{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:18:49Z","timestamp":1790705929746,"version":"4.1.0"},"reference-count":139,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Agence Nationale de la Recherche Jeunes Chercheuses Jeunes Chercheurs","award":["ANR-12-JSV1\u20130013-01"],"award-info":[{"award-number":["ANR-12-JSV1\u20130013-01"]}]},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM)"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.mce.2016.09.027","type":"journal-article","created":{"date-parts":[[2016,9,30]],"date-time":"2016-09-30T04:48:16Z","timestamp":1475210896000},"page":"42-51","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Hypothalamic regulation of body growth and appetite by ghrelin-derived peptides during balanced nutrition or undernutrition"],"prefix":"10.1016","volume":"438","author":[{"given":"Rim","family":"Hassouna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Labarthe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Tolle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2016.09.027_bib1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.regpep.2009.04.014","article-title":"Central administration of obestatin fails to show inhibitory effects on food and water intake in mice","volume":"156","author":"Annemie","year":"2009","journal-title":"Regul. Pept."},{"key":"10.1016\/j.mce.2016.09.027_bib2","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1093\/jn\/106.7.884","article-title":"Time sequence of lipogenic changes in adipose tissue of rats when converted from ad libitum feeding to meal-eating","volume":"106","author":"Armstrong","year":"1976","journal-title":"J.\u00a0Nutr."},{"key":"10.1016\/j.mce.2016.09.027_bib3","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1136\/gut.2004.038737","article-title":"Stomach regulates energy balance via acylated ghrelin and desacyl ghrelin","volume":"54","author":"Asakawa","year":"2005","journal-title":"Gut"},{"key":"10.1016\/j.mce.2016.09.027_bib4","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1136\/gut.52.7.947","article-title":"Antagonism of ghrelin receptor reduces food intake and body weight gain in mice","volume":"52","author":"Asakawa","year":"2003","journal-title":"Gut"},{"key":"10.1016\/j.mce.2016.09.027_bib5","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.biopsych.2006.07.018","article-title":"Exaggerated 5-HT1A but normal 5-HT2A receptor activity in individuals ill with anorexia nervosa","volume":"61","author":"Bailer","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.mce.2016.09.027_bib6","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.pscychresns.2012.06.010","article-title":"Interaction between serotonin transporter and dopamine D2\/D3 receptor radioligand measures is associated with harm avoidant symptoms in anorexia and bulimia nervosa","volume":"211","author":"Bailer","year":"2013","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.mce.2016.09.027_bib7","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1677\/JOE-06-0021","article-title":"Characterisation of proghrelin peptides in mammalian tissue and plasma","volume":"192","author":"Bang","year":"2007","journal-title":"J.\u00a0Endocrinol."},{"key":"10.1016\/j.mce.2016.09.027_bib8","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0031-9384(89)90242-4","article-title":"Metabolic changes caused by irregular-feeding schedule as compared with meal-feeding","volume":"46","author":"Bazotte","year":"1989","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.mce.2016.09.027_bib9","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s13023-016-0440-0","article-title":"High unacylated ghrelin levels support the concept of anorexia in infants with prader-willi syndrome","volume":"11","author":"Beauloye","year":"2016","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.mce.2016.09.027_bib10","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/sj.ejcn.1601387","article-title":"Meal patterns and obesity in Swedish women-a simple instrument describing usual meal types, frequency and temporal distribution","volume":"56","author":"Berteus Forslund","year":"2002","journal-title":"Eur. J. Clin. Nutr."},{"key":"10.1016\/j.mce.2016.09.027_bib11","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.neuroscience.2009.08.009","article-title":"Reduced anticipatory locomotor responses to scheduled meals in ghrelin receptor deficient mice","volume":"164","author":"Blum","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.mce.2016.09.027_bib12","doi-asserted-by":"crossref","first-page":"4745","DOI":"10.1210\/en.2010-0556","article-title":"Diet-induced obesity causes ghrelin resistance in arcuate NPY\/AgRP neurons","volume":"151","author":"Briggs","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2016.09.027_bib13","doi-asserted-by":"crossref","first-page":"3062","DOI":"10.1210\/jc.2003-031964","article-title":"Non-acylated ghrelin counteracts the metabolic but not the neuroendocrine response to acylated ghrelin in humans","volume":"89","author":"Broglio","year":"2004","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2016.09.027_bib14","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1124\/pr.113.008433","article-title":"Novel and conventional receptors for ghrelin, desacyl-ghrelin, and pharmacologically related compounds","volume":"66","author":"Callaghan","year":"2014","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.mce.2016.09.027_bib15","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1159\/000076042","article-title":"Agonist-specific coupling of growth hormone secretagogue receptor type 1a to different intracellular signaling systems. Role of adenosine","volume":"79","author":"Carreira","year":"2004","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.mce.2016.09.027_bib16","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1126\/science.1135047","article-title":"Comment on \u201cObestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake","volume":"315","author":"Chartrel","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.mce.2016.09.027_bib17","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aae0374","article-title":"Enhanced responsiveness of Ghsr Q343X rats to ghrelin results in enhanced adiposity without increased appetite","volume":"9","author":"Chebani","year":"2016","journal-title":"Sci. Signal."},{"key":"10.1016\/j.mce.2016.09.027_bib18","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1210\/en.2002-220783","article-title":"The role of ghrelin and growth hormone secretagogues receptor on rat adipogenesis","volume":"144","author":"Choi","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2016.09.027_bib19","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.mce.2011.08.034","article-title":"The truncated ghrelin receptor polypeptide (GHS-R1b) is localized in the endoplasmic reticulum where it forms heterodimers with ghrelin receptors (GHS-R1a) to attenuate their cell surface expression","volume":"348","author":"Chow","year":"2012","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2016.09.027_bib20","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1152\/ajplegacy.1959.196.5.965","article-title":"Changes in body composition attendant on force feeding","volume":"196","author":"Cohn","year":"1959","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.mce.2016.09.027_bib21","first-page":"381","article-title":"Effect of diet on body composition. I. The production of increased body fat without overweight (nonobese obesity) by force feeding the normal rat","volume":"6","author":"Cohn","year":"1957","journal-title":"Metabolism"},{"key":"10.1016\/j.mce.2016.09.027_bib22","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1159\/000328968","article-title":"GSK1614343, a novel ghrelin receptor antagonist, produces an unexpected increase of food intake and body weight in rodents and dogs","volume":"94","author":"Costantini","year":"2011","journal-title":"Neuroendocrinology"},{"issue":"14","key":"10.1016\/j.mce.2016.09.027_bib23","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1111\/bph.13502","article-title":"Obestatin as a key regulator of metabolism and cardiovascular function with emerging therapeutic potential for diabetes","volume":"173","author":"Cowan","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.mce.2016.09.027_bib24","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.physbeh.2006.05.022","article-title":"Ghrelin and the short- and long-term regulation of appetite and body weight","volume":"89","author":"Cummings","year":"2006","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.mce.2016.09.027_bib25","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1146\/annurev.med.54.101601.152147","article-title":"Growth hormone therapy in adults","volume":"54","author":"Cummings","year":"2003","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.mce.2016.09.027_bib26","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.2337\/diabetes.50.8.1714","article-title":"A\u00a0preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans","volume":"50","author":"Cummings","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2016.09.027_bib27","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.psyneuen.2006.11.003","article-title":"Family trios analysis of common polymorphisms in the obestatin\/ghrelin, BDNF and AGRP genes in patients with Anorexia nervosa: association with subtype, body-mass index, severity and age of onset","volume":"32","author":"Dardennes","year":"2007","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.mce.2016.09.027_bib28","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1096\/fj.12-221143","article-title":"Des-acyl ghrelin analogs prevent high-fat-diet-induced dysregulation of glucose homeostasis","volume":"27","author":"Delhanty","year":"2013","journal-title":"FASEB J."},{"key":"10.1016\/j.mce.2016.09.027_bib29","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1159\/000346059","article-title":"Des-acyl ghrelin: a metabolically active peptide","volume":"25","author":"Delhanty","year":"2013","journal-title":"Endocr. Dev."},{"key":"10.1016\/j.mce.2016.09.027_bib30","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1159\/000358345","article-title":"Should we consider des-acyl ghrelin as a separate hormone and if so, what does it do?","volume":"42","author":"Delhanty","year":"2014","journal-title":"Front. Horm. Res."},{"key":"10.1016\/j.mce.2016.09.027_bib31","doi-asserted-by":"crossref","first-page":"4287","DOI":"10.1210\/en.2013-2055","article-title":"Genetic manipulation of the ghrelin signaling system in male mice reveals bone compartment specificity of acylated and unacylated ghrelin in the regulation of bone remodeling","volume":"155","author":"Delhanty","year":"2014","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2016.09.027_bib32","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1021\/jm070024h","article-title":"Synthesis and pharmacological in\u00a0vitro and in\u00a0vivo evaluations of novel triazole derivatives as ligands of the ghrelin receptor. 1","volume":"50","author":"Demange","year":"2007","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.mce.2016.09.027_bib33","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.regpep.2009.04.002","article-title":"Targeting the ghrelin receptor to regulate food intake","volume":"156","author":"Depoortere","year":"2009","journal-title":"Regul. Pept."},{"key":"10.1016\/j.mce.2016.09.027_bib34","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1210\/endo.138.2.4907","article-title":"Induction of c-fos messenger ribonucleic acid in neuropeptide Y and growth hormone (GH)-releasing factor neurons in the rat arcuate nucleus following systemic injection of the GH secretagogue, GH-releasing peptide-6","volume":"138","author":"Dickson","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2016.09.027_bib35","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1038\/sj.ijo.0803001","article-title":"Ghrelin increases food intake in obese as well as lean subjects","volume":"29","author":"Druce","year":"2005","journal-title":"Int. J. Obes. (Lond)"},{"key":"10.1016\/j.mce.2016.09.027_bib36","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/sj.ijo.0800552","article-title":"Evidence that eating frequency is inversely related to body weight status in male, but not female, non-obese adults reporting valid dietary intakes","volume":"22","author":"Drummond","year":"1998","journal-title":"Int. J. Obes. Relat. Metab. Disord."},{"key":"10.1016\/j.mce.2016.09.027_bib37","doi-asserted-by":"crossref","first-page":"5175","DOI":"10.1210\/en.2007-0239","article-title":"Small-molecule ghrelin receptor antagonists improve glucose tolerance, suppress appetite, and promote weight loss","volume":"148","author":"Esler","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2016.09.027_bib38","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/S0140-6736(64)90510-0","article-title":"The frequency of meals. Its relation to overweight, hypercholesterolaemia, and decreased glucose-tolerance","volume":"2","author":"Fabry","year":"1964","journal-title":"Lancet"},{"key":"10.1016\/j.mce.2016.09.027_bib39","doi-asserted-by":"crossref","first-page":"2800","DOI":"10.1210\/jc.2007-2138","article-title":"Hyperghrelinemia precedes obesity in Prader-Willi syndrome","volume":"93","author":"Feigerlova","year":"2008","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2016.09.027_bib40","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1111\/j.1460-9568.2011.07787.x","article-title":"Ghrelin and obestatin modulate growth hormone-releasing hormone release and synaptic inputs onto growth hormone-releasing hormone neurons","volume":"34","author":"Feng","year":"2011","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.mce.2016.09.027_bib41","doi-asserted-by":"crossref","DOI":"10.1111\/jne.12349","article-title":"Des-acyl ghrelin directly targets the arcuate nucleus in a ghrelin-receptor independent manner and impairs the orexigenic effect of ghrelin","volume":"28","author":"Fernandez","year":"2016","journal-title":"J.\u00a0Neuroendocrinol."},{"key":"10.1016\/j.mce.2016.09.027_bib42","doi-asserted-by":"crossref","first-page":"G699","DOI":"10.1152\/ajpgi.00448.2007","article-title":"Possible entrainment of ghrelin to habitual meal patterns in humans","volume":"294","author":"Frecka","year":"2008","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.mce.2016.09.027_bib43","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.mce.2007.05.010","article-title":"Unacylated ghrelin is not a functional antagonist but a full agonist of the type 1a growth hormone secretagogue receptor (GHS-R)","volume":"274","author":"Gauna","year":"2007","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2016.09.027_bib44","first-page":"1","article-title":"Ghrelin and obestatin circadian levels differentiate bingeing-purging from restrictive anorexia nervosa","author":"Germain","year":"2010","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2016.09.027_bib45","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.psyneuen.2008.10.001","article-title":"Ghrelin\/obestatin ratio in two populations with low bodyweight: constitutional thinness and anorexia nervosa","volume":"34","author":"Germain","year":"2009","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.mce.2016.09.027_bib46","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1111\/acer.12499","article-title":"The effects of ghrelin antagonists [D-Lys(3) ]-GHRP-6 or JMV2959 on ethanol, water, and food intake in C57BL\/6J mice","volume":"38","author":"Gomez","year":"2014","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.mce.2016.09.027_bib47","doi-asserted-by":"crossref","first-page":"256","DOI":"10.3389\/fnins.2016.00256","article-title":"New insights in anorexia nervosa","volume":"10","author":"Gorwood","year":"2016","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.mce.2016.09.027_bib48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.regpep.2006.12.023","article-title":"Lack of obestatin effects on food intake: should obestatin be renamed ghrelin-associated peptide (GAP)?","volume":"141","author":"Gourcerol","year":"2007","journal-title":"Regul. Pept."},{"key":"10.1016\/j.mce.2016.09.027_bib49","doi-asserted-by":"crossref","first-page":"11133","DOI":"10.1073\/pnas.1411413111","article-title":"Insulin-like peptide 5 is an orexigenic gastrointestinal hormone","volume":"111","author":"Grosse","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mce.2016.09.027_bib50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mce.2006.05.007","article-title":"One ancestor, several peptides post-translational modifications of preproghrelin generate several peptides with antithetical effects","volume":"256","author":"Gualillo","year":"2006","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2016.09.027_bib51","doi-asserted-by":"crossref","first-page":"6320","DOI":"10.1073\/pnas.0800708105","article-title":"Ghrelin octanoylation mediated by an orphan lipid transferase","volume":"105","author":"Gutierrez","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"Suppl.\u00a01","key":"10.1016\/j.mce.2016.09.027_bib52","doi-asserted-by":"crossref","first-page":"S71","DOI":"10.1530\/eje.0.151S071","article-title":"Novel analogs of ghrelin: physiological and clinical implications","volume":"151","author":"Halem","year":"2004","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.mce.2016.09.027_bib53","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1159\/000088796","article-title":"A\u00a0novel growth hormone secretagogue-1a receptor antagonist that blocks ghrelin-induced growth hormone secretion but induces increased body weight gain","volume":"81","author":"Halem","year":"2005","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.mce.2016.09.027_bib54","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.biopsych.2007.04.005","article-title":"Obestatin, acyl ghrelin, and des-acyl ghrelin responses to an oral glucose tolerance test in the restricting type of anorexia nervosa","volume":"63","author":"Harada","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.mce.2016.09.027_bib55","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3389\/fendo.2013.00025","article-title":"Actions of agonists and antagonists of the ghrelin\/GHS-R pathway on GH secretion, appetite, and cFos activity","volume":"4","author":"Hassouna","year":"2013","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.mce.2016.09.027_bib56","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.1210\/en.2014-1126","article-title":"An early reduction in GH peak amplitude in preproghrelin-deficient male mice has a minor impact on linear growth","volume":"155","author":"Hassouna","year":"2014","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2016.09.027_bib57","doi-asserted-by":"crossref","first-page":"e51135","DOI":"10.1371\/journal.pone.0051135","article-title":"A\u00a0natural variant of obestatin, Q90L, inhibits ghrelin's action on food intake and GH secretion and targets NPY and GHRH neurons in mice","volume":"7","author":"Hassouna","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.mce.2016.09.027_bib58","doi-asserted-by":"crossref","first-page":"122","DOI":"10.2337\/db13-0414","article-title":"Both acyl and des-acyl ghrelin regulate adiposity and glucose metabolism via central nervous system ghrelin receptors","volume":"63","author":"Heppner","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2016.09.027_bib59","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.1210\/me.2005-0059","article-title":"Nonpeptide and peptide growth hormone secretagogues act both as ghrelin receptor agonist and as positive or negative allosteric modulators of ghrelin signaling","volume":"19","author":"Holst","year":"2005","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.mce.2016.09.027_bib60","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1210\/me.2003-0069","article-title":"High constitutive signaling of the ghrelin receptor\u2013identification of a potent inverse agonist","volume":"17","author":"Holst","year":"2003","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.mce.2016.09.027_bib61","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1210\/en.2006-0933","article-title":"GPR39 signaling is stimulated by zinc ions but not by obestatin","volume":"148","author":"Holst","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2016.09.027_bib62","doi-asserted-by":"crossref","first-page":"53806","DOI":"10.1074\/jbc.M407676200","article-title":"Common structural basis for constitutive activity of the ghrelin receptor family","volume":"279","author":"Holst","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.mce.2016.09.027_bib63","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.mce.2014.06.003","article-title":"Triazole GHS-R1a antagonists JMV4208 and JMV3002 attenuate food intake, body weight, and adipose tissue mass in mice","volume":"393","author":"Holubova","year":"2014","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2016.09.027_bib64","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1006\/bbrc.2000.4039","article-title":"Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue","volume":"279","author":"Hosoda","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mce.2016.09.027_bib65","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1507\/endocrj.K09E-168","article-title":"Ghrelin increases hunger and food intake in patients with restricting-type anorexia nervosa: a pilot study","volume":"56","author":"Hotta","year":"2009","journal-title":"Endocr. J."},{"key":"10.1016\/j.mce.2016.09.027_bib66","doi-asserted-by":"crossref","first-page":"16309","DOI":"10.1523\/JNEUROSCI.4622-13.2014","article-title":"Actions of NPY, and its Y1 and Y2 receptors on pulsatile growth hormone secretion during the fed and fasted state","volume":"34","author":"Huang","year":"2014","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.mce.2016.09.027_bib67","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1016\/j.peptides.2008.09.014","article-title":"Desacyl ghrelin inhibits the orexigenic effect of peripherally injected ghrelin in rats","volume":"29","author":"Inhoff","year":"2008","journal-title":"Peptides"},{"key":"10.1016\/j.mce.2016.09.027_bib68","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.peptides.2009.01.019","article-title":"Is desacyl ghrelin a modulator of food intake?","volume":"30","author":"Inhoff","year":"2009","journal-title":"Peptides"},{"key":"10.1016\/j.mce.2016.09.027_bib69","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1097\/01.wnr.0000215779.76602.93","article-title":"GPR39 receptor expression in the mouse brain","volume":"17","author":"Jackson","year":"2006","journal-title":"Neuroreport"},{"key":"10.1016\/j.mce.2016.09.027_bib70","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1210\/me.2005-0084","article-title":"Ghrelin amplifies dopamine signaling by cross talk involving formation of growth hormone secretagogue receptor\/dopamine receptor subtype 1 heterodimers","volume":"20","author":"Jiang","year":"2006","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.mce.2016.09.027_bib71","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.neuron.2011.10.038","article-title":"Apo-ghrelin receptor forms heteromers with DRD2 in hypothalamic neurons and is essential for anorexigenic effects of DRD2 agonism","volume":"73","author":"Kern","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.mce.2016.09.027_bib72","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/nm.1997","article-title":"GOAT links dietary lipids with the endocrine control of energy balance","volume":"15","author":"Kirchner","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.mce.2016.09.027_bib73","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/45230","article-title":"Ghrelin is a growth-hormone-releasing acylated peptide from stomach","volume":"402","author":"Kojima","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.mce.2016.09.027_bib74","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1152\/physrev.00012.2004","article-title":"Ghrelin: structure and function","volume":"85","author":"Kojima","year":"2005","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.mce.2016.09.027_bib75","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1055\/s-0030-1252017","article-title":"Changes in acyl ghrelin, des-acyl ghrelin, and ratio of acyl ghrelin to total ghrelin with short-term refeeding in female inpatients with restricting-type anorexia nervosa","volume":"42","author":"Koyama","year":"2010","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.mce.2016.09.027_bib76","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/ajmg.a.36810","article-title":"Hyperghrelinemia in Prader-Willi syndrome begins in early infancy long before the onset of hyperphagia","volume":"167A","author":"Kweh","year":"2015","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.mce.2016.09.027_bib77","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.bbrc.2006.09.141","article-title":"Obestatin does not activate orphan G protein-coupled receptor GPR39","volume":"351","author":"Lauwers","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mce.2016.09.027_bib78","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1210\/jc.2007-2235","article-title":"Novel ghrelin assays provide evidence for independent regulation of ghrelin acylation and secretion in healthy young men","volume":"93","author":"Liu","year":"2008","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2016.09.027_bib79","doi-asserted-by":"crossref","first-page":"27021","DOI":"10.1074\/jbc.M115.659250","article-title":"Agonism, antagonism, and inverse agonism bias at the ghrelin receptor signaling","volume":"290","author":"M'Kadmi","year":"2015","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.mce.2016.09.027_bib80","doi-asserted-by":"crossref","first-page":"24656","DOI":"10.1074\/jbc.M113.453423","article-title":"Heterodimerization with its splice variant blocks the ghrelin receptor 1a in a non-signaling conformation: a study with a purified heterodimer assembled into lipid discs","volume":"288","author":"Mary","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.mce.2016.09.027_bib81","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.cmet.2014.04.007","article-title":"Induced ablation of ghrelin cells in adult mice does not decrease food intake, body weight, or response to high-fat diet","volume":"20","author":"McFarlane","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.mce.2016.09.027_bib82","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1006\/geno.1997.5069","article-title":"Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors","volume":"46","author":"McKee","year":"1997","journal-title":"Genomics"},{"key":"10.1016\/j.mce.2016.09.027_bib83","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1210\/jc.2005-2304","article-title":"Ghrelin has partial or no effect on appetite, growth hormone, prolactin, and cortisol release in patients with anorexia nervosa","volume":"91","author":"Miljic","year":"2006","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2016.09.027_bib84","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1053\/j.gastro.2006.07.009","article-title":"Altered gastrointestinal and metabolic function in the GPR39-obestatin receptor-knockout mouse","volume":"131","author":"Moechars","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.mce.2016.09.027_bib85","doi-asserted-by":"crossref","first-page":"4418","DOI":"10.1210\/jc.2008-1138","article-title":"Plasma obestatin, ghrelin, and ghrelin\/obestatin ratio are increased in underweight patients with anorexia nervosa but not in symptomatic patients with bulimia nervosa","volume":"93","author":"Monteleone","year":"2008","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2016.09.027_bib86","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1134\/S0012496615010019","article-title":"Changes in feeding and drinking motivations and glucose content in male rats after single or chronic administration of obestatin or its fragment (1-4)","volume":"460","author":"Motorykina","year":"2015","journal-title":"Dokl. Biol. Sci."},{"key":"10.1016\/j.mce.2016.09.027_bib87","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s00726-012-1355-2","article-title":"The 1,2,4-triazole as a scaffold for the design of ghrelin receptor ligands: development of JMV 2959, a potent antagonist","volume":"44","author":"Moulin","year":"2013","journal-title":"Amino Acids"},{"key":"10.1016\/j.mce.2016.09.027_bib88","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1038\/ncomms2968","article-title":"The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms","volume":"4","author":"Muller","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mce.2016.09.027_bib89","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.biochi.2016.03.009","article-title":"Studies on the influence of CCK-8 on the ability of obestatin to reduce food intake, gain in body weight and related lipid parameters","volume":"125","author":"Nagaraj","year":"2016","journal-title":"Biochimie"},{"key":"10.1016\/j.mce.2016.09.027_bib90","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.biopsych.2007.08.005","article-title":"Plasma obestatin concentrations are negatively correlated with body mass index, insulin resistance index, and plasma leptin concentrations in obesity and anorexia nervosa","volume":"64","author":"Nakahara","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.mce.2016.09.027_bib91","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/35051587","article-title":"A\u00a0role for ghrelin in the central regulation of feeding","volume":"409","author":"Nakazato","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.mce.2016.09.027_bib92","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1210\/en.2006-0915","article-title":"Effects of obestatin on energy balance and growth hormone secretion in rodents","volume":"148","author":"Nogueiras","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2016.09.027_bib93","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1016\/S0024-3205(03)00147-4","article-title":"The role of circulating ghrelin in growth hormone (GH) secretion in freely moving male rats","volume":"72","author":"Okimura","year":"2003","journal-title":"Life Sci."},{"key":"10.1016\/j.mce.2016.09.027_bib94","doi-asserted-by":"crossref","first-page":"e9159","DOI":"10.1371\/journal.pone.0009159","article-title":"Ghrelin stimulation of growth hormone-releasing hormone neurons is direct in the arcuate nucleus","volume":"5","author":"Osterstock","year":"2010","journal-title":"PloS One"},{"key":"10.1016\/j.mce.2016.09.027_bib95","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1530\/EJE-13-0347","article-title":"Does des-acyl ghrelin improve glycemic control in obese diabetic subjects by decreasing acylated ghrelin levels?","volume":"170","author":"Ozcan","year":"2014","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.mce.2016.09.027_bib96","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1172\/JCI25303","article-title":"Loss of constitutive activity of the growth hormone secretagogue receptor in familial short stature","volume":"116","author":"Pantel","year":"2006","journal-title":"J.\u00a0Clin. Invest"},{"key":"10.1016\/j.mce.2016.09.027_bib97","doi-asserted-by":"crossref","first-page":"4334","DOI":"10.1210\/jc.2009-1327","article-title":"Recessive isolated growth hormone deficiency and mutations in the ghrelin receptor","volume":"94","author":"Pantel","year":"2009","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2016.09.027_bib98","doi-asserted-by":"crossref","first-page":"19003","DOI":"10.1073\/pnas.1209590109","article-title":"Modification of ghrelin receptor signaling by somatostatin receptor-5 regulates insulin release","volume":"109","author":"Park","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mce.2016.09.027_bib99","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.bbrc.2003.09.045","article-title":"C-terminal pro-ghrelin peptides are present in the human circulation","volume":"310","author":"Pemberton","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mce.2016.09.027_bib100","doi-asserted-by":"crossref","first-page":"4920","DOI":"10.1210\/en.2008-1638","article-title":"In\u00a0vivo characterization of high Basal signaling from the ghrelin receptor","volume":"150","author":"Petersen","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2016.09.027_bib101","doi-asserted-by":"crossref","first-page":"4920","DOI":"10.1210\/en.2008-1638","article-title":"In\u00a0vivo characterization of high basal signaling from the ghrelin receptor","volume":"150","author":"Petersen","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2016.09.027_bib102","doi-asserted-by":"crossref","first-page":"G610","DOI":"10.1152\/ajpgi.00321.2007","article-title":"Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure","volume":"294","author":"Pfluger","year":"2008","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.mce.2016.09.027_bib103","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ejphar.2009.03.066","article-title":"Anorexigenic and electrophysiological actions of novel ghrelin receptor (GHS-R1A) antagonists in rats","volume":"612","author":"Salome","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.mce.2016.09.027_bib104","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1111\/j.1365-2826.2009.01895.x","article-title":"On the central mechanism underlying ghrelin's chronic pro-obesity effects in rats: new insights from studies exploiting a potent ghrelin receptor antagonist","volume":"21","author":"Salome","year":"2009","journal-title":"J.\u00a0Neuroendocrinol."},{"key":"10.1016\/j.mce.2016.09.027_bib105","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1007\/s00018-015-1994-z","article-title":"beta-Arrestin scaffolds and signaling elements essential for the obestatin\/GPR39 system that determine the myogenic program in human myoblast cells","volume":"73","author":"Santos-Zas","year":"2016","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.mce.2016.09.027_bib106","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1074\/jbc.M112.382473","article-title":"Promiscuous dimerization of the growth hormone secretagogue receptor (GHS-R1a) attenuates ghrelin-mediated signaling","volume":"288","author":"Schellekens","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.mce.2016.09.027_bib107","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0143-4179(97)90002-0","article-title":"Characterization of the binding of MSH-B, HB-228, GHRP-6 and 153N-6 to the human melanocortin receptor subtypes","volume":"31","author":"Schioth","year":"1997","journal-title":"Neuropeptides"},{"key":"10.1016\/j.mce.2016.09.027_bib108","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jpeds.2003.10.036","article-title":"Ghrelin levels in obesity and anorexia nervosa: effect of weight reduction or recuperation","volume":"144","author":"Soriano-Guill\u00e9n","year":"2004","journal-title":"J.\u00a0Pediatr."},{"key":"10.1016\/j.mce.2016.09.027_bib109","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.cmet.2013.09.002","article-title":"Profiling of glucose-sensing neurons reveals that GHRH neurons are activated by hypoglycemia","volume":"18","author":"Stanley","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.mce.2016.09.027_bib110","doi-asserted-by":"crossref","first-page":"e98180","DOI":"10.1371\/journal.pone.0098180","article-title":"Unacylated ghrelin suppresses ghrelin-induced neuronal activity in the hypothalamus and brainstem of male rats [corrected]","volume":"9","author":"Stevanovic","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.mce.2016.09.027_bib111","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/cphy.c150002","article-title":"Neuroendocrine regulation of growth hormone secretion","volume":"6","author":"Steyn","year":"2016","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.mce.2016.09.027_bib112","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0006-291X(02)02572-X","article-title":"A\u00a0transient surge of ghrelin secretion before feeding is modified by different feeding regimens in sheep","volume":"298","author":"Sugino","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mce.2016.09.027_bib113","first-page":"513","article-title":"Relationship between feeding pattern and body mass index in 220 free-living people in four age groups","volume":"50","author":"Summerbell","year":"1996","journal-title":"Eur. J. Clin. Nutr."},{"key":"10.1016\/j.mce.2016.09.027_bib114","doi-asserted-by":"crossref","first-page":"7973","DOI":"10.1128\/MCB.23.22.7973-7981.2003","article-title":"Deletion of ghrelin impairs neither growth nor appetite","volume":"23","author":"Sun","year":"2003","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.mce.2016.09.027_bib115","doi-asserted-by":"crossref","first-page":"4679","DOI":"10.1073\/pnas.0305930101","article-title":"Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor","volume":"101","author":"Sun","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mce.2016.09.027_bib116","doi-asserted-by":"crossref","first-page":"9408","DOI":"10.1158\/0008-5472.CAN-06-1349","article-title":"The neuromedin U-growth hormone secretagogue receptor 1b\/neurotensin receptor 1 oncogenic signaling pathway as a therapeutic target for lung cancer","volume":"66","author":"Takahashi","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.mce.2016.09.027_bib117","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1210\/en.2002-220852","article-title":"Interrelationship between the novel peptide ghrelin and somatostatin\/growth hormone-releasing hormone in regulation of pulsatile growth hormone secretion","volume":"144","author":"Tannenbaum","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2016.09.027_bib118","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1172\/JCI25811","article-title":"Ghrelin action in the brain controls adipocyte metabolism","volume":"116","author":"Theander-Carrillo","year":"2006","journal-title":"J.\u00a0Clin. Invest"},{"key":"10.1016\/j.mce.2016.09.027_bib119","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1210\/en.2003-0899","article-title":"Ghrelin and des-octanoyl ghrelin promote adipogenesis directly in\u00a0vivo by a mechanism independent of the type 1a growth hormone secretagogue receptor","volume":"145","author":"Thompson","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2016.09.027_bib120","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1210\/endo.143.4.8712","article-title":"Ultradian rhythmicity of ghrelin secretion in relation with GH, feeding behavior, and sleep-wake patterns in rats","volume":"143","author":"Tolle","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2016.09.027_bib121","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1210\/jc.2002-020645","article-title":"Balance in ghrelin and leptin plasma levels in anorexia nervosa patients and constitutionally thin women","volume":"88","author":"Tolle","year":"2003","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2016.09.027_bib122","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1159\/000054620","article-title":"In\u00a0vivo and in\u00a0vitro effects of ghrelin\/motilin-related peptide on growth hormone secretion in the rat","volume":"73","author":"Tolle","year":"2001","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.mce.2016.09.027_bib123","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1053\/gast.2000.9371","article-title":"Identification and characterization of a novel gastric peptide hormone: the motilin-related peptide","volume":"119","author":"Tomasetto","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1016\/j.mce.2016.09.027_bib124","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1210\/en.2006-1275","article-title":"Normal food intake and body weight in mice lacking the G protein-coupled receptor GPR39","volume":"148","author":"Tremblay","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2016.09.027_bib125","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/35038090","article-title":"Ghrelin induces adiposity in rodents","volume":"407","author":"Tsch\u00f6p","year":"2000","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.mce.2016.09.027_bib126","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.euroneuro.2010.06.005","article-title":"Acute and chronic suppression of the central ghrelin signaling system reveals a role in food anticipatory activity","volume":"21","author":"Verhagen","year":"2011","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.mce.2016.09.027_bib127","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1210\/jc.2003-031395","article-title":"Ghrelin receptor gene: identification of several sequence variants in extremely obese children and adolescents, healthy normal-weight and underweight students, and children with short normal stature","volume":"89","author":"Wang","year":"2004","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2016.09.027_bib128","doi-asserted-by":"crossref","first-page":"8169","DOI":"10.3892\/mmr.2015.4470","article-title":"Obestatin stimulates differentiation and regulates lipolysis and leptin secretion in rat preadipocytes","volume":"12","author":"Wojciechowicz","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.mce.2016.09.027_bib129","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1073\/pnas.85.6.1859","article-title":"[D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P, a potent bombesin antagonist in murine Swiss 3T3 cells, inhibits the growth of human small cell lung cancer cells in\u00a0vitro","volume":"85","author":"Woll","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mce.2016.09.027_bib130","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1159\/000066629","article-title":"The hypothalamic mechanisms of the hypophysiotropic action of ghrelin","volume":"76","author":"Wren","year":"2002","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.mce.2016.09.027_bib131","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1111\/jne.12327","article-title":"Effect of deletion of ghrelin-O-acyltransferase on the pulsatile release of growth hormone in mice","volume":"27","author":"Xie","year":"2015","journal-title":"J.\u00a0Neuroendocrinol."},{"key":"10.1016\/j.mce.2016.09.027_bib132","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.cell.2008.01.017","article-title":"Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone","volume":"132","author":"Yang","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.mce.2016.09.027_bib133","doi-asserted-by":"crossref","first-page":"e32100","DOI":"10.1371\/journal.pone.0032100","article-title":"The GOAT-ghrelin system is not essential for hypoglycemia prevention during prolonged calorie restriction","volume":"7","author":"Yi","year":"2012","journal-title":"PloS One"},{"issue":"Suppl.\u00a01","key":"10.1016\/j.mce.2016.09.027_bib134","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.33549\/physiolres.931489","article-title":"Plasma obestatin levels in normal weight, obese and anorectic women","volume":"57","author":"Zamrazilov\u00e1","year":"2008","journal-title":"Physiol. Res."},{"key":"10.1016\/j.mce.2016.09.027_bib135","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1126\/science.1117255","article-title":"Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake","volume":"310","author":"Zhang","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.mce.2016.09.027_bib136","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1073\/pnas.1423643112","article-title":"Reduced autophagy in livers of fasted, fat-depleted, ghrelin-deficient mice: reversal by growth hormone","volume":"112","author":"Zhang","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mce.2016.09.027_bib137","doi-asserted-by":"crossref","first-page":"7467","DOI":"10.1073\/pnas.1002271107","article-title":"Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice","volume":"107","author":"Zhao","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mce.2016.09.027_bib138","doi-asserted-by":"crossref","first-page":"3836","DOI":"10.1210\/en.2005-0212","article-title":"Endogenous ghrelin regulates episodic growth hormone (GH) secretion by amplifying GH Pulse amplitude: evidence from antagonism of the GH secretagogue-R1a receptor","volume":"146","author":"Zizzari","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2016.09.027_bib139","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1210\/en.2006-1231","article-title":"Obestatin partially affects ghrelin stimulation of food intake and growth hormone secretion in rodents","volume":"148","author":"Zizzari","year":"2007","journal-title":"Endocrinology"}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720716304014?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720716304014?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,9]],"date-time":"2022-07-09T09:04:06Z","timestamp":1657357446000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720716304014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":139,"alternative-id":["S0303720716304014"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2016.09.027","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hypothalamic regulation of body growth and appetite by ghrelin-derived peptides during balanced nutrition or undernutrition","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2016.09.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}