{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T04:19:15Z","timestamp":1771474755616,"version":"3.50.1"},"reference-count":46,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1016\/j.mce.2012.09.003","type":"journal-article","created":{"date-parts":[[2012,9,20]],"date-time":"2012-09-20T17:19:15Z","timestamp":1348161555000},"page":"52-63","source":"Crossref","is-referenced-by-count":15,"title":["Testosterone deficiency accompanied by testicular and epididymal abnormalities in TMF\u2212\/\u2212 mice"],"prefix":"10.1016","volume":"365","author":[{"given":"Yoav","family":"Elkis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shai","family":"Bel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tali","family":"Lerer-Goldstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abraham","family":"Nyska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dianne M.","family":"Creasy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally","family":"Shpungin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uri","family":"Nir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.mce.2012.09.003_b0005","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/ijc.24277","article-title":"TMF\/ARA160 downregulates proangiogenic genes and attenuates the progression of PC3 xenografts","volume":"125","author":"Abrham","year":"2009","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.mce.2012.09.003_b0010","doi-asserted-by":"crossref","unstructured":"Ahmed, E.A., de Rooij, D.G., 2009. Staging of mouse seminiferous tubule cross-sections. Meiosis, vol 2: Cytological Methods. In: Keeney, S. (Ed.), vol. 558, pp. 263\u2013277.","DOI":"10.1007\/978-1-60761-103-5_16"},{"issue":"4","key":"10.1016\/j.mce.2012.09.003_b0015","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1095\/biolreprod.108.070128","article-title":"Expression of type-1 cannabinoid receptor during rat postnatal testicular development: possible involvement in adult leydig cell differentiation","volume":"79","author":"Cacciola","year":"2008","journal-title":"Biol. Reprod."},{"issue":"10","key":"10.1016\/j.mce.2012.09.003_b0020","first-page":"1130","article-title":"Azoospermia in an 8-month-old boar due to bilateral obstruction at the testis\/epididymis interface","volume":"51","author":"Clements","year":"2010","journal-title":"Can. Vet. J."},{"issue":"7","key":"10.1016\/j.mce.2012.09.003_b0025","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1177\/002215549704500702","article-title":"Major DNA fragmentation is a late event in apoptosis","volume":"45","author":"Collins","year":"1997","journal-title":"J. Histochem. Cytochem."},{"issue":"2","key":"10.1016\/j.mce.2012.09.003_b0030","doi-asserted-by":"crossref","first-page":"C316","DOI":"10.1152\/ajpcell.00521.2009","article-title":"A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells","volume":"299","author":"Costa","year":"2010","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"2","key":"10.1016\/j.mce.2012.09.003_b0035","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1177\/019262339702500201","article-title":"Evaluation of testicular toxicity in safety evaluation studies: the appropriate use of spermatogenic staging","volume":"25","author":"Creasy","year":"1997","journal-title":"Toxicol. Pathol."},{"issue":"1","key":"10.1016\/j.mce.2012.09.003_b0040","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1080\/019262301301418865","article-title":"Pathogenesis of male reproductive toxicity","volume":"29","author":"Creasy","year":"2001","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.mce.2012.09.003_b0045","doi-asserted-by":"crossref","unstructured":"Creasy, D.M., 2002. Histopathology of the male reproductive system II: interpretation. Curr. Protoc. Toxicol, Unit16 14 (Chapter 16).","DOI":"10.1002\/0471140856.tx1604s13"},{"issue":"243","key":"10.1016\/j.mce.2012.09.003_b0050","first-page":"33","article-title":"The cellular biology of mammalian spermatids: a review","volume":"78","author":"Dadoune","year":"1994","journal-title":"Bull. Assoc. Anat. (Nancy)"},{"issue":"1","key":"10.1016\/j.mce.2012.09.003_b0055","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3109\/10408449309104075","article-title":"Toxicological and pathological applications of proliferating cell nuclear antigen (PCNA), a novel endogenous marker for cell proliferation","volume":"23","author":"Dietrich","year":"1993","journal-title":"Crit. Rev. Toxicol."},{"issue":"5","key":"10.1016\/j.mce.2012.09.003_b0060","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s00345-003-0365-9","article-title":"Androgens and male fertility","volume":"21","author":"Dohle","year":"2003","journal-title":"World J. Urol."},{"issue":"3","key":"10.1016\/j.mce.2012.09.003_b0065","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1210\/me.2006-0534","article-title":"Hormonal regulation of testicular steroid and cholesterol homeostasis","volume":"22","author":"Eacker","year":"2008","journal-title":"Mol. Endocrinol."},{"issue":"5","key":"10.1016\/j.mce.2012.09.003_b0070","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1210\/endo-112-5-1763","article-title":"Effect of luteinizing hormone on Leydig cell structure and testosterone secretion","volume":"112","author":"Ewing","year":"1983","journal-title":"Endocrinology"},{"issue":"4","key":"10.1016\/j.mce.2012.09.003_b0075","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1210\/en.139.4.2128","article-title":"Orchidectomy induces a wave of apoptotic cell death in the epididymis","volume":"139","author":"Fan","year":"1998","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.mce.2012.09.003_b0080","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/0012-1606(75)90411-X","article-title":"The mammalian spermatozoon","volume":"44","author":"Fawcett","year":"1975","journal-title":"Dev. Biol."},{"issue":"4","key":"10.1016\/j.mce.2012.09.003_b0085","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1177\/002215540205000401","article-title":"Improved detection of apoptotic cells in archival paraffin sections: immunohistochemistry using antibodies to cleaved caspase 3","volume":"50","author":"Gown","year":"2002","journal-title":"J. Histochem. Cytochem."},{"issue":"5","key":"10.1016\/j.mce.2012.09.003_b0090","first-page":"1465","article-title":"In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: a cautionary note","volume":"21","author":"Grasl-Kraupp","year":"1995","journal-title":"Hepatology"},{"issue":"22","key":"10.1016\/j.mce.2012.09.003_b0095","doi-asserted-by":"crossref","first-page":"5931","DOI":"10.1182\/blood-2010-08-304485","article-title":"Protein disulfide isomerase blocks CEBPA translation and is up-regulated during the unfolded protein response in AML","volume":"117","author":"Haefliger","year":"2011","journal-title":"Blood"},{"issue":"6805","key":"10.1016\/j.mce.2012.09.003_b0100","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/35037710","article-title":"The biochemistry of apoptosis","volume":"407","author":"Hengartner","year":"2000","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.mce.2012.09.003_b0105","first-page":"47","article-title":"Methods of blood collection in the mouse","volume":"29","author":"Hoff","year":"2000","journal-title":"Lab. Anim."},{"issue":"3","key":"10.1016\/j.mce.2012.09.003_b0110","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/j.1939-4640.2001.tb02208.x","article-title":"Testosterone effects on luteinizing hormone and follicle-stimulating hormone responses to gonadotropin-releasing hormone in the mouse","volume":"22","author":"Huang","year":"2001","journal-title":"J. Androl."},{"issue":"6","key":"10.1016\/j.mce.2012.09.003_b0115","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/j.1365-2605.1983.tb00348.x","article-title":"Ontogeny of the secretory pattern of LH and FSH in male mice during sexual maturation","volume":"6","author":"Jean-Faucher","year":"1983","journal-title":"Int. J. Androl."},{"issue":"10","key":"10.1016\/j.mce.2012.09.003_b0120","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.steroids.2005.03.015","article-title":"Altered bioavailability of testosterone in androgen-binding protein-transgenic mice","volume":"70","author":"Jeyaraj","year":"2005","journal-title":"Steroids"},{"issue":"1","key":"10.1016\/j.mce.2012.09.003_b0125","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ydbio.2010.07.033","article-title":"TMF\/ARA160: A key regulator of sperm development","volume":"348","author":"Lerer-Goldshtein","year":"2010","journal-title":"Dev. Biol."},{"issue":"10","key":"10.1016\/j.mce.2012.09.003_b0130","doi-asserted-by":"crossref","first-page":"4092","DOI":"10.1210\/endo.139.10.6253","article-title":"Effects of castration and chronic steroid treatments on hypothalamic gonadotropin-releasing hormone content and pituitary gonadotropins in male wild-type and estrogen receptor-alpha knockout mice","volume":"139","author":"Lindzey","year":"1998","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2012.09.003_b0135","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1210\/en.139.10.4092","article-title":"In situ detection of apoptosis by the TUNEL assay: an overview of techniques","volume":"682","author":"Loo","year":"2011","journal-title":"Methods Mol. Biol."},{"issue":"3","key":"10.1016\/j.mce.2012.09.003_b0140","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1007\/978-1-60327-409-8_1","article-title":"Age-associated changes in plasma testosterone levels in male mice and their relation to social dominance or subordinance","volume":"15","author":"Machida","year":"1981","journal-title":"Horm. Behav."},{"issue":"1","key":"10.1016\/j.mce.2012.09.003_b0145","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/0018-506X(81)90013-1","article-title":"The effect of chronic luteinizing hormone treatment on adult rat Leydig cells","volume":"30","author":"Mendis-Handagama","year":"1998","journal-title":"Tissue Cell"},{"issue":"1\u20133","key":"10.1016\/j.mce.2012.09.003_b0150","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0040-8166(98)80007-4","article-title":"A putative nuclear receptor coactivator (TMF\/ARA160) associates with hbrm\/hSNF2 alpha and BRG-1\/hSNF2 beta and localizes in the Golgi apparatus","volume":"520","author":"Mori","year":"2002","journal-title":"FEBS Lett."},{"issue":"3","key":"10.1016\/j.mce.2012.09.003_b0155","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0014-5793(02)02803-X","article-title":"A description of spermiogenesis in the mouse and its use in analysis of the cycle of the seminiferous epithelium and germ cell renewal","volume":"99","author":"Oakberg","year":"1956","journal-title":"Am. J. Anat."},{"issue":"Pt 17","key":"10.1016\/j.mce.2012.09.003_b0160","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.1242\/jcs.115.17.3491","article-title":"Failure of normal adult Leydig cell development in androgen-receptor-deficient mice","volume":"115","author":"O\u2019Shaughnessy","year":"2002","journal-title":"J. Cell Sci."},{"issue":"6","key":"10.1016\/j.mce.2012.09.003_b0165","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1002\/aja.1000990303","article-title":"Insights into male germ cell apoptosis due to depletion of gonadotropins caused by GnRH antagonists","volume":"12","author":"Pareek","year":"2007","journal-title":"Apoptosis"},{"issue":"3","key":"10.1016\/j.mce.2012.09.003_b0170","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s10495-006-0039-3","article-title":"Hormonal regulation of cytochrome P450 enzymes, cholesterol side-chain cleavage and 17 alpha-hydroxylase\/C17-20 lyase in Leydig cells","volume":"42","author":"Payne","year":"1990","journal-title":"Biol. Reprod."},{"issue":"55","key":"10.1016\/j.mce.2012.09.003_b0175","doi-asserted-by":"crossref","first-page":"8908","DOI":"10.1095\/biolreprod42.3.399","article-title":"TMF\/ARA160 is a BC-box-containing protein that mediates the degradation of Stat3","volume":"23","author":"Perry","year":"2004","journal-title":"Oncogene"},{"issue":"2","key":"10.1016\/j.mce.2012.09.003_b0180","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/sj.onc.1208149","article-title":"Leydig cell hyperplasia and adenomas in mice treated with finasteride, a 5 alpha-reductase inhibitor: a possible mechanism","volume":"22","author":"Prahalada","year":"1994","journal-title":"Fundam. Appl. Toxicol."},{"issue":"2","key":"10.1016\/j.mce.2012.09.003_b0185","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1006\/faat.1994.1025","article-title":"Secretory granules and progesterone secretion by ovine corpora lutea in vitro","volume":"104","author":"Sawyer","year":"1979","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.mce.2012.09.003_b0190","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1210\/endo-104-2-476","article-title":"Temporal relationship between androgen-dependent changes in the volume of seminiferous tubule fluid, lumen size and seminiferous tubule protein secretion in rats","volume":"101","author":"Sharpe","year":"1994","journal-title":"J. Reprod. Fertil."},{"issue":"1\u20132","key":"10.1016\/j.mce.2012.09.003_b0195","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1530\/jrf.0.1010193","article-title":"Effect of deprival of LH on Leydig cell proliferation: involvement of PCNA, cyclin D3 and IGF-1","volume":"162","author":"Sriraman","year":"2000","journal-title":"Mol. Cell Endocrinol."},{"issue":"1","key":"10.1016\/j.mce.2012.09.003_b0200","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0303-7207(00)00201-X","article-title":"Castration induces apoptosis in the mouse epididymis during postnatal development","volume":"49","author":"Takagi-Morishita","year":"2002","journal-title":"Endocr. J."},{"issue":"1","key":"10.1016\/j.mce.2012.09.003_b0205","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1507\/endocrj.49.75","article-title":"Proliferative activity of gonocytes, sertoli cells and interstitial cells during testicular development in mice","volume":"93","author":"Vergouwen","year":"1991","journal-title":"J. Reprod. Fertil."},{"issue":"6","key":"10.1016\/j.mce.2012.09.003_b0210","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1089\/dna.2006.25.331","article-title":"Trnp: A conserved mammalian gene encoding a nuclear protein that accelerates cell-cycle progression","volume":"25","author":"Volpe","year":"2006","journal-title":"DNA Cell Biol."},{"issue":"2","key":"10.1016\/j.mce.2012.09.003_b0215","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1530\/jrf.0.0930233","article-title":"Androgen receptor roles in spermatogenesis and fertility: lessons from testicular cell-specific androgen receptor knockout mice","volume":"30","author":"Wang","year":"2009","journal-title":"Endocr. Rev."},{"issue":"2","key":"10.1016\/j.mce.2012.09.003_b0220","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1089\/dna.2006.25.331","article-title":"Adhesion and signaling proteins spatiotemporally associated with spermiation in the rat","volume":"20","author":"Wine","year":"1999","journal-title":"J. Androl."},{"issue":"1","key":"10.1016\/j.mce.2012.09.003_b0225","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1210\/er.2008-0025","article-title":"Infertility with defective spermatogenesis and steroidogenesis in male mice lacking androgen receptor in Leydig cells","volume":"32","author":"Xu","year":"2007","journal-title":"Endocrine"},{"issue":"3472","key":"10.1016\/j.mce.2012.09.003_b0230","first-page":"3485","article-title":"Functional involvement of TMF\/ARA160 in Rab6-dependent retrograde membrane traffic","volume":"313","author":"Yamane","year":"2007","journal-title":"Exp. Cell Res."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720712004352?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720712004352?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T16:21:54Z","timestamp":1714407714000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720712004352"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S0303720712004352"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2012.09.003","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]}}}