{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T16:47:29Z","timestamp":1781801249104,"version":"3.54.5"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Health and Medical Research Council of Australia","award":["1010420"],"award-info":[{"award-number":["1010420"]}]},{"DOI":"10.13039\/100008158","name":"Arthritis Foundation of Western Australia","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008158","id-type":"DOI","asserted-by":"crossref"}]},{"name":"University of Western Australia Research Collaboration Awards"},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81272020"],"award-info":[{"award-number":["81272020"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81228013"],"award-info":[{"award-number":["81228013"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1016\/j.mce.2014.10.016","type":"journal-article","created":{"date-parts":[[2014,11,3]],"date-time":"2014-11-03T07:53:42Z","timestamp":1415001222000},"page":"346-353","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"special_numbering":"C","title":["Triptolide inhibits osteoclast formation, bone resorption, RANKL-mediated NF-\u049bB activation and titanium particle-induced osteolysis in a mouse model"],"prefix":"10.1016","volume":"399","author":[{"given":"Jianbin","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huafei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Pavlos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shek Man","family":"Chim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinmin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren Xiang","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiming","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estabelle S.","family":"Ang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haotian","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Tickner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiake","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2014.10.016_bib0010","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1002\/jcp.21787","article-title":"Proteasome inhibitors impair RANKL-induced NF-kappaB activity in osteoclast-like cells via disruption of p62, TRAF6, CYLD, and IkappaBalpha signaling cascades","volume":"220","author":"Ang","year":"2009","journal-title":"J. Cell. Physiol"},{"key":"10.1016\/j.mce.2014.10.016_bib0015","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/j.1749-6632.2009.05315.x","article-title":"Functions of nuclear factor kappaB in bone","volume":"1192","author":"Boyce","year":"2010","journal-title":"Ann. N. Y. Acad. Sci"},{"key":"10.1016\/j.mce.2014.10.016_bib0020","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.bone.2003.11.018","article-title":"Osteoclastogenesis is decreased by cysteine proteinase inhibitors","volume":"34","author":"Brage","year":"2004","journal-title":"Bone"},{"key":"10.1016\/j.mce.2014.10.016_bib0025","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3109\/10428190109064582","article-title":"Triptolide, a novel immunosuppressive and anti-inflammatory agent purified from a Chinese herb Tripterygium wilfordii Hook F","volume":"42","author":"Chen","year":"2001","journal-title":"Leuk. Lymphoma"},{"key":"10.1016\/j.mce.2014.10.016_bib0030","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.neures.2006.02.013","article-title":"Triptolide inhibits COX-2 expression via NF-kappa B pathway in astrocytes","volume":"55","author":"Dai","year":"2006","journal-title":"Neurosci. Res"},{"key":"10.1016\/j.mce.2014.10.016_bib0035","first-page":"855","article-title":"PG490-88, a derivative of triptolide, causes tumor regression and sensitizes tumors to chemotherapy","volume":"2","author":"Fidler","year":"2003","journal-title":"Mol. Cancer Ther"},{"key":"10.1016\/j.mce.2014.10.016_bib0040","doi-asserted-by":"crossref","first-page":"6096","DOI":"10.1016\/j.biomaterials.2006.08.023","article-title":"Effects of orthopaedic wear particles on osteoprogenitor cells","volume":"27","author":"Goodman","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.mce.2014.10.016_bib0045","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1007\/BF02829571","article-title":"Effect of triptolide on expression of receptor activator of nuclear factor-kappaB ligand in rat adjuvant induced arthritis","volume":"26","author":"Hu","year":"2006","journal-title":"J. Huazhong Univ. Sci. Technolog. Med. Sci"},{"issue":"Suppl. 2","key":"10.1016\/j.mce.2014.10.016_bib0050","doi-asserted-by":"crossref","first-page":"ii32","DOI":"10.1136\/ard.61.suppl_2.ii32","article-title":"Role of RANKL and RANK in bone loss and arthritis","volume":"61","author":"Jones","year":"2002","journal-title":"Ann. Rheum. Dis"},{"key":"10.1016\/j.mce.2014.10.016_bib0055","first-page":"2666","article-title":"Antiproliferative and proapoptotic activities of triptolide (PG490), a natural product entering clinical trials, on primary cultures of human prostatic epithelial cells","volume":"8","author":"Kiviharju","year":"2002","journal-title":"Clin. Cancer Res"},{"key":"10.1016\/j.mce.2014.10.016_bib0060","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/16852","article-title":"OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis","volume":"397","author":"Kong","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.mce.2014.10.016_bib0065","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1471-2210-4-2","article-title":"Triptolide, an active compound identified in a traditional Chinese herb, induces apoptosis of rheumatoid synovial fibroblasts","volume":"4","author":"Kusunoki","year":"2004","journal-title":"BMC Pharmacol"},{"key":"10.1016\/j.mce.2014.10.016_bib0070","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.leukres.2004.05.014","article-title":"Triptolide inhibits transcription factor NF-kappaB and induces apoptosis of multiple myeloma cells","volume":"29","author":"Lou","year":"2005","journal-title":"Leuk. Res"},{"key":"10.1016\/j.mce.2014.10.016_bib0075","first-page":"267","article-title":"Triptolide induces anti-inflammatory cellular responses","volume":"1","author":"Matta","year":"2009","journal-title":"Am. J. Transl. Res"},{"key":"10.1016\/j.mce.2014.10.016_bib0080","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1084\/jem.20030116","article-title":"The IkappaB function of NF-kappaB2 p100 controls stimulated osteoclastogenesis","volume":"198","author":"Novack","year":"2003","journal-title":"J. Exp. Med"},{"key":"10.1016\/j.mce.2014.10.016_bib0085","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1128\/MCB.00834-10","article-title":"Tctex-1, a novel interaction partner of Rab3D, is required for osteoclastic bone resorption","volume":"31","author":"Pavlos","year":"2011","journal-title":"Mol. Cell. Biol"},{"key":"10.1016\/j.mce.2014.10.016_bib0090","doi-asserted-by":"crossref","first-page":"13443","DOI":"10.1074\/jbc.274.19.13443","article-title":"Immunosuppressant PG490 (triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box\/nuclear factor of activated T-cells and NF-kappaB transcriptional activation","volume":"274","author":"Qiu","year":"1999","journal-title":"J. Biol. Chem"},{"key":"10.1016\/j.mce.2014.10.016_bib0095","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1084\/jem.20042081","article-title":"I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss","volume":"201","author":"Ruocco","year":"2005","journal-title":"J. Exp. Med"},{"key":"10.1016\/j.mce.2014.10.016_bib0100","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0889-857X(05)70118-6","article-title":"The Chinese anti-inflammatory and immunosuppressive herbal remedy Tripterygium wilfordii Hook F","volume":"26","author":"Tao","year":"2000","journal-title":"Rheum. Dis. Clin. North Am"},{"key":"10.1016\/j.mce.2014.10.016_bib0105","first-page":"2160","article-title":"A phase I study of ethyl acetate extract of the Chinese antirheumatic herb Tripterygium wilfordii hook F in rheumatoid arthritis","volume":"28","author":"Tao","year":"2001","journal-title":"J. Rheumatol"},{"key":"10.1016\/j.mce.2014.10.016_bib0110","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1002\/art.10411","article-title":"Benefit of an extract of Tripterygium Wilfordii Hook F in patients with rheumatoid arthritis: a double-blind, placebo-controlled study","volume":"46","author":"Tao","year":"2002","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.mce.2014.10.016_bib0115","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1126\/science.289.5484.1504","article-title":"Bone resorption by osteoclasts","volume":"289","author":"Teitelbaum","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.mce.2014.10.016_bib0120","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1359\/jbmr.2003.18.12.2159","article-title":"12-O-tetradecanoylphorbol-13-acetate (TPA) inhibits osteoclastogenesis by suppressing RANKL-induced NF-kappaB activation","volume":"18","author":"Wang","year":"2003","journal-title":"J. Bone Miner. Res"},{"key":"10.1016\/j.mce.2014.10.016_bib0125","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.arth.2004.03.024","article-title":"Particle bioreactivity and wear-mediated osteolysis","volume":"19","author":"Wang","year":"2004","journal-title":"J. Arthroplasty"},{"key":"10.1016\/j.mce.2014.10.016_bib0130","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1007\/s11064-008-9691-z","article-title":"Therapeutic strategies for Parkinson's disease: the ancient meets the future \u2013 traditional Chinese herbal medicine, electroacupuncture, gene therapy and stem cells","volume":"33","author":"Wang","year":"2008","journal-title":"Neurochem. Res"},{"key":"10.1016\/j.mce.2014.10.016_bib0135","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1007\/s00223-007-9077-2","article-title":"Particle-induced osteolysis in three-dimensional micro-computed tomography","volume":"81","author":"Wedemeyer","year":"2007","journal-title":"Calcif. Tissue Int"},{"key":"10.1016\/j.mce.2014.10.016_bib0140","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1749-8546-4-13","article-title":"Effects of triptolide from Radix Tripterygium wilfordii (Leigongteng) on cartilage cytokines and transcription factor NF-kappaB: a study on induced arthritis in rats","volume":"4","author":"Xiao","year":"2009","journal-title":"Chin. Med"},{"key":"10.1016\/j.mce.2014.10.016_bib0145","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1359\/jbmr.2002.17.7.1200","article-title":"NF-kappaB p50 and p52 expression is not required for RANK-expressing osteoclast progenitor formation but is essential for RANK- and cytokine-mediated osteoclastogenesis","volume":"17","author":"Xing","year":"2002","journal-title":"J. Bone Miner. Res"},{"key":"10.1016\/j.mce.2014.10.016_bib0150","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1359\/jbmr.2000.15.11.2178","article-title":"Cloning, sequencing, and functional characterization of the rat homologue of receptor activator of NF-kappaB ligand","volume":"15","author":"Xu","year":"2000","journal-title":"J. Bone Miner. Res"},{"key":"10.1016\/j.mce.2014.10.016_bib0155","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.cytogfr.2008.11.007","article-title":"NF-kappaB modulators in osteolytic bone diseases","volume":"20","author":"Xu","year":"2009","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.mce.2014.10.016_bib0160","first-page":"65","article-title":"Triptolide inhibits the growth and metastasis of solid tumors","volume":"2","author":"Yang","year":"2003","journal-title":"Mol. Cancer Ther"},{"key":"10.1016\/j.mce.2014.10.016_bib0165","first-page":"506","article-title":"Effects of triptolide on proliferation and apoptosis of jurkat cell line in acute T lymphocytic leukemia","volume":"16","author":"Yao","year":"2008","journal-title":"Zhongguo Shi Yan Xue Ye Xue Za Zhi"},{"key":"10.1016\/j.mce.2014.10.016_bib0170","doi-asserted-by":"crossref","first-page":"3597","DOI":"10.1073\/pnas.95.7.3597","article-title":"Osteoclast differentiation factor is a ligand for osteoprotegerin\/osteoclastogenesis-inhibitory factor and is identical to TRANCE\/RANKL","volume":"95","author":"Yasuda","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mce.2014.10.016_bib0175","doi-asserted-by":"crossref","first-page":"503","DOI":"10.2353\/ajpath.2006.050960","article-title":"p62 ubiquitin binding-associated domain mediated the receptor activator of nuclear factor-kappaB ligand-induced osteoclast formation: a new insight into the pathogenesis of Paget's disease of bone","volume":"169","author":"Yip","year":"2006","journal-title":"Am. J. Pathol"},{"key":"10.1016\/j.mce.2014.10.016_bib0180","doi-asserted-by":"crossref","first-page":"11535","DOI":"10.1074\/jbc.M607999200","volume":"283","author":"Yoshitake","year":"2008","journal-title":"J. Biol. Chem"},{"key":"10.1016\/j.mce.2014.10.016_bib0185","doi-asserted-by":"crossref","first-page":"L958","DOI":"10.1152\/ajplung.2000.279.5.L958","article-title":"Anti-inflammatory effects of triptolide in human bronchial epithelial cells","volume":"279","author":"Zhao","year":"2000","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol"},{"key":"10.1016\/j.mce.2014.10.016_bib0190","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1124\/mol.108.052605","article-title":"A small-molecule triptolide suppresses angiogenesis and invasion of human anaplastic thyroid carcinoma cells via down-regulation of the nuclear factor-kappa B pathway","volume":"75","author":"Zhu","year":"2009","journal-title":"Mol. Pharmacol"}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030372071400327X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030372071400327X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T23:17:29Z","timestamp":1565997449000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030372071400327X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":37,"alternative-id":["S030372071400327X"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2014.10.016","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Triptolide inhibits osteoclast formation, bone resorption, RANKL-mediated NF-\u049bB activation and titanium particle-induced osteolysis in a mouse model","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2014.10.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}