{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T06:20:56Z","timestamp":1773469256687,"version":"3.50.1"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"International Postgraduate Research Scholarship"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.mce.2015.12.010","type":"journal-article","created":{"date-parts":[[2015,12,18]],"date-time":"2015-12-18T08:27:17Z","timestamp":1450427237000},"page":"115-124","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["PEDF attenuates insulin-dependent molecular pathways of glucose homeostasis in skeletal myocytes"],"prefix":"10.1016","volume":"422","author":[{"given":"Revathy","family":"Carnagarin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arun M.","family":"Dharmarajan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Crispin R.","family":"Dass","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2015.12.010_bib1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0959-437X(98)80062-2","article-title":"Mechanism of activation and function of protein kinase B","volume":"8","author":"Alessi","year":"1998","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.mce.2015.12.010_bib2","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.metabol.2005.08.013","article-title":"High-fat feeding effects on components of the CAP\/Cbl signaling cascade in Sprague-Dawley rat skeletal muscle","volume":"55","author":"Bernard","year":"2006","journal-title":"Metabolism"},{"key":"10.1016\/j.mce.2015.12.010_bib3","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.2337\/db10-0845","article-title":"Pigment epithelium-derived factor regulates lipid metabolism via adipose triglyceride lipase","volume":"60","author":"Borg","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2015.12.010_bib4","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.mce.2014.11.006","article-title":"PEDF-induced alteration of metabolism leading to insulin resistance","volume":"401","author":"Carnagarin","year":"2015","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2015.12.010_bib5","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.mce.2015.09.004","article-title":"Molecular aspects of glucose homeostasis in skeletal muscle - a focus on the molecular mechanisms of insulin resistance","volume":"417","author":"Carnagarin","year":"2015","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2015.12.010_bib6","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2119\/2005-00029.Saltiel","article-title":"Insulin signaling and the regulation of glucose transport","volume":"10","author":"Chang","year":"2004","journal-title":"Mol. Med."},{"key":"10.1016\/j.mce.2015.12.010_bib7","doi-asserted-by":"crossref","first-page":"5074","DOI":"10.1210\/jc.2010-0727","article-title":"Plasma level of pigment epithelium-derived factor is independently associated with the development of the metabolic syndrome in Chinese men: a 10-year prospective study","volume":"95","author":"Chen","year":"2010","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2015.12.010_bib8","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.cmet.2009.06.001","article-title":"Pigment epithelium-derived factor contributes to insulin resistance in obesity","volume":"10","author":"Crowe","year":"2009","journal-title":"Cell Metab."},{"key":"10.1016\/j.mce.2015.12.010_bib9","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1126\/science.285.5425.245","article-title":"Pigment epithelium-derived factor: a potent inhibitor of angiogenesis","volume":"285","author":"Dawson","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.mce.2015.12.010_bib10","doi-asserted-by":"crossref","first-page":"173","DOI":"10.2337\/diacare.14.3.173","article-title":"Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease","volume":"14","author":"DeFronzo","year":"2001","journal-title":"Diabetes Care"},{"key":"10.1016\/j.mce.2015.12.010_bib11","doi-asserted-by":"crossref","first-page":"S157","DOI":"10.2337\/dc09-S302","article-title":"Skeletal muscle insulin resistance is the primary defect in type 2 diabetes","volume":"32","author":"DeFronzo","year":"2009","journal-title":"Diabetes Care"},{"key":"10.1016\/j.mce.2015.12.010_bib12","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/ijo.2010.212","article-title":"Pigment epithelium-derived factor (PEDF) is one of the most abundant proteins secreted by human adipocytes and induces insulin resistance and inflammatory signaling in muscle and fat cells","volume":"35","author":"Famulla","year":"2011","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.mce.2015.12.010_bib13","doi-asserted-by":"crossref","first-page":"4384","DOI":"10.1096\/fj.13-232900","article-title":"Determination of mesenchymal stem cell fate by pigment epithelium-derived factor (PEDF) results in increased adiposity and reduced bone mineral content","volume":"27","author":"Gattu","year":"2013","journal-title":"FASEB J."},{"key":"10.1016\/j.mce.2015.12.010_bib14","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1038\/oby.2008.220","article-title":"High-fat diet\u00a0alters pp2a, tc10, and cip4 expression in visceral adipose tissue of rats","volume":"16","author":"Jun","year":"2008","journal-title":"Obesity"},{"key":"10.1016\/j.mce.2015.12.010_bib15","doi-asserted-by":"crossref","first-page":"22115","DOI":"10.1074\/jbc.C200198200","article-title":"A\u00a0method to identify serine kinase substrates: akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (gap) domain","volume":"277","author":"Kane","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.mce.2015.12.010_bib16","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.2337\/diabetes.54.6.1692","article-title":"Insulin-stimulated phosphorylation of the Akt substrate AS160 is impaired in skeletal muscle of type 2 diabetic subjects","volume":"54","author":"Karlsson","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2015.12.010_bib17","doi-asserted-by":"crossref","first-page":"E1367","DOI":"10.1152\/ajpendo.00046.2014","article-title":"Augmented expression and secretion of adipose-derived pigment epithelium-derived factor does not alter local angiogenesis or contribute to the development of systemic metabolic derangements","volume":"306","author":"Lakeland","year":"2014","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2015.12.010_bib18","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.ajpath.2013.12.032","article-title":"Pigment epithelium-derived factor improves metabolic derangements and ameliorates dysregulation of adipocytokines in obese type 2 diabetic rats","volume":"184","author":"Matsui","year":"2014","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.mce.2015.12.010_bib19","doi-asserted-by":"crossref","first-page":"7294","DOI":"10.1093\/emboj\/17.24.7294","article-title":"Inactivation and dephosphorylation of protein kinase B alpha (PKB alpha) promoted by hyperosmotic stress","volume":"17","author":"Meier","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.mce.2015.12.010_bib20","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1056\/NEJM199109263251307","article-title":"Insulin resistance - mechanisms, syndromes, and implications","volume":"325","author":"Moller","year":"1991","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.mce.2015.12.010_bib22","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.ijcard.2008.11.169","article-title":"Serum levels of pigment epithelium-derived factor (PEDF) are an independent determinant of insulin resistance in patients with essential hypertension","volume":"143","author":"Nakamura","year":"2010","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.mce.2015.12.010_bib23","doi-asserted-by":"crossref","first-page":"E1013","DOI":"10.1152\/ajpendo.00326.2011","article-title":"Proteomic identification of secreted proteins from human skeletal muscle cells and expression in response to strength training","volume":"301","author":"Norheim","year":"2011","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2015.12.010_bib24","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1042\/bj20030313","article-title":"Pigment-epithelium-derived factor (PEDF) occurs at a physiologically relevant concentration in human blood: purification and characterization","volume":"374","author":"Petersen","year":"2003","journal-title":"Biochem. J."},{"key":"10.1016\/j.mce.2015.12.010_bib25","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.2337\/diabetes.54.10.2939","article-title":"Tumor necrosis factor-\u03b1 induces skeletal muscle insulin resistance in healthy human subjects via inhibition of Akt substrate 160 phosphorylation","volume":"54","author":"Plomgaard","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2015.12.010_bib26","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1128\/MCB.18.2.872","article-title":"A\u00a0novel, multifunctional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes","volume":"18","author":"Ribon","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.mce.2015.12.010_bib27","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1517\/14728220903241641","article-title":"Pigment epithelium-derived factor (PEDF) as a therapeutic target in cardiovascular disease","volume":"13","author":"Rychli","year":"2009","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.mce.2015.12.010_bib28","doi-asserted-by":"crossref","first-page":"4720","DOI":"10.1210\/jc.2010-0630","article-title":"Circulating pigment epithelium-derived factor levels are associated with insulin resistance and decrease after weight loss","volume":"95","author":"Sabater","year":"2010","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2015.12.010_bib29","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/414799a","article-title":"Insulin signalling and the regulation of glucose and lipid metabolism","volume":"414","author":"Saltiel","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.mce.2015.12.010_bib30","doi-asserted-by":"crossref","first-page":"14599","DOI":"10.1074\/jbc.C300063200","article-title":"Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation","volume":"278","author":"Sano","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.mce.2015.12.010_bib31","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1042\/bj3130045","article-title":"Multiple mechanisms for the phosphorylation of C-terminal regulatory sites in rabbit muscle glycogen synthase expressed in COS cells","volume":"313","author":"Skurat","year":"1996","journal-title":"Biochem. J."},{"key":"10.1016\/j.mce.2015.12.010_bib32","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/978-1-4419-1399-9_4","article-title":"Pigment epithelium-derived factor receptor (PEDF-R): a plasma membrane-linked phospholipase with PEDF binding affinity","volume":"664","author":"Subramanian","year":"2010","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.mce.2015.12.010_bib33","doi-asserted-by":"crossref","first-page":"E2114","DOI":"10.1210\/jc.2012-1894","article-title":"Pigment epithelium-derived factor (PEDF) varies with body composition and insulin resistance in healthy young people","volume":"97","author":"Sunderland","year":"2012","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2015.12.010_bib34","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/0014-4835(91)90248-D","article-title":"PEDF: a pigment epithelium-derived factor with potent neuronal differentiative activity","volume":"53","author":"Tombran-Tink","year":"1991","journal-title":"Exp. Eye. Res."},{"key":"10.1016\/j.mce.2015.12.010_bib35","doi-asserted-by":"crossref","first-page":"5434","DOI":"10.1128\/MCB.24.12.5434-5446.2004","article-title":"Suppressor of cytokine signaling 1 (socs-1) and socs-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms","volume":"24","author":"Ueki","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.mce.2015.12.010_bib36","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1172\/JCI115656","article-title":"Decreased insulin activation of glycogen synthase in skeletal muscles in young nonobese Caucasian first-degree relatives of patients with non-insulin-dependent diabetes mellitus","volume":"89","author":"Vaag","year":"1992","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.mce.2015.12.010_bib37","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1023\/A:1006806722619","article-title":"The IRS-signalling system: a network of docking proteins that mediate insulin action","volume":"182","author":"White","year":"1998","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.mce.2015.12.010_bib38","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1210\/jc.2005-2654","article-title":"Elevated serum levels of pigment epithelium-derived factor in the metabolic syndrome","volume":"91","author":"Yamagishi","year":"2006","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2015.12.010_bib39","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.2174\/092986710791233670","article-title":"Pathophysiological role of pigment epithelium-derived factor (PEDF) in hepatic disorders","volume":"17","author":"Yamagishi","year":"2010","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.mce.2015.12.010_bib40","doi-asserted-by":"crossref","first-page":"3074","DOI":"10.1128\/MCB.16.6.3074","article-title":"Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice","volume":"16","author":"Yamauchi","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.mce.2015.12.010_bib41","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1210\/jc.2010-2140","article-title":"Serum pigment epithelium-derived factor is elevated in women with polycystic ovary syndrome and correlates with insulin resistance","volume":"96","author":"Yang","year":"2011","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2015.12.010_bib42","doi-asserted-by":"crossref","first-page":"4406","DOI":"10.1091\/mbc.E04-04-0333","article-title":"Insulin stimulation of GLUT4 exocytosis, but not its Inhibition of endocytosis, is dependent on RabGAP AS160","volume":"15","author":"Zeigerer","year":"2004","journal-title":"Mol. Biol. Cell"}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720715301659?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720715301659?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T17:56:51Z","timestamp":1567447011000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720715301659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":41,"alternative-id":["S0303720715301659"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2015.12.010","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PEDF attenuates insulin-dependent molecular pathways of glucose homeostasis in skeletal myocytes","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2015.12.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}