{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:42:54Z","timestamp":1792042974409,"version":"4.4.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81230017"],"award-info":[{"award-number":["81230017"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81170704"],"award-info":[{"award-number":["81170704"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.mce.2016.03.001","type":"journal-article","created":{"date-parts":[[2016,3,5]],"date-time":"2016-03-05T14:55:58Z","timestamp":1457189758000},"page":"21-32","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"special_numbering":"C","title":["Beneficial effects of urine-derived stem cells on fibrosis and apoptosis of myocardial, glomerular and bladder cells"],"prefix":"10.1016","volume":"427","author":[{"given":"Xingyou","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingzhen","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bishao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guolin","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenxing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3939-5647","authenticated-orcid":false,"given":"Longkun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2016.03.001_bib1","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/2251-6581-13-76","article-title":"A\u00a0comparative study of mesenchymal stem cell transplantation with its paracrine effect on control of hyperglycemia in type 1 diabetic rats","volume":"13","author":"Aali","year":"2014","journal-title":"J.\u00a0Diabetes Metab. Disord."},{"key":"10.1016\/j.mce.2016.03.001_bib2","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.mce.2015.05.017","article-title":"Streptozotocin induces endoplasmic reticulum stress and apoptosis via disruption of calcium homeostasis in mouse pancreas","volume":"412","author":"Ahn","year":"2015","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.mce.2016.03.001_bib3","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s13287-015-0142-x","article-title":"Comparison of adipose tissue- and bone marrow- derived mesenchymal stem cells for alleviating doxorubicin-induced cardiac dysfunction in diabetic rats","volume":"6","author":"Ammar","year":"2015","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.mce.2016.03.001_bib4","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.2337\/db11-0844","article-title":"Immune regulatory properties of allogeneic adipose-derived mesenchymal stem cells in the treatment of experimental autoimmune diabetes","volume":"61","author":"Bassi","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2016.03.001_bib5","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.3727\/096368913X665576","article-title":"Efficacy and safety of autologous bone marrow-derived stem cell transplantation in patients with type 2 diabetes mellitus: a randomized placebo-controlled study","volume":"23","author":"Bhansali","year":"2014","journal-title":"Cell Transpl."},{"key":"10.1016\/j.mce.2016.03.001_bib6","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1002\/stem.1424","article-title":"Multipotential differentiation of human urine-derived stem cells: potential for therapeutic applications in urology","volume":"31","author":"Bharadwaj","year":"2013","journal-title":"Stem Cells"},{"key":"10.1016\/j.mce.2016.03.001_bib7","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1089\/ten.tea.2010.0637","article-title":"Characterization of urine-derived stem cells obtained from upper urinary tract for use in cell-based urological tissue engineering","volume":"17","author":"Bharadwaj","year":"2011","journal-title":"Tissue Eng. Part A"},{"key":"10.1016\/j.mce.2016.03.001_bib8","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1042\/CBI20120210","article-title":"Human embryonic stem cell differentiation into insulin secreting beta-cells for diabetes","volume":"36","author":"Bose","year":"2012","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.mce.2016.03.001_bib9","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1615\/CritRevBiomedEng.v39.i6.40","article-title":"Role of substrates in diabetes therapy: stem cell differentiation and islet transplantation","volume":"39","author":"Candiello","year":"2011","journal-title":"Crit. Rev. Biomed. Eng."},{"issue":"A7","key":"10.1016\/j.mce.2016.03.001_bib10","first-page":"e1","article-title":"Us renal data system 2012 annual data report","volume":"61","author":"Collins","year":"2013","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.mce.2016.03.001_bib11","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.mad.2011.10.005","article-title":"Beneficial effect of melatonin treatment on inflammation, apoptosis and oxidative stress on pancreas of a senescence accelerated mice model","volume":"132","author":"Cuesta","year":"2011","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.mce.2016.03.001_bib12","first-page":"S18","article-title":"Diabetic bladder dysfunction: current translational knowledge","volume":"182","author":"Daneshgari","year":"2009","journal-title":"J.\u00a0Urol."},{"key":"10.1016\/j.mce.2016.03.001_bib13","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1001\/jama.2011.861","article-title":"Temporal trends in the prevalence of diabetic kidney disease in the United States","volume":"305","author":"de Boer","year":"2011","journal-title":"JAMA"},{"key":"10.1016\/j.mce.2016.03.001_bib14","doi-asserted-by":"crossref","first-page":"11192","DOI":"10.1038\/srep11192","article-title":"The actions of neurotensin in rat bladder detrusor contractility","volume":"5","author":"Dong","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mce.2016.03.001_bib15","first-page":"3714","article-title":"Transplanted bone marrow mesenchymal stem cells protects myocardium by regulating 14-3-3 protein in a rat model of diabetic cardiomyopathy","volume":"7","author":"Dong","year":"2014","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.mce.2016.03.001_bib16","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1016\/j.bbmt.2009.07.022","article-title":"Endovenous administration of bone-marrow-derived multipotent mesenchymal stromal cells prevents renal failure in diabetic mice","volume":"15","author":"Ezquer","year":"2009","journal-title":"Biol. Blood Marrow Transpl."},{"key":"10.1016\/j.mce.2016.03.001_bib17","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1152\/physrev.00045.2011","article-title":"Mechanisms of diabetic complications","volume":"93","author":"Forbes","year":"2013","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.mce.2016.03.001_bib18","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1900\/RDS.2010.7.144","article-title":"Bone marrow-derived stem cell transplantation for the treatment of insulin-dependent diabetes","volume":"7","author":"Fotino","year":"2010","journal-title":"Rev. Diabet. Stud."},{"key":"10.1016\/j.mce.2016.03.001_bib19","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1464-5491.2011.03433.x","article-title":"Stem cell-based treatments for Type 1 diabetes mellitus: bone marrow, embryonic, hepatic, pancreatic and induced pluripotent stem cells","volume":"29","author":"Godfrey","year":"2012","journal-title":"Diabet. Med."},{"key":"10.1016\/j.mce.2016.03.001_bib20","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s11892-015-0685-3","article-title":"Therapies on the horizon for diabetic kidney disease","volume":"15","author":"Khan","year":"2015","journal-title":"Curr. Diab Rep."},{"key":"10.1016\/j.mce.2016.03.001_bib21","doi-asserted-by":"crossref","first-page":"E143","DOI":"10.1111\/bju.12172","article-title":"Cannabinoid receptors 1 and 2 are associated with bladder dysfunction in an experimental diabetic rat model","volume":"112","author":"Li","year":"2013","journal-title":"BJU Int."},{"key":"10.1016\/j.mce.2016.03.001_bib22","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1507\/endocrj.EJ15-0186","article-title":"Embryonic stem cell-derived pancreatic endoderm transplant with MCT1-suppressing miR-495 attenuates type II diabetes in mice","volume":"62","author":"Liang","year":"2015","journal-title":"Endocr. J."},{"key":"10.1016\/j.mce.2016.03.001_bib23","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1196\/annals.1447.011","article-title":"Induction of apoptosis of Beta cells of the pancreas by advanced glycation end-products, important mediators of chronic complications of diabetes mellitus","volume":"1150","author":"Lim","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.mce.2016.03.001_bib25","doi-asserted-by":"crossref","first-page":"e104771","DOI":"10.1371\/journal.pone.0104771","article-title":"NLRP3 gene silencing ameliorates diabetic cardiomyopathy in a type 2 diabetes rat model","volume":"9","author":"Luo","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.mce.2016.03.001_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/01.RES.0000233141.65522.3e","article-title":"Diabetic cardiomyopathy: a \u201ccardiac stem cell disease\u201d involving p66Shc, an attractive novel molecular target for heart failure therapy","volume":"99","author":"Messina","year":"2006","journal-title":"Circ. Res."},{"key":"10.1016\/j.mce.2016.03.001_bib28","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1634\/stemcells.2007-0795","article-title":"Human bone marrow mesenchymal stem cells accelerate recovery of acute renal injury and prolong survival in mice","volume":"26","author":"Morigi","year":"2008","journal-title":"Stem Cells"},{"key":"10.1016\/j.mce.2016.03.001_bib29","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/978-1-61779-468-1_15","article-title":"Intravenous human mesenchymal stem cells transplantation in NOD\/SCID mice preserve liver integrity of irradiation damage","volume":"826","author":"Mouiseddine","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.mce.2016.03.001_bib47","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1369\/0022155415599039","article-title":"Adipose-Derived Mesenchymal Stem Cells Transplantation Alleviates Renal Injury in Streptozotocin-Induced Diabetic Nephropathy","volume":"63","author":"Ni","year":"2015","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.mce.2016.03.001_bib30","doi-asserted-by":"crossref","first-page":"e92825","DOI":"10.1371\/journal.pone.0092825","article-title":"Human urine-derived stem cells alone or genetically-modified with FGF2 Improve type 2 diabetic erectile dysfunction in a rat model","volume":"9","author":"Ouyang","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.mce.2016.03.001_bib31","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1161\/01.RES.0000207406.94146.c2","article-title":"Diabetic cardiomyopathy: the search for a unifying hypothesis","volume":"98","author":"Poornima","year":"2006","journal-title":"Circ. Res."},{"key":"10.1016\/j.mce.2016.03.001_bib32","first-page":"1620","article-title":"Diabetes mellitus is independently associated with an increased risk of mortality in patients with Clear cell renal cell carcinoma","volume":"192","author":"Psutka","year":"2014","journal-title":"J.\u00a0Urol."},{"key":"10.1016\/j.mce.2016.03.001_bib33","doi-asserted-by":"crossref","DOI":"10.1186\/scrt458","article-title":"Urine-derived stem cells for potential use in bladder repair","volume":"5","author":"Qin","year":"2014","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.mce.2016.03.001_bib34","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/jmp.12122","article-title":"Comparisons of phenotype and immunomodulatory capacity among rhesus bone-marrow-derived mesenchymal stem\/stromal cells, multipotent adult progenitor cells, and dermal fibroblasts","volume":"43","author":"Sindberg","year":"2014","journal-title":"J.\u00a0Med. Primatol."},{"key":"10.1016\/j.mce.2016.03.001_bib35","doi-asserted-by":"crossref","first-page":"157","DOI":"10.2337\/diabetes.49.2.157","article-title":"Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice","volume":"49","author":"Soria","year":"2000","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2016.03.001_bib36","first-page":"411","article-title":"Diabetic cardiomyopathy: from pathophysiology to treatment","volume":"55","author":"Trachanas","year":"2014","journal-title":"Hell. J. Cardiol."},{"key":"10.1016\/j.mce.2016.03.001_bib37","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1177\/1756287214553968","article-title":"The potential role of stem cells in the treatment of urinary incontinence","volume":"7","author":"Tran","year":"2015","journal-title":"Ther. Adv. Urol."},{"key":"10.1016\/j.mce.2016.03.001_bib38","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3109\/07435800.2013.797432","article-title":"Intraportal injection of insulin-producing cells generated from human bone marrow mesenchymal stem cells decreases blood glucose level in diabetic rats","volume":"39","author":"Tsai","year":"2014","journal-title":"Endocr. Res."},{"key":"10.1016\/j.mce.2016.03.001_bib39","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1007\/s12015-014-9563-7","article-title":"Comparison of therapeutic characteristics of islet cell transplantation simultaneous with pancreatic mesenchymal stem cell transplantation in rats with Type 1 diabetes mellitus","volume":"11","author":"Unsal","year":"2015","journal-title":"Stem Cell Rev."},{"key":"10.1016\/j.mce.2016.03.001_bib40","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1161\/STROKEAHA.107.502047","article-title":"Dual-modality monitoring of targeted intraarterial delivery of mesenchymal stem cells after transient ischemia","volume":"39","author":"Walczak","year":"2008","journal-title":"Stroke"},{"key":"10.1016\/j.mce.2016.03.001_bib41","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.bbmt.2013.01.001","article-title":"Mesenchymal stem cells ameliorate podocyte injury and proteinuria in a type 1 diabetic nephropathy rat model","volume":"19","author":"Wang","year":"2013","journal-title":"Biol. Blood Marrow Transpl."},{"key":"10.1016\/j.mce.2016.03.001_bib42","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.hlc.2013.06.007","article-title":"Mesenchymal stem cell therapy improves diabetic cardiac autonomic neuropathy and decreases the inducibility of ventricular arrhythmias","volume":"22","author":"Wang","year":"2013","journal-title":"Heart Lung Circ."},{"key":"10.1016\/j.mce.2016.03.001_bib43","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.gendis.2014.07.001","article-title":"Urine-derived stem cells: a novel and versatile progenitor source for cell-based therapy and regenerative medicine","volume":"1","author":"Zhang","year":"2014","journal-title":"Genes Dis."},{"key":"10.1016\/j.mce.2016.03.001_bib44","doi-asserted-by":"crossref","first-page":"704045","DOI":"10.1155\/2008\/704045","article-title":"The characterization of high-fat diet and multiple low-dose streptozotocin induced type 2 diabetes rat model","volume":"2008","author":"Zhang","year":"2008","journal-title":"Exp. Diabetes Res."},{"key":"10.1016\/j.mce.2016.03.001_bib45","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/WNR.0b013e32835e2e44","article-title":"Noninvasive urine-derived cell lines derived from neurological genetic patients","volume":"24","author":"Zhang","year":"2013","journal-title":"Neuroreport"},{"key":"10.1016\/j.mce.2016.03.001_bib46","doi-asserted-by":"crossref","first-page":"526367","DOI":"10.1155\/2013\/526367","article-title":"Kidney-targeted transplantation of mesenchymal stem cells by ultrasound-targeted microbubble destruction promotes kidney repair in diabetic nephropathy rats","volume":"2013","author":"Zhang","year":"2013","journal-title":"Biomed. Res. Int."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720716300491?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720716300491?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T11:25:48Z","timestamp":1536924348000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720716300491"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":45,"alternative-id":["S0303720716300491"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2016.03.001","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Beneficial effects of urine-derived stem cells on fibrosis and apoptosis of myocardial, glomerular and bladder cells","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2016.03.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}