{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T11:56:30Z","timestamp":1768910190454,"version":"3.49.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1016\/j.mce.2013.12.008","type":"journal-article","created":{"date-parts":[[2013,12,19]],"date-time":"2013-12-19T10:19:53Z","timestamp":1387448393000},"page":"147-158","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Valproic acid enhances Oct4 promoter activity through PI3K\/Akt\/mTOR pathway activated nuclear receptors"],"prefix":"10.1016","volume":"383","author":[{"given":"Han Fang","family":"Teng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei Ning","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duen Ren","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sin Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng Tao","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moo Rung","family":"Loo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien Han","family":"Kao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwang Huei","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shen Liang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2013.12.008_b0005","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1021\/tx950216s","article-title":"Further branching of valproate-related carboxylic acids reduces the teratogenic activity, but not the anticonvulsant effect","volume":"9","author":"Bojic","year":"1996","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.mce.2013.12.008_b0010","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1210\/endo.139.6.6049","article-title":"Differential expression of peroxisome proliferator-activated receptor-alpha, -beta, and -gamma during rat embryonic development","volume":"139","author":"Braissant","year":"1998","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2013.12.008_b0015","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1158\/0008-5472.CAN-04-3011","article-title":"Valproic acid stimulates proliferation and self-renewal of hematopoietic stem cells","volume":"65","author":"Bug","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.mce.2013.12.008_b0020","doi-asserted-by":"crossref","first-page":"3093","DOI":"10.1210\/en.2005-1317","article-title":"Myogenic basic helix-loop-helix proteins regulate the expression of peroxisomal proliferator activated receptor-gamma coactivator-1alpha","volume":"147","author":"Chang","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2013.12.008_b0025","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1046\/j.1471-4159.2000.0721327.x","article-title":"The mood-stabilizing agent valproate inhibits the activity of glycogen synthase kinase-3","volume":"72","author":"Chen","year":"1999","journal-title":"J. Neurochem."},{"key":"10.1016\/j.mce.2013.12.008_b0030","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1002\/stem.623","article-title":"Promyelocytic leukemia protein in retinoic acid-induced chromatin remodeling of Oct4 gene promoter","volume":"29","author":"Chuang","year":"2011","journal-title":"Stem Cells"},{"key":"10.1016\/j.mce.2013.12.008_b0295","first-page":"33","article-title":"FoxO6 and PGC-1alpha form a regulatory loop in myogenic cells","author":"Chung","year":"2013","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.mce.2013.12.008_b0040","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1210\/me.2003-0151","article-title":"The peroxisome proliferator-activated receptor beta\/delta agonist, GW501516, regulates the expression of genes involved in lipid catabolism and energy uncoupling in skeletal muscle cells","volume":"17","author":"Dressel","year":"2003","journal-title":"Mol. Endocrinol."},{"issue":"Suppl 3","key":"10.1016\/j.mce.2013.12.008_b0045","doi-asserted-by":"crossref","first-page":"S161","DOI":"10.1007\/s10072-004-0278-4","article-title":"Anticonvulsant drugs in primary headaches prophylaxis","volume":"25","author":"Frediani","year":"2004","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.mce.2013.12.008_b0050","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S1534-5807(01)00038-7","article-title":"Mouse germline restriction of Oct4 expression by germ cell nuclear factor","volume":"1","author":"Fuhrmann","year":"2001","journal-title":"Dev. Cell"},{"key":"10.1016\/j.mce.2013.12.008_b0055","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1001\/jama.290.11.1467","article-title":"Suicide risk in bipolar disorder during treatment with lithium and divalproex","volume":"290","author":"Goodwin","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.mce.2013.12.008_b0060","doi-asserted-by":"crossref","first-page":"6969","DOI":"10.1093\/emboj\/20.24.6969","article-title":"Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells","volume":"20","author":"Gottlicher","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.mce.2013.12.008_b0065","doi-asserted-by":"crossref","first-page":"2822","DOI":"10.1210\/en.2002-0180","article-title":"Valproic acid increases the stimulatory effect of estrogens on proliferation of human endometrial adenocarcinoma cells","volume":"144","author":"Graziani","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2013.12.008_b0070","doi-asserted-by":"crossref","first-page":"11424","DOI":"10.1073\/pnas.0710561105","article-title":"Retinoic acid-stimulated sequential phosphorylation, PML recruitment, and SUMOylation of nuclear receptor TR2 to suppress Oct4 expression","volume":"105","author":"Gupta","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mce.2013.12.008_b0075","doi-asserted-by":"crossref","first-page":"999","DOI":"10.2353\/ajpath.2009.080537","article-title":"Valproic acid activates the PI3K\/Akt\/mTOR pathway in muscle and ameliorates pathology in a mouse model of Duchenne muscular dystrophy","volume":"174","author":"Gurpur","year":"2009","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.mce.2013.12.008_b0080","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1158\/0008-5472.CAN-03-0799","article-title":"Histone deacetylase is a target of valproic acid-mediated cellular differentiation","volume":"64","author":"Gurvich","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.mce.2013.12.008_b0085","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/nbt1418","article-title":"Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds","volume":"26","author":"Huangfu","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.mce.2013.12.008_b0090","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1038\/nbt.1502","article-title":"Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2","volume":"26","author":"Huangfu","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.mce.2013.12.008_b0095","doi-asserted-by":"crossref","first-page":"525","DOI":"10.3858\/emm.2009.41.8.091","article-title":"Nuclear receptor regulation of stemness and stem cell differentiation","volume":"41","author":"Jeong","year":"2009","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.mce.2013.12.008_b0100","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/1471-2121-9-66","article-title":"Valproic acid induces differentiation and inhibition of proliferation in neural progenitor cells via the beta-catenin-Ras-ERK-p21Cip\/WAF1 pathway","volume":"9","author":"Jung","year":"2008","journal-title":"BMC Cell Biol."},{"key":"10.1016\/j.mce.2013.12.008_b0105","doi-asserted-by":"crossref","first-page":"e28068","DOI":"10.1371\/journal.pone.0028068","article-title":"Metformin represses self-renewal of the human breast carcinoma stem cells via inhibition of estrogen receptor-mediated OCT4 expression","volume":"6","author":"Jung","year":"2011","journal-title":"PloS One"},{"key":"10.1016\/j.mce.2013.12.008_b0110","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1124\/mol.104.009340","article-title":"Modulation of peroxisome proliferator-activated receptor delta activity affects neural cell adhesion molecule and polysialyltransferase ST8SiaIV induction by teratogenic valproic acid analogs in F9 cell differentiation","volume":"68","author":"Lampen","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.mce.2013.12.008_b0115","doi-asserted-by":"crossref","first-page":"C43","DOI":"10.1152\/ajpcell.00468.2008","article-title":"Simultaneous overexpression of Oct4 and Nanog abrogates terminal myogenesis","volume":"297","author":"Lang","year":"2009","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.mce.2013.12.008_b0120","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.tips.2009.10.002","article-title":"Small molecules that modulate embryonic stem cell fate and somatic cell reprogramming","volume":"31","author":"Li","year":"2009","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.mce.2013.12.008_b0125","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1038\/nbt1108-1246","article-title":"The many ways to make an iPS cell","volume":"26","author":"Lowry","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.mce.2013.12.008_b0130","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1073\/pnas.0711983105","article-title":"Generation of human induced pluripotent stem cells from dermal fibroblasts","volume":"105","author":"Lowry","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mce.2013.12.008_b0135","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1083\/jcb.9.2.493","article-title":"Satellite cell of skeletal muscle fibers","volume":"9","author":"Mauro","year":"1961","journal-title":"J. Biophys. Biochem. Cytol."},{"key":"10.1016\/j.mce.2013.12.008_b0140","first-page":"887","article-title":"Cardiovascular disease and PPARdelta: targeting the risk factors","volume":"6","author":"Muscat","year":"2005","journal-title":"Curr. Opin. Invest. Drugs"},{"key":"10.1016\/j.mce.2013.12.008_b0145","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1002\/j.1460-2075.1991.tb07850.x","article-title":"The oct3 gene, a gene for an embryonic transcription factor, is controlled by a retinoic acid repressible enhancer","volume":"10","author":"Okazawa","year":"1991","journal-title":"EMBO J."},{"key":"10.1016\/j.mce.2013.12.008_b0150","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nature05934","article-title":"Generation of germline-competent induced pluripotent stem cells","volume":"448","author":"Okita","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.mce.2013.12.008_b0155","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1126\/science.1164270","article-title":"Generation of mouse induced pluripotent stem cells without viral vectors","volume":"322","author":"Okita","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.mce.2013.12.008_b0165","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nsmb1185","article-title":"SUMOylation of Tr2 orphan receptor involves Pml and fine-tunes Oct4 expression in stem cells","volume":"14","author":"Park","year":"2007","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.mce.2013.12.008_b0160","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1016\/j.cellsig.2008.03.004","article-title":"Akt stabilizes estrogen receptor alpha with the concomitant reduction in its transcriptional activity","volume":"20","author":"Park","year":"2008","journal-title":"Cell. Signal."},{"key":"10.1016\/j.mce.2013.12.008_b0170","doi-asserted-by":"crossref","first-page":"e23667","DOI":"10.1371\/journal.pone.0023667","article-title":"Efficient non-viral reprogramming of myoblasts to stemness with a single small molecule to generate cardiac progenitor cells","volume":"6","author":"Pasha","year":"2011","journal-title":"PloS One"},{"key":"10.1016\/j.mce.2013.12.008_b0175","doi-asserted-by":"crossref","first-page":"3690","DOI":"10.1073\/pnas.051003198","article-title":"Akt phosphorylates and regulates the orphan nuclear receptor Nur77","volume":"98","author":"Pekarsky","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mce.2013.12.008_b0180","doi-asserted-by":"crossref","first-page":"695","DOI":"10.2165\/00023210-200216100-00004","article-title":"Pharmacological and therapeutic properties of valproate: a summary after 35years of clinical experience","volume":"16","author":"Perucca","year":"2002","journal-title":"CNS Drugs"},{"key":"10.1016\/j.mce.2013.12.008_b0185","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1128\/MCB.14.2.1026","article-title":"Retinoic acid represses Oct-3\/4 gene expression through several retinoic acid-responsive elements located in the promoter-enhancer region","volume":"14","author":"Pikarsky","year":"1994","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.mce.2013.12.008_b0300","article-title":"How many human embryonic stem cell lines are sufficient? A U.S. Perspective","author":"Rao","year":"2006","journal-title":"Stem Cells"},{"key":"10.1016\/j.mce.2013.12.008_b0195","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1128\/MCB.14.2.1122","article-title":"Characterization of a negative retinoic acid response element in the murine Oct4 promoter","volume":"14","author":"Schoorlemmer","year":"1994","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.mce.2013.12.008_b0200","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1006\/dbio.1999.9565","article-title":"A new look at the origin, function, and \u201cstem-cell\u201d status of muscle satellite cells","volume":"218","author":"Seale","year":"2000","journal-title":"Dev. Biol."},{"key":"10.1016\/j.mce.2013.12.008_b0205","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.stem.2008.10.004","article-title":"Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds","volume":"3","author":"Shi","year":"2008","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.mce.2013.12.008_b0210","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.stem.2008.05.011","article-title":"A combined chemical and genetic approach for the generation of induced pluripotent stem cells","volume":"2","author":"Shi","year":"2008","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.mce.2013.12.008_b0215","doi-asserted-by":"crossref","first-page":"6419","DOI":"10.1021\/jm7009233","article-title":"Potent anticonvulsant urea derivatives of constitutional isomers of valproic acid","volume":"50","author":"Shimshoni","year":"2007","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.mce.2013.12.008_b0220","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1124\/mol.106.030601","article-title":"The effects of central nervous system-active valproic acid constitutional isomers, cyclopropyl analogs, and amide derivatives on neuronal growth cone behavior","volume":"71","author":"Shimshoni","year":"2007","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.mce.2013.12.008_b0225","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1210\/en.2008-1165","article-title":"Roles of testicular orphan nuclear receptors 2 and 4 in early embryonic development and embryonic stem cells","volume":"150","author":"Shyr","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2013.12.008_b0230","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1126\/science.1162494","article-title":"Induced pluripotent stem cells generated without viral integration","volume":"322","author":"Stadtfeld","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.mce.2013.12.008_b0235","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.yexcr.2005.03.033","article-title":"Skeletal muscle stem and progenitor cells: reconciling genetics and lineage","volume":"306","author":"Tajbakhsh","year":"2005","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.mce.2013.12.008_b0245","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","article-title":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors","volume":"126","author":"Takahashi","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.mce.2013.12.008_b0240","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","article-title":"Induction of pluripotent stem cells from adult human fibroblasts by defined factors","volume":"131","author":"Takahashi","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.mce.2013.12.008_b0250","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1002\/jcb.22613","article-title":"Valproic acid enhances Oct4 promoter activity in myogenic cells","volume":"110","author":"Teng","year":"2010","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.mce.2013.12.008_b0255","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1126\/science.282.5391.1145","article-title":"Embryonic stem cell lines derived from human blastocysts","volume":"282","author":"Thomson","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.mce.2013.12.008_b0260","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1124\/mol.59.5.1269","article-title":"Induction of differentiation in F9 cells and activation of peroxisome proliferator-activated receptor delta by valproic acid and its teratogenic derivatives","volume":"59","author":"Werling","year":"2001","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.mce.2013.12.008_b0265","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/nature05944","article-title":"In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state","volume":"448","author":"Wernig","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.mce.2013.12.008_b0270","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1210\/me.2008-0465","article-title":"Expression profiling of nuclear receptors in human and mouse embryonic stem cells","volume":"23","author":"Xie","year":"2009","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.mce.2013.12.008_b0275","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1002\/jcb.21244","article-title":"Transcriptional regulation of human Oct4 by steroidogenic factor-1","volume":"101","author":"Yang","year":"2007","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.mce.2013.12.008_b0280","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1242\/dev.122.3.881","article-title":"Germline regulatory element of Oct-4 specific for the totipotent cycle of embryonal cells","volume":"122","author":"Yeom","year":"1996","journal-title":"Development"},{"key":"10.1016\/j.mce.2013.12.008_b0305","doi-asserted-by":"crossref","DOI":"10.1126\/science.1151526","article-title":"Induced pluripotent stem cell lines derived from human somatic cells","author":"Yu","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.mce.2013.12.008_b0290","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.stem.2010.11.015","article-title":"Reprogramming of human primary somatic cells by OCT4 and chemical compounds","volume":"7","author":"Zhu","year":"2010","journal-title":"Cell Stem Cell"}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720713005236?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720713005236?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,20]],"date-time":"2022-03-20T07:49:44Z","timestamp":1647762584000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720713005236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":58,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["S0303720713005236"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2013.12.008","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Valproic acid enhances Oct4 promoter activity through PI3K\/Akt\/mTOR pathway activated nuclear receptors","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2013.12.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}