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International Diabetes Foundation, Brussels."},{"key":"10.1016\/j.mce.2013.04.002_b0720","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1093\/bioinformatics\/btq615","article-title":"DmGWAS: dense module searching for genome-wide association studies in protein\u2013protein interaction networks","volume":"27","author":"Jia","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.mce.2013.04.002_b0705","doi-asserted-by":"crossref","first-page":"D277","DOI":"10.1093\/nar\/gkh063","article-title":"The KEGG resource for deciphering the genome","volume":"32","author":"Kanehisa","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mce.2013.04.002_b0135","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1007\/BF02221682","article-title":"Concordance for type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes mellitus in a population-based cohort of twins in Finland","volume":"35","author":"Kaprio","year":"1992","journal-title":"Diabetologia"},{"key":"10.1016\/j.mce.2013.04.002_b0080","doi-asserted-by":"crossref","first-page":"S125","DOI":"10.2337\/diabetes.54.suppl_2.S125","article-title":"Environmental triggers and determinants of type 1 diabetes","volume":"54","author":"Knip","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2013.04.002_b0125","series-title":"The Genetics of Diabetes Mellitus","first-page":"201","article-title":"Empirical risk figures for first-degree relatives of non-insulin dependent diabetics","author":"K\u00f6bberling","year":"1982"},{"key":"10.1016\/j.mce.2013.04.002_b0540","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/nature08625","article-title":"Parental origin of sequence variants associated with complex diseases","volume":"462","author":"Kong","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.mce.2013.04.002_b0050","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1136\/bmj.311.7010.913","article-title":"Concordance rates of insulin dependent diabetes mellitus: a population based study of young Danish twins","volume":"311","author":"Kyvik","year":"1995","journal-title":"BMJ"},{"key":"10.1016\/j.mce.2013.04.002_b0725","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1101\/gr.118992.110","article-title":"Prioritizing candidate disease genes by network-based boosting of genome-wide association data","volume":"21","author":"Lee","year":"2011","journal-title":"Genome Res."},{"key":"10.1016\/j.mce.2013.04.002_b0655","first-page":"25","article-title":"Gene-environment interactions and epigenetic basis of human diseases","volume":"10","author":"Liu","year":"2008","journal-title":"Curr. 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Metab."},{"key":"10.1016\/j.mce.2013.04.002_b0595","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1159\/000099179","article-title":"Detection of gene\u00d7gene interactions in genome-wide association studies of human population data","volume":"63","author":"Musani","year":"2007","journal-title":"Hum. Hered."},{"key":"10.1016\/j.mce.2013.04.002_b0635","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/ng.311","article-title":"Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways","volume":"41","author":"Nair","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mce.2013.04.002_b0150","first-page":"353","article-title":"Diabetes mellitus: a \u201cthrifty\u201d genotype rendered detrimental by \u201cprogress\u201d?","volume":"14","author":"Neel","year":"1962","journal-title":"Am. J. Hum. 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Engl. J. Med."},{"key":"10.1016\/j.mce.2013.04.002_b0070","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1007\/BF02743266","article-title":"Transfer of type 1 (insulin-dependent) diabetes mellitus associated autoimmunity to mice with severe combined immunodeficiency (SCID)","volume":"36","author":"Petersen","year":"1993","journal-title":"Diabetologia"},{"key":"10.1016\/j.mce.2013.04.002_b0600","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/nrg2452","article-title":"Epistasis \u2013 the essential role of gene interactions in the structure and evolution of genetic systems","volume":"9","author":"Phillips","year":"2008","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.mce.2013.04.002_b0155","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1007\/s001250051058","article-title":"Is type II diabetes mellitus a disease of the innate immune system?","volume":"41","author":"Pickup","year":"1998","journal-title":"Diabetologia"},{"key":"10.1016\/j.mce.2013.04.002_b0055","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1007\/BF00400364","article-title":"A nationwide population-based study of the familial aggregation of type 1 (insulin-dependent) diabetes mellitus in Denmark. 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Genet."},{"key":"10.1016\/j.mce.2013.04.002_b0475","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1007\/s00125-009-1391-y","article-title":"No association of multiple type 2 diabetes loci with type 1 diabetes","volume":"52","author":"Raj","year":"2009","journal-title":"Diabetologia"},{"key":"10.1016\/j.mce.2013.04.002_b0800","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1093\/hmg\/ddp041","article-title":"Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden","volume":"18","author":"Renstrom","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mce.2013.04.002_b0310","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1086\/377139","article-title":"Localization of a susceptibility gene for type 2 diabetes to chromosome 5q34-q35.2","volume":"73","author":"Reynisdottir","year":"2003","journal-title":"Am. J. Hum. 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Genet."},{"key":"10.1016\/j.mce.2013.04.002_b0385","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/ng2043","article-title":"A variant in CDKAL1 influences insulin response and risk of type 2 diabetes","volume":"39","author":"Steinthorsdottir","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mce.2013.04.002_b0670","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/nature10354","article-title":"Human metabolic individuality in biomedical and pharmaceutical research","volume":"477","author":"Suhre","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.mce.2013.04.002_b0025","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/j.1399-5448.2008.00483.x","article-title":"Long-term trends in the incidence of type 1 diabetes in Denmark: the seasonal variation changes over time","volume":"10","author":"Svensson","year":"2009","journal-title":"Pediatr. Diabetes"},{"key":"10.1016\/j.mce.2013.04.002_b0730","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.cmet.2012.06.006","article-title":"A systems genetics approach identifies genes and pathways for type 2 diabetes in human islets","volume":"16","author":"Taneera","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.mce.2013.04.002_b0180","first-page":"339","article-title":"Mild familial diabetes with dominant inheritance","volume":"43","author":"Tattersall","year":"1974","journal-title":"Q. J. Med."},{"key":"10.1016\/j.mce.2013.04.002_b0660","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1136\/jmg.39.12.872","article-title":"Transient neonatal diabetes, a disorder of imprinting","volume":"39","author":"Temple","year":"2002","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.mce.2013.04.002_b0425","doi-asserted-by":"crossref","unstructured":"The Wellcome Trust Case Control Consortium, 2007. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447, 661\u2013678.","DOI":"10.1038\/nature05911"},{"key":"10.1016\/j.mce.2013.04.002_b0795","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/ng.274","article-title":"Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity","volume":"41","author":"Thorleifsson","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mce.2013.04.002_b0160","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.2337\/diacare.28.8.2019","article-title":"Metabolic syndrome in type 1 diabetes: association with diabetic nephropathy and glycemic control (the FinnDiane study)","volume":"28","author":"Thorn","year":"2005","journal-title":"Diabetes Care"},{"key":"10.1016\/j.mce.2013.04.002_b0625","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/ng2068","article-title":"Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes","volume":"39","author":"Todd","year":"2007","journal-title":"Nat. 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Genet."},{"key":"10.1016\/j.mce.2013.04.002_b0355","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.2337\/dc06-0513","article-title":"Association of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma with Pre-diabetic phenotypes: meta-analysis of 57 studies on nondiabetic individuals","volume":"29","author":"Tonjes","year":"2006","journal-title":"Diabetes Care"},{"key":"10.1016\/j.mce.2013.04.002_b0770","doi-asserted-by":"crossref","first-page":"e1000847","DOI":"10.1371\/journal.pgen.1000847","article-title":"A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese","volume":"6","author":"Tsai","year":"2010","journal-title":"PLoS Genet."},{"key":"10.1016\/j.mce.2013.04.002_b0175","doi-asserted-by":"crossref","first-page":"359","DOI":"10.2337\/diab.42.2.359","article-title":"Antibodies to glutamic acid decarboxylase reveal latent autoimmune diabetes mellitus in adults with a non-insulin-dependent onset of disease","volume":"42","author":"Tuomi","year":"1993","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2013.04.002_b0170","doi-asserted-by":"crossref","first-page":"150","DOI":"10.2337\/diabetes.48.1.150","article-title":"Clinical and genetic characteristics of type 2 diabetes with and without GAD antibodies","volume":"48","author":"Tuomi","year":"1999","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2013.04.002_b0455","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1038\/ng.208","article-title":"SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations","volume":"40","author":"Unoki","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mce.2013.04.002_b0100","doi-asserted-by":"crossref","unstructured":"Vaarala, O., 2005. In: Koletzko, B. et al. (Eds.), Is Type 1 Diabetes a Disease of the Gut Immune System Triggered by Cow\u2019s Milk Insulin? Early Nutrition and its Later Consequences: New Opportunities. Springer, Netherlands, pp. 151\u2013156.","DOI":"10.1007\/1-4020-3535-7_22"},{"key":"10.1016\/j.mce.2013.04.002_b0195","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/ng0892-368","article-title":"Mutation in mitochondrial tRNALeu(UUR) gene in a large pedigree with maternally transmitted type II diabetes mellitus and deafness","volume":"1","author":"van den Ouweland","year":"1992","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mce.2013.04.002_b0190","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/ng.609","article-title":"Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis","volume":"42","author":"Voight","year":"2010","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mce.2013.04.002_b0535","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/ng.493","article-title":"The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes","volume":"42","author":"Wallace","year":"2010","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mce.2013.04.002_b0335","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1086\/379285","article-title":"Meta-analysis and a large association study confirm a role for calpain-10 variation in type 2 diabetes susceptibility","volume":"73","author":"Weedon","year":"2003","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.mce.2013.04.002_b0805","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/ng.287","article-title":"Six new loci associated with body mass index highlight a neuronal influence on body weight regulation","volume":"41","author":"Willer","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mce.2013.04.002_b0755","doi-asserted-by":"crossref","first-page":"886","DOI":"10.2337\/diabetes.54.3.886","article-title":"Association testing of variants in the hepatocyte nuclear factor 4alpha gene with risk of type 2 diabetes in 7,883 people","volume":"54","author":"Winckler","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2013.04.002_b0075","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.2337\/diabetes.53.10.2581","article-title":"Investigation of the role of B-cells in type 1 diabetes in the NOD mouse","volume":"53","author":"Wong","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2013.04.002_b0215","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/384455a0","article-title":"Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3)","volume":"384","author":"Yamagata","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.mce.2013.04.002_b0220","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/384458a0","article-title":"Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)","volume":"384","author":"Yamagata","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.mce.2013.04.002_b0460","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1038\/ng.207","article-title":"Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus","volume":"40","author":"Yasuda","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mce.2013.04.002_b0390","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1126\/science.1142364","article-title":"Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes","volume":"316","author":"Zeggini","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.mce.2013.04.002_b0565","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/ng.120","article-title":"Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes","volume":"40","author":"Zeggini","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mce.2013.04.002_b0830","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1073\/pnas.1119675109","article-title":"The mystery of missing heritability: Genetic interactions create phantom heritability","volume":"109","author":"Zuk","year":"2012","journal-title":"Proc. Natl. Acad. Sci. 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