{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T15:01:05Z","timestamp":1790521265929,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Health and Labour Science Research Grants"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.mce.2014.07.001","type":"journal-article","created":{"date-parts":[[2014,7,8]],"date-time":"2014-07-08T15:48:04Z","timestamp":1404834484000},"page":"37-46","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Inhibitory effects of SOM230 on adrenocorticotropic hormone production and corticotroph tumor cell proliferation in vitro and in vivo"],"prefix":"10.1016","volume":"394","author":[{"given":"Shingo","family":"Murasawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunori","family":"Kageyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Sugiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Ishigame","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanako","family":"Niioka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Suda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Daimon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2014.07.001_b0005","doi-asserted-by":"crossref","first-page":"4482","DOI":"10.1210\/jc.2006-1245","article-title":"The effects of SOM230 on cell proliferation and adrenocorticotropin secretion in human corticotroph pituitary adenomas","volume":"91","author":"Batista","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2014.07.001_b0010","doi-asserted-by":"crossref","first-page":"3564","DOI":"10.1073\/pnas.88.9.3564","article-title":"PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues","volume":"88","author":"Benjannet","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mce.2014.07.001_b0015","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1210\/jc.2012-3200","article-title":"Approach to the Cushing\u2019s disease patient with persistent\/recurrent hypercortisolism after pituitary surgery","volume":"98","author":"Bertagna","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2014.07.001_b0020","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1530\/eje.0.1460707","article-title":"SOM230: a novel somatostatin peptidomimetic with broad somatotropin release inhibiting factor (SRIF) receptor binding and a unique antisecretory profile","volume":"146","author":"Bruns","year":"2002","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.mce.2014.07.001_b0030","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1159\/000327429","article-title":"Effect of SOM230 (pasireotide) on corticotropic cells: action in dogs with Cushing\u2019s disease","volume":"94","author":"Castillo","year":"2011","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.mce.2014.07.001_b0040","doi-asserted-by":"crossref","first-page":"e17924","DOI":"10.1371\/journal.pone.0017924","article-title":"Lineage-specific restraint of pituitary gonadotroph cell adenoma growth","volume":"6","author":"Chesnokova","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.mce.2014.07.001_b0035","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1210\/me.2012-1158","article-title":"Clusterin and FOXL2 act concordantly to regulate pituitary gonadotroph adenoma growth","volume":"26","author":"Chesnokova","year":"2012","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.mce.2014.07.001_b0025","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1056\/NEJMoa1105743","article-title":"A 12-month phase 3 study of pasireotide in Cushing\u2019s disease","volume":"366","author":"Colao","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mce.2014.07.001_b0045","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s11154-008-9082-4","article-title":"Somatostatin and dopamine receptors as targets for medical treatment of Cushing\u2019s syndrome","volume":"10","author":"de Bruin","year":"2009","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.mce.2014.07.001_b0050","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1056\/NEJMc1000094","article-title":"Pasireotide alone or with cabergoline and ketoconazole in Cushing\u2019s disease","volume":"362","author":"Feelders","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mce.2014.07.001_b0055","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1677\/JME-08-0162","article-title":"The clinical\u2013molecular interface of somatostatin, dopamine and their receptors in pituitary pathophysiology","volume":"42","author":"Ferone","year":"2009","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.mce.2014.07.001_b0060","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.neulet.2004.06.006","article-title":"Effects of corticotropin-releasing hormone (CRH) on the synthesis and secretion of proopiomelanocortin-related peptides in the anterior pituitary: a study using CRH-deficient mice","volume":"367","author":"Fukuda","year":"2004","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.mce.2014.07.001_b0065","doi-asserted-by":"crossref","first-page":"4712","DOI":"10.1172\/JCI60417","article-title":"EGFR as a therapeutic target for human, canine, and mouse ACTH-secreting pituitary adenomas","volume":"121","author":"Fukuoka","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mce.2014.07.001_b0070","doi-asserted-by":"crossref","first-page":"3446","DOI":"10.1210\/jc.2013-1771","article-title":"Hyperglycemia associated with pasireotide: results from a mechanistic study in healthy volunteers","volume":"98","author":"Henry","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2014.07.001_b0075","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.mce.2007.10.015","article-title":"Somatostatin and somatostatin receptors in Cushing\u2019s disease","volume":"286","author":"Hofland","year":"2008","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2014.07.001_b0080","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1530\/eje.1.01876","article-title":"The multi-ligand somatostatin analogue SOM230 inhibits ACTH secretion by cultured human corticotroph adenomas via somatostatin receptor type 5","volume":"152","author":"Hofland","year":"2005","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.mce.2014.07.001_b0085","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.1002\/art.30410","article-title":"Differential antiinflammatory and antinociceptive effects of the somatostatin analogs octreotide and pasireotide in a mouse model of immune-mediated arthritis","volume":"63","author":"Imhof","year":"2011","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.mce.2014.07.001_b0095","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1210\/en.2005-0376","article-title":"G protein-coupled receptor kinase 2 involvement in desensitization of corticotropin-releasing factor (CRF) receptor type 1 by CRF in murine corticotrophs","volume":"147","author":"Kageyama","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2014.07.001_b0090","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.mce.2006.08.011","article-title":"Differential regulation of CREB and ERK phosphorylation through corticotropin-releasing factor receptors type 1 and 2 in AtT-20 and A7r5 cells","volume":"263","author":"Kageyama","year":"2007","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2014.07.001_b0100","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.regpep.2009.02.012","article-title":"Differential regulation of urocortins1-3 mRNA in human umbilical vein endothelial cells","volume":"155","author":"Kageyama","year":"2009","journal-title":"Regul. Pept."},{"key":"10.1016\/j.mce.2014.07.001_b0105","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.regpep.2010.02.006","article-title":"Differential regulation and roles of urocortins in human adrenal H295R cells","volume":"162","author":"Kageyama","year":"2010","journal-title":"Regul. Pept."},{"key":"10.1016\/j.mce.2014.07.001_b0110","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1507\/endocrj.EJ12-0299","article-title":"Evaluation of the diagnostic criteria for Cushing\u2019s disease in Japan","volume":"6","author":"Kageyama","year":"2013","journal-title":"Endocr. J."},{"key":"10.1016\/j.mce.2014.07.001_b0115","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1210\/jc.2008-1919","article-title":"Differential effects of octreotide and pasireotide on somatostatin receptor internalization and trafficking in vitro","volume":"94","author":"Lesche","year":"2009","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2014.07.001_b0120","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.mce.2005.09.010","article-title":"Differential regulation of corticotropin-releasing factor receptor type 1 (CRF1 receptor) mRNA via protein kinase A and mitogen-activated protein kinase pathways in rat anterior pituitary cells","volume":"243","author":"Moriyama","year":"2005","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2014.07.001_b0125","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1159\/000079037","article-title":"Cell cycle dysregulation in pituitary oncogenesis","volume":"32","author":"Mu\u015fat","year":"2004","journal-title":"Front. Horm. Res."},{"key":"10.1016\/j.mce.2014.07.001_b0130","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1210\/jc.2008-0125","article-title":"The diagnosis of Cushing\u2019s syndrome: an endocrine society clinical practice guideline","volume":"93","author":"Nieman","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2014.07.001_b0135","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0303-7207(91)90004-C","article-title":"Growth and cell cycle regulation of mRNA levels in GH3 cells","volume":"82","author":"Rhode","year":"1991","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2014.07.001_b0140","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1530\/JOE-11-0224","article-title":"Effects of somatostatin analogs on glucose homeostasis in rats","volume":"212","author":"Schmid","year":"2012","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.mce.2014.07.001_b0145","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1517\/14728210903413522","article-title":"Drugs in the medical treatment of Cushing\u2019s syndrome","volume":"14","author":"Schteingart","year":"2009","journal-title":"Exp. Opin. Emerg. Drugs"},{"key":"10.1016\/j.mce.2014.07.001_b0150","doi-asserted-by":"crossref","first-page":"R7","DOI":"10.1530\/eje.1.01998","article-title":"Regulation of CRH-induced secretion of ACTH and corticosterone by SOM230 in rats","volume":"153","author":"Silva","year":"2005","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.mce.2014.07.001_b0155","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1677\/joe.1.06418","article-title":"Suppressive effects of dehydroepiandrosterone and the nuclear factor-kappaB inhibitor parthenolide on corticotroph tumor cell growth and function in vitro and in vivo","volume":"188","author":"Taguchi","year":"2006","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.mce.2014.07.001_b0160","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1507\/endocrj.K08E-186","article-title":"Differential expression of somatostatin and dopamine receptor subtype genes in adrenocorticotropin (ACTH)-secreting pituitary tumors and silent corticotroph adenomas","volume":"56","author":"Tateno","year":"2009","journal-title":"Endocr. J."},{"key":"10.1016\/j.mce.2014.07.001_b0165","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1158\/0008-5472.CAN-05-1189","article-title":"Octreotide, a somatostatin analogue, mediates its antiproliferative action in pituitary tumor cells by altering phosphatidylinositol 3-kinase signaling and inducing Zac1 expression","volume":"66","author":"Theodoropoulou","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.mce.2014.07.001_b0170","doi-asserted-by":"crossref","unstructured":"Trementino, L., Cardinaletti, M., Concettoni, C., Marcelli, G., Polenta, B., Spinello, M., Boscaro, M., Arnaldi, G., 2014. Salivary cortisol is a useful tool to assess the early response to pasireotide in patients with Cushing\u2019s disease. Pituitary (in press).","DOI":"10.1007\/s11102-014-0557-x"},{"key":"10.1016\/j.mce.2014.07.001_b0175","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1210\/en.2009-1102","article-title":"Effects of bone morphogenetic protein (BMP) on adrenocorticotropin production by pituitary corticotrope cells: involvement of up-regulation of BMP receptor signaling by somatostatin analogs","volume":"151","author":"Tsukamoto","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2014.07.001_b0180","doi-asserted-by":"crossref","first-page":"E278","DOI":"10.1152\/ajpendo.00004.2005","article-title":"Distinct functional properties of native somatostatin receptor subtype 5 compared with subtype 2 in the regulation of ACTH release by corticotroph tumor cells","volume":"289","author":"van der Hoek","year":"2005","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2014.07.001_b0185","doi-asserted-by":"crossref","unstructured":"Yang, Y., Sheng, M., Huang, F., Bu, D., Liu, X., Yao, Y., Dai, C., Sun, B., Zhu, J., Jiao, Y., Wei, Z., Zhu, H., Lu, L., Zhao Y., Jiang, C., Wang, R., 2014. Downregulation of insulin-like growth factor binding protein 6 is associated with ACTH-secreting pituitary adenoma growth. Pituitary (in press).","DOI":"10.1007\/s11102-013-0535-8"},{"key":"10.1016\/j.mce.2014.07.001_b0190","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1210\/jcem.84.2.5432","article-title":"Pituitary tumor transforming gene (PTTG) expression in pituitary adenomas","volume":"84","author":"Zhang","year":"1999","journal-title":"J. Clin. Endocrinol. Metab."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720714002056?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720714002056?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T20:52:59Z","timestamp":1538427179000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720714002056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":38,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["S0303720714002056"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2014.07.001","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibitory effects of SOM230 on adrenocorticotropic hormone production and corticotroph tumor cell proliferation in vitro and in vivo","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2014.07.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}