{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T07:21:07Z","timestamp":1779175267597,"version":"3.51.4"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100008666","name":"Fundaci\u00f3 la Marat\u00f3 de TV3","doi-asserted-by":"publisher","award":["082610"],"award-info":[{"award-number":["082610"]}],"id":[{"id":"10.13039\/100008666","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.mce.2016.04.004","type":"journal-article","created":{"date-parts":[[2016,4,9]],"date-time":"2016-04-09T23:59:06Z","timestamp":1460246346000},"page":"77-88","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Gene expression profiling in hearts of diabetic mice uncovers a potential role of estrogen-related receptor \u03b3 in diabetic cardiomyopathy"],"prefix":"10.1016","volume":"430","author":[{"given":"Jaime","family":"Lasheras","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Vil\u00e0","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f2nica","family":"Zamora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Efr\u00e9n","family":"Riu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosario","family":"Pardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos","family":"Poncelas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ildefonso","family":"Cases","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marisol","family":"Ruiz-Meana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan E.","family":"Feliu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Sim\u00f3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Garc\u00eda-Dorado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep A.","family":"Villena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2016.04.004_bib1","doi-asserted-by":"crossref","first-page":"434","DOI":"10.2337\/diabetes.52.2.434","article-title":"Age-dependent changes in metabolism, contractile function, and ischemic sensitivity in hearts from db\/db mice","volume":"52","author":"Aasum","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2016.04.004_bib2","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.cmet.2007.06.007","article-title":"ERRgamma directs and maintains the transition to oxidative metabolism in the postnatal heart","volume":"6","author":"Alaynick","year":"2007","journal-title":"Cell Metab."},{"key":"10.1016\/j.mce.2016.04.004_bib3","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1016\/j.jprot.2011.12.023","article-title":"Proteome changes in the myocardium of experimental chronic diabetes and hypertension: role of PPARalpha in the associated hypertrophy","volume":"75","author":"Ares-Carrasco","year":"2011","journal-title":"J.\u00a0Proteomics"},{"key":"10.1016\/j.mce.2016.04.004_bib4","doi-asserted-by":"crossref","first-page":"E1104","DOI":"10.1152\/ajpendo.2000.279.5.E1104","article-title":"Altered metabolism causes cardiac dysfunction in perfused hearts from diabetic (db\/db) mice","volume":"279","author":"Belke","year":"2000","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2016.04.004_bib5","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.2337\/diacare.26.10.2791","article-title":"Diabetes and idiopathic cardiomyopathy: a nationwide case-control study","volume":"26","author":"Bertoni","year":"2003","journal-title":"Diabetes Care"},{"key":"10.1016\/j.mce.2016.04.004_bib6","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.1161\/CIRCULATIONAHA.105.554360","article-title":"Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair myocardial energetics in obesity","volume":"112","author":"Boudina","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.mce.2016.04.004_bib7","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.2337\/db07-0481","article-title":"Mitochondrial energetics in the heart in obesity-related diabetes: direct evidence for increased uncoupled respiration and activation of uncoupling proteins","volume":"56","author":"Boudina","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2016.04.004_bib8","doi-asserted-by":"crossref","first-page":"5341","DOI":"10.1210\/en.2005-0938","article-title":"Reduced cardiac efficiency and altered substrate metabolism precedes the onset of hyperglycemia and contractile dysfunction in two mouse models of insulin resistance and obesity","volume":"146","author":"Buchanan","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2016.04.004_bib9","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1042\/CS20070166","article-title":"Molecular mechanisms for myocardial mitochondrial dysfunction in the metabolic syndrome","volume":"114","author":"Bugger","year":"2008","journal-title":"Clin. Sci. Lond"},{"key":"10.1016\/j.mce.2016.04.004_bib10","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1007\/s00125-014-3171-6","article-title":"Molecular mechanisms of diabetic cardiomyopathy","volume":"57","author":"Bugger","year":"2014","journal-title":"Diabetologia"},{"key":"10.1016\/j.mce.2016.04.004_bib11","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.2337\/db09-0259","article-title":"Tissue-specific remodeling of the mitochondrial proteome in type 1 diabetic akita mice","volume":"58","author":"Bugger","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2016.04.004_bib12","first-page":"3930","article-title":"Nuclear receptors PPARbeta\/delta and PPARalpha direct distinct metabolic regulatory programs in the mouse heart","volume":"117","author":"Burkart","year":"2007","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.mce.2016.04.004_bib13","doi-asserted-by":"crossref","first-page":"E449","DOI":"10.1152\/ajpendo.00329.2003","article-title":"Treatment of type 2 diabetic db\/db mice with a novel PPARgamma agonist improves cardiac metabolism but not contractile function","volume":"286","author":"Carley","year":"2004","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2016.04.004_bib14","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.1073\/pnas.95.6.2979","article-title":"HL-1 cells: a cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte","volume":"95","author":"Claycomb","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mce.2016.04.004_bib15","doi-asserted-by":"crossref","first-page":"e12584","DOI":"10.1371\/journal.pone.0012584","article-title":"A\u00a0PPARalpha promoter variant impairs ERR-dependent transactivation and decreases mortality after acute coronary ischemia in patients with diabetes","volume":"5","author":"Cresci","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.mce.2016.04.004_bib16","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1748-1716.2010.02102.x","article-title":"Impaired cardiac functional reserve in type 2 diabetic db\/db mice is associated with metabolic, but not structural, remodelling","volume":"200","author":"Daniels","year":"2010","journal-title":"Acta Physiol. Oxf"},{"key":"10.1016\/j.mce.2016.04.004_bib17","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1097\/HJH.0b013e3283331169","article-title":"Diabetes and incident heart failure in hypertensive and normotensive participants of the Strong Heart Study","volume":"28","author":"de Simone","year":"2010","journal-title":"J.\u00a0Hypertens."},{"key":"10.1016\/j.mce.2016.04.004_bib18","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1161\/01.CIR.101.19.2271","article-title":"Impact of diabetes on cardiac structure and function: the strong heart study","volume":"101","author":"Devereux","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.mce.2016.04.004_bib19","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1002\/(SICI)1096-9136(199604)13:4<321::AID-DIA3>3.0.CO;2-7","article-title":"Diastolic dysfunction in patients with non-insulin-dependent diabetes mellitus of short duration","volume":"13","author":"Di Bonito","year":"1996","journal-title":"Diabet. Med."},{"key":"10.1016\/j.mce.2016.04.004_bib20","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1172\/JCI3949","article-title":"A\u00a0gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator- activated receptor alpha- deficient mice","volume":"102","author":"Djouadi","year":"1998","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.mce.2016.04.004_bib21","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.cmet.2007.03.007","article-title":"Genome-wide orchestration of cardiac functions by the orphan nuclear receptors ERRalpha and gamma","volume":"5","author":"Dufour","year":"2007","journal-title":"Cell Metab."},{"key":"10.1016\/j.mce.2016.04.004_bib22","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1161\/CIRCULATIONAHA.106.662296","article-title":"Insulin-resistant heart exhibits a mitochondrial biogenic response driven by the peroxisome proliferator-activated receptor-alpha\/PGC-1alpha gene regulatory pathway","volume":"115","author":"Duncan","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.mce.2016.04.004_bib23","doi-asserted-by":"crossref","first-page":"14598","DOI":"10.1074\/jbc.M111.220525","article-title":"Peroxisome proliferator-activated receptor (PPAR) gene profiling uncovers insulin-like growth factor-1 as a PPARalpha target gene in cardioprotection","volume":"286","author":"el Azzouzi","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.mce.2016.04.004_bib24","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.molmet.2013.05.004","article-title":"Mice lacking PGC-1beta in adipose tissues reveal a dissociation between mitochondrial dysfunction and insulin resistance","volume":"2","author":"Enguix","year":"2013","journal-title":"Mol. Metab."},{"key":"10.1016\/j.mce.2016.04.004_bib25","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1210\/er.2003-0012","article-title":"Diabetic cardiomyopathy: evidence, mechanisms, and therapeutic implications","volume":"25","author":"Fang","year":"2004","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.mce.2016.04.004_bib26","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1172\/JCI0214080","article-title":"The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus","volume":"109","author":"Finck","year":"2002","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.mce.2016.04.004_bib27","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1073\/pnas.0336724100","article-title":"A\u00a0critical role for PPARalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat content","volume":"100","author":"Finck","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mce.2016.04.004_bib28","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.jacc.2005.09.030","article-title":"Increased myocardial fatty acid metabolism in patients with type 1 diabetes mellitus","volume":"47","author":"Herrero","year":"2006","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.mce.2016.04.004_bib29","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang da","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.mce.2016.04.004_bib30","doi-asserted-by":"crossref","first-page":"9079","DOI":"10.1128\/MCB.24.20.9079-9091.2004","article-title":"Estrogen-related receptor alpha directs peroxisome proliferator-activated receptor alpha signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle","volume":"24","author":"Huss","year":"2004","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.mce.2016.04.004_bib31","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.yjmcc.2013.09.011","article-title":"Estrogen-related receptor gamma induces cardiac hypertrophy by activating GATA4","volume":"65","author":"Kwon","year":"2013","journal-title":"J.\u00a0Mol. Cell Cardiol."},{"key":"10.1016\/j.mce.2016.04.004_bib32","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1172\/JCI10268","article-title":"Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis","volume":"106","author":"Lehman","year":"2000","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.mce.2016.04.004_bib33","doi-asserted-by":"crossref","first-page":"7473","DOI":"10.1073\/pnas.96.13.7473","article-title":"A\u00a0critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders","volume":"96","author":"Leone","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mce.2016.04.004_bib34","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/1471-2261-14-141","article-title":"Speckle tracking echocardiography in the diagnosis of early left ventricular systolic dysfunction in type II diabetic mice","volume":"14","author":"Li","year":"2014","journal-title":"BMC Cardiovasc Disord."},{"key":"10.1016\/j.mce.2016.04.004_bib35","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.4049\/jimmunol.120.4.1375","article-title":"Impairment of cell-mediated immunity in mutation diabetic mice (db\/db)","volume":"120","author":"Mandel","year":"1978","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.mce.2016.04.004_bib36","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.2337\/diabetes.53.9.2366","article-title":"Impaired cardiac efficiency and increased fatty acid oxidation in insulin-resistant ob\/ob mouse hearts","volume":"53","author":"Mazumder","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2016.04.004_bib37","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/0895-7061(95)00022-H","article-title":"Left ventricular diastolic filling in diabetes mellitus with and without hypertension","volume":"8","author":"Nicolino","year":"1995","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.mce.2016.04.004_bib38","doi-asserted-by":"crossref","first-page":"e26989","DOI":"10.1371\/journal.pone.0026989","article-title":"Rosiglitazone-induced mitochondrial biogenesis in white adipose tissue is independent of peroxisome proliferator-activated receptor gamma coactivator-1alpha","volume":"6","author":"Pardo","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.mce.2016.04.004_bib39","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1093\/cvr\/cvq376","article-title":"Sirt1 acts in association with PPARalpha to protect the heart from hypertrophy, metabolic dysregulation, and inflammation","volume":"90","author":"Planavila","year":"2010","journal-title":"Cardiovasc Res."},{"key":"10.1016\/j.mce.2016.04.004_bib40","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1172\/JCI108843","article-title":"Evidence for cardiomyopathy in familial diabetes mellitus","volume":"60","author":"Regan","year":"1977","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.mce.2016.04.004_bib41","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1016\/j.jacc.2008.07.062","article-title":"Myocardial steatosis is an independent predictor of diastolic dysfunction in type 2 diabetes mellitus","volume":"52","author":"Rijzewijk","year":"2008","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.mce.2016.04.004_bib42","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/0002-9149(72)90595-4","article-title":"New type of cardiomyopathy associated with diabetic glomerulosclerosis","volume":"30","author":"Rubler","year":"1972","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.mce.2016.04.004_bib43","doi-asserted-by":"crossref","first-page":"9013","DOI":"10.1074\/jbc.M212923200","article-title":"The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor alpha (ERRalpha)","volume":"278","author":"Schreiber","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.mce.2016.04.004_bib44","doi-asserted-by":"crossref","first-page":"H976","DOI":"10.1152\/ajpheart.00088.2002","article-title":"Echocardiographic assessment of cardiac function in diabetic db\/db and transgenic db\/db-hGLUT4 mice","volume":"283","author":"Semeniuk","year":"2002","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.mce.2016.04.004_bib45","doi-asserted-by":"crossref","first-page":"39897","DOI":"10.1074\/jbc.M608657200","article-title":"Estrogen-related receptors stimulate pyruvate dehydrogenase kinase isoform 4 gene expression","volume":"281","author":"Zhang","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.mce.2016.04.004_bib46","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1073\/pnas.97.4.1784","article-title":"Lipotoxic heart disease in obese rats: implications for human obesity","volume":"97","author":"Zhou","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720716301095?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720716301095?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T16:17:02Z","timestamp":1718468222000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720716301095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":46,"alternative-id":["S0303720716301095"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2016.04.004","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gene expression profiling in hearts of diabetic mice uncovers a potential role of estrogen-related receptor \u03b3 in diabetic cardiomyopathy","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2016.04.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}