{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:47:03Z","timestamp":1787878023183,"version":"build-2784847793"},"reference-count":98,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Child Health Research Appeal Trust","award":["V1268"],"award-info":[{"award-number":["V1268"]}]},{"DOI":"10.13039\/501100003141","name":"CONACYT","doi-asserted-by":"publisher","award":["215293"],"award-info":[{"award-number":["215293"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UCL-CONACYT"},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["520525"],"award-info":[{"award-number":["520525"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.mce.2016.10.005","type":"journal-article","created":{"date-parts":[[2016,10,10]],"date-time":"2016-10-10T07:30:09Z","timestamp":1476084609000},"page":"27-34","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Stem cells and their role in pituitary tumorigenesis"],"prefix":"10.1016","volume":"445","author":[{"given":"Gabriela","family":"Carreno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1554-0363","authenticated-orcid":false,"given":"Jose Mario","family":"Gonzalez-Meljem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Haston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Pedro","family":"Martinez-Barbera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2016.10.005_bib1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/2001-1326-2-3","article-title":"Mechanisms of chemoresistance in cancer stem cells","volume":"2","author":"Abdullah","year":"2013","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.mce.2016.10.005_bib2","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s11060-013-1354-5","article-title":"Epidemiology and etiopathogenesis of pituitary adenomas","volume":"117","author":"Aflorei","year":"2014","journal-title":"J.\u00a0Neurooncol."},{"key":"10.1016\/j.mce.2016.10.005_bib3","doi-asserted-by":"crossref","first-page":"3983","DOI":"10.1073\/pnas.0530291100","article-title":"Prospective identification of tumorigenic breast cancer cells","volume":"100","author":"Al-Hajj","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mce.2016.10.005_bib4","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1172\/JCI114705","article-title":"Clinically nonfunctioning pituitary tumors are monoclonal in origin","volume":"86","author":"Alexander","year":"1990","journal-title":"J.\u00a0Clin. Investig."},{"key":"10.1016\/j.mce.2016.10.005_bib5","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s00441-007-0510-7","article-title":"Stem cells and cancer: a deadly mix","volume":"331","author":"Alison","year":"2008","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.mce.2016.10.005_bib6","doi-asserted-by":"crossref","DOI":"10.1007\/s00401-012-0957-9","article-title":"Identification of novel pathways involved in the pathogenesis of human adamantinomatous craniopharyngioma","author":"Andoniadou","year":"2012","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.mce.2016.10.005_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.stem.2013.07.004","article-title":"The Sox2\u00a0+ population of the adult murine pituitary includes progenitor\/stem cells with tumour-inducing potential","author":"Andoniadou","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.mce.2016.10.005_bib8","doi-asserted-by":"crossref","first-page":"19903","DOI":"10.1073\/pnas.1007404107","article-title":"Tumor formation initiated by nondividing epidermal cells via an inflammatory infiltrate","volume":"107","author":"Arwert","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mce.2016.10.005_bib9","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1006\/frne.1998.0176","article-title":"Pathophysiological role of the cytokine network in the anterior pituitary gland","volume":"20","author":"Arzt","year":"1999","journal-title":"Front. Neuroendocrinol"},{"key":"10.1016\/j.mce.2016.10.005_bib10","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1677\/JME-06-0014","article-title":"Role of stromal cell-derived factor 1 (SDF1\/CXCL12) in regulating anterior pituitary function","volume":"38","author":"Barbieri","year":"2007","journal-title":"J.\u00a0Mol. Endocrinol."},{"key":"10.1016\/j.mce.2016.10.005_bib11","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/753524","article-title":"Emerging targets in pituitary adenomas: role of the CXCL12\/CXCR4-R7 system","volume":"2014","author":"Barbieri","year":"2014","journal-title":"Int. J. Endocrinol."},{"key":"10.1016\/j.mce.2016.10.005_bib12","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/nrc3597","article-title":"Unravelling cancer stem cell potential","volume":"13","author":"Beck","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.mce.2016.10.005_bib13","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1046\/j.1365-2265.2002.01524.x","article-title":"Pituitary tumours are multiclonal from the outset: evidence from a case with dural metastases","volume":"56","author":"Buch","year":"2002","journal-title":"Clin. Endocrinol. Oxf."},{"key":"10.1016\/j.mce.2016.10.005_bib14","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s00401-005-1004-x","article-title":"Common mutations of beta-catenin in adamantinomatous craniopharyngiomas but not in other tumours originating from the sellar region","volume":"109","author":"Buslei","year":"2005","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.mce.2016.10.005_bib15","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s00401-006-0184-3","article-title":"Nuclear beta-catenin accumulation associates with epithelial morphogenesis in craniopharyngiomas","volume":"113","author":"Buslei","year":"2007","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.mce.2016.10.005_bib16","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1210\/er.2010-0011","article-title":"Pituitary stem cell update and potential implications for treating hypopituitarism","volume":"32","author":"Castinetti","year":"2011","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.mce.2016.10.005_bib17","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1159\/000371806","article-title":"Aggressive pituitary tumors","volume":"101","author":"Chatzellis","year":"2015","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.mce.2016.10.005_bib18","doi-asserted-by":"crossref","first-page":"3985","DOI":"10.1210\/en.2005-0185","article-title":"The adult pituitary contains a cell population displaying stem\/progenitor cell and early embryonic characteristics","volume":"146","author":"Chen","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2016.10.005_bib19","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1002\/stem.51","article-title":"Pituitary progenitor cells tracked down by side population dissection","volume":"27","author":"Chen","year":"2009","journal-title":"Stem Cells"},{"key":"10.1016\/j.mce.2016.10.005_bib20","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.canlet.2014.03.031","article-title":"Evidence of brain tumor stem progenitor-like cells with low proliferative capacity in human benign pituitary adenoma","volume":"349","author":"Chen","year":"2014","journal-title":"Cancer Lett."},{"key":"10.1016\/j.mce.2016.10.005_bib21","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.cell.2006.03.011","article-title":"Stem cells and cancer: two faces of eve","volume":"124","author":"Clarke","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.mce.2016.10.005_bib22","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1750-3639.2001.tb00402.x","article-title":"Clonality of pituitary tumours: more complicated than initially envisaged?","volume":"11","author":"Clayton","year":"2006","journal-title":"Brain Pathol."},{"key":"10.1016\/j.mce.2016.10.005_bib23","first-page":"3973","article-title":"Different patterns of allelic loss (loss of heterozygosity) in recurrent human pituitary tumors provide evidence for multiclonal origins","volume":"6","author":"Clayton","year":"2000","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.mce.2016.10.005_bib24","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nm.2304","article-title":"The cancer stem cell: premises, promises and challenges","volume":"17","author":"Clevers","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.mce.2016.10.005_bib25","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1146\/annurev.neuro.24.1.327","article-title":"Signaling and transcriptional mechanisms in pituitary development","volume":"24","author":"Dasen","year":"2001","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.mce.2016.10.005_bib26","article-title":"Atypical pituitary adenomas: clinical characteristics and role of ki-67 and p53 in prognostic and therapeutic evaluation. A series of 50 patients","author":"Del Basso De Caro","year":"2016","journal-title":"Neurosurg. Rev."},{"key":"10.1016\/j.mce.2016.10.005_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2826.2007.01616.x","article-title":"Paracrinicity: the story of 30 years of cellular pituitary crosstalk","volume":"20","author":"Denef","year":"2008","journal-title":"J.\u00a0Neuroendocrinol."},{"issue":"80","key":"10.1016\/j.mce.2016.10.005_bib28","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1126\/science.1248373","article-title":"Beta-catenin activation regulates tissue growth non-cell autonomously in the hair stem cell niche","volume":"343","author":"Deschene","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.mce.2016.10.005_bib29","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/nrendo.2014.64","article-title":"Aggressive pituitary adenomas\u2014diagnosis and emerging treatments","volume":"10","author":"Di Leva","year":"2014","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.mce.2016.10.005_bib30","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1530\/ERC-13-0229","article-title":"Sca1+ murine pituitary adenoma cells show tumor-growth advantage","volume":"21","author":"Donangelo","year":"2014","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.mce.2016.10.005_bib31","series-title":"The Pituitary","first-page":"3","article-title":"Pituitary development","author":"Drouin","year":"2011"},{"key":"10.1016\/j.mce.2016.10.005_bib32","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.1073\/pnas.0707886105","article-title":"SOX2-expressing progenitor cells generate all of the major cell types in the adult mouse pituitary gland","volume":"105","author":"Fauquier","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mce.2016.10.005_bib33","doi-asserted-by":"crossref","first-page":"e0130808","DOI":"10.1371\/journal.pone.0130808","article-title":"Identification and characterization of CXCR4-positive gastric Cancer stem cells","volume":"10","author":"Fujita","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.mce.2016.10.005_bib34","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1159\/000345673","article-title":"Genetics of pituitary adenomas","volume":"41","author":"Gadelha","year":"2013","journal-title":"Endocr. Tumor Syndr. Their Genet."},{"key":"10.1016\/j.mce.2016.10.005_bib35","doi-asserted-by":"crossref","first-page":"e11443","DOI":"10.1371\/journal.pone.0011443","article-title":"Nestin-Cre mice are affected by hypopituitarism, which is not due to significant activity of the transgene in the pituitary gland","volume":"5","author":"Galichet","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.mce.2016.10.005_bib36","doi-asserted-by":"crossref","first-page":"e4815","DOI":"10.1371\/journal.pone.0004815","article-title":"A\u00a0GRFa2\/Prop1\/stem (GPS) cell niche in the pituitary","volume":"4","author":"Garcia-Lavandeira","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.mce.2016.10.005_bib37","first-page":"1","article-title":"Craniopharyngiomas express embryonic stem cell markers (SOX2, OCT4, KLF4, and SOX9) as pituitary stem cells but do not coexpress RET\/GFRA3 receptors","volume":"97","author":"Garcia-Lavandeira","year":"2011","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2016.10.005_bib38","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1159\/000375502","article-title":"Pituitary cell turnover: from adult stem cell recruitment through differentiation to death","volume":"101","author":"Garcia-Lavandeira","year":"2015","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.mce.2016.10.005_bib39","doi-asserted-by":"crossref","first-page":"11482","DOI":"10.1073\/pnas.1101553108","article-title":"Increased Wingless (Wnt) signaling in pituitary progenitor\/stem cells gives rise to pituitary tumors in mice and humans","volume":"1088","author":"Gaston-Massuet","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mce.2016.10.005_bib40","doi-asserted-by":"crossref","first-page":"6332","DOI":"10.1073\/pnas.0801644105","article-title":"Genetic approaches identify adult pituitary stem cells","volume":"105","author":"Gleiberman","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mce.2016.10.005_bib41","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1084\/jem.183.4.1797","article-title":"Isolation and functional properties of murine hematopoietic stem cells that are replicating in\u00a0vivo","volume":"183","author":"Goodell","year":"1996","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.mce.2016.10.005_bib42","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1530\/eje.0.1510595","article-title":"Involvement of the gp130 cytokine transducer in MtT\/S pituitary somatotroph tumour development in an autocrine-paracrine model","volume":"151","author":"Graciarena","year":"2004","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.mce.2016.10.005_bib43","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1089\/scd.2011.0496","article-title":"Activated phenotype of the pituitary stem\/progenitor cell compartment during the early-postnatal maturation phase of the gland","volume":"21","author":"Gremeaux","year":"2012","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.mce.2016.10.005_bib44","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nature06933","article-title":"Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation","volume":"453","author":"Guo","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.mce.2016.10.005_bib45","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1210\/jcem-71-6-1427","article-title":"Clonal origin of pituitary adenomas","volume":"71","author":"Herman","year":"1990","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2016.10.005_bib46","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.stem.2007.06.002","article-title":"Distinct populations of Cancer stem cells determine tumor growth and metastatic activity in human pancreatic Cancer","volume":"1","author":"Hermann","year":"2007","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.mce.2016.10.005_bib47","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s00441-014-1861-5","article-title":"PRRX1 and PRRX2 distinctively participate in pituitary organogenesis and a cell-supply system","volume":"357","author":"Higuchi","year":"2014","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.mce.2016.10.005_bib48","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1097\/01.pas.0000213328.64121.12","article-title":"Nuclear beta-catenin accumulation as reliable marker for the differentiation between cystic craniopharyngiomas and rathke cleft cysts: a clinico-pathologic approach","volume":"30","author":"Hofmann","year":"2006","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.mce.2016.10.005_bib49","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1007\/s11102-013-0543-8","article-title":"Adamantinomatous craniopharyngiomas express tumor stem cell markers in cells with activated Wnt signaling: further evidence for the existence of a tumor stem cell niche?","volume":"17","author":"H\u00f6lsken","year":"2013","journal-title":"Pituitary"},{"key":"10.1016\/j.mce.2016.10.005_bib50","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1210\/en.2011-1937","article-title":"Expression of chemokine CXCL12 and its receptor CXCR4 in folliculostellate (FS) cells of the rat anterior pituitary gland: the CXCL12\/CXCR4 Axis induces interconnection of FS cells","volume":"153","author":"Horiguchi","year":"2012","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2016.10.005_bib51","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/nm.3643","article-title":"Emerging interactions between skin stem cells and their niches","volume":"20","author":"Hsu","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.mce.2016.10.005_bib52","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/onc.2012.37","article-title":"Upregulation of CXCR4 is functionally crucial for maintenance of stemness in drug-resistant non-small cell lung cancer cells","volume":"32","author":"Jung","year":"2013","journal-title":"Oncogene"},{"key":"10.1016\/j.mce.2016.10.005_bib53","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ando.2012.03.039","article-title":"Prevalence and incidence of pituitary adenomas","volume":"73","author":"Karavitaki","year":"2012","journal-title":"Ann. Endocrinol. Paris"},{"key":"10.1016\/j.mce.2016.10.005_bib54","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/nature12883","article-title":"Leukaemogenesis induced by an activating \u03b2-catenin mutation in osteoblasts","volume":"506","author":"Kode","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.mce.2016.10.005_bib55","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.stem.2014.02.006","article-title":"Evolution of the cancer stem cell model","volume":"14","author":"Kreso","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.mce.2016.10.005_bib56","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1210\/en.2004-1209","article-title":"Nestin-immunoreactive cells in rat pituitary are neither hormonal nor typical folliculo-stellate cells","volume":"146","author":"Krylyshkina","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2016.10.005_bib57","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.yexcr.2005.04.023","article-title":"Identification and enrichment of colony-forming cells from the adult murine pituitary","volume":"308","author":"Lepore","year":"2005","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.mce.2016.10.005_bib58","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.mce.2015.08.024","article-title":"Animal models of pituitary neoplasia","volume":"421","author":"Lines","year":"2016","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2016.10.005_bib59","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.cell.2013.03.020","article-title":"Non-cell-autonomous tumor suppression by p53","volume":"153","author":"Lujambio","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.mce.2016.10.005_bib60","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1002\/cncr.10676","article-title":"Clinicopathologic study of 123 cases of prolactin-secreting pituitary adenomas with special reference to multihormone production and clonality of the adenomas","volume":"95","author":"Ma","year":"2002","journal-title":"Cancer"},{"key":"10.1016\/j.mce.2016.10.005_bib61","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nrendo.2011.40","article-title":"Pathogenesis of pituitary tumors","volume":"7","author":"Melmed","year":"2011","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.mce.2016.10.005_bib62","first-page":"208","article-title":"Pituitary tumors","volume":"44","author":"Melmed","year":"2015","journal-title":"Endocrinol. Metab. Clin. NA"},{"key":"10.1016\/j.mce.2016.10.005_bib63","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1530\/ERC-14-0546","article-title":"Pituitary tumors contain a side population with tumor stem cell-associated characteristics","volume":"22","author":"Mertens","year":"2015","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.mce.2016.10.005_bib64","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/nrendo.2010.168","article-title":"Childhood craniopharyngioma\u2013current concepts in diagnosis, therapy and follow-up","volume":"6","author":"M\u00fcller","year":"2010","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.mce.2016.10.005_bib65","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1586\/14737175.2014.875470","article-title":"Childhood craniopharyngioma: treatment strategies and outcomes","volume":"14","author":"M\u00fcller","year":"2014","journal-title":"Expert Rev. Neurother."},{"key":"10.1016\/j.mce.2016.10.005_bib66","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/ng.2481","article-title":"Dclk1 distinguishes between tumor and normal stem cells in the intestine","volume":"45","author":"Nakanishi","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mce.2016.10.005_bib67","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nrc3184","article-title":"Cancer stem cells: an evolving concept","volume":"12","author":"Nguyen","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.mce.2016.10.005_bib68","doi-asserted-by":"crossref","DOI":"10.1038\/ng1099","article-title":"Notch1 functions as a tumor suppressor in mouse skin","volume":"33","author":"Nicolas","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mce.2016.10.005_bib69","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s11060-009-9835-2","article-title":"Stromal cell-derived factor-1 expression in pituitary adenoma tissues and upregulation in hypoxia","volume":"94","author":"Nomura","year":"2009","journal-title":"J.\u00a0Neurooncol."},{"key":"10.1016\/j.mce.2016.10.005_bib70","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/cgt.2014.63","article-title":"Isolation and characterization of progenitor mesenchymal cells in human pituitary tumors","volume":"22","author":"Orciani","year":"2015","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.mce.2016.10.005_bib71","doi-asserted-by":"crossref","first-page":"496218","DOI":"10.1155\/2013\/496218","article-title":"Therapeutic potential of mesenchymal stem cells in regenerative medicine","volume":"2013","author":"Patel","year":"2013","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.mce.2016.10.005_bib72","doi-asserted-by":"crossref","first-page":"e14470","DOI":"10.7554\/eLife.14470","article-title":"PROP1 triggers epithelial-mesenchymal transition-like process in pituitary stem cells","volume":"5","author":"P\u00e9rez Mill\u00e1n","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.mce.2016.10.005_bib73","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1084\/jem.103.5.653","article-title":"Action of x-rays on mammalian cells","volume":"103","author":"Puck","year":"1956","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.mce.2016.10.005_bib74","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.stem.2013.07.006","article-title":"Mobilized adult pituitary stem cells contribute to endocrine regeneration in response to physiological demand","volume":"13","author":"Rizzoti","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.mce.2016.10.005_bib75","doi-asserted-by":"crossref","DOI":"10.1038\/331173a0","article-title":"Basic fibroblast growth factor fused to a signal peptide transforms cells","volume":"331","author":"Rogelj","year":"1988","journal-title":"Nature"},{"key":"10.1016\/j.mce.2016.10.005_bib76","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.tice.2005.03.005","article-title":"Intercellular communications within the rat anterior pituitary XII: immunohistochemical and physiological evidences for the gap junctional coupling of the folliculo-stellate cells in the rat anterior pituitary","volume":"37","author":"Sato","year":"2005","journal-title":"Tissue Cell"},{"issue":"80","key":"10.1016\/j.mce.2016.10.005_bib77","first-page":"449","article-title":"Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas","volume":"337","author":"Schepers","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.mce.2016.10.005_bib78","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1210\/jcem-73-6-1302","article-title":"Clonal composition of pituitary adenomas in patients with Cushing's disease: determination by X-chromosome inactivation analysis","volume":"73","author":"Schulte","year":"1991","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2016.10.005_bib79","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/(SICI)1097-0029(19971015)39:2<138::AID-JEMT5>3.0.CO;2-H","article-title":"Folliculo-stellate cells and intercellular communication within the rat anterior pituitary gland","volume":"39","author":"Soji","year":"1997","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.mce.2016.10.005_bib80","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1002\/stem.1475","article-title":"Concise review: the yin and yang of intestinal (cancer) stem cells and their progenitors","volume":"31","author":"Stange","year":"2013","journal-title":"Stem Cells"},{"key":"10.1016\/j.mce.2016.10.005_bib81","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1111\/j.1365-2826.2012.02336.x","article-title":"Paired-related homeodomain proteins Prx1 and Prx2 are expressed in embryonic pituitary stem\/progenitor cells and may be involved in the early stage of pituitary differentiation","volume":"24","author":"Susa","year":"2012","journal-title":"J.\u00a0Neuroendocrinol."},{"key":"10.1016\/j.mce.2016.10.005_bib82","doi-asserted-by":"crossref","first-page":"687","DOI":"10.3109\/09553002.2014.906766","article-title":"CXCR4 as biomarker for radioresistant cancer stem cells","volume":"90","author":"Trautmann","year":"2014","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.mce.2016.10.005_bib83","first-page":"5275","article-title":"Induction of brain tumors in mice using a recombinant platelet-derived growth factor B-chain retrovirus","volume":"58","author":"Uhrbom","year":"1998","journal-title":"Cancer Res."},{"key":"10.1016\/j.mce.2016.10.005_bib84","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/nrc3368","article-title":"Cancer stem cell definitions and terminology: the devil is in the details","volume":"12","author":"Valent","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.mce.2016.10.005_bib85","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1038\/ncb2581","article-title":"Dll1+ secretory progenitor cells revert to stem cells upon crypt damage","volume":"14","author":"van Es","year":"2012","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.mce.2016.10.005_bib86","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.semcdb.2007.04.006","article-title":"Non-hormonal cell types in the pituitary candidating for stem cell","volume":"18","author":"Vankelecom","year":"2007","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.mce.2016.10.005_bib87","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1111\/j.1460-9568.2010.07523.x","article-title":"Pituitary stem\/progenitor cells: embryonic players in the adult gland?","volume":"32","author":"Vankelecom","year":"2010","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.mce.2016.10.005_bib88","article-title":"Pituitary stem cells: where do we stand?","author":"Vankelecom","year":"2013","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2016.10.005_bib89","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/nrc2499","article-title":"Cancer stem cells in solid tumours: accumulating evidence and unresolved questions","volume":"8","author":"Visvader","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.mce.2016.10.005_bib90","doi-asserted-by":"crossref","first-page":"309","DOI":"10.5414\/NPP28309","article-title":"Evidence for a progenitor cell population in the human pituitary","volume":"28","author":"Weiss","year":"2009","journal-title":"Clin. Neuropathol."},{"key":"10.1016\/j.mce.2016.10.005_bib91","first-page":"144","article-title":"CXCL12 modulation of CXCR4 and CXCR7 activity in human glioblastoma stem-like cells and regulation of the tumor microenvironment","volume":"8","author":"W\u00fcrth","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.mce.2016.10.005_bib92","doi-asserted-by":"crossref","DOI":"10.1007\/s12035-016-0025-x","article-title":"Phenotypical and pharmacological characterization of stem-like cells in human pituitary adenomas","author":"W\u00fcrth","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.mce.2016.10.005_bib93","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/sj.bjc.6605142","article-title":"Isolation of tumour stem-like cells from benign tumours","volume":"101","author":"Xu","year":"2009","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.mce.2016.10.005_bib94","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2009.05.027","article-title":"PROP1 coexists with SOX2 and induces PIT1-commitment cells","author":"Yoshida","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mce.2016.10.005_bib95","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17010075","article-title":"Regulatory system for stem\/progenitor cell niches in the adult rodent pituitary","volume":"17","author":"Yoshida","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mce.2016.10.005_bib96","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1172\/JCI78173","article-title":"STAT3 upregulation in pituitary somatotroph adenomas induces growth hormone hypersecretion","volume":"125","author":"Zhou","year":"2015","journal-title":"J.\u00a0Clin. Investig."},{"key":"10.1016\/j.mce.2016.10.005_bib97","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1152\/physrev.00006.2006","article-title":"Molecular physiology of pituitary Development: signaling and transcriptional networks","volume":"87","author":"Zhu","year":"2007","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.mce.2016.10.005_bib98","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1002\/stem.1296","article-title":"Brief report: intravital imaging of cancer stem cell plasticity in mammary tumors","volume":"31","author":"Zomer","year":"2013","journal-title":"Stem Cells"}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720716304130?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720716304130?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T21:13:43Z","timestamp":1718831623000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720716304130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":98,"alternative-id":["S0303720716304130"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2016.10.005","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Stem cells and their role in pituitary tumorigenesis","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2016.10.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2016 Published by Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}