{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:19:54Z","timestamp":1791346794302,"version":"4.3.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81072641"],"award-info":[{"award-number":["81072641"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81273499"],"award-info":[{"award-number":["81273499"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81200096"],"award-info":[{"award-number":["81200096"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"crossref","award":["S2011030003190"],"award-info":[{"award-number":["S2011030003190"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"crossref","award":["2008A030201013"],"award-info":[{"award-number":["2008A030201013"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"crossref","award":["2012A080201007"],"award-info":[{"award-number":["2012A080201007"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Major Project of Guangdong Province"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1016\/j.mce.2014.05.010","type":"journal-article","created":{"date-parts":[[2014,5,21]],"date-time":"2014-05-21T10:02:37Z","timestamp":1400666557000},"page":"14-22","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["AG-690\/11026014, a novel PARP-1 inhibitor, protects cardiomyocytes from AngII-induced hypertrophy"],"prefix":"10.1016","volume":"392","author":[{"given":"Min","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Wen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo-Ming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0394-8879","authenticated-orcid":false,"given":"Lu-Ping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Tao","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Bin","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Qing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2014.05.010_b0150","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1161\/01.RES.0000267723.65696.4a","article-title":"Sirt1 regulates aging and resistance to oxidative stress in the heart","volume":"100","author":"Alcendor","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.mce.2014.05.010_b0020","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1002\/bies.20085","article-title":"The PARP superfamily","volume":"26","author":"Ame","year":"2004","journal-title":"Bioessays"},{"key":"10.1016\/j.mce.2014.05.010_b0045","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/FJC.0b013e3181855cef","article-title":"Effect of L-2286, a poly(ADP-ribose)polymerase inhibitor and enalapril on myocardial remodeling and heart failure","volume":"52","author":"Bartha","year":"2008","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.mce.2014.05.010_b0145","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.febslet.2012.02.014","article-title":"Nmnat2 protects cardiomyocytes from hypertrophy via activation of SIRT6","volume":"586","author":"Cai","year":"2012","journal-title":"FEBS Lett."},{"key":"10.1016\/j.mce.2014.05.010_b0110","first-page":"1169","article-title":"An improved nonisotopic test to screen a large series of new inhibitor molecules of poly(ADP-ribose) polymerase activity for therapeutic applications","volume":"5","author":"Decker","year":"1999","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.mce.2014.05.010_b0085","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.trsl.2007.11.005","article-title":"Tanshinone IIA protects neonatal rat cardiomyocytes from adriamycin-induced apoptosis","volume":"151","author":"Gao","year":"2008","journal-title":"Trans. Res."},{"key":"10.1016\/j.mce.2014.05.010_b0135","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1042\/BJ20101484","article-title":"Ca2+-induced PARP-1 activation and ANF expression are coupled events in cardiomyocytes","volume":"438","author":"Geistrikh","year":"2011","journal-title":"Biochem. J."},{"key":"10.1016\/j.mce.2014.05.010_b0090","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/j.bbrc.2012.11.132","article-title":"PARP-2 knockdown protects cardiomyocytes from hypertrophy via activation of SIRT1","volume":"430","author":"Geng","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mce.2014.05.010_b0155","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1146\/annurev.pathol.4.110807.092250","article-title":"Mammalian sirtuins: biological insights and disease relevance","volume":"5","author":"Haigis","year":"2010","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.mce.2014.05.010_b0015","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nrd1718","article-title":"Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors","volume":"4","author":"Jagtap","year":"2005","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.mce.2014.05.010_b0060","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1021\/jm020406h","article-title":"Surflex: fully automatic flexible molecular docking using a molecular similarity-based search engine","volume":"46","author":"Jain","year":"2003","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.mce.2014.05.010_b0115","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1038\/bjc.2011.382","article-title":"The role of PARP in DNA repair and its therapeutic exploitation","volume":"105","author":"Javle","year":"2011","journal-title":"Br. J. Cancer."},{"key":"10.1016\/j.mce.2014.05.010_b0105","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.ejmech.2012.02.001","article-title":"Synthesis and SAR optimization of quinazolin-4(3H)-ones as poly(ADP-ribose)polymerase-1 inhibitors","volume":"50","author":"Kulkarni","year":"2012","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.mce.2014.05.010_b0080","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.abb.2011.11.024","article-title":"PPARalpha activation inhibits endothelin-1-induced cardiomyocyte hypertrophy by prevention of NFATc4 binding to GATA-4","volume":"518","author":"Le","year":"2012","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.mce.2014.05.010_b0025","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1101\/gad.183509.111","article-title":"On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1","volume":"26","author":"Luo","year":"2012","journal-title":"Genes Dev."},{"key":"10.1016\/j.mce.2014.05.010_b0170","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.yjmcc.2010.12.018","article-title":"Regulation of myocardial growth and death by NADPH oxidase","volume":"50","author":"Maejima","year":"2011","journal-title":"J. Mol. Cell Cardiol."},{"key":"10.1016\/j.mce.2014.05.010_b0030","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1124\/jpet.108.143719","volume":"328","author":"Oh","year":"2009","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.mce.2014.05.010_b0035","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1527-3466.2007.00018.x","article-title":"Role of poly(ADP-ribose) polymerase 1 (PARP-1) in cardiovascular diseases: the therapeutic potential of PARP inhibitors","volume":"25","author":"Pacher","year":"2007","journal-title":"Cardiovasc. Drug Rev."},{"key":"10.1016\/j.mce.2014.05.010_b0005","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.freeradbiomed.2009.04.008","article-title":"PARP inhibitors: new partners in the therapy of cancer and inflammatory diseases","volume":"47","author":"Peralta-Leal","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mce.2014.05.010_b0125","doi-asserted-by":"crossref","first-page":"H486","DOI":"10.1152\/ajpheart.00437.2004","article-title":"Increased expression of poly(ADP-ribose) polymerase-1 contributes to caspase-independent myocyte cell death during heart failure","volume":"288","author":"Pillai","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.mce.2014.05.010_b0040","doi-asserted-by":"crossref","first-page":"43121","DOI":"10.1074\/jbc.M506162200","article-title":"Poly(ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2alpha deacetylase activity","volume":"280","author":"Pillai","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2014.05.010_b0010","doi-asserted-by":"crossref","first-page":"H1545","DOI":"10.1152\/ajpheart.01124.2005","article-title":"Poly(ADP-ribose) polymerase-1-deficient mice are protected from angiotensin II-induced cardiac hypertrophy","volume":"291","author":"Pillai","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.mce.2014.05.010_b0140","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.1074\/jbc.M109.077271","article-title":"Exogenous NAD blocks cardiac hypertrophic response via activation of the SIRT3-LKB1-AMP-activated kinase pathway","volume":"285","author":"Pillai","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2014.05.010_b0075","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ab.2003.11.015","article-title":"An enzymatic assay for poly(ADP-ribose) polymerase-1 (PARP-1) via the chemical quantitation of NAD(+): application to the high-throughput screening of small molecules as potential inhibitors","volume":"326","author":"Putt","year":"2004","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.mce.2014.05.010_b0050","doi-asserted-by":"crossref","first-page":"3893","DOI":"10.1021\/bi972383s","article-title":"Inhibitor and NAD+ binding to poly(ADP-ribose) polymerase as derived from crystal structures and homology modeling","volume":"37","author":"Ruf","year":"1998","journal-title":"Biochemistry"},{"key":"10.1016\/j.mce.2014.05.010_b0120","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.phrs.2005.02.017","article-title":"Cardioprotective effects of poly(ADP-ribose) polymerase inhibition","volume":"52","author":"Szabo","year":"2005","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.mce.2014.05.010_b0100","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/j.bmcl.2005.10.099","article-title":"Synthesis and structure-activity relationships of novel poly(ADP-ribose) polymerase-1 inhibitors","volume":"16","author":"Tao","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.mce.2014.05.010_b0070","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S1093-3263(02)00164-X","article-title":"LigandFit: a novel method for the shape-directed rapid docking of ligands to protein active sites","volume":"21","author":"Venkatachalam","year":"2003","journal-title":"J. Mol. Graph. Model."},{"key":"10.1016\/j.mce.2014.05.010_b0055","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.2174\/156802608786786624","article-title":"Medicinal chemistry and the molecular operating environment (MOE): application of QSAR and molecular docking to drug discovery","volume":"8","author":"Vilar","year":"2008","journal-title":"Curr. Top Med. Chem."},{"key":"10.1016\/j.mce.2014.05.010_b0160","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.freeradbiomed.2013.08.179","article-title":"NADPH oxidases mediate a cellular \u201cmemory\u201d of angiotensin II stress in hypertensive cardiac hypertrophy","volume":"65","author":"Wang","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mce.2014.05.010_b0130","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/S0008-6363(99)00145-5","article-title":"The renin-angiotensin system and experimental heart failure","volume":"43","author":"Wollert","year":"1999","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.mce.2014.05.010_b0065","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1002\/jcc.10306","article-title":"Detailed analysis of grid-based molecular docking: A case study of CDOCKER-A CHARMm-based MD docking algorithm","volume":"24","author":"Wu","year":"2003","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.mce.2014.05.010_b0095","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1476-5381.2012.01903.x","article-title":"Sirtuin 6 protects cardiomyocytes from hypertrophy in vitro via inhibition of NF-kappaB-dependent transcriptional activity","volume":"168","author":"Yu","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.mce.2014.05.010_b0165","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1016\/j.freeradbiomed.2012.07.010","article-title":"Oxidative and nitrosative stress in the maintenance of myocardial function","volume":"53","author":"Zhang","year":"2012","journal-title":"Free Radic. Biol. Med."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030372071400152X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030372071400152X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T23:37:30Z","timestamp":1589240250000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030372071400152X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":34,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["S030372071400152X"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2014.05.010","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"AG-690\/11026014, a novel PARP-1 inhibitor, protects cardiomyocytes from AngII-induced hypertrophy","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2014.05.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}