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(Lausanne)"},{"key":"10.1016\/j.mce.2016.08.049_bib103","doi-asserted-by":"crossref","DOI":"10.1016\/j.freeradbiomed.2016.03.008","article-title":"Mitochondrial stress induces cellular senescence in an mTORC1-dependent manner","author":"Nacarelli","year":"2016","journal-title":"Free Radic. Biol. 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