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Chem."},{"key":"10.1016\/j.mce.2011.05.031_b0440","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1172\/JCI21867","article-title":"Possible involvement of pregnane X receptor-enhanced CYP24 expression in drug-induced osteomalacia","volume":"115","author":"Pascussi","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mce.2011.05.031_b0175","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1056\/NEJM199610103351505","article-title":"A familial syndrome of hypocalcemia with hypercalciuria due to mutations in the calcium-sensing receptor","volume":"335","author":"Pearce","year":"1996","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mce.2011.05.031_b0005","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1196\/annals.1402.088","article-title":"Progress, paradox, and potential: parathyroid hormone research over five decades","volume":"1117","author":"Potts","year":"2007","journal-title":"Ann. N.Y. Acad. 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Metab."},{"key":"10.1016\/j.mce.2011.05.031_b0395","first-page":"348","article-title":"Comparison of glomerular injury in juvenile versus mature rats in a remnant kidney model","volume":"121","author":"Schwartz","year":"1993","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.mce.2011.05.031_b0390","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1093\/carcin\/bgh086","article-title":"Pancreatic cancer cells express 25-hydroxyvitamin D-1 alpha-hydroxylase and their proliferation is inhibited by the prohormone 25-hydroxyvitamin D3","volume":"25","author":"Schwartz","year":"2004","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.mce.2011.05.031_b0305","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1210\/jc.87.6.2967","article-title":"25-Hydroxyvitamin D(3)-1alpha-hydroxylase expression in normal and pathological parathyroid glands","volume":"87","author":"Segersten","year":"2002","journal-title":"J. Clin. Endocrinol. 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Dial."},{"key":"10.1016\/j.mce.2011.05.031_b0295","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.bone.2008.11.016","article-title":"Serum 25-hydroxyvitamin D as an independent determinant of 1\u201384 PTH and bone mineral density in non-diabetic predialysis CKD patients","volume":"44","author":"Tomida","year":"2009","journal-title":"Bone"},{"key":"10.1016\/j.mce.2011.05.031_b0215","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/nature05315","article-title":"Klotho converts canonical FGF receptor into a specific receptor for FGF23","volume":"444","author":"Urakawa","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.mce.2011.05.031_b0280","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1210\/jc.2002-021064","article-title":"Age-related changes in the 25-hydroxyvitamin D versus parathyroid hormone relationship suggest a different reason why older adults require more vitamin D","volume":"88","author":"Vieth","year":"2003","journal-title":"J. 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Endocrinol."},{"key":"10.1016\/j.mce.2011.05.031_b0165","doi-asserted-by":"crossref","first-page":"20082","DOI":"10.1016\/S0021-9258(19)88668-4","article-title":"Up-regulation of the vitamin D receptor in response to 1,25-dihydroxyvitamin D3 results from ligand-induced stabilization","volume":"267","author":"Wiese","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2011.05.031_b0435","first-page":"F203","article-title":"Expression of the renal 25-hydroxyvitamin D-24-hydroxylase gene: regulation by dietary phosphate","volume":"271","author":"Wu","year":"1996","journal-title":"Am. J. 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