{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:08:43Z","timestamp":1790842123264,"version":"4.1.0"},"reference-count":183,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1016\/j.mce.2012.01.025","type":"journal-article","created":{"date-parts":[[2012,2,4]],"date-time":"2012-02-04T15:31:30Z","timestamp":1328369490000},"page":"43-52","source":"Crossref","is-referenced-by-count":50,"title":["Cell-type specific modulation of pituitary cells by activin, inhibin and follistatin"],"prefix":"10.1016","volume":"359","author":[{"given":"Louise M.","family":"Bilezikjian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Justice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alissa N.","family":"Blackler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezra","family":"Wiater","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wylie W.","family":"Vale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2012.01.025_b0105","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1210\/jc.81.2.783","article-title":"Tumor-specific expression and alternate splicing of messenger ribonucleic acid encoding activin\/transforming growth factor-beta receptors in human pituitary adenomas","volume":"81","author":"Alexander","year":"1996","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2012.01.025_b0320","doi-asserted-by":"crossref","first-page":"7643","DOI":"10.1073\/pnas.0602558103","article-title":"Structure of the ternary signaling complex of a TGF-b superfamily member","volume":"103","author":"Allendorph","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mce.2012.01.025_b0035","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0303-7207(01)00562-7","article-title":"Endocrine regulation of testicular function in men: implications for contraceptive development","volume":"182","author":"Amory","year":"2001","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2012.01.025_b0250","doi-asserted-by":"crossref","first-page":"33059","DOI":"10.1074\/jbc.M804190200","article-title":"An activin\/furin regulatory loop modulates the processing and secretion of inhibin alpha- and betaB-subunit dimers in pituitary gonadotrope cells","volume":"283","author":"Antenos","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2012.01.025_b0370","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0955-0674(99)00081-2","article-title":"Smads as transcriptional co-modulators","volume":"12","author":"Attisano","year":"2000","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.mce.2012.01.025_b0750","doi-asserted-by":"crossref","first-page":"5409","DOI":"10.1038\/sj.onc.1204720","article-title":"FLRG, an activin-binding protein, is a new target of TGFbeta transcription activation through Smad proteins","volume":"20","author":"Bartholin","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.mce.2012.01.025_b0755","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1038\/sj.onc.1205294","article-title":"Transcription activation of FLRG and follistatin by activin A, through Smad proteins, participates in a negative feedback loop to modulate activin A function","volume":"21","author":"Bartholin","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.mce.2012.01.025_b0700","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1210\/en.137.5.1634","article-title":"Gonadotropin-releasing hormone regulation of pituitary follistatin gene expression during the primary follicle-stimulating hormone surge","volume":"137","author":"Bauer-Dantoin","year":"1996","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2012.01.025_b0900","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.tig.2011.03.003","article-title":"Forkhead transcription factors: key players in health and disease","volume":"27","author":"Benayoun","year":"2011","journal-title":"Trends Genet."},{"key":"10.1016\/j.mce.2012.01.025_b0190","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1016\/j.fertnstert.2010.03.034","article-title":"Mechanisms of FSH synthesis: what we know, what we don\u2019t, and why you should care","volume":"93","author":"Bernard","year":"2010","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.mce.2012.01.025_b0695","doi-asserted-by":"crossref","first-page":"3667","DOI":"10.1210\/en.137.9.3667","article-title":"Gonadotropin-releasing hormone regulates follicle-stimulating hormone-\u03b2 gene expression through an activin\/follistatin autocrine or paracrine loop","volume":"137","author":"Besecke","year":"1996","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2012.01.025_b0705","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1210\/en.138.7.2841","article-title":"Pituitary follistatin regulates activin-mediated production of follicle-stimulating hormone during the rat estrous cycle","volume":"138","author":"Besecke","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2012.01.025_b0180","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1210\/endo-126-5-2369","article-title":"Activin-A modulates growth hormone secretion from cultures of rat anterior pituitary cells","volume":"126","author":"Bilezikjian","year":"1990","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2012.01.025_b0680","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1210\/en.133.6.2554","article-title":"Activin-A regulates follistatin secretion from cultured rat anterior pituitary cells","volume":"133","author":"Bilezikjian","year":"1993","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2012.01.025_b0225","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1210\/en.133.6.2545","article-title":"Characterization and the regulation of inhibin\/activin subunit proteins of cultured rat anterior pituitary cells","volume":"133","author":"Bilezikjian","year":"1993","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2012.01.025_b0265","doi-asserted-by":"crossref","first-page":"4277","DOI":"10.1210\/en.137.10.4277","article-title":"Pituitary follistatin and inhibin subunit mRNA levels are differentially regulated by local and hormonal factors","volume":"137","author":"Bilezikjian","year":"1996","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2012.01.025_b0260","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1210\/en.142.3.1065","article-title":"Regulation and actions of Smad7 in the modulation of activin, inhibin and TGFb signaling in anterior pituitary cells","volume":"142","author":"Bilezikjian","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2012.01.025_b0220","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1210\/en.2002-220703","article-title":"Rat anterior pituitary folliculo-stellate cells are targets of interleukin-1b and a major source of intrapituitary follistatin","volume":"144","author":"Bilezikjian","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2012.01.025_b0025","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1530\/rep.1.01073","article-title":"Pituitary actions of ligands of the transforming growth factor-b family: activins and inhibin","volume":"132","author":"Bilezikjian","year":"2006","journal-title":"Reproduction"},{"key":"10.1016\/j.mce.2012.01.025_b0185","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1210\/mend-4-2-356","article-title":"Inhibition of somatotroph growth and GH biosynthesis by activin in vitro","volume":"4","author":"Billestrup","year":"1990","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.mce.2012.01.025_b0740","doi-asserted-by":"crossref","first-page":"7016","DOI":"10.1074\/jbc.M709502200","article-title":"A SMAD-binding element in intron 1 participates in activin-dependent regulation of the follistatin gene","volume":"283","author":"Blount","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2012.01.025_b0745","doi-asserted-by":"crossref","first-page":"7631","DOI":"10.1074\/jbc.M806676200","article-title":"FoxL2 and Smad3 coordinately regulate follistatin gene transcription","volume":"284","author":"Blount","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2012.01.025_b0725","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1095\/biolreprod62.3.636","article-title":"Follistatin suppresses steroid-enhanced follicle-stimulating hormone release in vitro in rats","volume":"62","author":"Bohnsack","year":"2000","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2012.01.025_b0420","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/jcb.21255","article-title":"A tale of two proteins: differential roles and regulation of Smad2 and Smad3 in TGF-beta signaling","volume":"101","author":"Brown","year":"2007","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.mce.2012.01.025_b0015","doi-asserted-by":"crossref","first-page":"12515","DOI":"10.1073\/pnas.1105929108","article-title":"Related pituitary cell lineages develop into interdigitated 3D cell networks","volume":"108","author":"Budry","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mce.2012.01.025_b0040","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1677\/jme.1.01600","article-title":"Regulation of gonadotropin subunit gene transcription","volume":"33","author":"Burger","year":"2004","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.mce.2012.01.025_b0270","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1210\/er.2002-0003","article-title":"Genetic analysis of the mammalian transforming growth factor-beta superfamily","volume":"23","author":"Chang","year":"2002","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.mce.2012.01.025_b0485","doi-asserted-by":"crossref","first-page":"5640","DOI":"10.1210\/en.2003-0670","article-title":"Betaglycan localization in the female rat pituitary: implications for the regulation of follicle-stimulating hormone by inhibin","volume":"144","author":"Chapman","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2012.01.025_b0395","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/38008","article-title":"Smad4 and FAST-1 in the assembly of activin-responsive factor","volume":"389","author":"Chen","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.mce.2012.01.025_b0915","doi-asserted-by":"crossref","first-page":"e17924","DOI":"10.1371\/journal.pone.0017924","article-title":"Lineage-specific restraint of pituitary gonadotroph cell adenoma growth","volume":"6","author":"Chesnokova","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.mce.2012.01.025_b0450","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1210\/en.141.7.2600","article-title":"Structure and expression of a membrane component of the inhibin receptor system [see comments]","volume":"141","author":"Chong","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2012.01.025_b0805","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1136\/jmg.39.12.916","article-title":"Evolution and expression of FOXL2","volume":"39","author":"Cocquet","year":"2002","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.mce.2012.01.025_b0885","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1210\/me.2009-0425","article-title":"FoxL2 Is required for activin induction of the mouse and human follicle-stimulating hormone beta-subunit genes","volume":"24","author":"Corpuz","year":"2010","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.mce.2012.01.025_b0200","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1210\/endo-128-3-1682","article-title":"Evidence for an autocrine role of activin B within rat anterior pituitary cultures","volume":"128","author":"Corrigan","year":"1991","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2012.01.025_b0245","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1210\/me.2005-0047","article-title":"Activin regulates luteinizing hormone beta-subunit gene expression through Smad-binding and homeobox elements","volume":"19","author":"Coss","year":"2005","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.mce.2012.01.025_b0810","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/84781","article-title":"The putative forkhead transcription factor FOXL2 is mutated in blepharophimosis\/ptosis\/epicanthus inversus syndrome","volume":"27","author":"Crisponi","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mce.2012.01.025_b0720","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1210\/en.139.6.2818","article-title":"Regulation of pituitary follistatin and inhibin\/activin subunit messenger ribonucleic acids (mRNAs) in male and female rats: evidence for inhibin regulation of follistatin mRNA in females","volume":"139","author":"Dalkin","year":"1998","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2012.01.025_b0095","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1210\/jc.85.3.1009","article-title":"Activin effects on neoplastic proliferation of human pituitary tumors","volume":"85","author":"Danila","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2012.01.025_b0120","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.mce.2009.12.012","article-title":"Molecular mechanisms of pituitary organogenesis: in search of novel regulatory genes","volume":"323","author":"Davis","year":"2010","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2012.01.025_b0845","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1093\/hmg\/10.15.1591","article-title":"Spectrum of FOXL2 gene mutations in blepharophimosis\u2013ptosis\u2013epicanthus inversus (BPES) families demonstrates a genotype\u2013phenotype correlation","volume":"10","author":"De Baere","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mce.2012.01.025_b0765","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1023\/A:1007159031000","article-title":"Cloning and analysis of the mouse follistatin promoter","volume":"27","author":"de Groot","year":"2000","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.mce.2012.01.025_b0530","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/humupd\/8.6.529","article-title":"Inhibins, activins and follistatin in reproduction","volume":"8","author":"de Kretser","year":"2002","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.mce.2012.01.025_b0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2826.2007.01616.x","article-title":"Paracrinicity: the story of 30years of cellular pituitary crosstalk","volume":"20","author":"Denef","year":"2008","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.mce.2012.01.025_b0565","doi-asserted-by":"crossref","first-page":"328","DOI":"10.3181\/00379727-214-44100","article-title":"Inhibins, activins, and follistatins: the saga continues","volume":"214","author":"DePaolo","year":"1997","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.mce.2012.01.025_b0610","doi-asserted-by":"crossref","first-page":"500","DOI":"10.3181\/00379727-198-43286A","article-title":"Follistatin and activin: a potential intrinsic regulatory system within diverse tissues","volume":"198","author":"DePaolo","year":"1991","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.mce.2012.01.025_b0205","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1210\/en.130.3.1741","article-title":"Passive immunoneutralization with a monoclonal antibody reveals a role for endogenous activin-B in mediating FSH hypersecretion during estrus and following ovariectomy of hypophysectomized, pituitary-grafted rats","volume":"130","author":"DePaolo","year":"1992","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2012.01.025_b0690","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1210\/en.132.5.2221","article-title":"Increased follistatin (activin-binding protein) gene expression in rat anterior pituitary tissue after ovariectomy may be mediated by pituitary activin","volume":"132","author":"DePaolo","year":"1993","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2012.01.025_b0365","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0092-8674(00)81696-7","article-title":"Smads: transcriptional activators of TGF-beta responses","volume":"95","author":"Derynck","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.mce.2012.01.025_b0445","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1074\/jbc.273.1.398","article-title":"Identification of an inhibin receptor in gonadal tumors from inhibin alpha-subunit knockout mice","volume":"273","author":"Draper","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2012.01.025_b0415","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1242\/dev.01072","article-title":"Combinatorial activities of Smad2 and Smad3 regulate mesoderm formation and patterning in the mouse embryo","volume":"131","author":"Dunn","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.mce.2012.01.025_b0870","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/modpathol.2010.169","article-title":"Expression of FOXL2 in human normal pituitaries and pituitary adenomas","volume":"24","author":"Egashira","year":"2011","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.mce.2012.01.025_b0240","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0303-7207(03)00235-1","article-title":"The gonadotropin releasing hormone (GnRH) receptor activating sequence (GRAS) is a composite regulatory element that interacts with multiple classes of transcription factors including Smads, AP-1 and a forkhead DNA binding protein","volume":"206","author":"Ellsworth","year":"2003","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2012.01.025_b0865","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.1210\/me.2005-0303","article-title":"FOXL2 in the pituitary: molecular, genetic, and developmental analysis","volume":"20","author":"Ellsworth","year":"2006","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.mce.2012.01.025_b0130","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1242\/dev.125.6.1005","article-title":"Integrated FGF and BMP signaling controls the progression of progenitor cell differentiation and the emergence of pattern in the embryonic anterior pituitary","volume":"125","author":"Ericson","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.mce.2012.01.025_b0495","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.mce.2009.03.021","article-title":"Reducing betaglycan expression by RNA interference (RNAi) attenuates inhibin bioactivity in LbetaT2 gonadotropes","volume":"307","author":"Escalona","year":"2009","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2012.01.025_b0600","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1210\/mend-1-11-849","article-title":"Structural characterization of follistatin: a novel follicle-stimulating hormone release-inhibiting polypeptide from the gonad","volume":"1","author":"Esch","year":"1987","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.mce.2012.01.025_b0500","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1210\/me.2002-0014","article-title":"Transforming Growth Factor-\u03b2 Modulates Inhibin A Bioactivity in the L\u03b2T2 Gonadotrope Cell Line by Competing for Binding to Betaglycan","volume":"16","author":"Ethier","year":"2002","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.mce.2012.01.025_b0675","doi-asserted-by":"crossref","first-page":"4397","DOI":"10.1210\/en.136.10.4397","article-title":"Ovine anterior pituitary production of follistatin in vitro","volume":"136","author":"Farnworth","year":"1995","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2012.01.025_b0435","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0303-7207(01)00499-3","article-title":"Inhibin binding sites and proteins in pituitary, gonadal, adrenal and bone cells","volume":"180","author":"Farnworth","year":"2001","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2012.01.025_b0510","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1677\/joe.1.06444","article-title":"Rodent adrenocortical cells display high affinity binding sites and proteins for inhibin A, and express components required for autocrine signalling by activins and bone morphogenetic proteins","volume":"188","author":"Farnworth","year":"2006","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.mce.2012.01.025_b0465","doi-asserted-by":"crossref","first-page":"3462","DOI":"10.1210\/en.2006-0023","article-title":"Inhibins differentially antagonize activin and bone morphogenetic protein action in a mouse adrenocortical cell line","volume":"147","author":"Farnworth","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2012.01.025_b0010","doi-asserted-by":"crossref","first-page":"8891","DOI":"10.1073\/pnas.151339598","article-title":"Folliculostellate cell network: a route for long-distance communication in the anterior pituitary","volume":"98","author":"Fauquier","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mce.2012.01.025_b0150","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1677\/joe.1.05988","article-title":"BMP-4 inhibits follicle-stimulating hormone secretion in ewe pituitary","volume":"186","author":"Faure","year":"2005","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.mce.2012.01.025_b0580","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1677\/joe.0.1760061","article-title":"Residues in the C-terminal region of activin-A determine specificity for follistatin and type II receptor binding","volume":"176","author":"Fischer","year":"2003","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.mce.2012.01.025_b0665","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/0006-291X(89)91068-1","article-title":"Pituitary follicular cells secrete both vascular endothelial growth factor and follistatin","volume":"165","author":"Gospadarowicz","year":"1989","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mce.2012.01.025_b0325","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S1097-2765(03)00094-7","article-title":"The BMP7\/ActRII extracellular domain complex provides new insights into the cooperative nature of receptor assembly","volume":"11","author":"Greenwald","year":"2003","journal-title":"Mol. Cell"},{"key":"10.1016\/j.mce.2012.01.025_b0380","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1126\/science.271.5247.350","article-title":"DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1","volume":"271","author":"Hahn","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.mce.2012.01.025_b0685","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1385\/ENDO:29:3:399","article-title":"Stimulation of FSHbeta transcription by blockade of endogenous pituitary follistatin production: efficacy of adenoviral-delivered antisense RNA in the rat","volume":"29","author":"Haisenleder","year":"2006","journal-title":"Endocrine"},{"key":"10.1016\/j.mce.2012.01.025_b0590","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/sj.emboj.7601000","article-title":"Structural basis for the inhibition of activin signalling by follistatin","volume":"25","author":"Harrington","year":"2006","journal-title":"Embo J."},{"key":"10.1016\/j.mce.2012.01.025_b0440","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1210\/en.142.4.1393","article-title":"Identification of specific inhibin A-binding proteins on mouse Leydig (TM3) and sertoli (TM4) cell lines","volume":"142","author":"Harrison","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2012.01.025_b0055","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.tem.2005.01.003","article-title":"Antagonists of activin signaling: mechanisms and potential biological applications","volume":"16","author":"Harrison","year":"2005","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.mce.2012.01.025_b0595","doi-asserted-by":"crossref","first-page":"2744","DOI":"10.1210\/en.2006-0131","article-title":"Activin-A binds follistatin and type II receptors through overlapping binding sites: generation of mutants with isolated binding activities","volume":"147","author":"Harrison","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2012.01.025_b0165","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1210\/en.141.3.859","article-title":"Transforming growth factor-beta3 stimulates lactotrope cell growth by increasing basic fibroblast growth factor from folliculo-stellate cells","volume":"141","author":"Hentges","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2012.01.025_b0535","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1210\/jc.81.4.1321","article-title":"Inhibin-b: a likely candidate for the physiologically important form of inhibin in men","volume":"81","author":"Illingworth","year":"1996","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2012.01.025_b0635","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1210\/endo-129-2-815","article-title":"Recombinant expression of human follistatin with 315 and 288 amino acids: chemical and biological comparison with native porcine follistatin","volume":"129","author":"Inouye","year":"1991","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2012.01.025_b0875","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1210\/me.2011-0093","article-title":"Impaired FSHbeta expression in the pituitaries of Fox12 mutant animals","volume":"25","author":"Justice","year":"2011","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.mce.2012.01.025_b0715","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1172\/JCI116488","article-title":"Regulation of follistatin messenger ribonucleic acid levels in the rat pituitary","volume":"91","author":"Kaiser","year":"1993","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mce.2012.01.025_b0655","doi-asserted-by":"crossref","first-page":"3048","DOI":"10.1210\/en.130.5.3048","article-title":"Follistatin gene expression in the pituitary: localization in gonadotropes and folliculostellate cells in diestrous rats","volume":"130","author":"Kaiser","year":"1992","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2012.01.025_b0430","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.tcb.2009.05.008","article-title":"New regulatory mechanisms of TGF-beta receptor function","volume":"19","author":"Kang","year":"2009","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.mce.2012.01.025_b0585","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1210\/me.2003-0112","article-title":"The role of follistatin domains in follistatin biological action","volume":"18","author":"Keutmann","year":"2004","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.mce.2012.01.025_b0780","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1507\/endocrj.53.225","article-title":"Activation of follistatin promoter by GnRH in LbetaT2 gonadotroph cells","volume":"53","author":"Kihara","year":"2006","journal-title":"Endocr. J."},{"key":"10.1016\/j.mce.2012.01.025_b0255","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.mce.2011.05.036","article-title":"A truncated, activin-induced Smad3 isoform acts as a transcriptional repressor of FSHbeta expression in mouse pituitary","volume":"342","author":"Kim","year":"2011","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2012.01.025_b0640","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1210\/en.2009-1176","article-title":"The follistatin-288 isoform alone is sufficient for survival but not for normal fertility in mice","volume":"151","author":"Kimura","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2012.01.025_b0855","doi-asserted-by":"crossref","first-page":"14378","DOI":"10.1073\/pnas.96.25.14378","article-title":"Pax6 is essential for establishing ventral\u2013dorsal cell boundaries in pituitary gland development","volume":"96","author":"Kioussi","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mce.2012.01.025_b0735","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1210\/en.135.3.876","article-title":"Gonadotropin-releasing hormone pulse frequency regulates expression of pituitary follistatin messenger ribonucleic acid: a mechanism for differential gonadotrope function","volume":"135","author":"Kirk","year":"1994","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2012.01.025_b0175","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/S0006-291X(88)80009-3","article-title":"Activin-A: a modulator of multiple types of anterior pituitary cells","volume":"157","author":"Kitaoka","year":"1988","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mce.2012.01.025_b0670","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1210\/endo-128-3-1434","article-title":"Activin-binding protein is present in pituitary","volume":"128","author":"Kogawa","year":"1991","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2012.01.025_b0620","doi-asserted-by":"crossref","first-page":"5686","DOI":"10.1158\/0008-5472.CAN-05-3821","article-title":"Dissociation of angiogenesis and tumorigenesis in follistatin- and activin-expressing tumors","volume":"66","author":"Krneta","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.mce.2012.01.025_b0275","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.mce.2003.09.019","article-title":"Regulation of FSH\u03b2 and GnRH receptor gene expression in activin receptor II knockout male mice","volume":"212","author":"Kumar","year":"2003","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2012.01.025_b0880","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1210\/me.2008-0324","article-title":"A novel role for the forkhead transcription factor FOXL2 in activin A-regulated follicle-stimulating hormone beta subunit transcription","volume":"23","author":"Lamba","year":"2009","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.mce.2012.01.025_b0890","doi-asserted-by":"crossref","first-page":"5456","DOI":"10.1210\/en.2010-0605","article-title":"Activin A regulates porcine follicle-stimulating hormone {beta}-subunit transcription via cooperative actions of SMADs and FOXL2","volume":"151","author":"Lamba","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2012.01.025_b0660","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1177\/41.7.8515053","article-title":"Expression of follistatin mRNA by somatotropes and mammotropes early in the rat estrous cycle","volume":"41","author":"Lan-Lee","year":"1993","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.mce.2012.01.025_b0730","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1159\/000070896","article-title":"Regulation of follicle-stimulating hormone secretion by the interactions of activinA, dexamethasone and testosterone in anterior pituitary cell cultures of male rats","volume":"77","author":"Leal","year":"2003","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.mce.2012.01.025_b0170","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/978-1-4419-1664-8_7","article-title":"Activin, TGF-beta and menin in pituitary tumorigenesis","volume":"668","author":"Lebrun","year":"2009","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.mce.2012.01.025_b0425","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1210\/me.13.1.15","article-title":"Roles of pathway-specific and inhibitory Smads in activin receptor signaling","volume":"13","author":"Lebrun","year":"1999","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.mce.2012.01.025_b0155","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1677\/jme.1.02196","article-title":"Bone morphogenetic protein 2 and activin A synergistically stimulate follicle-stimulating hormone beta subunit transcription","volume":"38","author":"Lee","year":"2007","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.mce.2012.01.025_b0455","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/35006129","article-title":"Betaglycan binds inhibin and can mediate functional antagonism of activin signaling","volume":"404","author":"Lewis","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.mce.2012.01.025_b0645","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1210\/me.2006-0529","article-title":"Female infertility and disrupted angiogenesis are actions of specific follistatin isoforms","volume":"22","author":"Lin","year":"2008","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.mce.2012.01.025_b0230","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1507\/endocrj.43.39","article-title":"Regulation of immunoreactive activin-A secretion from cultured rat anterior pituitary cells","volume":"43","author":"Liu","year":"1996","journal-title":"Endocr. J."},{"key":"10.1016\/j.mce.2012.01.025_b0385","doi-asserted-by":"crossref","first-page":"3157","DOI":"10.1101\/gad.11.23.3157","article-title":"Dual role of the Smad4\/DPC4 tumor suppressor in TGF beta-inducible transcriptional complexes","volume":"11","author":"Liu","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/j.mce.2012.01.025_b0505","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1210\/me.2008-0374","article-title":"Inhibin-A antagonizes TGFbeta2 signaling by downregulating cell surface expression of the TGFbeta coreceptor Betaglycan","volume":"24","author":"Looyenga","year":"2010","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.mce.2012.01.025_b0475","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/0092-8674(91)90073-8","article-title":"Structure and expression of the membrane proteoglycan betaglycan, a component of the TGF-beta receptor system","volume":"67","author":"Lopez-Casillas","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.mce.2012.01.025_b0480","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1210\/en.143.3.1066","article-title":"The distribution of betaglycan protein and mRNA in rat brain, pituitary and gonads: Implications for a role in inhibin-mediated reproductive functions","volume":"143","author":"MacConell","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2012.01.025_b0520","doi-asserted-by":"crossref","first-page":"4784","DOI":"10.1210\/en.2008-1783","article-title":"Inhibin B is a more potent suppressor of rat follicle-stimulating hormone release than inhibin a in vitro and in vivo","volume":"150","author":"Makanji","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2012.01.025_b0515","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/B978-0-12-385961-7.00014-7","article-title":"Feedback regulation by inhibins A and B of the pituitary secretion of follicle-stimulating hormone","volume":"85","author":"Makanji","year":"2011","journal-title":"Vitam Horm"},{"key":"10.1016\/j.mce.2012.01.025_b0080","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2008.07.001","article-title":"TGFbeta in Cancer","volume":"134","author":"Massague","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.mce.2012.01.025_b0305","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1016\/j.febslet.2006.04.033","article-title":"The logic of TGFbeta signaling","volume":"580","author":"Massague","year":"2006","journal-title":"FEBS Lett."},{"key":"10.1016\/j.mce.2012.01.025_b0065","first-page":"41","article-title":"Serine\/threonine kinase receptors: mediators of transforming growth factor beta family signals","volume":"27","author":"Massague","year":"1996","journal-title":"Cancer Surv."},{"key":"10.1016\/j.mce.2012.01.025_b0360","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1101\/gad.1350705","article-title":"Smad transcription factors","volume":"19","author":"Massague","year":"2005","journal-title":"Genes Dev."},{"key":"10.1016\/j.mce.2012.01.025_b0085","doi-asserted-by":"crossref","first-page":"8817","DOI":"10.1073\/pnas.91.19.8817","article-title":"Development of cancer cachexia-like syndrome and adrenal tumors in inhibin-deficient mice","volume":"91","author":"Matzuk","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mce.2012.01.025_b0615","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/374360a0","article-title":"Multiple defects and perinatal death in mice deficient in follistatin","volume":"374","author":"Matzuk","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.mce.2012.01.025_b0605","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0006-291X(05)81072-1","article-title":"Rat follistatin \u2013 gonadal and extragonadal expression and evidence for alternative splicing","volume":"173","author":"Michel","year":"1990","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mce.2012.01.025_b0560","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0303-7207(93)90248-I","article-title":"Follistatins: more than follicle-stimulating hormone suppressing proteins","volume":"91","author":"Michel","year":"1993","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2012.01.025_b0760","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0303-7207(93)90080-4","article-title":"Structural and functional characterization of the rat follistatin (activin-binding protein) gene promoter","volume":"92","author":"Miyanaga","year":"1993","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2012.01.025_b0310","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/jb\/mvp148","article-title":"Bone morphogenetic protein receptors and signal transduction","volume":"147","author":"Miyazono","year":"2010","journal-title":"J. Biochem."},{"key":"10.1016\/j.mce.2012.01.025_b0340","doi-asserted-by":"crossref","first-page":"3699","DOI":"10.1242\/dev.030338","article-title":"The regulation of TGFbeta signal transduction","volume":"136","author":"Moustakas","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.mce.2012.01.025_b0345","first-page":"1","article-title":"Non-Smad signaling pathways","volume":"1","author":"Mu","year":"2011","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.mce.2012.01.025_b0790","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.mce.2009.02.030","article-title":"Follistatin gene expression by gonadotropin-releasing hormone: a role for cyclic AMP and mitogen-activated protein kinase signaling pathways in clonal gonadotroph LbetaT2 cells","volume":"307","author":"Mutiara","year":"2009","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2012.01.025_b0235","doi-asserted-by":"crossref","first-page":"37469","DOI":"10.1074\/jbc.M206571200","article-title":"Direct binding of AP-1 (Fos\/Jun) proteins to a SMAD binding element facilitates both gonadotropin-releasing hormone (GnRH)- and activin-mediated transcriptional activation of the mouse GnRH receptor gene","volume":"277","author":"Norwitz","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2012.01.025_b0140","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1210\/me.2004-0425","article-title":"Bone morphogenic protein (Smad)-mediated repression of proopiomelanocortin transcription by interference with Pitx\/Tpit activity","volume":"19","author":"Nudi","year":"2005","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.mce.2012.01.025_b0625","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1158\/1078-0432.CCR-07-1221","article-title":"Follistatin suppresses the production of experimental multiple-organ metastasis by small cell lung cancer cells in natural killer cell-depleted SCID mice","volume":"14","author":"Ogino","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.mce.2012.01.025_b0280","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1101\/gad.11.14.1812","article-title":"The signaling pathway mediated by the type IIB activin receptor controls axial patterning and lateral asymmetry in the mouse","volume":"11","author":"Oh","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/j.mce.2012.01.025_b0410","doi-asserted-by":"crossref","first-page":"8873","DOI":"10.1074\/jbc.M309698200","article-title":"Distinct roles of Smad2-, Smad3-, and ERK-dependent pathways in transforming growth factor-beta1 regulation of pancreatic stellate cellular functions","volume":"279","author":"Ohnishi","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2012.01.025_b0145","doi-asserted-by":"crossref","first-page":"4938","DOI":"10.1210\/en.2002-220929","article-title":"A novel function of bone morphogenetic protein-15 in the pituitary: selective synthesis and secretion of FSH by gonadotropes","volume":"143","author":"Otsuka","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2012.01.025_b0135","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1073\/pnas.0237312100","article-title":"Involvement of bone morphogenetic protein 4 (BMP-4) in pituitary prolactinoma pathogenesis through a Smad\/estrogen receptor crosstalk","volume":"100","author":"Paez-Pereda","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mce.2012.01.025_b0815","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1677\/jme.1.01947","article-title":"FOXL2 activates P450 aromatase gene transcription: towards a better characterization of the early steps of mammalian ovarian development","volume":"36","author":"Pannetier","year":"2006","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.mce.2012.01.025_b0570","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1006\/frne.1998.0169","article-title":"Follistatin: a multifunctional regulatory protein","volume":"19","author":"Phillips","year":"1998","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.mce.2012.01.025_b0825","doi-asserted-by":"crossref","first-page":"3424","DOI":"10.1210\/en.2003-1141","article-title":"Forkhead l2 is expressed in the ovary and represses the promoter activity of the steroidogenic acute regulatory gene","volume":"145","author":"Pisarska","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2012.01.025_b0905","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1210\/en.2010-1041","article-title":"Minireview: roles of the forkhead transcription factor FOXL2 in granulosa cell biology and pathology","volume":"152","author":"Pisarska","year":"2011","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2012.01.025_b0710","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1095\/biolreprod.103.021733","article-title":"Pituitary follistatin gene expression in female rats: evidence that inhibin regulates transcription","volume":"70","author":"Prendergast","year":"2004","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2012.01.025_b0800","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/84735","article-title":"A fork in the road to fertility","volume":"27","author":"Prueitt","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mce.2012.01.025_b0100","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1210\/er.22.6.836","article-title":"Activins and inhibins in endocrine and other tumors","volume":"22","author":"Risbridger","year":"2001","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.mce.2012.01.025_b0215","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1159\/000126231","article-title":"Inhibin\/activin subunits are costored with FSH and LH in secretory granules of the rat anterior pituitary gland","volume":"56","author":"Roberts","year":"1992","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.mce.2012.01.025_b0160","doi-asserted-by":"crossref","first-page":"3620","DOI":"10.1210\/en.139.8.3620","article-title":"Role of transforming growth factor (TGF)-beta type I and TGF-beta type II receptors in the TGF-beta1-regulated gene expression in pituitary prolactin-secreting lactotropes","volume":"139","author":"Sarkar","year":"1998","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2012.01.025_b0550","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1080\/08977190701833619","article-title":"Differential expression of TGFBR3 (betaglycan) in mouse ovary and testis during gonadogenesis","volume":"25","author":"Sarraj","year":"2007","journal-title":"Growth Factors"},{"key":"10.1016\/j.mce.2012.01.025_b0830","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1242\/dev.00969","article-title":"The murine winged-helix transcription factor Foxl2 is required for granulosa cell differentiation and ovary maintenance","volume":"131","author":"Schmidt","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.mce.2012.01.025_b0335","doi-asserted-by":"crossref","DOI":"10.1038\/nrm2297","article-title":"TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility","author":"Schmierer","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mce.2012.01.025_b0330","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.tibs.2003.08.001","article-title":"The interaction of BMP-7 and ActRII implicates a new mode of receptor assembly","volume":"28","author":"Sebald","year":"2003","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.mce.2012.01.025_b0020","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0303-7207(99)00011-8","article-title":"Targeted ablation of gonadotrophs in transgenic mice affects embryonic development of lactotrophs","volume":"150","author":"Seuntjens","year":"1999","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2012.01.025_b0850","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1056\/NEJMoa0902542","article-title":"Mutation of FOXL2 in granulosa-cell tumors of the ovary","volume":"360","author":"Shah","year":"2009","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.mce.2012.01.025_b0390","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0092-8674(00)81600-1","article-title":"Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling","volume":"94","author":"Shi","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.mce.2012.01.025_b0630","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0006-291X(88)80097-4","article-title":"Porcine follistatin gene structure supports two forms of mature follistatin produced by alternative splicing","volume":"152","author":"Shimasaki","year":"1988","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mce.2012.01.025_b0350","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1046\/j.1365-2443.1998.00174.x","article-title":"Identification of receptors and Smad proteins involved in activin signalling in a human epidermal keratinocyte cell line","volume":"3","author":"Shimizu","year":"1998","journal-title":"Genes Cells"},{"key":"10.1016\/j.mce.2012.01.025_b0555","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1210\/endo-128-6-3313","article-title":"Follistatin binds to both activin and inhibin through the common beta-subunit","volume":"128","author":"Shimonaka","year":"1991","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2012.01.025_b0060","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.tem.2009.11.009","article-title":"Inhibins: from reproductive hormones to tumor suppressors","volume":"21","author":"Stenvers","year":"2010","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.mce.2012.01.025_b0545","doi-asserted-by":"crossref","first-page":"4371","DOI":"10.1128\/MCB.23.12.4371-4385.2003","article-title":"Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos","volume":"23","author":"Stenvers","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.mce.2012.01.025_b0295","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1210\/me.2004-0475","article-title":"Smad3 mediates activin-induced transcription of follicle-stimulating hormone beta-subunit gene","volume":"19","author":"Suszko","year":"2005","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.mce.2012.01.025_b0110","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/S0006-291X(03)01052-0","article-title":"Involvement of activin\/BMP system in development of human pituitary gonadotropinomas and nonfunctioning adenomas","volume":"306","author":"Takeda","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mce.2012.01.025_b0775","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1677\/JOE-07-0138","article-title":"Effects of peroxisome proliferator-activated receptor activation on gonadotropin transcription and cell mitosis induced by bone morphogenetic proteins in mouse gonadotrope LbetaT2 cells","volume":"194","author":"Takeda","year":"2007","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.mce.2012.01.025_b0375","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0968-0004(99)01519-4","article-title":"Signaling inputs converge on nuclear effectors in TGF-beta signaling","volume":"25","author":"ten Dijke","year":"2000","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.mce.2012.01.025_b0195","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.mce.2009.09.003","article-title":"Hormones in synergy: regulation of the pituitary gonadotropin genes","volume":"314","author":"Thackray","year":"2010","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2012.01.025_b0315","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1093\/emboj\/cdg156","article-title":"Structures of an ActRIIB:activin A complex reveal a novel binding mode for TGF-beta ligand:receptor interactions","volume":"22","author":"Thompson","year":"2003","journal-title":"Embo J."},{"key":"10.1016\/j.mce.2012.01.025_b0575","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.devcel.2005.09.008","article-title":"The structure of the follistatin:activin complex reveals antagonism of both type I and type II receptor binding","volume":"9","author":"Thompson","year":"2005","journal-title":"Dev. Cell"},{"key":"10.1016\/j.mce.2012.01.025_b0895","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1210\/me.2010-0480","article-title":"SMADs and FOXL2 synergistically regulate murine FSHbeta transcription via a conserved proximal promoter element","volume":"25","author":"Tran","year":"2011","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.mce.2012.01.025_b0860","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1101\/gad.12.11.1691","article-title":"Multistep signaling requirements for pituitary organogenesis in vivo","volume":"12","author":"Treier","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/j.mce.2012.01.025_b0300","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.mce.2004.03.009","article-title":"Activin isoforms signal through type I receptor serine\/threonine kinase ALK7","volume":"220","author":"Tsuchida","year":"2004","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2012.01.025_b0115","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1023\/A:1011431123208","article-title":"Localization of inhibin\/activin subunits in normal pituitary and in pituitary adenomas","volume":"3","author":"Uccella","year":"2000","journal-title":"Pituitary"},{"key":"10.1016\/j.mce.2012.01.025_b0835","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1093\/hmg\/ddh124","article-title":"Foxl2 disruption causes mouse ovarian failure by pervasive blockage of follicle development","volume":"13","author":"Uda","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mce.2012.01.025_b0910","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1530\/REP-11-0092","article-title":"Forkhead transcription factors in ovarian function","volume":"142","author":"Uhlenhaut","year":"2011","journal-title":"Reproduction"},{"key":"10.1016\/j.mce.2012.01.025_b0840","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.cell.2009.11.021","article-title":"Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation","volume":"139","author":"Uhlenhaut","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.mce.2012.01.025_b0045","series-title":"Peptide Growth Factors and Their Receptors, Handbook of Experimental Pharmacology","first-page":"211","article-title":"The inhibin\/activin family of growth factors","author":"Vale","year":"1990"},{"key":"10.1016\/j.mce.2012.01.025_b0285","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1101\/gad.8.4.414","article-title":"Activin\/Inhibin beta b subunit gene disruption leads to defects in eyelid development and female reproduction","volume":"8","author":"Vassalli","year":"1994","journal-title":"Genes Dev."},{"key":"10.1016\/j.mce.2012.01.025_b0405","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0092-8674(00)81407-5","article-title":"Smad2 signaling in extraembryonic tissues determines anterior\u2013posterior polarity of the early mouse embryo","volume":"92","author":"Waldrip","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.mce.2012.01.025_b0820","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1210\/me.2006-0248","article-title":"Foxl2 up-regulates aromatase gene transcription in a female-specific manner by binding to the promoter as well as interacting with ad4 binding protein\/steroidogenic factor 1","volume":"21","author":"Wang","year":"2007","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.mce.2012.01.025_b0210","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1210\/en.131.3.1403","article-title":"Dynamic regulation of follicle-stimulating hormone-\u03b2 messenger ribonucleic acid levels by activin and gonadotropin-releasing hormone in perifused rat pituitary cells","volume":"131","author":"Weiss","year":"1992","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2012.01.025_b0525","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1210\/jc.86.1.330","article-title":"Differential regulation of inhibin B and inhibin a by follicle-stimulating hormone and local growth factors in human granulosa cells from small antral follicles","volume":"86","author":"Welt","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2012.01.025_b0050","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1177\/153537020222700905","article-title":"Activins, inhibins, and follistatins: from endocrinology to signaling. A paradigm for the new millennium","volume":"227","author":"Welt","year":"2002","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.mce.2012.01.025_b0460","doi-asserted-by":"crossref","first-page":"7934","DOI":"10.1074\/jbc.M209710200","article-title":"Inhibin is an antagonist of bone morphogenetic protein signaling","volume":"278","author":"Wiater","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2012.01.025_b0470","doi-asserted-by":"crossref","first-page":"17011","DOI":"10.1074\/jbc.M601459200","article-title":"Identification of distinct inhibin and transforming growth factor b-binding sites on betaglycan: functional separation of betaglycan co-receptor actions","volume":"281","author":"Wiater","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2012.01.025_b0490","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1210\/me.2009-0021","article-title":"Endogenous betaglycan is essential for high potency inhibin antagonism in gonadotropes","volume":"23","author":"Wiater","year":"2009","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.mce.2012.01.025_b0770","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1471-213X-2-8","article-title":"A transcriptional response to Wnt protein in human embryonic carcinoma cells","volume":"2","author":"Willert","year":"2002","journal-title":"BMC Dev. Biol."},{"key":"10.1016\/j.mce.2012.01.025_b0650","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1530\/rep.1.00195","article-title":"Intra-pituitary regulation of gonadotrophs in male rodents and primates","volume":"128","author":"Winters","year":"2004","journal-title":"Reproduction"},{"key":"10.1016\/j.mce.2012.01.025_b0795","doi-asserted-by":"crossref","first-page":"4324","DOI":"10.1210\/en.138.10.4324","article-title":"Evidence that pituitary adenylate cyclase activating polypeptide suppresses follicle-stimulating hormone-beta messenger ribonucleic acid levels by stimulating follistatin gene transcription","volume":"138","author":"Winters","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2012.01.025_b0785","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.mce.2007.03.006","article-title":"Transcriptional regulation of follistatin expression by GnRH in mouse gonadotroph cell lines: evidence for a role for cAMP signaling","volume":"271","author":"Winters","year":"2007","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2012.01.025_b0030","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1146\/annurev.ph.57.030195.001251","article-title":"Inhibin, activin and the female reproductive axis","volume":"57","author":"Woodruff","year":"1995","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.mce.2012.01.025_b0540","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1210\/en.132.6.2332","article-title":"Recombinant human inhibin A and recombinant human activin A regulate pituitary and avarian function in the adult rat","author":"Woodruff","year":"1993","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2012.01.025_b0355","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S1359-6101(99)00024-6","article-title":"The Smad pathway","volume":"11","author":"Wrana","year":"2000","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.mce.2012.01.025_b0070","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.devcel.2009.02.012","article-title":"Tgf-beta superfamily signaling in embryonic development and homeostasis","volume":"16","author":"Wu","year":"2009","journal-title":"Dev. Cell"},{"key":"10.1016\/j.mce.2012.01.025_b0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1677\/JOE-08-0549","article-title":"The biology of activin: recent advances in structure, regulation and function","volume":"202","author":"Xia","year":"2009","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.mce.2012.01.025_b0400","first-page":"121","article-title":"Characterization of human FAST-1, a TGF beta and activin signal transducer","volume":"2","author":"Zhou","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.mce.2012.01.025_b0090","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1210\/me.14.12.2066","article-title":"Truncated activin type I receptor Alk4 isoforms are dominant negative receptors inhibiting activin signaling","volume":"14","author":"Zhou","year":"2000","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.mce.2012.01.025_b0290","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0092-8674(00)81730-4","article-title":"Smad3 mutant mice develop metastatic colorectal cancer","volume":"94","author":"Zhu","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.mce.2012.01.025_b0125","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.ceb.2007.09.011","article-title":"Signaling and epigenetic regulation of pituitary development","volume":"19","author":"Zhu","year":"2007","journal-title":"Curr. Opin. Cell Biol."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720712000755?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720712000755?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T00:05:15Z","timestamp":1713485115000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720712000755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":183,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S0303720712000755"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2012.01.025","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]}}}