{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T12:49:18Z","timestamp":1776689358850,"version":"3.51.2"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"VA Office of Research and Development Biomedical Laboratory Research and Development Service Award","award":["I01-BX002255"],"award-info":[{"award-number":["I01-BX002255"]}]},{"name":"NIH\/NHLBI","award":["HL-86787"],"award-info":[{"award-number":["HL-86787"]}]},{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"publisher","award":["HL-70241"],"award-info":[{"award-number":["HL-70241"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"publisher","award":["HL-80682"],"award-info":[{"award-number":["HL-80682"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Intramural Research Program of the NIH\/NIAID"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.mce.2016.03.038","type":"journal-article","created":{"date-parts":[[2016,4,2]],"date-time":"2016-04-02T18:33:39Z","timestamp":1459622019000},"page":"84-92","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["TRAF3IP2 mediates aldosterone\/salt-induced cardiac hypertrophy and fibrosis"],"prefix":"10.1016","volume":"429","author":[{"given":"Siva S.V.P.","family":"Sakamuri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony J.","family":"Valente","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jalahalli M.","family":"Siddesha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrice","family":"Delafontaine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Siebenlist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason D.","family":"Gardner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandrasekar","family":"Bysani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2016.03.038_bib1","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.cell.2010.11.036","article-title":"C\/EBPbeta controls exercise-induced cardiac growth and protects against pathological cardiac remodeling","volume":"143","author":"Bostrom","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.mce.2016.03.038_bib2","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.4049\/jimmunol.182.3.1617","article-title":"The adaptor protein CIKS\/Act1 is essential for IL-25-mediated allergic airway inflammation","volume":"182","author":"Claudio","year":"2009","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.mce.2016.03.038_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1677\/joe.1.06017","article-title":"The new biology of aldosterone","volume":"186","author":"Connell","year":"2005","journal-title":"J.\u00a0Endocrinol."},{"key":"10.1016\/j.mce.2016.03.038_bib4","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s00403-013-1407-9","article-title":"Common variants of ZNF750, RPTOR and TRAF3IP2 genes and psoriasis risk","volume":"306","author":"Debniak","year":"2014","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.mce.2016.03.038_bib5","doi-asserted-by":"crossref","first-page":"H1279","DOI":"10.1152\/ajpheart.00148.2008","article-title":"Aldosterone induces interleukin-18 through endothelin-1, angiotensin II, Rho\/Rho-kinase, and PPARs in cardiomyocytes. American journal of physiology","volume":"295","author":"Doi","year":"2008","journal-title":"Heart Circ. Physiol."},{"key":"10.1016\/j.mce.2016.03.038_bib6","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1186\/ar4071","article-title":"New insight into the functions of the interleukin-17 receptor adaptor protein Act1 in psoriatic arthritis","volume":"14","author":"Doyle","year":"2012","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.mce.2016.03.038_bib7","doi-asserted-by":"crossref","first-page":"7543","DOI":"10.1073\/pnas.94.14.7543","article-title":"Angiotensin II type1a receptor gene expression in the heart: AP-1 and GATA-4 participate in the response to pressure overload","volume":"94","author":"Herzig","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mce.2016.03.038_bib8","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1161\/CIRCULATIONAHA.108.809194","volume":"119","author":"Iraqi","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.mce.2016.03.038_bib9","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1038\/nn.3505","article-title":"Act1 mediates IL-17-induced EAE pathogenesis selectively in NG2+ glial cells","volume":"16","author":"Kang","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.mce.2016.03.038_bib10","doi-asserted-by":"crossref","first-page":"10494","DOI":"10.1073\/pnas.190245697","article-title":"CIKS, a connection to Ikappa B kinase and stress-activated protein kinase","volume":"97","author":"Leonardi","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mce.2016.03.038_bib11","doi-asserted-by":"crossref","first-page":"10489","DOI":"10.1073\/pnas.160265197","article-title":"Act1, an NF-kappa B-activating protein","volume":"97","author":"Li","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mce.2016.03.038_bib12","doi-asserted-by":"crossref","first-page":"4970","DOI":"10.1210\/en.2008-0120","article-title":"Aldosterone induces cardiotrophin-1 expression in HL-1 adult cardiomyocytes","volume":"149","author":"Lopez-Andres","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2016.03.038_bib13","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/S0008-6363(97)00091-6","article-title":"Aldosterone blockade reduces vascular collagen turnover, improves heart rate variability and reduces early morning rise in heart rate in heart failure patients","volume":"35","author":"MacFadyen","year":"1997","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.mce.2016.03.038_bib14","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.amjhyper.2005.05.013","article-title":"Role of aldosterone in left ventricular hypertrophy in hypertension","volume":"19","author":"Matsumura","year":"2006","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.mce.2016.03.038_bib15","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1161\/HYPERTENSIONAHA.109.148635","article-title":"Interleukin 6 mediates myocardial fibrosis, concentric hypertrophy, and diastolic dysfunction in rats","volume":"56","author":"Melendez","year":"2010","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2016.03.038_bib16","first-page":"716","article-title":"Left ventricular hypertrophy and geometry in untreated essential hypertension is associated with blood levels of aldosterone and procollagen type III amino-terminal peptide","volume":"71","author":"Nakahara","year":"2007","journal-title":"Circ. J. Off. J. Jpn. Circ. Soc."},{"key":"10.1016\/j.mce.2016.03.038_bib17","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1161\/HYPERTENSIONAHA.109.135392","article-title":"Critical role of apoptosis signal-regulating kinase 1 in aldosterone\/salt-induced cardiac inflammation and fibrosis","volume":"54","author":"Nakamura","year":"2009","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2016.03.038_bib18","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.cardfail.2004.03.002","article-title":"Aldosterone directly stimulates cardiac myocyte hypertrophy","volume":"10","author":"Okoshi","year":"2004","journal-title":"J.\u00a0Card. Fail."},{"key":"10.1016\/j.mce.2016.03.038_bib19","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1007\/s00251-013-0717-6","article-title":"TRAF3IP2 gene and systemic lupus erythematosus: association with disease susceptibility and pericarditis development","volume":"65","author":"Perricone","year":"2013","journal-title":"Immunogenetics"},{"key":"10.1016\/j.mce.2016.03.038_bib20","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/ni1439","article-title":"The adaptor Act1 is required for interleukin 17-dependent signaling associated with autoimmune and inflammatory disease","volume":"8","author":"Qian","year":"2007","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.mce.2016.03.038_bib21","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1210\/en.2003-1544","article-title":"Direct and indirect effects of aldosterone on cyclooxygenase-2 and interleukin-6 expression in rat cardiac cells in culture and after myocardial infarction","volume":"145","author":"Rebsamen","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2016.03.038_bib22","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1161\/01.HYP.33.4.981","article-title":"Angiotensin AT1 receptor subtype as a cardiac target of aldosterone: role in aldosterone-salt-induced fibrosis","volume":"33","author":"Robert","year":"1999","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2016.03.038_bib23","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1161\/01.HYP.26.6.971","article-title":"Biological determinants of aldosterone-induced cardiac fibrosis in rats","volume":"26","author":"Robert","year":"1995","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2016.03.038_bib24","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1161\/01.HYP.27.5.1039","article-title":"Changes in left ventricular anatomy and function in hypertension and primary aldosteronism","volume":"27","author":"Rossi","year":"1996","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2016.03.038_bib25","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1161\/01.HYP.0000176236.55322.18","article-title":"Aldosterone stimulates matrix metalloproteinases and reactive oxygen species in adult rat ventricular cardiomyocytes","volume":"46","author":"Rude","year":"2005","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2016.03.038_bib26","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1016\/j.cellsig.2015.07.001","article-title":"Aldosterone-induced cardiomyocyte growth, and fibroblast migration and proliferation are mediated by TRAF3IP2","volume":"27","author":"Somanna","year":"2015","journal-title":"Cell. Signal."},{"key":"10.1016\/j.mce.2016.03.038_bib27","doi-asserted-by":"crossref","first-page":"H176","DOI":"10.1152\/ajpheart.00421.2002","article-title":"Aldosterone stimulates proliferation of cardiac fibroblasts by activating Ki-RasA and MAPK1\/2 signaling. American journal of physiology","volume":"284","author":"Stockand","year":"2003","journal-title":"Heart Circ. Physiol."},{"key":"10.1016\/j.mce.2016.03.038_bib28","doi-asserted-by":"crossref","first-page":"5070","DOI":"10.1210\/jc.2005-0681","article-title":"Evidence for abnormal left ventricular structure and function in normotensive individuals with familial hyperaldosteronism type I","volume":"90","author":"Stowasser","year":"2005","journal-title":"J.\u00a0Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.mce.2016.03.038_bib29","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/S0002-9440(10)64454-9","article-title":"Aldosterone-induced inflammation in the rat heart : role of oxidative stress","volume":"161","author":"Sun","year":"2002","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.mce.2016.03.038_bib30","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1161\/01.HYP.0000254415.31362.a7","article-title":"Role of oxidative stress in cardiac hypertrophy and remodeling","volume":"49","author":"Takimoto","year":"2007","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2016.03.038_bib31","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ijcard.2013.06.046","article-title":"Cross-talk between mineralocorticoid receptor\/angiotensin II type 1 receptor and mitogen-activated protein kinase pathways underlies aldosterone-induced atrial fibrotic responses in HL-1 cardiomyocytes","volume":"169","author":"Tsai","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.mce.2016.03.038_bib32","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.yjmcc.2012.04.009","article-title":"CIKS (Act1 or TRAF3IP2) mediates Angiotensin-II-induced Interleukin-18 expression, and Nox2-dependent cardiomyocyte hypertrophy","volume":"53","author":"Valente","year":"2012","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.mce.2016.03.038_bib33","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1016\/j.cellsig.2013.07.013","article-title":"TRAF3IP2 mediates interleukin-18-induced cardiac fibroblast migration and differentiation","volume":"25","author":"Valente","year":"2013","journal-title":"Cell. Signal."},{"key":"10.1016\/j.mce.2016.03.038_bib34","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.freeradbiomed.2013.02.012","article-title":"Advanced oxidation protein products induce cardiomyocyte death via Nox2\/Rac1\/superoxide-dependent TRAF3IP2\/JNK signaling","volume":"60","author":"Valente","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mce.2016.03.038_bib35","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.cardiores.2005.08.023","article-title":"Cardiac transgenic matrix metalloproteinase-2 expression directly induces impaired contractility","volume":"69","author":"Wang","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.mce.2016.03.038_bib36","doi-asserted-by":"crossref","first-page":"465","DOI":"10.2119\/molmed.2010.00028","article-title":"Overexpression of interleukin-18 aggravates cardiac fibrosis and diastolic dysfunction in fructose-fed rats","volume":"16","author":"Xing","year":"2010","journal-title":"Mol. Med."},{"key":"10.1016\/j.mce.2016.03.038_bib37","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1161\/01.CIR.102.22.2700","article-title":"Limitation of excessive extracellular matrix turnover may contribute to survival benefit of spironolactone therapy in patients with congestive heart failure: insights from the randomized aldactone evaluation study (RALES). Rales Investigators","volume":"102","author":"Zannad","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.mce.2016.03.038_bib38","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.it.2011.02.007","article-title":"IL-17 receptor signaling and T helper 17-mediated autoimmune demyelinating disease","volume":"32","author":"Zepp","year":"2011","journal-title":"Trends Immunol."},{"key":"10.1016\/j.mce.2016.03.038_bib39","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.4049\/jimmunol.1202922","article-title":"Crystal structure of IL-17 receptor B SEFIR domain","volume":"190","author":"Zhang","year":"2013","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.mce.2016.03.038_bib40","first-page":"173","article-title":"Role of mitogen-activated protein kinase in cardiac hypertrophy and heart failure","volume":"8","author":"Zhang","year":"2003","journal-title":"Exp. Clin. Cardiol."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720716300958?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720716300958?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,13]],"date-time":"2018-09-13T15:29:47Z","timestamp":1536852587000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720716300958"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":40,"alternative-id":["S0303720716300958"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2016.03.038","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TRAF3IP2 mediates aldosterone\/salt-induced cardiac hypertrophy and fibrosis","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2016.03.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}