{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T08:02:42Z","timestamp":1767859362726,"version":"3.49.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Science and Technology Research Promotion Program for Ministry of Agriculture, Forestry and Fisheries","award":["25030AB"],"award-info":[{"award-number":["25030AB"]}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["15K18767"],"award-info":[{"award-number":["15K18767"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.mce.2016.06.017","type":"journal-article","created":{"date-parts":[[2016,6,22]],"date-time":"2016-06-22T23:31:42Z","timestamp":1466638302000},"page":"81-92","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Regulation of epithelial to mesenchymal transition in bovine conceptuses through the interaction between follistatin and activin A"],"prefix":"10.1016","volume":"434","author":[{"given":"Kazuya","family":"Kusama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rulan","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Ideta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshito","family":"Aoyagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoshi","family":"Okuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Imakawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2016.06.017_bib1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1530\/REP-13-0655","article-title":"Involvement of VCAM1 in the bovine conceptus adhesion to the uterine endometrium","volume":"148","author":"Bai","year":"2014","journal-title":"Reproduction"},{"key":"10.1016\/j.mce.2016.06.017_bib2","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1095\/biolreprod.109.082354","article-title":"Effect of elevated circulating progesterone concentration on bovine blastocyst development and global transcriptome following endoscopic transfer of in\u00a0vitro produced embryos to the bovine oviduct","volume":"83","author":"Carter","year":"2010","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2016.06.017_bib3","doi-asserted-by":"crossref","first-page":"4697","DOI":"10.1038\/ncomms5697","article-title":"Twist1 induces endothelial differentiation of tumour cells through the Jagged1-KLF4 axis","volume":"5","author":"Chen","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mce.2016.06.017_bib4","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1095\/biolreprod.111.091587","article-title":"Transcriptome changes at the initiation of elongation in the bovine conceptus","volume":"85","author":"Clemente","year":"2011","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2016.06.017_bib5","doi-asserted-by":"crossref","first-page":"R75","DOI":"10.1530\/REP-13-0474","article-title":"Fetal-maternal communication: the role of Notch signalling in embryo implantation","volume":"147","author":"Cuman","year":"2014","journal-title":"Reproduction"},{"key":"10.1016\/j.mce.2016.06.017_bib6","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1095\/biolreprod54.5.1080","article-title":"Ovine endometrial expression of transforming growth factor beta isoforms during the peri-implantation period","volume":"54","author":"Dor\u00e9","year":"1996","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2016.06.017_bib7","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1095\/biolreprod.110.085910","article-title":"Changes in the endometrial transcriptome during the bovine estrous cycle: effect of low circulating progesterone and consequences for conceptus elongation","volume":"84","author":"Forde","year":"2011","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2016.06.017_bib8","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1095\/biolreprod.108.074336","article-title":"Progesterone-regulated changes in endometrial gene expression contribute to advanced conceptus development in cattle","volume":"81","author":"Forde","year":"2009","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2016.06.017_bib9","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1095\/biolreprod.110.090019","article-title":"Conceptus-induced changes in the endometrial transcriptome: how soon does the cow know she is pregnant?","volume":"85","author":"Forde","year":"2011","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2016.06.017_bib10","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1152\/physiolgenomics.00067.2012","article-title":"Evidence for an early endometrial response to pregnancy in cattle: both dependent upon and independent of interferon tau","volume":"44","author":"Forde","year":"2012","journal-title":"Physiol. Genom."},{"key":"10.1016\/j.mce.2016.06.017_bib11","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1530\/REP-13-0010","article-title":"Proteomic analysis of uterine fluid during the pre-implantation period of pregnancy in cattle","volume":"147","author":"Forde","year":"2014","journal-title":"Reproduction"},{"key":"10.1016\/j.mce.2016.06.017_bib12","first-page":"321","article-title":"Alterations in expression of endometrial genes coding for proteins secreted into the uterine lumen during conceptus elongation in cattle. BMC","volume":"14","author":"Forde","year":"2013","journal-title":"Genomics"},{"key":"10.1016\/j.mce.2016.06.017_bib13","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1095\/biolreprod.112.103424","article-title":"Effects of low progesterone on the endometrial transcriptome in cattle","volume":"87","author":"Forde","year":"2012","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2016.06.017_bib14","doi-asserted-by":"crossref","first-page":"e100010","DOI":"10.1371\/journal.pone.0100010","article-title":"Amino acids in the uterine luminal fluid reflects the temporal changes in transporter expression in the endometrium and conceptus during early pregnancy in cattle","volume":"9","author":"Forde","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.mce.2016.06.017_bib15","doi-asserted-by":"crossref","first-page":"19452","DOI":"10.1074\/jbc.M109.011833","article-title":"Differential regulation of transforming growth factor beta signaling pathways by Notch in human endothelial cells","volume":"284","author":"Fu","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.mce.2016.06.017_bib16","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1210\/endo-114-1-120","article-title":"Ovine trophoblast protein 1, an early secreted blastocyst protein, binds specifically to uterine endometrium and affects protein synthesis","volume":"114","author":"Godkin","year":"1984","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2016.06.017_bib17","doi-asserted-by":"crossref","first-page":"re8","DOI":"10.1126\/scisignal.2005189","article-title":"Signaling mechanisms of the epithelial-mesenchymal transition","volume":"7","author":"Gonzalez","year":"2014","journal-title":"Sci. Signal"},{"key":"10.1016\/j.mce.2016.06.017_bib18","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0248-4900(90)90309-Q","article-title":"Cellular localization of an embryonic interferon, ovine trophoblastin and its mRNA in sheep embryos during early pregnancy","volume":"68","author":"Guillomot","year":"1990","journal-title":"Biol. Cell"},{"key":"10.1016\/j.mce.2016.06.017_bib19","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1089\/clo.2007.0017","article-title":"Early developmentin utero of bovine nuclear transfer embryos using early G1 and G0 phasecells","volume":"9","author":"Ideta","year":"2007","journal-title":"Cloning. Stem. Cells"},{"key":"10.1016\/j.mce.2016.06.017_bib20","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/330377a0","article-title":"Interferon-like sequence of ovine trophoblast protein secreted by embryonic trophectoderm","volume":"330","author":"Imakawa","year":"1987","journal-title":"Nature"},{"key":"10.1016\/j.mce.2016.06.017_bib21","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1507\/endocrj.45.441","article-title":"Co-expression of transforming growth factor beta and interferon tau during peri-implantation period in the ewe","volume":"45","author":"Imakawa","year":"1998","journal-title":"Endocr. J."},{"key":"10.1016\/j.mce.2016.06.017_bib22","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/S1043-2760(01)00559-8","article-title":"Potential roles for endometrial inhibins, activins and follistatin during human embryo implantation and early pregnancy","volume":"13","author":"Jones","year":"2002","journal-title":"Trends. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2016.06.017_bib23","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.4161\/cc.10.17.17188","article-title":"Tracking the intermediate stages of epithelial-mesenchymal transition in epithelial stem cells and cancer","volume":"10","author":"Jordan","year":"2011","journal-title":"Cell Cycle"},{"key":"10.1016\/j.mce.2016.06.017_bib24","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.placenta.2010.06.017","article-title":"Cadherins in the human placenta-epithelial-mesenchymal transition (EMT) and placental development","volume":"31","author":"Kokkinos","year":"2010","journal-title":"Placenta"},{"key":"10.1016\/j.mce.2016.06.017_bib25","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1530\/JME-14-0162","article-title":"EPAC2-mediated calreticulin regulates LIF and COX2 expression in human endometrial glandular cells","volume":"54","author":"Kusama","year":"2015","journal-title":"J.\u00a0Mol. Endocrinol."},{"key":"10.1016\/j.mce.2016.06.017_bib26","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/nrm3758","article-title":"Molecular mechanisms of epithelial-mesenchymal transition","volume":"15","author":"Lamouille","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mce.2016.06.017_bib27","doi-asserted-by":"crossref","first-page":"E2216","DOI":"10.1210\/jc.2014-2118","article-title":"Activin A, B, and AB increase human trophoblast cell invasion by up-regulating N-Cadherin","volume":"99","author":"Li","year":"2014","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2016.06.017_bib28","doi-asserted-by":"crossref","first-page":"3471","DOI":"10.1242\/dev.071209","article-title":"Epithelial-mesenchymal transitions: insights from development","volume":"139","author":"Lim","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.mce.2016.06.017_bib29","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1152\/physiolgenomics.90404.2008","article-title":"Gene expression profiles of bovine caruncular and intercaruncular endometrium at implantation","volume":"39","author":"Mansouri-Attia","year":"2009","journal-title":"Physiol. Genom."},{"key":"10.1016\/j.mce.2016.06.017_bib30","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1016\/j.bbagen.2014.02.004","article-title":"TGF\u03b2 and matrix-regulated epithelial to mesenchymal transition","volume":"1840","author":"Moustakas","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mce.2016.06.017_bib31","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1093\/gbe\/evt007","article-title":"Dynamic evolution of endogenous retrovirus-derived genes expressed in bovine conceptuses during the period of placentation","volume":"5","author":"Nakagawa","year":"2013","journal-title":"Genome Biol. Evol."},{"key":"10.1016\/j.mce.2016.06.017_bib32","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1083\/jcb.200710067","article-title":"Slug is a direct Notch target required for initiation of cardiac cushion cellularization","volume":"182","author":"Niessen","year":"2008","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.mce.2016.06.017_bib33","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.placenta.2005.06.007","article-title":"Fibroblast growth factor (FGF)-1, FGF2, FGF7 and FGF receptors are uniformly expressed in trophoblast giant cells during restricted trophoblast invasion in cows","volume":"27","author":"Pfarrer","year":"2006","journal-title":"Placenta"},{"key":"10.1016\/j.mce.2016.06.017_bib34","first-page":"432","article-title":"Interferons as hormones of pregnancy","volume":"13","author":"Roberts","year":"1992","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.mce.2016.06.017_bib35","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1095\/biolreprod.112.100180","article-title":"Coculture system that mimics in\u00a0vivo attachment processes in bovine trophoblast cells","volume":"87","author":"Sakurai","year":"2012","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2016.06.017_bib36","doi-asserted-by":"crossref","first-page":"e80427","DOI":"10.1371\/journal.pone.0080427","article-title":"Transcriptional regulation of two conceptus interferon tau genes expressed in Japanese black cattle during peri-implantation period","volume":"8","author":"Sakurai","year":"2013","journal-title":"PLoSOne"},{"key":"10.1016\/j.mce.2016.06.017_bib37","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1677\/joe.0.117R001","article-title":"Interferon-\u03b1 mimics effects of ovine trophoblast protein-1 on prostaglandin and protein secretion by ovine endometrial cells","volume":"117","author":"Salamonsen","year":"1988","journal-title":"J.\u00a0Endocrinol."},{"key":"10.1016\/j.mce.2016.06.017_bib38","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1095\/biolreprod62.5.1116","article-title":"Production of prostaglandin F2 by cultured bovine endometrial cells in response to tumor necrosis factor: cell type specificity and intracellular mechanisms","volume":"62","author":"Skarzynski","year":"2000","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2016.06.017_bib39","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1210\/endo.137.3.8603586","article-title":"Ovine interferon-s suppresses transcription of the estrogen receptor and oxytocin receptor genes in the ovine endometrium","volume":"137","author":"Spencer","year":"1996","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2016.06.017_bib40","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1530\/REP-07-0327","article-title":"Genes involved in conceptus-endometrial interactions in ruminants: insights from reductionism and thoughts on holistic approaches","volume":"135","author":"Spencer","year":"2008","journal-title":"Reproduction"},{"key":"10.1016\/j.mce.2016.06.017_bib41","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0012-1606(03)00130-1","article-title":"Mechanisms of implantation in the mouse: differentiation and functional importance of trophoblast giant cell behavior","volume":"258","author":"Sutherland","year":"2003","journal-title":"Dev. Biol."},{"key":"10.1016\/j.mce.2016.06.017_bib42","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1095\/biolreprod62.2.235","article-title":"Bovine blastocyst-derived trophectoderm and endoderm cell cultures: interferon tau and transferrin expression as respective in\u00a0vitro markers","volume":"62","author":"Talbot","year":"2000","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2016.06.017_bib43","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1677\/JOE-08-0237","article-title":"Regulation of prostaglandin biosynthesis by interleukin-1 in cultured bovine endometrial cells","volume":"199","author":"Tanikawa","year":"2008","journal-title":"J.\u00a0Endocrinol."},{"key":"10.1016\/j.mce.2016.06.017_bib44","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1046\/j.1439-0531.2003.00435.x","article-title":"Embryo-maternal communication in bovine - strategies for deciphering a complex cross-talk","volume":"38","author":"Wolf","year":"2003","journal-title":"Reprod. Domest. Anim."},{"key":"10.1016\/j.mce.2016.06.017_bib45","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1530\/REP-11-0364","article-title":"Expression of mesenchymal-related genes by the bovine trophectoderm following conceptus attachment to the endometrial epithelium","volume":"143","author":"Yamakoshi","year":"2012","journal-title":"Reproduction"}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720716302192?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720716302192?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T10:32:28Z","timestamp":1572949948000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720716302192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":45,"alternative-id":["S0303720716302192"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2016.06.017","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regulation of epithelial to mesenchymal transition in bovine conceptuses through the interaction between follistatin and activin A","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2016.06.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}