{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:36:24Z","timestamp":1761708984664,"version":"3.40.4"},"reference-count":55,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.mce.2014.05.020","type":"journal-article","created":{"date-parts":[[2014,6,3]],"date-time":"2014-06-03T00:32:15Z","timestamp":1401755535000},"page":"16-23","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Transcriptomic effects of estradiol treatment on cultured human uterine smooth muscle cells"],"prefix":"10.1016","volume":"393","author":[{"given":"Sreenath","family":"Chandran","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael T.","family":"Cairns","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"O\u2019Brien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terry J.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2014.05.020_b0005","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1093\/molehr\/6.12.1141","article-title":"Application of a functional genomics approach to identify differentially expressed genes in human myometrium during pregnancy and labour","volume":"6","author":"Aguan","year":"2000","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.mce.2014.05.020_b0010","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1093\/humupd\/dmq016","article-title":"Physiological pathways and molecular mechanisms regulating uterine contractility","volume":"16","author":"Aguilar","year":"2010","journal-title":"Hum. Reprod. Update"},{"issue":"Suppl 5","key":"10.1016\/j.mce.2014.05.020_b0015","doi-asserted-by":"crossref","first-page":"811","DOI":"10.2307\/3454311","article-title":"Comparing regulation of the connexin43 gene by estrogen in uterine leiomyoma and pregnancy myometrium","volume":"108","author":"Andersen","year":"2000","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.mce.2014.05.020_b0020","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1530\/JME-10-0116","article-title":"Pharmacological inhibition of sphingosine kinase isoforms alters estrogen receptor signaling in human breast cancer","volume":"46","author":"Antoon","year":"2011","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.mce.2014.05.020_b0025","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1093\/molehr\/gan045","article-title":"Potential link between estrogen receptor-alpha gene hypomethylation and uterine fibroid formation","volume":"14","author":"Asada","year":"2008","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.mce.2014.05.020_b0030","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jep.2012.06.042","article-title":"Uterine contractility of plants used to facilitate childbirth in Nigerian ethnomedicine","volume":"143","author":"Attah","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.mce.2014.05.020_b0035","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1113\/eph8602178","article-title":"Overview of current research in parturition","volume":"86","author":"Bernal","year":"2001","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.mce.2014.05.020_b0040","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1210\/me.2003-0007","article-title":"Microarray analysis of uterine gene expression in mouse and human pregnancy","volume":"17","author":"Bethin","year":"2003","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.mce.2014.05.020_b0045","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/S0899-9007(01)00637-2","article-title":"Vitamin E kinetics and the function of tocopherol regulatory proteins","volume":"17","author":"Blatt","year":"2001","journal-title":"Nutrition"},{"key":"10.1016\/j.mce.2014.05.020_b0050","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.mce.2014.05.020_b0055","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1677\/joe.0.1620401","article-title":"Expression of G-protein-coupled receptor kinases in pregnant term and non-pregnant human myometrium","volume":"162","author":"Brenninkmeijer","year":"1999","journal-title":"J. Endocrinol."},{"issue":"Suppl 1","key":"10.1016\/j.mce.2014.05.020_b0060","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1186\/1471-2393-7-S1-S4","article-title":"Functional genomics of the pregnant uterus: from expectations to reality, a compilation of studies in the myometrium","volume":"7","author":"Breuiller-Fouche","year":"2007","journal-title":"BMC Preg. Childbirth"},{"key":"10.1016\/j.mce.2014.05.020_b0065","doi-asserted-by":"crossref","first-page":"9805","DOI":"10.1073\/pnas.0803223105","article-title":"Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1","volume":"105","author":"Cha","year":"2008","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.mce.2014.05.020_b0070","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1095\/biolreprod.102.013763","article-title":"A functional genomic study to identify differential gene expression in the preterm and term human myometrium","volume":"68","author":"Charpigny","year":"2003","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2014.05.020_b0075","doi-asserted-by":"crossref","first-page":"47329","DOI":"10.1074\/jbc.M107666200","article-title":"The angiogenic factor Cyr61 activates a genetic program for wound healing in human skin fibroblasts","volume":"276","author":"Chen","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2014.05.020_b0080","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1095\/biolreprod.107.065375","article-title":"Characterization of antiestrogenic activity of the Chinese herb, prunella vulgaris, using in vitro and in vivo (Mouse Xenograft) models","volume":"80","author":"Collins","year":"2009","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2014.05.020_b0085","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.prostaglandins.2008.03.001","article-title":"Effects of lubiprostone on human uterine smooth muscle cells","volume":"86","author":"Cuppoletti","year":"2008","journal-title":"Prostagl. Other Lipid Mediat."},{"key":"10.1016\/j.mce.2014.05.020_b0090","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.tibs.2004.09.001","article-title":"Vinculin\u2013a dynamic regulator of cell adhesion","volume":"29","author":"Demali","year":"2004","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.mce.2014.05.020_b0095","doi-asserted-by":"crossref","first-page":"P3","DOI":"10.1186\/gb-2003-4-5-p3","article-title":"DAVID: database for annotation, visualization, and integrated discovery","volume":"4","author":"Dennis","year":"2003","journal-title":"Genome Biol."},{"key":"10.1016\/j.mce.2014.05.020_b0100","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1093\/molehr\/7.7.671","article-title":"Oestriol and oestradiol increase cell to cell communication and connexin43 protein expression in human myometrium","volume":"7","author":"Di","year":"2001","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.mce.2014.05.020_b0105","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1095\/biolreprod.110.086942","article-title":"Altered spatiotemporal expression of collagen types I, III, IV, and VI in Lpar3-deficient peri-implantation mouse uterus","volume":"84","author":"Diao","year":"2011","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2014.05.020_b0110","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.mce.2005.11.014","article-title":"Regulation of CD 38 expression and function by steroid hormones in myometrium","volume":"246","author":"Dogan","year":"2006","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2014.05.020_b0115","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1101\/gad.3.5.628","article-title":"A gene with homology to the myc similarity region of Myod1 is expressed during myogenesis and is sufficient to activate the muscle differentiation program","volume":"3","author":"Edmondson","year":"1989","journal-title":"Genes Dev."},{"key":"10.1016\/j.mce.2014.05.020_b0120","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.ajog.2004.12.021","article-title":"The use of cDNA microarray to identify differentially expressed labor-associated genes within the human myometrium during labor","volume":"193","author":"Esplin","year":"2005","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.mce.2014.05.020_b0125","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1477-7827-7-2","article-title":"Modulation of human uterine smooth muscle cell collagen contractility by thrombin, Y-27632, TNF alpha and indomethacin","volume":"7","author":"Fitzgibbon","year":"2009","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.mce.2014.05.020_b0130","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.2174\/138161212800626139","article-title":"Estrogen receptor beta in cancer: an attractive target for therapy","volume":"18","author":"Gallo","year":"2012","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.mce.2014.05.020_b0135","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/biof.191","article-title":"Biochemical investigation and gene analysis of equol: a plant and soy-derived isoflavonoid with antiaging and antioxidant properties with potential human skin applications","volume":"38","author":"Gopaul","year":"2012","journal-title":"BioFactors"},{"key":"10.1016\/j.mce.2014.05.020_b0140","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S0022-3565(24)29301-0","article-title":"Recombinant human interleukin-11 restores smooth muscle function in the jejunum and colon of human leukocyte antigen-B27 rats with intestinal inflammation","volume":"299","author":"Greenwood-Van Meerveld","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.mce.2014.05.020_b0145","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1095\/biolreprod.104.032979","article-title":"Human myometrial gene expression before and during parturition","volume":"72","author":"Havelock","year":"2005","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2014.05.020_b0150","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1152\/physiolgenomics.00290.2007","article-title":"Changes in global gene expression in rat myometrium in transition from late pregnancy to parturition","volume":"36","author":"Helguera","year":"2009","journal-title":"Physiol. Genomics"},{"key":"10.1016\/j.mce.2014.05.020_b0155","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1677\/joe.0.1810157","article-title":"Analysis of estrogen-regulated genes in mouse uterus using cDNA microarray and laser capture microdissection","volume":"181","author":"Hong","year":"2004","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.mce.2014.05.020_b0160","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1083\/jcb.201006044","article-title":"KIF17 stabilizes microtubules and contributes to epithelial morphogenesis by acting at MT plus ends with EB1 and APC","volume":"190","author":"Jaulin","year":"2010","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.mce.2014.05.020_b0165","doi-asserted-by":"crossref","first-page":"21183","DOI":"10.1073\/pnas.1311183110","article-title":"Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design","volume":"110","author":"Koehbach","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mce.2014.05.020_b0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00441-008-0657-x","article-title":"Remodeling of uterine innervation","volume":"334","author":"Latini","year":"2008","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.mce.2014.05.020_b0175","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1159\/000061038","article-title":"Roles of estrogen and progesterone in human parturition","volume":"27","author":"Mesiano","year":"2001","journal-title":"Front. Horm. Res"},{"key":"10.1016\/j.mce.2014.05.020_b0180","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.steroids.2010.01.007","article-title":"Influence of the estrous cycle on clock gene expression in reproductive tissues: effects of fluctuating ovarian steroid hormone levels","volume":"75","author":"Nakamura","year":"2010","journal-title":"Steroids"},{"key":"10.1016\/j.mce.2014.05.020_b0185","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1113\/jphysiol.2005.090951","article-title":"Electrophysiological and molecular identification of voltage-gated sodium channels in murine vascular myocytes","volume":"568","author":"Saleh","year":"2005","journal-title":"J. Physiol."},{"key":"10.1016\/j.mce.2014.05.020_b0190","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1111\/j.1582-4934.2010.01250.x","article-title":"Effects of S1P on skeletal muscle repair\/regeneration during eccentric contraction","volume":"15","author":"Sassoli","year":"2011","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.mce.2014.05.020_b0195","doi-asserted-by":"crossref","first-page":"17005","DOI":"10.1074\/jbc.M412584200","article-title":"The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling","volume":"280","author":"Schoenemeyer","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2014.05.020_b0200","doi-asserted-by":"crossref","first-page":"4669","DOI":"10.1210\/en.2008-1756","article-title":"Signaling pathways involved in sphingosine kinase activation and sphingosine-1-phosphate release in rat myometrium in late pregnancy: role in the induction of cyclooxygenase 2","volume":"149","author":"Serrano-Sanchez","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2014.05.020_b0205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1095\/biolreprod26.1.1","article-title":"Immunologic and endocrine interrelationships in pregnancy","volume":"26","author":"Siiteri","year":"1982","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2014.05.020_b0210","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1177\/1933719111398150","article-title":"Effects of progesterone treatment on expression of genes involved in uterine quiescence","volume":"18","author":"Soloff","year":"2011","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.mce.2014.05.020_b0215","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s11010-006-2388-1","article-title":"Functional changes in bladder tissue from type III collagen-deficient mice","volume":"283","author":"Stevenson","year":"2006","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.mce.2014.05.020_b0220","first-page":"283","article-title":"The cytoskeleton in skeletal, cardiac and smooth muscle cells","volume":"13","author":"Stromer","year":"1998","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.mce.2014.05.020_b0225","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1083\/jcb.200506033","article-title":"Estrogen transactivates EGFR via the sphingosine 1-phosphate receptor Edg-3: the role of sphingosine kinase-1","volume":"173","author":"Sukocheva","year":"2006","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.mce.2014.05.020_b0230","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1093\/molehr\/gah174","article-title":"Estrogen-induced changes in IGF-I, Myb family and MAP kinase pathway genes in human uterine leiomyoma and normal uterine smooth muscle cell lines","volume":"11","author":"Swartz","year":"2005","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.mce.2014.05.020_b0235","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/sj.bjp.0702996","article-title":"Pharmacologic characterization of the oxytocin receptor in human uterine smooth muscle cells","volume":"129","author":"Tahara","year":"2000","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.mce.2014.05.020_b0240","doi-asserted-by":"crossref","first-page":"D533","DOI":"10.1093\/nar\/gkh083","article-title":"ERGDB: estrogen responsive genes database","volume":"32","author":"Tang","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mce.2014.05.020_b0245","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1006\/geno.1998.5719","article-title":"Human bHLH transcription factor gene myogenin (MYOG): genomic sequence and negative mutation analysis in patients with severe congenital myopathies","volume":"57","author":"Tseng","year":"1999","journal-title":"Genomics"},{"key":"10.1016\/j.mce.2014.05.020_b0250","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.cellsig.2004.09.013","article-title":"The role of sphingosine-1-phosphate in smooth muscle contraction","volume":"17","author":"Watterson","year":"2005","journal-title":"Cell. Signal."},{"key":"10.1016\/j.mce.2014.05.020_b0255","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1002\/ar.a.20274","article-title":"Three-dimensional fiber architecture of the nonpregnant human uterus determined ex vivo using magnetic resonance diffusion tensor imaging","volume":"288A","author":"Weiss","year":"2006","journal-title":"Anat. Rec. Part A"},{"key":"10.1016\/j.mce.2014.05.020_b0260","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s12672-012-0103-0","article-title":"Glucocorticoids regulate gene expression and repress cellular proliferation in human uterine leiomyoma cells","volume":"3","author":"Whirledge","year":"2012","journal-title":"Horm Cancer"},{"key":"10.1016\/j.mce.2014.05.020_b0265","doi-asserted-by":"crossref","first-page":"E55","DOI":"10.1152\/ajpendo.00553.2011","article-title":"Increased MMPs expression and decreased contraction in the rat myometrium during pregnancy and in response to prolonged stretch and sex hormones","volume":"303","author":"Yin","year":"2012","journal-title":"Am. J. Physiol. \u2013 Endocrinol. Metab."},{"key":"10.1016\/j.mce.2014.05.020_b0270","first-page":"1685","article-title":"Enhanced induction of prostatic dysplasia and carcinoma in Noble rat model by combination of neonatal estrogen exposure and hormonal treatments at adulthood","volume":"27","author":"Yuen","year":"2005","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.mce.2014.05.020_b0275","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1095\/biolreprod.107.064485","article-title":"Multiple signals regulate phospholipase CBeta3 in human myometrial cells","volume":"78","author":"Zhong","year":"2008","journal-title":"Biol. Reprod."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720714001695?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720714001695?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T06:14:19Z","timestamp":1746252859000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720714001695"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":55,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["S0303720714001695"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2014.05.020","relation":{},"ISSN":["0303-7207"],"issn-type":[{"type":"print","value":"0303-7207"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transcriptomic effects of estradiol treatment on cultured human uterine smooth muscle cells","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2014.05.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}