","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1210\/mend.13.6.0299","article-title":"The actions and interactions of sex steroids and growth factors\/cytokines on the skeleton","volume":"13","author":"Spelsberg","year":"1999","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.mce.2011.01.018_bib0180","doi-asserted-by":"crossref","first-page":"25163","DOI":"10.1074\/jbc.M000322200","article-title":"The osteoblast-specific transcription factor Cbfa1 contributes to the expression of osteoprotegerin, a potent inhibitor of osteoclast differentiation and function","volume":"275","author":"Thirunavukkarasu","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2011.01.018_bib0185","doi-asserted-by":"crossref","first-page":"36241","DOI":"10.1074\/jbc.M104319200","article-title":"Stimulation of osteoprotegerin (OPG) gene expression by transforming growth factor-\u03b2 (TGF-\u03b2): mapping of the OPG promoter region that mediates TGF-\u03b2 effects","volume":"276","author":"Thirunavukkarasu","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2011.01.018_bib0190","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1211\/0022357001773652","article-title":"Tissue distribution and pharmacological potential of SM-16896, a novel oestrogen\u2013bisphosphonate hybrid compound","volume":"52","author":"Tsushima","year":"2000","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.mce.2011.01.018_bib0195","doi-asserted-by":"crossref","first-page":"4206","DOI":"10.1210\/jc.2002-021877","article-title":"Raloxifene concurrently stimulatesosteoprotegerin and inhibits interleukin-6 production by human trabecular osteoblasts","volume":"88","author":"Viereck","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2011.01.018_bib0200","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1002\/jcb.10087","article-title":"The phytoestrogen genistein stimulates the production of osteoprotegerin by human trabecular osteoblasts","volume":"84","author":"Viereck","year":"2002","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.mce.2011.01.018_bib0205","first-page":"555","article-title":"Inhibitory effect of diacerein on osteoclastic bone destruction and its possible mechanism of action","volume":"41","author":"Wang","year":"2006","journal-title":"Yao Xue Xue Bao"},{"key":"10.1016\/j.mce.2011.01.018_bib0210","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.steroids.2005.03.002","article-title":"Signaling from the membrane via membrane estrogen receptor-alpha: estrogens, xenoestrogens, and phytoestrogens","volume":"70","author":"Watson","year":"2005","journal-title":"Steroids"},{"key":"10.1016\/j.mce.2011.01.018_bib0215","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1177\/153537020322801106","article-title":"Proteins of multiple classes may participate in nongenomic steroid actions","volume":"228","author":"Watson","year":"2003","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.mce.2011.01.018_bib0220","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/0960-894X(96)00164-3","article-title":"Bone targeted drugs 1: identification of heterocycles with hydroxyapatite affinity","volume":"6","author":"Willson","year":"1996","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.mce.2011.01.018_bib0225","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1001\/jama.288.3.321","article-title":"Risks and benefits of estrogen plus progestin in healthy postmenopausal women. Principal results from the women's health initiative randomized controlled trial","volume":"288","author":"Writing Group for the Women's Health Initiative Investigators","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.mce.2011.01.018_bib0230","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1210\/endo.142.3.8024","article-title":"Selective delivery of estradiol to bone by aspartic acid oligopeptide and its effects on ovariectomized mice","volume":"142","author":"Yokogawa","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2011.01.018_bib0235","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1248\/bpb.29.1229","article-title":"Pharmacokinetic advantage of an intranasal preparation of a novel anti-osteoporosis drug, l-asp-hexapeptide-conjugated estradiol","volume":"29","author":"Yokogawa","year":"2006","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.mce.2011.01.018_bib0240","first-page":"1048","article-title":"Research on absorbance ability of radix anthraquinone compounds by hydroxyapatite","volume":"17","author":"Zhang","year":"2008","journal-title":"Acta Academiae Medicinae CPAF"},{"key":"10.1016\/j.mce.2011.01.018_bib0245","first-page":"841","article-title":"The effects of rhein\u2013estrone on the bone mineral density and uterus in ovariectomized rats","volume":"19","author":"Zhang","year":"2010","journal-title":"Acta Academiae Medicinae CPAF"}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720711000542?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720711000542?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T14:01:42Z","timestamp":1759586502000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720711000542"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4]]},"references-count":49,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["S0303720711000542"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2011.01.018","relation":{},"ISSN":["0303-7207"],"issn-type":[{"type":"print","value":"0303-7207"}],"subject":[],"published":{"date-parts":[[2011,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"LC, a novel estrone\u2013rhein hybrid compound, concurrently stimulates osteoprotegerin and inhibits receptor activator of NF-\u03baB ligand (RANKL) and interleukin-6 production by human osteoblastic cells","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2011.01.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}