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Med."},{"key":"10.1016\/j.mce.2012.04.011_b0350","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s00125-003-1097-5","article-title":"IRS1 degradation and increased serine phosphorylation cannot predict the degree of metabolic insulin resistance induced by oxidative stress","volume":"46","author":"Potashnik","year":"2003","journal-title":"Diabetologia"},{"key":"10.1016\/j.mce.2012.04.011_b0355","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/dna.1992.11.1","article-title":"Sequence alignment of the G-protein coupled receptor superfamily","volume":"11","author":"Probst","year":"1992","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.mce.2012.04.011_b0360","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1152\/physrev.1995.75.3.473","article-title":"Pathophysiology of insulin resistance in human disease","volume":"75","author":"Reaven","year":"1995","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.mce.2012.04.011_b0365","doi-asserted-by":"crossref","first-page":"E920","DOI":"10.1152\/ajpendo.1999.277.5.E920","article-title":"Angiotensin II induces insulin resistance independent of changes in interstitial insulin","volume":"277","author":"Richey","year":"1999","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2012.04.011_b0370","doi-asserted-by":"crossref","first-page":"E529","DOI":"10.1152\/ajpendo.00013.2004","article-title":"Interactions of exercise training and R-(+)-alpha-lipoic acid on insulin signaling in skeletal muscle of obese Zucker rats","volume":"287","author":"Saengsirisuwan","year":"2004","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2012.04.011_b0375","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1161\/01.HYP.0000251865.35728.2f","article-title":"Angiotensin-(1\u20137) through receptor Mas mediates endothelial nitric oxide synthase activation via Akt dependent pathways","volume":"49","author":"Sampaio","year":"2007","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2012.04.011_b0380","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1210\/en.131.2.807","article-title":"The role of the adrenal gland in hypertensive transgenic rat TGR(mREN2)27","volume":"131","author":"Sander","year":"1992","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2012.04.011_b0385","doi-asserted-by":"crossref","first-page":"14599","DOI":"10.1074\/jbc.C300063200","article-title":"Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation","volume":"278","author":"Sano","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2012.04.011_b0390","doi-asserted-by":"crossref","first-page":"8258","DOI":"10.1073\/pnas.1432869100","article-title":"Angiotensin-(1\u20137) is an endogenous ligand for the G protein coupled receptor Mas","volume":"100","author":"Santos","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mce.2012.04.011_b0395","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1113\/expphysiol.2008.042002","article-title":"Recent advances in the angiotensin-converting enzyme 2-angiotensin(1\u20137)-Mas axis","volume":"93","author":"Santos","year":"2008","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.mce.2012.04.011_b0405","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/0895-7061(94)00181-A","article-title":"The effect of enalapril with and without hydrochlorothiazide on insulin sensitivity and other metabolic abnormalities of hypertensive patients with NIDDM","volume":"8","author":"Shamiss","year":"1995","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.mce.2012.04.011_b0410","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1056\/NEJM199907223410406","article-title":"Glucose transporters and insulin action\u2013implications for insulin resistance and diabetes mellitus","volume":"341","author":"Shepherd","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mce.2012.04.011_b0415","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1093\/ajh\/5.8.506","article-title":"Improvements in metabolic risk factors for coronary heart disease associated with cilazapril treatment","volume":"5","author":"Shieh","year":"1992","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.mce.2012.04.011_b0420","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1172\/JCI10583","article-title":"Cellular mechanisms of insulin resistance","volume":"106","author":"Shulman","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mce.2012.04.011_b0425","doi-asserted-by":"crossref","first-page":"E1074","DOI":"10.1152\/ajpendo.00396.2004","article-title":"J. S. Kim, E. J. Henriksen. Defective insulin signaling in skeletal muscle of the hypertensive TG(mREN2)27 rat","volume":"288","author":"Sloniger","year":"2005","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2012.04.011_b0430","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1016\/j.metabol.2005.06.016","article-title":"Selective angiotensin II receptor antagonism enhances whole-body insulin sensitivity and muscle glucose transport in hypertensive TG(mREN2)27 rats","volume":"54","author":"Sloniger","year":"2005","journal-title":"Metabolism"},{"key":"10.1016\/j.mce.2012.04.011_b0435","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1152\/jappl.1999.86.6.2044","article-title":"Interactions of exercise training and ACE inhibition on insulin action in obese Zucker rats","volume":"86","author":"Steen","year":"1999","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.mce.2012.04.011_b0440","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.3109\/10641969509037407","article-title":"Normalization of insulin resistance in non-obese essential hypertension by cilazapril treatment","volume":"17","author":"Suzuki","year":"1995","journal-title":"Clin. Exp. Hypertens."},{"key":"10.1016\/j.mce.2012.04.011_b0445","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nrm1837","article-title":"Critical nodes in signalling pathways: insights into insulin action","volume":"7","author":"Taniguchi","year":"2006","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1016\/j.mce.2012.04.011_b0450","doi-asserted-by":"crossref","first-page":"33238","DOI":"10.1074\/jbc.M002615200","article-title":"A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase","volume":"275","author":"Tipnis","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2012.04.011_b0455","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1007\/BF00398058","article-title":"Effect on insulin sensitivity of angiotensin converting enzyme inhibitors with or without a sulphydryl group: Bradykinin may improve insulin resistance in dogs and humans","volume":"37","author":"Uehara","year":"1994","journal-title":"Diabetologia"},{"key":"10.1016\/j.mce.2012.04.011_b0460","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ng1294-373","article-title":"Parental imprinting of the Mas protooncogene in mouse","volume":"8","author":"Villar","year":"1994","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mce.2012.04.011_b0465","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1007\/BF02938391","article-title":"Aliskiren: the first direct renin inhibitor for hypertension","volume":"9","author":"Van den Meiracker","year":"2007","journal-title":"Curr. Cardiol. Rep."},{"key":"10.1016\/j.mce.2012.04.011_b0470","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1161\/01.HYP.21.4.491","article-title":"Arteriolar constriction and local renin-angiotensin system in rat microcirculation","volume":"21","author":"Vicaut","year":"1993","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2012.04.011_b0535","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0026-0495(95)90293-7","article-title":"Antihypertensive therapy with enalapril improves glucose storage and insulin sensitivity in hypertensive patients with non-insulin-dependent diabetes mellitus","volume":"44","author":"Vuirinen-Makkola","year":"1995","journal-title":"Metabolism"},{"key":"10.1016\/j.mce.2012.04.011_b0480","doi-asserted-by":"crossref","first-page":"35137","DOI":"10.1074\/jbc.M601320200","article-title":"Angiotensin II-induced NADPH oxidase activation impairs insulin signaling in skeletal muscle cells","volume":"281","author":"Wei","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2012.04.011_b0485","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1161\/HYPERTENSIONAHA.107.089284","article-title":"NADPH oxidase contributes to vascular inflammation, insulin resistance, and remodeling in the transgenic (mRen2) rat","volume":"50","author":"Wei","year":"2007","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2012.04.011_b0490","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1097\/00004872-200502000-00025","article-title":"Aliskiren, a novel, orally effective renin inhibitor, lowers blood pressure in marmosets and spontaneously hypertensive rats","volume":"23","author":"Wood","year":"2005","journal-title":"J. Hypertens."},{"key":"10.1016\/j.mce.2012.04.011_b0495","doi-asserted-by":"crossref","first-page":"R804","DOI":"10.1152\/ajpregu.00222.2010","article-title":"ACE2\/ANG-(1\u20137)\/Mas pathway in the brain: the axis of good","volume":"300","author":"Xu","year":"2011","journal-title":"Am. J. Physiol. 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