{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T02:59:22Z","timestamp":1784861962495,"version":"3.55.0"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"The Academy of Finland"},{"DOI":"10.13039\/501100006306","name":"Sigrid Jus\u00e9lius Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006306","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.mce.2016.03.013","type":"journal-article","created":{"date-parts":[[2016,3,14]],"date-time":"2016-03-14T18:39:59Z","timestamp":1457980799000},"page":"143-154","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["Targeted inactivation of the mouse epididymal beta-defensin 41 alters sperm flagellar beat pattern and zona pellucida binding"],"prefix":"10.1016","volume":"427","author":[{"given":"Ida","family":"Bj\u00f6rkgren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Alvarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelli","family":"Blank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Balbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heikki","family":"Turunen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teemu Daniel","family":"Laajala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jussi","family":"Toivanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Krutskikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Wahlberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilpo","family":"Huhtaniemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matti","family":"Poutanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar","family":"Wachten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Sipil\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2016.03.013_bib1","doi-asserted-by":"crossref","first-page":"6248","DOI":"10.1074\/jbc.M112.439356","article-title":"Ca2+ signals generated by CatSper and Ca2+ stores regulate different behaviors in human sperm","volume":"288","author":"Alasmari","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.mce.2016.03.013_bib2","doi-asserted-by":"crossref","first-page":"e16","DOI":"10.1093\/nar\/27.17.e16","article-title":"Simplified generation of targeting constructs using ET recombination","volume":"27","author":"Angrand","year":"1999","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mce.2016.03.013_bib3","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1096\/fj.14-259382","article-title":"Imbalanced lipid homeostasis in the conditional Dicer1 knockout mouse epididymis causes instability of the sperm membrane","volume":"29","author":"Bj\u00f6rkgren","year":"2014","journal-title":"FASEB J."},{"key":"10.1016\/j.mce.2016.03.013_bib4","doi-asserted-by":"crossref","first-page":"e38457","DOI":"10.1371\/journal.pone.0038457","article-title":"Dicer1 ablation in the mouse epididymis causes dedifferentiation of the epithelium and imbalance in sex steroid signaling","volume":"7","author":"Bj\u00f6rkgren","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.mce.2016.03.013_bib5","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1095\/biolreprod.109.079210","article-title":"A\u00a0gradient of 2-arachidonoylglycerol regulates mouse epididymal sperm cell start-up","volume":"82","author":"Cobellis","year":"2010","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2016.03.013_bib6","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1093\/humupd\/dmn055","article-title":"New insights into epididymal biology and function","volume":"15","author":"Cornwall","year":"2009","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.mce.2016.03.013_bib7","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1152\/physrev.00028.2010","article-title":"Calcium channels in the development, maturation, and function of spermatozoa","volume":"91","author":"Darszon","year":"2011","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.mce.2016.03.013_bib8","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1073\/pnas.0308114100","article-title":"A\u00a0Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis","volume":"101","author":"De Gendt","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mce.2016.03.013_bib9","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1073\/pnas.0400050101","article-title":"Mice deficient for soluble adenylyl cyclase are infertile because of a severe sperm-motility defect","volume":"101","author":"Esposito","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mce.2016.03.013_bib10","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/gene.2012.13","article-title":"mBin1b transgenic mice show enhanced resistance to epididymal infection by bacteria challenge","volume":"13","author":"Fei","year":"2012","journal-title":"Genes Immun."},{"key":"10.1016\/j.mce.2016.03.013_bib11","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/j.1745-7262.2007.00298.x","article-title":"Characterization and functions of beta defensins in the epididymis","volume":"9","author":"Hall","year":"2007","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.mce.2016.03.013_bib12","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1210\/endo.141.3.7389","article-title":"HE2beta and HE2gamma, new members of an epididymis-specific family of androgen-regulated proteins in the human","volume":"141","author":"Hamil","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2016.03.013_bib13","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/1477-7827-12-76","article-title":"Androgenic regulation of beta-defensins in the mouse epididymis","volume":"12","author":"Hu","year":"2014","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.mce.2016.03.013_bib14","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1095\/biolreprod65.2.575","article-title":"Epididymal specificity and androgen regulation of rat EP2","volume":"65","author":"Ibrahim","year":"2001","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2016.03.013_bib15","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.bbaexp.2005.05.010","article-title":"Discovery and characterization of new epididymis-specific beta-defensins in mice","volume":"1730","author":"Jalkanen","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mce.2016.03.013_bib16","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/(SICI)1097-0169(1996)35:2<147::AID-CM7>3.0.CO;2-7","article-title":"Changes in flagellar movement of rat spermatozoa along the length of the epididymis: manual and computer-aided image analysis","volume":"35","author":"Jeulin","year":"1996","journal-title":"Cell Motil. Cytoskelet."},{"key":"10.1016\/j.mce.2016.03.013_bib17","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1095\/biolreprod.107.060186","article-title":"Catsper3 and Catsper4 are essential for sperm hyperactivated motility and male fertility in the mouse","volume":"77","author":"Jin","year":"2007","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2016.03.013_bib18","doi-asserted-by":"crossref","first-page":"4892","DOI":"10.1073\/pnas.1018202108","article-title":"Most fertilizing mouse spermatozoa begin their acrosome reaction before contact with the zona pellucida during in\u00a0vitro fertilization","volume":"108","author":"Jin","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mce.2016.03.013_bib19","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/nature04417","article-title":"Whole-cell patch-clamp measurements of spermatozoa reveal an alkaline-activated Ca2+ channel","volume":"439","author":"Kirichok","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.mce.2016.03.013_bib20","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/nri1860","article-title":"Defensins in innate antiviral immunity","volume":"6","author":"Klotman","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.mce.2016.03.013_bib21","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/psc.749","article-title":"Synthesis and structure-activity relationship of beta-defensins, multi-functional peptides of the immune system","volume":"12","author":"Kl\u00fcver","year":"2006","journal-title":"J.\u00a0Pept. Sci."},{"key":"10.1016\/j.mce.2016.03.013_bib22","doi-asserted-by":"crossref","first-page":"e1003960","DOI":"10.1371\/journal.pgen.1003960","article-title":"CRIS-a novel cAMP-binding protein controlling spermiogenesis and the development of flagellar bending","volume":"9","author":"Krahling","year":"2013","journal-title":"PLoS Genet."},{"key":"10.1016\/j.mce.2016.03.013_bib23","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.mce.2016.03.013_bib24","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1095\/biolreprod64.5.1545","article-title":"Impact of epididymal maturation on the tyrosine phosphorylation patterns exhibited by rat spermatozoa","volume":"64","author":"Lewis","year":"2001","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2016.03.013_bib25","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1093\/humrep\/den084","article-title":"Cloning and identification of a novel sperm binding protein, HEL-75, with antibacterial activity and expressed in the human epididymis","volume":"23","author":"Lin","year":"2008","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.mce.2016.03.013_bib26","doi-asserted-by":"crossref","first-page":"4529","DOI":"10.1210\/endo.142.10.8422","article-title":"Primate epididymis-specific proteins: characterization of ESC42, a novel protein containing a trefoil-like motif in monkey and human","volume":"142","author":"Liu","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2016.03.013_bib27","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0010-7824(00)00093-7","article-title":"Baboon spermatozoa-zona pellucida binding assay","volume":"61","author":"Mahony","year":"2000","journal-title":"Contraception"},{"key":"10.1016\/j.mce.2016.03.013_bib28","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.ydbio.2006.11.007","article-title":"Contributions of extracellular and intracellular Ca2+ to regulation of sperm motility: release of intracellular stores can hyperactivate CatSper1 and CatSper2 null sperm","volume":"303","author":"Marquez","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.mce.2016.03.013_bib29","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.1128\/IAI.70.6.3053-3060.2002","article-title":"Characterization of the mouse beta defensin 1, Defb1, mutant mouse model","volume":"70","author":"Morrison","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/j.mce.2016.03.013_bib30","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1093\/molbev\/msg060","article-title":"Signal sequence conservation and mature peptide divergence within subgroups of the murine beta-defensin gene family","volume":"20","author":"Morrison","year":"2003","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.mce.2016.03.013_bib31","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.1128\/IAI.70.6.3068-3072.2002","article-title":"beta-Defensin 1 contributes to pulmonary innate immunity in mice","volume":"70","author":"Moser","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/j.mce.2016.03.013_bib32","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1006\/jmbi.2000.4042","article-title":"T-Coffee: a novel method for fast and accurate multiple sequence alignment","volume":"302","author":"Notredame","year":"2000","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.mce.2016.03.013_bib33","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1095\/biolreprod.102.008953","volume":"68","author":"Palladino","year":"2003","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2016.03.013_bib34","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1152\/physiolgenomics.00104.2005","article-title":"Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract","volume":"23","author":"Patil","year":"2005","journal-title":"Physiol. Genomics"},{"key":"10.1016\/j.mce.2016.03.013_bib35","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1021\/pr800796j","article-title":"Use of differential isotopic labeling and mass spectrometry to analyze capacitation-associated changes in the phosphorylation status of mouse sperm proteins","volume":"8","author":"Platt","year":"2009","journal-title":"J.\u00a0Proteome Res."},{"key":"10.1016\/j.mce.2016.03.013_bib36","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1073\/pnas.0610286104","article-title":"All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility","volume":"104","author":"Qi","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mce.2016.03.013_bib37","doi-asserted-by":"crossref","first-page":"14869","DOI":"10.1073\/pnas.2136654100","article-title":"Hyperactivated sperm motility driven by CatSper2 is required for fertilization","volume":"100","author":"Quill","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mce.2016.03.013_bib38","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/35098027","article-title":"A\u00a0sperm ion channel required for sperm motility and male fertility","volume":"413","author":"Ren","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.mce.2016.03.013_bib39","series-title":"Testis, Epididymis and Technologies in the Year 2000","first-page":"229","article-title":"The coming of age of the epididymis","author":"Robaire","year":"2000"},{"key":"10.1016\/j.mce.2016.03.013_bib40","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1006\/bbrc.1997.7111","article-title":"A\u00a0transgenic mouse line that retains Cre recombinase activity in mature oocytes irrespective of the cre transgene transmission. Biochem","volume":"237","author":"Sakai","year":"1997","journal-title":"Biophys. Res. Commun."},{"key":"10.1016\/j.mce.2016.03.013_bib41","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s11248-015-9897-1","article-title":"Blastocyst genotyping for quality control of mouse mutant archives: an ethical and economical approach","volume":"24","author":"Scavizzi","year":"2015","journal-title":"Transgenic Res."},{"key":"10.1016\/j.mce.2016.03.013_bib42","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1073\/pnas.042692699","article-title":"Discovery of five conserved beta -defensin gene clusters using a computational search strategy","volume":"99","author":"Schutte","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mce.2016.03.013_bib43","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/ni1206","article-title":"Mammalian defensins in the antimicrobial immune response","volume":"6","author":"Selsted","year":"2005","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.mce.2016.03.013_bib44","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1159\/000336619","article-title":"\u03b2-Defensins: multifunctional modulators of infection, inflammation and more","volume":"4","author":"Semple","year":"2012","journal-title":"J.\u00a0Innate Immun."},{"key":"10.1016\/j.mce.2016.03.013_bib45","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/gene.10023","article-title":"Codon-improved Cre recombinase (iCre) expression in the mouse","volume":"32","author":"Shimshek","year":"2002","journal-title":"Genesis"},{"key":"10.1016\/j.mce.2016.03.013_bib46","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/j.1939-4640.1992.tb01631.x","article-title":"Movement characteristics of boar sperm obtained from the oviduct or hyperactivated in\u00a0vitro","volume":"13","author":"Suarez","year":"1992","journal-title":"J.\u00a0Androl."},{"key":"10.1016\/j.mce.2016.03.013_bib47","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1095\/biolreprod44.2.375","article-title":"Evidence for the function of hyperactivated motility in sperm","volume":"44","author":"Suarez","year":"1991","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2016.03.013_bib48","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1093\/molbev\/mst197","article-title":"Mega6: molecular evolutionary genetics analysis version 6.0","volume":"30","author":"Tamura","year":"2013","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.mce.2016.03.013_bib49","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3002289","article-title":"A\u00a0common mutation in the defensin DEFB126 causes impaired sperm function and subfertility","volume":"3","author":"Tollner","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.mce.2016.03.013_bib50","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1093\/humrep\/den276","article-title":"Macaque sperm coating protein DEFB126 facilitates sperm penetration of cervical mucus","volume":"23","author":"Tollner","year":"2008","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.mce.2016.03.013_bib51","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1002\/mrd.20132","article-title":"Macaque sperm release ESP13.2 and PSP94 during capacitation: the absence of ESP13.2 is linked to sperm-zona recognition and binding","volume":"69","author":"Tollner","year":"2004","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.mce.2016.03.013_bib52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1095\/biolreprod.111.092403","article-title":"Loss of cysteine-rich secretory protein 4 (crisp4) leads to deficiency in sperm-zona pellucida interaction in mice","volume":"86","author":"Turunen","year":"2012","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2016.03.013_bib53","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1242\/dev.121.4.1129","article-title":"Capacitation of mouse spermatozoa. I. Correlation between the capacitation state and protein tyrosine phosphorylation","volume":"121","author":"Visconti","year":"1995","journal-title":"Development"},{"key":"10.1016\/j.mce.2016.03.013_bib54","doi-asserted-by":"crossref","first-page":"e15061","DOI":"10.1371\/journal.pone.0015061","article-title":"Role of carbonic anhydrase IV in the bicarbonate-mediated activation of murine and human sperm","volume":"5","author":"Wandernoth","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.mce.2016.03.013_bib55","doi-asserted-by":"crossref","first-page":"35539","DOI":"10.1074\/jbc.M804586200","article-title":"Chloride is essential for capacitation and for the capacitation-associated increase in tyrosine phosphorylation","volume":"283","author":"Wertheimer","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.mce.2016.03.013_bib56","series-title":"The Physiology of Reproduction","first-page":"189","article-title":"Mammalian fertilization","author":"Yanagimachi","year":"1994"},{"key":"10.1016\/j.mce.2016.03.013_bib57","doi-asserted-by":"crossref","first-page":"3165","DOI":"10.1210\/en.2003-1698","article-title":"The androgen-regulated epididymal sperm-binding protein, human beta-defensin 118 (DEFB118) (formerly ESC42), is an antimicrobial beta-defensin","volume":"145","author":"Yenugu","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2016.03.013_bib58","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1095\/biolreprod49.2.274","article-title":"Changes in movement characteristics of human spermatozoa along the length of the epididymis","volume":"49","author":"Yeung","year":"1993","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2016.03.013_bib59","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1530\/jrf.0.0960427","article-title":"Characterization of the motility of maturing rat spermatozoa by computer-aided objective measurement","volume":"96","author":"Yeung","year":"1992","journal-title":"J.\u00a0Reprod. Fertil."},{"key":"10.1016\/j.mce.2016.03.013_bib60","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/S0015-0282(00)00529-X","article-title":"Zona pellucida binding improvement effect of different sperm preparation techniques is not related to changes in sperm motility characterizations","volume":"73","author":"Yogev","year":"2000","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.mce.2016.03.013_bib61","doi-asserted-by":"crossref","first-page":"12270","DOI":"10.1074\/jbc.M112.411884","article-title":"The novel human beta-defensin 114 regulates lipopolysaccharide (LPS)-mediated inflammation and protects sperm from motility loss","volume":"288","author":"Yu","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.mce.2016.03.013_bib62","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1095\/biolreprod.103.016105","article-title":"ESP13.2, a member of the beta-defensin family, is a macaque sperm surface-coating protein involved in the capacitation process","volume":"69","author":"Yudin","year":"2003","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2016.03.013_bib63","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1530\/REP-08-0164","article-title":"Beta-defensin 22 is a major component of the mouse sperm glycocalyx","volume":"136","author":"Yudin","year":"2008","journal-title":"Reproduction"},{"key":"10.1016\/j.mce.2016.03.013_bib64","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1007\/s00018-010-0478-4","article-title":"The epididymis-specific antimicrobial peptide beta-defensin 15 is required for sperm motility and male fertility in the rat (Rattus norvegicus)","volume":"68","author":"Zhao","year":"2011","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.mce.2016.03.013_bib65","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/ncb1127","article-title":"An epididymis-specific beta-defensin is important for the initiation of sperm maturation","volume":"6","author":"Zhou","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.mce.2016.03.013_bib66","doi-asserted-by":"crossref","first-page":"e1003826","DOI":"10.1371\/journal.pgen.1003826","article-title":"Partial deletion of chromosome 8 beta-defensin cluster confers sperm dysfunction and infertility in male mice","volume":"9","author":"Zhou","year":"2013","journal-title":"PLoS Genet."},{"key":"10.1016\/j.mce.2016.03.013_bib67","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1096\/fj.02-0598fje","article-title":"Compartmentalization of bicarbonate-sensitive adenylyl cyclase in distinct signaling microdomains","volume":"17","author":"Zippin","year":"2003","journal-title":"FASEB J."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720716300612?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720716300612?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T00:35:56Z","timestamp":1718411756000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720716300612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":67,"alternative-id":["S0303720716300612"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2016.03.013","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeted inactivation of the mouse epididymal beta-defensin 41 alters sperm flagellar beat pattern and zona pellucida binding","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2016.03.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}