{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:41:46Z","timestamp":1783485706615,"version":"3.55.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["IG 5346"],"award-info":[{"award-number":["IG 5346"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007076","name":"Fondazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013101","name":"National Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013101","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004462","name":"Consiglio Nazionale delle Ricerche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004462","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1016\/j.mce.2014.03.002","type":"journal-article","created":{"date-parts":[[2014,3,28]],"date-time":"2014-03-28T14:28:01Z","timestamp":1396016881000},"page":"1-7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":75,"title":["miR-23b and miR-130b expression is downregulated in pituitary adenomas"],"prefix":"10.1016","volume":"390","author":[{"given":"Vincenza","family":"Leone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concetta","family":"Langella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"D\u2019Angelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Mussnich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0186-6645","authenticated-orcid":false,"given":"Anne","family":"Wierinckx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Terracciano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Raverot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Lachuer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Rotondi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Lise","family":"Jaffrain-Rea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Trouillas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Fusco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2014.03.002_b0005","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1210\/jc.2008-1451","article-title":"MicroRNAs differentially expressed in ACTH-secreting pituitary tumors","volume":"94","author":"Amaral","year":"2009","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2014.03.002_b0010","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1677\/erc.0.0080287","article-title":"Pituitary tumors: pathophysiology, clinical manifestations and management","volume":"8","author":"Arafah","year":"2001","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.mce.2014.03.002_b0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000079035","article-title":"Molecular basis of pituitary development and cytogenesis","volume":"32","author":"Asa","year":"2004","journal-title":"Front Horm. Res."},{"key":"10.1016\/j.mce.2014.03.002_b0020","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.mce.2014.03.002_b0025","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1002\/jcp.20832","article-title":"Identification of differentially expressed microRNAs by microarray: a possible role for microRNA genes in pituitary adenomas","volume":"210","author":"Bottoni","year":"2007","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.mce.2014.03.002_b0030","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/s11102-010-0268-x","article-title":"MicroRNA profile indicates downregulation of the TGF\u03b2 pathway in sporadic non-functioningpituitary adenomas","volume":"14","author":"Butz","year":"2011","journal-title":"Pituitary"},{"key":"10.1016\/j.mce.2014.03.002_b0035","first-page":"320","article-title":"Differential expression analysis of prolactinoma-related microRNAs","volume":"92","author":"Chen","year":"2012","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"10.1016\/j.mce.2014.03.002_b0040","doi-asserted-by":"crossref","first-page":"3229","DOI":"10.1002\/jcb.24200","article-title":"MiR-301a promotes pancreatic cancer cell proliferation by directly inhibiting bim expression","volume":"113","author":"Chen","year":"2012","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.mce.2014.03.002_b0045","article-title":"Altered microRNA expression profile in human pituitary GH adenomas: down-regulation of miRNA targeting HMGA1, HMGA2, and E2F1","volume":"97","author":"D\u2019Angelo","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2014.03.002_b0050","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1158\/0008-5472.CAN-08-4133","article-title":"HMGA proteins up-regulate CCNB2 gene in mouse and human pituitary adenomas","volume":"69","author":"De Martino","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.mce.2014.03.002_b0055","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1530\/EJE-13-0081","article-title":"Transforming growth factor beta 1 (TGF-\u03b21) is not a reliable biomarker for valvular fibrosis but could be a potential serum marker for invasiveness of prolactinomas (pilot study)","volume":"169","author":"Elenkova","year":"2013","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.mce.2014.03.002_b0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/PPO.0b013e318164145e","article-title":"MicroRNAs","volume":"14","author":"Fabbri","year":"2008","journal-title":"Cancer J."},{"key":"10.1016\/j.mce.2014.03.002_b0065","doi-asserted-by":"crossref","first-page":"3190","DOI":"10.1038\/sj.onc.1205428","article-title":"Overexpression of the HMGA2 gene in transgenic mice leads to the onset of pituitary adenomas","volume":"21","author":"Fedele","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.mce.2014.03.002_b0070","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.ccr.2006.04.024","article-title":"HMGA2 induces pituitary tumorigenesis by enhancing E2F1 activity","volume":"9","author":"Fedele","year":"2006","journal-title":"Cancer Cell"},{"key":"10.1016\/j.mce.2014.03.002_b0075","first-page":"2398","article-title":"The High Mobility Group A2 gene is amplified and overexpressed in human prolactinomas","volume":"62","author":"Finelli","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.mce.2014.03.002_b0080","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1530\/ERC-13-0043","article-title":"Aip regulates cAMP signalling and GH secretion in GH3 cells","volume":"20","author":"Formosa","year":"2013","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.mce.2014.03.002_b0085","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1159\/000345673","article-title":"Genetics of pituitary adenomas","volume":"41","author":"Gadelha","year":"2013","journal-title":"Front Horm. Res."},{"key":"10.1016\/j.mce.2014.03.002_b0090","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.urolonc.2007.01.019","article-title":"Micro-RNA profiling in kidney and bladder cancers","volume":"25","author":"Gottardo","year":"2007","journal-title":"Urol. Oncol."},{"key":"10.1016\/j.mce.2014.03.002_b0095","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1097\/CCO.0b013e32835b6371","article-title":"TGF-\u03b2 signaling and epithelial\u2013mesenchymal transition in cancer progression","volume":"25","author":"Katsuno","year":"2013","journal-title":"Curr. Opin. Oncol."},{"key":"10.1016\/j.mce.2014.03.002_b0100","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1158\/0008-5472.CAN-11-3671","article-title":"MiRNA-130a targets ATG2B and DICER1 to inhibit autophagy and trigger killing of chronic lymphocytic leukemia cells","volume":"72","author":"Kovaleva","year":"2012","journal-title":"Cancer Res."},{"key":"10.1016\/j.mce.2014.03.002_b0105","doi-asserted-by":"crossref","first-page":"3292","DOI":"10.1210\/jc.2012-1349","article-title":"Thyrotropin regulates thyroid cell proliferation by up-regulating miR-23b and miR-29b that target SMAD3","volume":"97","author":"Leone","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2014.03.002_b0110","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.mce.2014.03.002_b0115","unstructured":"Lloyd, R.V., Kovacs, K., Young, Jr W.F., Farrel, W.E., Asa, S.L., Trouillas, J., Kontogeorgos, G., Sano, T., Scheithauer, B., Horvath, E., 2004. Pituitary tumours: introduction. In chapter 1: tumours of the pituitary. Pathology and genetics of tumours of endocrine organs. World Hearth Organization Classification of Tumours. Delellis RA, Lloyd RV, Heitz PU, Eng C (Eds.), IARC Press, Lyon, p. 10\u201313."},{"key":"10.1016\/j.mce.2014.03.002_b0120","doi-asserted-by":"crossref","first-page":"E2","DOI":"10.3171\/2010.7.FOCUS10169","article-title":"Growth hormone-secreting adenomas: pathology and cell biology","volume":"29","author":"Lopes","year":"2010","journal-title":"Neurosurg. Focus"},{"key":"10.1016\/j.mce.2014.03.002_b0125","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1172\/JCI20401","article-title":"Mechanisms for pituitary tumorigenesis: the plastic pituitary","volume":"112","author":"Melmed","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mce.2014.03.002_b0130","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.gde.2005.08.005","article-title":"How microRNAs control cell division, differentiation and death","volume":"15","author":"Miska","year":"2005","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.mce.2014.03.002_b0135","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1055\/s-0032-1331697","article-title":"AIP mutation identified in a patient with acromegaly caused by pituitary somatotroph adenoma with neuronal choristoma","volume":"121","author":"Nishizawa","year":"2013","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"issue":"31","key":"10.1016\/j.mce.2014.03.002_b0140","doi-asserted-by":"crossref","first-page":"3857","DOI":"10.1038\/onc.2011.557","article-title":"Downregulation of HMGA-targeting microRNAs has a critical role in human pituitary tumorigenesis","volume":"23","author":"Palmieri","year":"2012","journal-title":"Oncogene"},{"key":"10.1016\/j.mce.2014.03.002_b0145","doi-asserted-by":"crossref","first-page":"4196","DOI":"10.1038\/onc.2011.583","article-title":"Direct regulation of microRNA biogenesis and expression by estrogen receptor beta in hormone-responsive breast cancer","volume":"31","author":"Paris","year":"2012","journal-title":"Oncogene"},{"key":"10.1016\/j.mce.2014.03.002_b0150","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1677\/erc.1.01049","article-title":"High-mobility group A2 gene expression is frequently induced in non-functioning pituitary adenomas (NFPAs), even in the absence of chromosome 12 polysomy","volume":"12","author":"Pierantoni","year":"2005","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.mce.2014.03.002_b0155","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/modpathol.2008.202","article-title":"Overexpression of HMGA2 relates to reduction of the let-7 and its relationship to clinicopathological features in pituitary adenomas","volume":"22","author":"Qian","year":"2009","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.mce.2014.03.002_b0160","doi-asserted-by":"crossref","first-page":"2966","DOI":"10.1111\/j.1742-4658.2009.07014.x","article-title":"MicroRNA-23b mediates urokinase and c-met downmodulation and a decreased migration of human hepatocellular carcinoma cells","volume":"276","author":"Salvi","year":"2009","journal-title":"FEBS J."},{"key":"10.1016\/j.mce.2014.03.002_b0165","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1177\/039463201002300427","article-title":"MicroRNA expression profiling of oral carcinoma identifies new markers of tumor progression","volume":"23","author":"Scapoli","year":"2010","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"10.1016\/j.mce.2014.03.002_b0170","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1227\/01.NEU.0000223437.51435.6E","article-title":"Pathobiology of pituitary adenomas and carcinomas","volume":"59","author":"Scheithauer","year":"2006","journal-title":"Neurosurgery"},{"key":"10.1016\/j.mce.2014.03.002_b0175","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.1158\/0008-5472.CAN-10-3369","article-title":"MicroRNA-301 mediates proliferation and invasion in human breast cancer","volume":"71","author":"Shi","year":"2011","journal-title":"Cancer Res."},{"issue":"326","key":"10.1016\/j.mce.2014.03.002_b0180","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.mce.2009.12.028","article-title":"Chromatin remodeling and histone modifications in pituitary tumors","volume":"15","author":"Tateno","year":"2010","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2014.03.002_b0185","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/cgt.2008.77","article-title":"MicroRNA profile analysis of human prostate cancers","volume":"16","author":"Tong","year":"2009","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.mce.2014.03.002_b0190","first-page":"42","article-title":"The human gonadotropic adenoma: pathologic diagnosis and hormonal correlations in 26 tumors","volume":"3","author":"Trouillas","year":"1986","journal-title":"Semin. Diagn. Pathol."},{"issue":"8","key":"10.1016\/j.mce.2014.03.002_b0195","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/nrendo.2012.54","article-title":"The pituitary tumour epigenome: aberrations and prospects for targeted therapy","volume":"24","author":"Yacqub-Usman","year":"2012","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.mce.2014.03.002_b0200","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1007\/s00018-002-8510-y","article-title":"Cyclin A in cell cycle control and cancer","volume":"59","author":"Yam","year":"2002","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.mce.2014.03.002_b0205","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1097\/MAJ.0b013e3181e892a0","article-title":"Expression of miRNA-130a in nonsmall cell lung cancer","volume":"340","author":"Yang","year":"2010","journal-title":"Am. J. Med. Sci."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720714000847?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720714000847?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T20:44:26Z","timestamp":1782161066000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720714000847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":41,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["S0303720714000847"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2014.03.002","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2014,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"miR-23b and miR-130b expression is downregulated in pituitary adenomas","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2014.03.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ireland Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}