{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T14:35:14Z","timestamp":1759588514826},"reference-count":36,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1016\/j.mce.2012.07.012","type":"journal-article","created":{"date-parts":[[2012,8,2]],"date-time":"2012-08-02T04:59:32Z","timestamp":1343883572000},"page":"92-99","source":"Crossref","is-referenced-by-count":6,"title":["Androgen receptor repression of gonadotropin-releasing hormone gene transcription via enhancer 1"],"prefix":"10.1016","volume":"363","author":[{"given":"Melissa J.","family":"Brayman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia A.","family":"Pepa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela L.","family":"Mellon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2012.07.012_b0005","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1210\/en.139.3.1108","article-title":"Regulation of gonadotropin-releasing hormone (GnRH) gene expression by 5alpha-dihydrotestosterone in GnRH-secreting GT1-7 hypothalamic neurons","volume":"139","author":"Belsham","year":"1998","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2012.07.012_b0010","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1210\/me.14.2.212","article-title":"Transcription factors Oct-1 and C\/EBP \u03b2 (CCAAT\/enhancer binding protein-\u03b2) are involved in the glutamate\/nitric oxide\/cyclic guanosine 5\u2032-monophosphate-mediated repression of gonadotropin-releasing hormone gene expression","volume":"14","author":"Belsham","year":"2000","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.mce.2012.07.012_b0015","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principles of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.mce.2012.07.012_b0020","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1210\/me.2011-1015","article-title":"Androgen receptor repression of GnRH gene transcription","volume":"26","author":"Brayman","year":"2012","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.mce.2012.07.012_b0025","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/ijc.11404","article-title":"Constitutive activation of the androgen receptor by a point mutation in the hinge region: a new mechanism for androgen-independent growth in prostate cancer","volume":"108","author":"Ceraline","year":"2004","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.mce.2012.07.012_b0030","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1074\/jbc.274.4.2372","article-title":"The glucocorticoid receptor is tethered to DNA-bound Oct-1 at the mouse gonadotropin-releasing hormone distal negative glucocorticoid response element","volume":"274","author":"Chandran","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2012.07.012_b0035","doi-asserted-by":"crossref","first-page":"11202","DOI":"10.1523\/JNEUROSCI.23-35-11202.2003","article-title":"Circadian gene expression regulates pulsatile gonadotropin-releasing hormone (GnRH) secretory patterns in the hypothalamic GnRH-secreting GT1-7 cell line","volume":"23","author":"Chappell","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mce.2012.07.012_b0040","doi-asserted-by":"crossref","first-page":"6169","DOI":"10.1128\/MCB.15.11.6169","article-title":"The POU homeodomain transcription factor Oct-1 is essential for activity of the gonadotropin-releasing hormone neuron-specific enhancer","volume":"15","author":"Clark","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.mce.2012.07.012_b0045","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.1210\/me.2003-0437","article-title":"Phylogenetic footprinting reveals functional upstream regions of the gonadotropin-releasing hormone gene that enhance cell-specific expression","volume":"18","author":"Givens","year":"2004","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.mce.2012.07.012_b0050","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1006\/frne.2001.0219","article-title":"New evidence for estrogen receptors in gonadotropin-releasing hormone neurons","volume":"22","author":"Herbison","year":"2001","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.mce.2012.07.012_b0055","doi-asserted-by":"crossref","first-page":"3506","DOI":"10.1210\/en.141.9.3506","article-title":"Detection of estrogen receptor-beta messenger ribonucleic acid and 125I-estrogen binding sites in luteinizing hormone-releasing hormone neurons of the rat brain","volume":"141","author":"Hrabovszky","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2012.07.012_b0060","doi-asserted-by":"crossref","first-page":"3261","DOI":"10.1210\/en.142.7.3261","article-title":"Estrogen receptor-beta immunoreactivity in luteinizing hormone-releasing hormone neurons of the rat brain","volume":"142","author":"Hrabovszky","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2012.07.012_b0065","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0014-5793(98)00701-7","article-title":"Heterodimerization is mainly responsible for the dominant negative activity of amino-terminally truncated rat androgen receptor forms","volume":"430","author":"Ikonen","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/j.mce.2012.07.012_b0070","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1210\/en.135.4.1359","article-title":"Stimulation of androgen-regulated transactivation by modulators of protein phosphorylation","volume":"135","author":"Ikonen","year":"1994","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2012.07.012_b0075","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1210\/me.2010-0156","article-title":"Enhancers of GnRH transcription embedded in an upstream gene use homeodomain proteins to specify hypothalamic expression","volume":"24","author":"Iyer","year":"2010","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.mce.2012.07.012_b0080","doi-asserted-by":"crossref","first-page":"3596","DOI":"10.1128\/MCB.16.7.3596","article-title":"GATA factors are essential for activity of the neuron-specific enhancer of the gonadotropin-releasing hormone gene","volume":"16","author":"Lawson","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.mce.2012.07.012_b0085","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1210\/en.131.3.1397","article-title":"B1-adrenergic regulation of the GT1 gonadotropin-releasing hormone (GnRH) neuronal cell lines: Stimulation of GnRH release via receptors positively coupled to adenylate cyclase","volume":"131","author":"Martinez de la Escalera","year":"1992","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2012.07.012_b0090","series-title":"Functional Anatomy of the Endocrine Hypothalamus","first-page":"104","article-title":"Immortalized hypothalamic gonadotropin-releasing hormone neurons","author":"Mellon","year":"1992"},{"key":"10.1016\/j.mce.2012.07.012_b0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0896-6273(90)90028-E","article-title":"Immortalization of hypothalamic GnRH neurons by genetically targeted tumorigenesis","volume":"5","author":"Mellon","year":"1990","journal-title":"Neuron"},{"key":"10.1016\/j.mce.2012.07.012_b0100","first-page":"11","article-title":"Optimal alignments in linear space","volume":"4","author":"Myers","year":"1988","journal-title":"Comput Appl Biosci."},{"key":"10.1016\/j.mce.2012.07.012_b0105","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1210\/me.2003-0040","article-title":"Regulation of cyclic adenosine 3\u2032,5\u2032-monophosphate signaling and pulsatile neurosecretion by Gi-coupled plasma membrane estrogen receptors in immortalized gonadotropin-releasing hormone neurons","volume":"17","author":"Navarro","year":"2003","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.mce.2012.07.012_b0110","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0303-7207(98)00043-4","article-title":"The GnRH promoter: target of transcription factors, hormones, and signaling pathways","volume":"140","author":"Nelson","year":"1998","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2012.07.012_b0115","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1210\/me.14.9.1509","article-title":"Neuron-specific expression of the rat gonadotropin-releasing hormone gene is conferred by interactions of a defined promoter element with the enhancer in GT1-7 cells","volume":"14","author":"Nelson","year":"2000","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.mce.2012.07.012_b0120","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1210\/en.2005-1297","article-title":"Ligand-independent effects of estrogen receptor beta on mouse gonadotropin releasing hormone (GnRH) promoter activity","volume":"147","author":"Pak","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2012.07.012_b0125","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1046\/j.1365-2826.2001.00635.x","article-title":"5Alpha-reductase type 2 and androgen receptor expression in gonadotropin releasing hormone GT1-1 cells","volume":"13","author":"Poletti","year":"2001","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.mce.2012.07.012_b0130","doi-asserted-by":"crossref","first-page":"30287","DOI":"10.1074\/jbc.M402960200","article-title":"TALE homeodomain proteins regulate gonadotropin-releasing hormone gene expression independently and via interactions with Oct-1","volume":"279","author":"Rave-Harel","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2012.07.012_b0135","doi-asserted-by":"crossref","first-page":"30975","DOI":"10.1074\/jbc.M502315200","article-title":"The Groucho-related gene family regulates the gonadotropin-releasing hormone gene through interaction with the homeodomain proteins MSX1 and OCT1","volume":"280","author":"Rave-Harel","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2012.07.012_b0140","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1210\/endo-126-2-1080","article-title":"Testosterone regulates progonadotropin-releasing hormone levels in the preoptic area and basal hypothalamus of the male rat","volume":"126","author":"Roselli","year":"1990","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2012.07.012_b0145","doi-asserted-by":"crossref","first-page":"5045","DOI":"10.1210\/en.140.11.5045","article-title":"Estrogen directly represses gonadotropin-releasing hormone (GnRH) gene expression in estrogen receptor-alpha (ERalpha)- and ERbeta-expressing GT1-7 GnRH neurons","volume":"140","author":"Roy","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2012.07.012_b0150","doi-asserted-by":"crossref","first-page":"6419","DOI":"10.1093\/nar\/17.15.6419","article-title":"Rapid detection of octamer binding proteins with mini-extracts prepared from a small number of cells","volume":"17","author":"Schreiber","year":"1989","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.mce.2012.07.012_b0155","unstructured":"Schug, J., Overton, G.C., 1997. TESS: Transcription Element Search Software on the WWW. In: Technical Report CBIL-TR-1997-1001-v0.0 School of Medicine, University of Pennsylvania, Computational Biology and Informatics Laboratory."},{"key":"10.1016\/j.mce.2012.07.012_b0160","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.1210\/me.2002-0011","article-title":"Differential regulation of gonadotropin-releasing hormone secretion and gene expression by androgen: membrane versus nuclear receptor activation","volume":"16","author":"Shakil","year":"2002","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.mce.2012.07.012_b0165","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1210\/me.2003-0115","article-title":"Androgen regulates FSH\u03b2 gene expression in an activin-dependent manner in immortalized gonadotropes","volume":"18","author":"Spady","year":"2004","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.mce.2012.07.012_b0170","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1210\/me.2004-0463","article-title":"The protein kinase C pathway acts through multiple transcription factors to repress gonadotropin-releasing hormone gene expression in hypothalamic GT1-7 neuronal cells","volume":"19","author":"Tang","year":"2005","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.mce.2012.07.012_b0175","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1210\/mend-3-11-1748","article-title":"Regulation of pro-gonadotropin-releasing hormone gene expression by sex steroids in the brain of male and female rats","volume":"3","author":"Toranzo","year":"1989","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.mce.2012.07.012_b0180","doi-asserted-by":"crossref","first-page":"4149","DOI":"10.1073\/pnas.89.9.4149","article-title":"Intrinsic pulsatile secretory activity of immortalized LHRH secreting neurons","volume":"89","author":"Wetsel","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720712003802?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720712003802?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T11:58:47Z","timestamp":1562068727000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720712003802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":36,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["S0303720712003802"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2012.07.012","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2012,11]]}}}