{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:36:00Z","timestamp":1762101360280},"reference-count":33,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1016\/j.mce.2012.10.006","type":"journal-article","created":{"date-parts":[[2012,10,26]],"date-time":"2012-10-26T02:33:43Z","timestamp":1351218823000},"page":"139-145","source":"Crossref","is-referenced-by-count":7,"title":["Prolonged stimulation with thyrotropin-releasing hormone and pituitary adenylate cyclase-activating polypeptide desensitize their receptor functions in prolactin-producing GH3 cells"],"prefix":"10.1016","volume":"365","author":[{"given":"Tselmeg","family":"Mijiddorj","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruhiko","family":"Kanasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sukhbaatar","family":"Unurjargal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aki","family":"Oride","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Indri","family":"Purwana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohji","family":"Miyazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2012.10.006_b0120","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1111\/j.1365-2826.2004.01249.x","article-title":"Inter-relationships between the secretory dynamics of thyrotrophin-releasing hormone, thyrotrophin and prolactin in periovulatory mares: effect of hypothyroidism","volume":"16","author":"Alexander","year":"2004","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.mce.2012.10.006_b0065","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0006-8993(94)91592-X","article-title":"Pituitary adenylate cyclase-activating polypeptide (PACAP) increases prolactin release and tuberoinfundibular dopaminergic neuronal activity","volume":"655","author":"Arbogast","year":"1994","journal-title":"Brain Res."},{"key":"10.1016\/j.mce.2012.10.006_b0005","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1210\/edrv.22.6.0451","article-title":"Dopamine as a prolactin (PRL) inhibitor","volume":"22","author":"Ben-Jonathan","year":"2001","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.mce.2012.10.006_b0115","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.1749-6632.1971.tb45254.x","article-title":"The role of cyclic AMP in the release of anterior pituitary hormones","volume":"185","author":"Bowers","year":"1971","journal-title":"Ann. NY Acad. Sci."},{"key":"10.1016\/j.mce.2012.10.006_b0040","doi-asserted-by":"crossref","first-page":"R1-4","DOI":"10.1677\/joe.0.142R001","article-title":"Pituitary adenylate cyclase-activating peptide-38 (PACAP)-38 is released into hypophysial portal blood in the normal male and female rat","volume":"142","author":"Dow","year":"1994","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.mce.2012.10.006_b0020","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1146\/annurev.ph.48.030186.002503","article-title":"Mechanism of thyrotropin releasing hormone stimulation of pituitary hormone secretion","volume":"48","author":"Gershengorn","year":"1986","journal-title":"Ann. Rev. Physiol."},{"key":"10.1016\/j.mce.2012.10.006_b0130","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1210\/jcem-63-3-661","article-title":"Pulsatile secretion of thyrotropin in man","volume":"63","author":"Greenspan","year":"1986","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2012.10.006_b0105","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1095\/biolreprod.107.060327","volume":"77","author":"Harada","year":"2007","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2012.10.006_b0050","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1677\/joe.0.1340033","article-title":"Effects of a novel hypothalamic peptide, pituitary adenylate cyclase-activating polypeptide, on pituitary hormone release in rats","volume":"134","author":"Hart","year":"1992","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.mce.2012.10.006_b0060","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0739-7240(94)90004-3","article-title":"Effects of pituitary adenylate cyclase-activating polypeptide (PACAP), prostaglandin E2 (PGE2) and growth hormone releasing factor (GRF) on the release of growth hormone from cultured bovine anterior pituitary cells in vitro","volume":"11","author":"Hashizume","year":"1994","journal-title":"Domest. Anim. Endocrinol."},{"key":"10.1016\/j.mce.2012.10.006_b0095","doi-asserted-by":"crossref","first-page":"3845","DOI":"10.1021\/bi00688a017","article-title":"Thyrotropin-releasing hormone regulates the number of its own receptors in the GH3 strain of pituitary cells in culture","volume":"14","author":"Hinkle","year":"1975","journal-title":"Biochemistry"},{"key":"10.1016\/j.mce.2012.10.006_b0025","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1095\/biolreprod61.1.319","article-title":"Mitogen-activated protein kinase activation by stimulation with thyrotropin-releasing hormone in rat pituitary GH3 cells","volume":"61","author":"Kanasaki","year":"1999","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2012.10.006_b0100","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1095\/biolreprod67.1.107","article-title":"Differential regulation of pituitary hormone secretion and gene expression by thyrotropin-releasing hormone. A role for mitogen-activated protein kinase signaling cascade in rat pituitary GH3 cells","volume":"67","author":"Kanasaki","year":"2002","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2012.10.006_b0140","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1095\/biolreprod.108.074765","article-title":"Pulse frequency-dependent gonadotropin gene expression by adenylate cyclase-activating polypeptide 1 in perifused mouse pituitary gonadotroph LbetaT2 cells","volume":"81","author":"Kanasaki","year":"2009","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2012.10.006_b0090","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1095\/biolreprod24.1.44","article-title":"Patterns of hypophysiotropic signals and gonadotropin secretion in the rhesus monkey","volume":"24","author":"Knobil","year":"1981","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2012.10.006_b0085","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.mce.2011.04.010","article-title":"Stimulatory effect of pituitary adenylate-cyclase activating polypeptide (PACAP) and its PACAP type I receptor (PAC1R) on prolactin synthesis in rat pituitary somatolactotroph GH3 cells","volume":"339","author":"Mijiddorj","year":"2011","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.mce.2012.10.006_b0035","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/0006-291X(89)91757-9","article-title":"Isolation of a novel 38 residue-hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells","volume":"164","author":"Miyata","year":"1989","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mce.2012.10.006_b0030","doi-asserted-by":"crossref","first-page":"3783","DOI":"10.1016\/S0021-9258(17)41928-4","article-title":"Thyrotropin-releasing hormone stimulates MAP kinase activity in GH3 cells by divergent pathways. Evidence of a role for early tyrosine phosphorylation","volume":"269","author":"Ohmichi","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2012.10.006_b0150","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1523\/JNEUROSCI.17-04-01291.1997","article-title":"Neurotransmitter- and growth factor-induced cAMP response element binding protein phosphorylation in glial cell progenitors: role of calcium ions, protein kinase C, and mitogen-activated protein kinase\/ribosomal S6 kinase pathway","volume":"17","author":"Pende","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mce.2012.10.006_b0165","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.bbrc.2011.05.135","article-title":"Expression of the pituitary adenylate cyclase-activating polypeptide (PACAP) type 1 receptor (PAC1R) potentiates the effects of GnRH on gonadotropin subunit gene expression","volume":"410","author":"Purwana","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mce.2012.10.006_b0075","first-page":"4","article-title":"Pituitary adenylate cyclase-activating polypeptide (PACAP) and PACAP\/vasoactive intestinal polypeptide receptors: actions on the anterior pituitary gland","volume":"17","author":"Rawlings","year":"1996","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.mce.2012.10.006_b0125","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1159\/000122525","article-title":"Dynamic studies of growth hormone and prolactin secretion in the female rat","volume":"21","author":"Saunders","year":"1976","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.mce.2012.10.006_b0055","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1046\/j.1365-2826.1997.00580.x","article-title":"Effects of pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal polypeptide (VIP) on hormone secretion from sheep pituitary cells in vitro","volume":"9","author":"Sawangjaroen","year":"1997","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.mce.2012.10.006_b0110","first-page":"161","article-title":"Expression and signal transduction pathways of gonadotropin-releasing hormone receptors","volume":"50","author":"Stojilkovic","year":"1995","journal-title":"Recent Prog. Horm. Res."},{"key":"10.1016\/j.mce.2012.10.006_b0145","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/0024-3205(95)00047-A","article-title":"Effects of pulsatile pituitary adenylate cyclase activating polypeptide (PACAP) on gonadotropin secretion and subunit mRNA levels in perifused rat pituitary cells","volume":"56","author":"Tsujii","year":"1995","journal-title":"Life Sci."},{"key":"10.1016\/j.mce.2012.10.006_b0135","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1210\/endo.135.3.7915230","article-title":"Effects of pituitary adenylate cyclase-activating polypeptide on gonadotropin secretion and subunit messenger ribonucleic acids in perifused rat pituitary cells","volume":"135","author":"Tsujii","year":"1994","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2012.10.006_b0045","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1124\/pr.109.001370","article-title":"Pituitary adenylate cyclase-activating polypeptide and its receptors: 20years after the discovery","volume":"61","author":"Vaudry","year":"2009","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.mce.2012.10.006_b0080","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0303-7207(95)03626-I","article-title":"Differential alternative splicing of PACAP receptor in pituitary cell subpopulations","volume":"113","author":"Vertongen","year":"1995","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.mce.2012.10.006_b0070","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0196-9781(93)90011-5","article-title":"Cytochemical characterization of anterior pituitary target cells for the neuropeptide, pituitary adenylate cyclase activating polypeptide (PACAP), using biotinylated ligands","volume":"14","author":"Vigh","year":"1993","journal-title":"Peptides"},{"key":"10.1016\/j.mce.2012.10.006_b0155","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1126\/science.273.5277.959","article-title":"Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase","volume":"273","author":"Xing","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.mce.2012.10.006_b0015","doi-asserted-by":"crossref","first-page":"10862","DOI":"10.1073\/pnas.94.20.10862","article-title":"Tertiary hypothyroidism and hyperglycemia in mice with targeted disruption of the thyrotropin-releasing hormone gene","volume":"94","author":"Yamada","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mce.2012.10.006_b0010","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1210\/en.2005-1326","article-title":"Prolactin secretion in mice with thyrotropin-releasing hormone deficiency","volume":"147","author":"Yamada","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2012.10.006_b0160","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1210\/endo.142.7.8226","article-title":"Involvement of mitogen-activated protein kinase in cyclic adenosine 3\u2032,5\u2032-monophosphate-induced hormone gene expression in rat pituitary GH(3) cells","volume":"142","author":"Yonehara","year":"2001","journal-title":"Endocrinology"}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720712004583?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720712004583?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,1,30]],"date-time":"2022-01-30T15:03:17Z","timestamp":1643554997000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720712004583"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S0303720712004583"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2012.10.006","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]}}}