{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:38:12Z","timestamp":1791189492357,"version":"4.1.0"},"reference-count":91,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["NS055159"],"award-info":[{"award-number":["NS055159"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["GM093290"],"award-info":[{"award-number":["GM093290"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1016\/j.mce.2011.10.023","type":"journal-article","created":{"date-parts":[[2011,10,28]],"date-time":"2011-10-28T22:02:58Z","timestamp":1319839378000},"page":"68-74","source":"Crossref","is-referenced-by-count":80,"title":["Regulation of TRPM8 channel activity"],"prefix":"10.1016","volume":"353","author":[{"given":"Yevgen","family":"Yudin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tibor","family":"Rohacs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2011.10.023_b0005","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.molbrainres.2005.01.013","article-title":"TRPM8 protein localization in trigeminal ganglion and taste papillae","volume":"136","author":"Abe","year":"2005","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.mce.2011.10.023_b0010","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.neulet.2005.12.005","article-title":"Ca2+-dependent PKC activation mediates menthol-induced desensitization of transient receptor potential M8","volume":"397","author":"Abe","year":"2006","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.mce.2011.10.023_b0015","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1248\/bpb.27.1174","article-title":"Cellular function of calcium-independent phospholipase A2","volume":"27","author":"Akiba","year":"2004","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.mce.2011.10.023_b0020","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.1523\/JNEUROSCI.4846-06.2007","article-title":"Modulation of the cold-activated channel TRPM8 by lysophospholipids and polyunsaturated fatty acids","volume":"27","author":"Andersson","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mce.2011.10.023_b0025","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1111\/j.1460-9568.2006.04941.x","article-title":"A novel type of cold-sensitive neuron in rat dorsal root ganglia with rapid adaptation to cooling stimuli","volume":"24","author":"Babes","year":"2006","journal-title":"Eur. J. NeuroSci."},{"key":"10.1016\/j.mce.2011.10.023_b0030","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nn1665","article-title":"High-throughput random mutagenesis screen reveals TRPM8 residues specifically required for activation by menthol","volume":"9","author":"Bandell","year":"2006","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.mce.2011.10.023_b0035","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/nature05910","article-title":"The menthol receptor TRPM8 is the principal detector of environmental cold","volume":"448","author":"Bautista","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.mce.2011.10.023_b0040","doi-asserted-by":"crossref","first-page":"9410","DOI":"10.1074\/jbc.M109.069377","article-title":"The transient receptor potential channel TRPM8 is inhibited via the alpha 2A adrenoreceptor signaling pathway","volume":"285","author":"Bavencoffe","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2011.10.023_b0045","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/sj.bjp.0705652","article-title":"Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay","volume":"141","author":"Behrendt","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.mce.2011.10.023_b0055","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1677\/erc.1.00969","article-title":"Evidence for specific TRPM8 expression in human prostate secretory epithelial cells: functional androgen receptor requirement","volume":"12","author":"Bidaux","year":"2005","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.mce.2011.10.023_b0050","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1172\/JCI30168","article-title":"Prostate cell differentiation status determines transient receptor potential melastatin member 8 channel subcellular localization and function","volume":"117","author":"Bidaux","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mce.2011.10.023_b0060","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.ceca.2007.03.005","article-title":"Characterisation of TRPM8 as a pharmacophore receptor","volume":"42","author":"Bodding","year":"2007","journal-title":"Cell Calcium"},{"key":"10.1016\/j.mce.2011.10.023_b0065","doi-asserted-by":"crossref","first-page":"15494","DOI":"10.1073\/pnas.0406773101","article-title":"Clues to understanding cold sensation: thermodynamics and electrophysiological analysis of the cold receptor TRPM8","volume":"101","author":"Brauchi","year":"2004","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.mce.2011.10.023_b0070","doi-asserted-by":"crossref","first-page":"e7383","DOI":"10.1371\/journal.pone.0007383","article-title":"The contribution of TRPM8 and TRPA1 channels to cold allodynia and neuropathic pain","volume":"4","author":"Caspani","year":"2009","journal-title":"PLoS ONE"},{"key":"10.1016\/j.mce.2011.10.023_b0075","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/1471-2407-10-212","article-title":"Estrogen regulation of TRPM8 expression in breast cancer cells","volume":"10","author":"Chodon","year":"2010","journal-title":"BMC Cancer"},{"key":"10.1016\/j.mce.2011.10.023_b0080","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.neuron.2004.08.038","article-title":"The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel","volume":"43","author":"Chuang","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.mce.2011.10.023_b0085","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nature02196","article-title":"TRP channels as cellular sensors","volume":"426","author":"Clapham","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.mce.2011.10.023_b0090","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.neuron.2007.04.017","article-title":"Attenuated cold sensitivity in TRPM8 null mice","volume":"54","author":"Colburn","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.mce.2011.10.023_b0095","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1074\/jbc.M807270200","article-title":"The activity of the neuronal cold sensor TRPM8 is regulated by phospholipase C via the phospholipid phosphoinositol-4,5-bisphosphate","volume":"284","author":"Daniels","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2011.10.023_b0100","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1016\/j.yexcr.2007.01.008","article-title":"Regulation of transient receptor potential channels of melastatin type 8 (TRPM8): effect of cAMP, cannabinoid CB(1) receptors and endovanilloids","volume":"313","author":"De Petrocellis","year":"2007","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.mce.2011.10.023_b0110","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.neuron.2007.02.024","article-title":"TRPM8 is required for cold sensation in mice","volume":"54","author":"Dhaka","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.mce.2011.10.023_b0105","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1523\/JNEUROSCI.3976-07.2008","article-title":"Visualizing cold spots: TRPM8-expressing sensory neurons and their projections","volume":"28","author":"Dhaka","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mce.2011.10.023_b0115","first-page":"56","article-title":"Menthol-induced asthma: a case report","volume":"11","author":"dos Santos","year":"2001","journal-title":"J. Investig. Allergol. Clin. Immunol."},{"key":"10.1016\/j.mce.2011.10.023_b0120","first-page":"221","article-title":"Multiple tumor marker analyses (PSA, hK2, PSCA, trp-p8) in primary prostate cancers using quantitative RT-PCR","volume":"23","author":"Fuessel","year":"2003","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.mce.2011.10.023_b0125","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0304-3940(01)02527-7","article-title":"Menthol: a natural analgesic compound","volume":"322","author":"Galeotti","year":"2002","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.mce.2011.10.023_b0130","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1744-8069-6-4","article-title":"The roles of iPLA2, TRPM8 and TRPA1 in chemically induced cold hypersensitivity","volume":"6","author":"Gentry","year":"2010","journal-title":"Mol. Pain"},{"key":"10.1016\/j.mce.2011.10.023_b0140","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1139\/h95-023","article-title":"Exercise- and cold-induced asthma","volume":"20","author":"Giesbrecht","year":"1995","journal-title":"Can. J. Appl. Physiol."},{"key":"10.1016\/j.mce.2011.10.023_b0135","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1152\/jappl.1993.74.1.24","article-title":"Cooling the pulmonary blood in dogs alters activity of pulmonary vagal afferents","volume":"74","author":"Giesbrecht","year":"1993","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.mce.2011.10.023_b0145","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/j.pain.2011.01.027","article-title":"A novel role for TRPM8 in visceral afferent function","volume":"152","author":"Harrington","year":"2011","journal-title":"Pain"},{"key":"10.1016\/j.mce.2011.10.023_b0150","first-page":"4196","article-title":"Survival analysis of genome-wide gene expression profiles of prostate cancers identifies new prognostic targets of disease relapse","volume":"63","author":"Henshall","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.mce.2011.10.023_b0155","doi-asserted-by":"crossref","unstructured":"Hilgemann, D.W., Feng, S., Nasuhoglu, C., 2001. The complex and intriguing lives of PIP2 with ion channels and transporters. Sci. STKE RE19.","DOI":"10.1126\/stke.2001.111.re19"},{"key":"10.1016\/j.mce.2011.10.023_b0160","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/35882","article-title":"Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by G\u03b2\u03b3","volume":"391","author":"Huang","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.mce.2011.10.023_b0165","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.pupt.2008.07.001","article-title":"Inhibition by the cold receptor agonists menthol and icilin of airway smooth muscle contraction","volume":"21","author":"Ito","year":"2008","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.mce.2011.10.023_b0170","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0034-5687(83)90112-3","article-title":"Respiratory effects of cold air breathing in anesthetized cats","volume":"54","author":"Jammes","year":"1983","journal-title":"Respir. Physiol."},{"key":"10.1016\/j.mce.2011.10.023_b0175","doi-asserted-by":"crossref","first-page":"H1868","DOI":"10.1152\/ajpheart.01112.2008","article-title":"Transient receptor potential melastatin 8 channel involvement in the regulation of vascular tone","volume":"296","author":"Johnson","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.mce.2011.10.023_b0180","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/nature02282","article-title":"Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1","volume":"427","author":"Jordt","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.mce.2011.10.023_b0185","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0954-6111(96)90300-5","article-title":"Menthol and aspirin-induced asthma","volume":"90","author":"Kawane","year":"1996","journal-title":"Respir. Med."},{"key":"10.1016\/j.mce.2011.10.023_b0190","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.bbr.2010.04.015","article-title":"Topical application of l-menthol induces heat analgesia, mechanical allodynia, and a biphasic effect on cold sensitivity in rats","volume":"212","author":"Klein","year":"2010","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.mce.2011.10.023_b0195","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.pain.2010.05.021","article-title":"TRPM8, but not TRPA1, is required for neural and behavioral responses to acute noxious cold temperatures and cold-mimetics in vivo","volume":"150","author":"Knowlton","year":"2010","journal-title":"Pain"},{"key":"10.1016\/j.mce.2011.10.023_b0200","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.jss.2006.09.034","article-title":"Androgen receptor blockade in experimental combination therapy of pancreatic cancer","volume":"142","author":"Konduri","year":"2007","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.mce.2011.10.023_b0205","doi-asserted-by":"crossref","first-page":"F803","DOI":"10.1152\/ajprenal.90269.2008","article-title":"AMTB, a TRPM8 channel blocker: evidence in rats for activity in overactive bladder and painful bladder syndrome","volume":"295","author":"Lashinger","year":"2008","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.mce.2011.10.023_b0210","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s00221-006-0712-3","article-title":"Desensitization of cold- and menthol-sensitive rat dorsal root ganglion neurones by inflammatory mediators","volume":"178","author":"Linte","year":"2007","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.mce.2011.10.023_b0215","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1523\/JNEUROSCI.3632-04.2005","article-title":"Functional control of cold- and menthol-sensitive TRPM8 ion channels by phosphatidylinositol 4,5-bisphosphate","volume":"25","author":"Liu","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mce.2011.10.023_b0220","doi-asserted-by":"crossref","first-page":"7070","DOI":"10.1523\/JNEUROSCI.1866-07.2007","article-title":"Dual regulation of TRPV1 by phosphoinositides","volume":"27","author":"Lukacs","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mce.2011.10.023_b0225","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1113\/jphysiol.2006.123059","article-title":"Bidirectional shifts of TRPM8 channel gating by temperature and chemical agents modulate the cold sensitivity of mammalian thermoreceptors","volume":"581","author":"Malkia","year":"2007","journal-title":"J. Physiol."},{"key":"10.1016\/j.mce.2011.10.023_b0230","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/nature719","article-title":"Identification of a cold receptor reveals a general role for TRP channels in thermosensation","volume":"416","author":"McKemy","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.mce.2011.10.023_b0235","doi-asserted-by":"crossref","first-page":"13338","DOI":"10.1523\/JNEUROSCI.2108-10.2010","article-title":"Ca2+-dependent desensitization of TRPV2 channels is mediated by hydrolysis of phosphatidylinositol 4,5-bisphosphate","volume":"30","author":"Mercado","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mce.2011.10.023_b0240","doi-asserted-by":"crossref","unstructured":"Montell, C., 2001. Physiology, phylogeny, and functions of the TRP superfamily of cation channels. Sci STKE RE1.","DOI":"10.1126\/stke.2001.90.re1"},{"key":"10.1016\/j.mce.2011.10.023_b0245","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1471-2490-6-6","article-title":"Cool and menthol receptor TRPM8 in human urinary bladder disorders and clinical correlations","volume":"6","author":"Mukerji","year":"2006","journal-title":"BMC Urol."},{"key":"10.1016\/j.mce.2011.10.023_b0250","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.ceca.2006.07.008","article-title":"Many cold sensitive peripheral neurons of the mouse do not express TRPM8 or TRPA1","volume":"41","author":"Munns","year":"2007","journal-title":"Cell Calcium"},{"key":"10.1016\/j.mce.2011.10.023_b0255","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1038\/emboj.2008.217","article-title":"Transient receptor potential channels meet phosphoinositides","volume":"27","author":"Nilius","year":"2008","journal-title":"EMBO J."},{"key":"10.1016\/j.mce.2011.10.023_b0260","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1038\/emboj.2009.57","article-title":"The mechano-activated K+ channels TRAAK and TREK-1 control both warm and cold perception","volume":"28","author":"Noel","year":"2009","journal-title":"EMBO J."},{"key":"10.1016\/j.mce.2011.10.023_b0270","doi-asserted-by":"crossref","first-page":"3994","DOI":"10.1523\/JNEUROSCI.22-10-03994.2002","article-title":"Ionic basis of cold receptors acting as thermostats","volume":"22","author":"Okazawa","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mce.2011.10.023_b0265","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.neulet.2004.01.074","article-title":"Noxious heat receptors present in cold-sensory cells in rats","volume":"359","author":"Okazawa","year":"2004","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.mce.2011.10.023_b0275","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S0092-8674(02)00652-9","article-title":"A TRP channel that senses cold stimuli and menthol","volume":"108","author":"Peier","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.mce.2011.10.023_b0280","doi-asserted-by":"crossref","first-page":"11322","DOI":"10.1523\/JNEUROSCI.3006-05.2005","article-title":"Downregulation of transient receptor potential melastatin 8 by protein kinase C-mediated dephosphorylation","volume":"25","author":"Premkumar","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mce.2011.10.023_b0285","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/j.cub.2006.07.061","article-title":"Analgesia mediated by the TRPM8 cold receptor in chronic neuropathic pain","volume":"16","author":"Proudfoot","year":"2006","journal-title":"Curr. Biol."},{"key":"10.1016\/j.mce.2011.10.023_b0290","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1146\/annurev.physiol.68.040204.100431","article-title":"An introduction to TRP channels","volume":"68","author":"Ramsey","year":"2006","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.mce.2011.10.023_b0295","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1007\/s00424-005-1437-z","article-title":"ThermoTRP channels and cold sensing: what are they really up to?","volume":"451","author":"Reid","year":"2005","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.mce.2011.10.023_b0300","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/35097164","article-title":"Physiology. Cold current in thermoreceptive neurons","volume":"413","author":"Reid","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.mce.2011.10.023_b0305","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.ceca.2009.03.011","article-title":"Phosphoinositide regulation of non-canonical transient receptor potential channels","volume":"45","author":"Rohacs","year":"2009","journal-title":"Cell Calcium"},{"key":"10.1016\/j.mce.2011.10.023_b0310","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/nn1451","article-title":"PI(4,5)2 regulates the activation and desensitization of TRPM8 channels through the TRP domain","volume":"8","author":"Rohacs","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.mce.2011.10.023_b0315","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s12035-008-8027-y","article-title":"Phospholipase C mediated modulation of TRPV1 channels","volume":"37","author":"Rohacs","year":"2008","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.mce.2011.10.023_b0320","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1744-8069-6-47","article-title":"Menthol response and adaptation in nociceptive-like and nonnociceptive-like neurons: role of protein kinases","volume":"6","author":"Sarria","year":"2010","journal-title":"Mol. Pain"},{"key":"10.1016\/j.mce.2011.10.023_b0325","doi-asserted-by":"crossref","unstructured":"Sarria, I., Ling, J., Zhu, M.X., Gu, J.G., in press. TRPM8 acute desensitization is mediated by calmodulin and requires PIP2: distinction from tachyphylaxis. J. Neurophysiol.","DOI":"10.1152\/jn.00544.2011"},{"key":"10.1016\/j.mce.2011.10.023_b0330","first-page":"242","article-title":"Characterization of selective TRPM8 ligands and their structure activity response (S.A.R.) relationship","volume":"13","author":"Sherkheli","year":"2010","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.mce.2011.10.023_b0335","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1097\/01.wnr.0000126559.35631.54","article-title":"Cold-sensitive, menthol-insensitive neurons in the murine sympathetic nervous system","volume":"15","author":"Smith","year":"2004","journal-title":"NeuroReport"},{"key":"10.1016\/j.mce.2011.10.023_b0340","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1097\/01.ju.0000134880.55119.cf","article-title":"Cool (TRPM8) and hot (TRPV1) receptors in the bladder and male genital tract","volume":"172","author":"Stein","year":"2004","journal-title":"J. Urol."},{"key":"10.1016\/j.mce.2011.10.023_b0345","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S0092-8674(03)00158-2","article-title":"ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures","volume":"112","author":"Story","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.mce.2011.10.023_b0350","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1146\/annurev.biophys.37.032807.125859","article-title":"PIP2 is a necessary cofactor for ion channel function: how and why?","volume":"37","author":"Suh","year":"2008","journal-title":"Annu. Rev. Biophys."},{"key":"10.1016\/j.mce.2011.10.023_b0355","doi-asserted-by":"crossref","first-page":"14147","DOI":"10.1523\/JNEUROSCI.4578-07.2007","article-title":"Diversity in the neural circuitry of cold sensing revealed by genetic axonal labeling of transient receptor potential melastatin 8 neurons","volume":"27","author":"Takashima","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mce.2011.10.023_b0360","doi-asserted-by":"crossref","first-page":"39423","DOI":"10.1074\/jbc.M503544200","article-title":"Novel role of cold\/menthol-sensitive transient receptor potential melastatine family member 8 (TRPM8) in the activation of store-operated channels in LNCaP human prostate cancer epithelial cells","volume":"280","author":"Thebault","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2011.10.023_b0370","doi-asserted-by":"crossref","first-page":"48149","DOI":"10.1074\/jbc.M103977200","article-title":"Expression of Trp3 determines sensitivity of capacitative Ca2+ entry to nitric oxide and mitochondrial Ca2+ handling: evidence for a role of Trp3 as a subunit of capacitative Ca2+ entry channels","volume":"276","author":"Thyagarajan","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2011.10.023_b0365","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1124\/mol.108.052449","article-title":"Phospholipase C mediated regulation of TRPV6 channels: implications in active intestinal Ca2+transport","volume":"75","author":"Thyagarajan","year":"2009","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.mce.2011.10.023_b0375","first-page":"3760","article-title":"Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins","volume":"61","author":"Tsavaler","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.mce.2011.10.023_b0380","doi-asserted-by":"crossref","first-page":"40174","DOI":"10.1074\/jbc.M605779200","article-title":"Ca2+-independent phospholipase A2-dependent gating of TRPM8 by lysophospholipids","volume":"281","author":"Vanden Abeele","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2011.10.023_b0385","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1083\/jcb.200607116","article-title":"Rapidly inducible changes in phosphatidylinositol 4,5-bisphosphate levels influence multiple regulatory functions of the lipid in intact cells","volume":"175","author":"Varnai","year":"2006","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.mce.2011.10.023_b0390","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/nature02732","article-title":"The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels","volume":"430","author":"Voets","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.mce.2011.10.023_b0395","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1111\/j.1526-4637.2007.00290.x","article-title":"The effect of menthol on cold allodynia in patients with neuropathic pain","volume":"9","author":"Wasner","year":"2008","journal-title":"Pain Med."},{"key":"10.1016\/j.mce.2011.10.023_b0400","doi-asserted-by":"crossref","unstructured":"Willis, D.N., Liu, B., Ha, M.A., Jordt, S.E., Morris, J.B., in press. Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritants. FASEB J.","DOI":"10.1096\/fj.11-188383"},{"key":"10.1016\/j.mce.2011.10.023_b0405","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1038\/sj.bjp.0701319","article-title":"Capsaicin and neurokinin A-induced bronchoconstriction in the anaesthetised guinea-pig: evidence for a direct action of menthol on isolated bronchial smooth muscle","volume":"121","author":"Wright","year":"1997","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.mce.2011.10.023_b0410","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1744-8069-4-22","article-title":"TRPM8 mechanism of autonomic nerve response to cold in respiratory airway","volume":"4","author":"Xing","year":"2008","journal-title":"Mol. Pain"},{"key":"10.1016\/j.mce.2011.10.023_b0415","doi-asserted-by":"crossref","first-page":"C296","DOI":"10.1152\/ajpcell.00499.2007","article-title":"TRPM8 activation suppresses cellular viability in human melanoma","volume":"295","author":"Yamamura","year":"2008","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.mce.2011.10.023_b0420","doi-asserted-by":"crossref","first-page":"L1267","DOI":"10.1152\/ajplung.00515.2005","article-title":"Functional expression of transient receptor potential melastatin- and vanilloid-related channels in pulmonary arterial and aortic smooth muscle","volume":"290","author":"Yang","year":"2006","journal-title":"Am. J Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.mce.2011.10.023_b0425","doi-asserted-by":"crossref","first-page":"e46","DOI":"10.1371\/journal.pbio.1000046","article-title":"Interaction with phosphoinositides confers adaptation onto the TRPV1 pain receptor","volume":"7","author":"Yao","year":"2009","journal-title":"PLoS Biol."},{"key":"10.1016\/j.mce.2011.10.023_b0430","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.canlet.2010.04.023","article-title":"Transient receptor potential channel TRPM8 is over-expressed and required for cellular proliferation in pancreatic adenocarcinoma","volume":"297","author":"Yee","year":"2010","journal-title":"Cancer Lett."},{"key":"10.1016\/j.mce.2011.10.023_b0435","doi-asserted-by":"crossref","unstructured":"Yudin, Y., Lukacs, V., Cao, C., Rohacs, T., in press. Decrease in phosphatidylinositol 4,5-bisphosphate levels mediates desensitization of the cold sensor TRPM8 channels. J. Physiol.","DOI":"10.1113\/jphysiol.2011.220228"},{"key":"10.1016\/j.mce.2011.10.023_b0445","doi-asserted-by":"crossref","first-page":"e5404","DOI":"10.1371\/journal.pone.0005404","article-title":"Inorganic polyphosphate modulates TRPM8 channels","volume":"4","author":"Zakharian","year":"2009","journal-title":"PLoS ONE"},{"key":"10.1016\/j.mce.2011.10.023_b0440","doi-asserted-by":"crossref","first-page":"12526","DOI":"10.1523\/JNEUROSCI.3189-10.2010","article-title":"Gating of Transient Receptor Potential Melastatin 8 (TRPM8) channels activated by cold and chemical agonists in planar lipid bilayers","volume":"30","author":"Zakharian","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mce.2011.10.023_b0455","doi-asserted-by":"crossref","first-page":"8365","DOI":"10.1158\/0008-5472.CAN-04-2146","article-title":"Evidence that TRPM8 is an androgen-dependent Ca2+ channel required for the survival of prostate cancer cells","volume":"64","author":"Zhang","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.mce.2011.10.023_b0450","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/11103","article-title":"Activation of inwardly rectifying K+ channels by distinct PtdIns(4,5)P2 interactions","volume":"1","author":"Zhang","year":"1999","journal-title":"Nat. Cell Biol."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030372071100637X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030372071100637X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T15:50:48Z","timestamp":1560873048000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030372071100637X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":91,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S030372071100637X"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2011.10.023","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]}}}