{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:06:01Z","timestamp":1791846361537,"version":"4.3.4"},"reference-count":36,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":441,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1016\/j.mce.2012.02.009","type":"journal-article","created":{"date-parts":[[2012,2,22]],"date-time":"2012-02-22T03:18:42Z","timestamp":1329880722000},"page":"180-187","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Differential placental expression profile of human Growth Hormone\/Chorionic Somatomammotropin genes in pregnancies with pre-eclampsia and gestational diabetes mellitus"],"prefix":"10.1016","volume":"355","author":[{"given":"Jaana","family":"M\u00e4nnik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pille","family":"Vaas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristiina","family":"Rull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pille","family":"Teesalu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maris","family":"Laan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2012.02.009_b0005","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1067\/mob.2002.121256","article-title":"Human placental growth hormone causes severe insulin resistance in transgenic mice","volume":"186","author":"Barbour","year":"2002","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.mce.2012.02.009_b0010","doi-asserted-by":"crossref","first-page":"3939","DOI":"10.1093\/nar\/11.12.3939","article-title":"The human growth hormone gene family: structure and evolution of the chromosomal locus","volume":"11","author":"Barsh","year":"1983","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mce.2012.02.009_b0015","first-page":"2878","article-title":"Cloning of two novel growth hormone transcripts expressed in human placenta","volume":"83","author":"Boguszewski","year":"1998","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2012.02.009_b0020","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/S0168-9525(01)02626-9","article-title":"Alternative splicing: multiple control mechanisms and involvement in human disease","volume":"18","author":"Caceres","year":"2002","journal-title":"Trends Genet."},{"key":"10.1016\/j.mce.2012.02.009_b0025","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1210\/jcem.87.6.8544","article-title":"Longitudinal study of serum placental GH in 455 normal pregnancies: correlation to gestational age, fetal gender, and weight","volume":"87","author":"Chellakooty","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2012.02.009_b0030","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1210\/jc.2003-030282","article-title":"A longitudinal study of intrauterine growth and the placental growth hormone (GH)-insulin-like growth factor I axis in maternal circulation: association between placental GH and fetal growth","volume":"89","author":"Chellakooty","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2012.02.009_b0035","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/0888-7543(89)90271-1","article-title":"The human growth hormone locus: nucleotide sequence, biology, and evolution","volume":"4","author":"Chen","year":"1989","journal-title":"Genomics"},{"key":"10.1016\/j.mce.2012.02.009_b0040","doi-asserted-by":"crossref","first-page":"8996","DOI":"10.1016\/S0021-9258(18)68407-8","article-title":"Two distinct species of human growth hormone-variant mRNA in the human placenta predict the expression of novel growth hormone proteins","volume":"263","author":"Cooke","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2012.02.009_b0045","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1172\/JCI113582","article-title":"Human growth hormone gene and the highly homologous growth hormone variant gene display different splicing patterns","volume":"82","author":"Cooke","year":"1988","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mce.2012.02.009_b0050","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.cell.2009.02.011","article-title":"RNA and disease","volume":"136","author":"Cooper","year":"2009","journal-title":"Cell"},{"issue":"Suppl 3","key":"10.1016\/j.mce.2012.02.009_b0055","first-page":"41","article-title":"Regulation of maternal metabolism by pituitary and placental hormones: roles in fetal development and metabolic programming","volume":"65","author":"Freemark","year":"2006","journal-title":"Horm. Res."},{"key":"10.1016\/j.mce.2012.02.009_b0060","doi-asserted-by":"crossref","first-page":"4355","DOI":"10.1210\/jc.2003-030726","article-title":"Human placental growth hormone, insulin-like growth factor I and -II, and insulin requirements during pregnancy in type 1 diabetes","volume":"88","author":"Fuglsang","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2012.02.009_b0065","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1007\/BF00282009","article-title":"The genes for growth hormone and chorionic somatomammotropin are on the long arm of human chromosome 17 in region q21 to qter","volume":"57","author":"George","year":"1981","journal-title":"Hum. Genet."},{"key":"10.1016\/j.mce.2012.02.009_b0070","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/1477-7827-7-70","article-title":"Potential markers of preeclampsia \u2013 a review","volume":"7","author":"Grill","year":"2009","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.mce.2012.02.009_b0075","first-page":"1","article-title":"The growth hormone gene cluster: physiological actions and regulation during pregnancy","volume":"25","author":"Handwerger","year":"2009","journal-title":"Growth, Genetics and Hormones"},{"key":"10.1016\/j.mce.2012.02.009_b0080","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1515\/JPEM.2000.13.4.343","article-title":"The roles of placental growth hormone and placental lactogen in the regulation of human fetal growth and development","volume":"13","author":"Handwerger","year":"2000","journal-title":"J. Pediatr. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2012.02.009_b0085","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.tem.2003.11.004","article-title":"Activation of the human GH gene cluster: roles for targeted chromatin modification","volume":"15","author":"Ho","year":"2004","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.mce.2012.02.009_b0090","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0303-7207(99)00152-5","article-title":"Detection of placental growth hormone variant and chorionic somatomammotropin-L RNA expression in normal and diabetic pregnancy by reverse transcriptase-polymerase chain reaction","volume":"157","author":"Hu","year":"1999","journal-title":"Mol. Cell. Endocrinol."},{"issue":"Suppl 3","key":"10.1016\/j.mce.2012.02.009_b0095","doi-asserted-by":"crossref","first-page":"S96","DOI":"10.1016\/S0049-3848(11)70026-3","article-title":"Placental pathology in pregnancy complications","volume":"127","author":"Huppertz","year":"2011","journal-title":"Thromb Res."},{"key":"10.1016\/j.mce.2012.02.009_b0100","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/path.2719","article-title":"Pre-eclampsia: fitting together the placental, immune and cardiovascular pieces","volume":"221","author":"James","year":"2010","journal-title":"J. Pathol."},{"key":"10.1016\/j.mce.2012.02.009_b0105","first-page":"299","article-title":"S\u00fcnnikaalu jaotumine raseduse kestuse j\u00e4rgi Eestis aastail 1992\u20131994","volume":"4","author":"Karro","year":"1997","journal-title":"Eesti Arst"},{"key":"10.1016\/j.mce.2012.02.009_b0110","doi-asserted-by":"crossref","first-page":"6555","DOI":"10.1128\/MCB.00273-07","article-title":"Epigenetic activation of the human growth hormone gene cluster during placental cytotrophoblast differentiation","volume":"27","author":"Kimura","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.mce.2012.02.009_b0115","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1126\/science.1184208","article-title":"Regulation of alternative splicing by histone modifications","volume":"327","author":"Luco","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.mce.2012.02.009_b0120","doi-asserted-by":"crossref","first-page":"14219","DOI":"10.1016\/S0021-9258(19)49700-7","article-title":"Developmental control and alternative splicing of the placentally expressed transcripts from the human growth hormone gene cluster","volume":"267","author":"MacLeod","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2012.02.009_b0125","first-page":"1143","article-title":"Placental growth hormone (GH), GH-binding protein, and insulin-like growth factor axis in normal, growth-retarded, and diabetic pregnancies: correlations with fetal growth","volume":"85","author":"McIntyre","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2012.02.009_b0130","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1210\/jc.2010-0023","article-title":"Differential expression profile of growth hormone\/chorionic somatomammotropin genes in placenta of small- and large-for-gestational-age newborns","volume":"95","author":"M\u00e4nnik","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2012.02.009_b0135","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1203\/00006450-199310000-00011","article-title":"Placental growth hormone levels in normal pregnancy and in pregnancies with intrauterine growth retardation","volume":"34","author":"Mirlesse","year":"1993","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.mce.2012.02.009_b0140","doi-asserted-by":"crossref","first-page":"23220","DOI":"10.1016\/S0021-9258(17)31642-3","article-title":"Complex alternative splicing partially inactivates the human chorionic somatomammotropin-like (hCS-L) gene","volume":"269","author":"Misra-Press","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2012.02.009_b0145","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1080\/14767050701463571","article-title":"Placental growth hormone is increased in the maternal and fetal serum of patients with preeclampsia","volume":"20","author":"Mittal","year":"2007","journal-title":"J. Matern. Fetal. Neonatal. Med."},{"key":"10.1016\/j.mce.2012.02.009_b0150","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1097\/MED.0b013e32834c800d","article-title":"Placental hormones and the control of maternal metabolism and fetal growth","volume":"18","author":"Newbern","year":"2011","journal-title":"Curr Opin Endocrinol Diabetes Obes."},{"key":"10.1016\/j.mce.2012.02.009_b0155","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.placenta.2007.04.008","article-title":"In vitro differentiation of villous trophoblasts from pregnancies complicated by intrauterine growth restriction with and without pre-eclampsia","volume":"28","author":"Newhouse","year":"2007","journal-title":"Placenta"},{"key":"10.1016\/j.mce.2012.02.009_b0160","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1111\/j.1600-0897.2010.00831.x","article-title":"Immunology of preeclampsia","volume":"63","author":"Redman","year":"2010","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.mce.2012.02.009_b0165","first-page":"313","article-title":"Role of placental growth hormone in the alteration of maternal arterial resistance in pregnancy","volume":"52","author":"Schiessl","year":"2007","journal-title":"J. Reprod. Med."},{"key":"10.1016\/j.mce.2012.02.009_b0170","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1002\/humu.20767","article-title":"Complex signatures of locus-specific selective pressures and gene conversion on Human Growth Hormone\/Chorionic Somatomammotropin genes","volume":"29","author":"Sedman","year":"2008","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.mce.2012.02.009_b0175","first-page":"291","article-title":"Glucagon, insulin and glucose levels in maternal and imbilical cord plasma with studies of placental transfer","volume":"47","author":"Spellacy","year":"1976","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.mce.2012.02.009_b0180","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0303-7207(00)00287-2","article-title":"An unusual member of the human growth hormone\/placental lactogen (GH\/PL) family, the testicular alternative splicing variant hPL-A2: recombinant expression revealed a membrane-associated growth factor molecule","volume":"167","author":"Untergasser","year":"2000","journal-title":"Mol. Cell. Endocrinol."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720712001104?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720712001104?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T14:01:41Z","timestamp":1759586501000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720712001104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["S0303720712001104"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2012.02.009","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2012,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differential placental expression profile of human Growth Hormone\/Chorionic Somatomammotropin genes in pregnancies with pre-eclampsia and gestational diabetes mellitus","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2012.02.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Ireland Ltd.","name":"copyright","label":"Copyright"}]}}