{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:08:39Z","timestamp":1791461319588,"version":"4.3.4"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Rio de Janeiro State Foundation for Scientific Research","doi-asserted-by":"publisher","award":["26\/110.104\/2013"],"award-info":[{"award-number":["26\/110.104\/2013"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Rio de Janeiro State Foundation for Scientific Research","doi-asserted-by":"publisher","award":["E-26\/202.808\/2015"],"award-info":[{"award-number":["E-26\/202.808\/2015"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.mce.2016.10.021","type":"journal-article","created":{"date-parts":[[2016,10,22]],"date-time":"2016-10-22T15:03:53Z","timestamp":1477148633000},"page":"54-64","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Differential effects of angiotensin receptor blockers on pancreatic islet remodelling and glucose homeostasis in diet-induced obese mice"],"prefix":"10.1016","volume":"439","author":[{"given":"Francielle","family":"Graus-Nunes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thatiany de Souza","family":"Marinho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Barbosa-da-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia Barbosa","family":"Aguila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Alberto","family":"Mandarim-de-Lacerda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2510-9569","authenticated-orcid":false,"given":"Vanessa","family":"Souza-Mello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2016.10.021_bib1","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1053\/j.gastro.2007.03.054","article-title":"Biology of incretins: GLP-1 and GIP","volume":"132","author":"Baggio","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.mce.2016.10.021_bib2","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1172\/JCI200420016","article-title":"Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells","volume":"114","author":"Bernal-Mizrachi","year":"2004","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.mce.2016.10.021_bib3","first-page":"891","article-title":"Insulin resistance and PPAR insulin sensitizers","volume":"7","author":"Bhatia","year":"2006","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"10.1016\/j.mce.2016.10.021_bib4","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.numecd.2007.05.004","article-title":"Protection of pancreatic beta-cells: is it feasible?","volume":"18","author":"Bonora","year":"2008","journal-title":"Nutr. Metab. Cardiovasc Dis."},{"key":"10.1016\/j.mce.2016.10.021_bib5","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/mnfr.201500398","article-title":"Adverse effects of vitamin D deficiency on the Pi3k\/Akt pathway and pancreatic islet morphology in diet-induced obese mice","volume":"60","author":"Borges","year":"2016","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.mce.2016.10.021_bib6","article-title":"High fat diet modulation of glucose sensing in the beta-cell","volume":"13","author":"Cerf","year":"2007","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.mce.2016.10.021_bib7","first-page":"1","article-title":"Involvement of telmisartan on the protective effects mediated by the peroxisome proliferator-activated receptor-\u03b3 pathway in mice","author":"Chenghu Huang","year":"2014","journal-title":"Int. J. Diab. Clin. Res."},{"key":"10.1016\/j.mce.2016.10.021_bib8","first-page":"54","volume":"vol. 23","author":"Chetty","year":"2014"},{"key":"10.1016\/j.mce.2016.10.021_bib9","doi-asserted-by":"crossref","first-page":"367","DOI":"10.2337\/diabetes.55.02.06.db05-1022","article-title":"Angiotensin II type 1 receptor blockade improves beta-cell function and glucose tolerance in a mouse model of type 2 diabetes","volume":"55","author":"Chu","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2016.10.021_bib10","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1189\/jlb.0213075","article-title":"Accumulation of M1-like macrophages in type2 diabetic islets is followed by a systemic shift in macrophage polarization","volume":"95","author":"Cucak","year":"2014","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.mce.2016.10.021_bib11","doi-asserted-by":"crossref","first-page":"4144","DOI":"10.2337\/db12-1657","article-title":"Pancreatic islet vasculature adapts to insulin resistance through dilation and not angiogenesis","volume":"62","author":"Dai","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2016.10.021_bib12","doi-asserted-by":"crossref","first-page":"727","DOI":"10.2337\/diabetes.54.3.727","article-title":"Functional and molecular defects of pancreatic islets in human type 2 diabetes","volume":"54","author":"Del Guerra","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2016.10.021_bib13","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1210\/endo.143.4.8753","article-title":"Increased islet cell proliferation, decreased apoptosis, and greater vascularization leading to beta-cell hyperplasia in mutant mice lacking insulin","volume":"143","author":"Duvillie","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2016.10.021_bib14","doi-asserted-by":"crossref","first-page":"11523","DOI":"10.1016\/S0021-9258(19)78155-1","article-title":"GLUT-2 gene transfer into insulinoma cells confers both low and high affinity glucose-stimulated insulin release. Relationship to glucokinase activity","volume":"269","author":"Ferber","year":"1994","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.mce.2016.10.021_bib15","doi-asserted-by":"crossref","first-page":"e28050","DOI":"10.1371\/journal.pone.0028050","article-title":"Altered insulin receptor signalling and beta-cell cycle dynamics in type 2 diabetes mellitus","volume":"6","author":"Folli","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.mce.2016.10.021_bib16","doi-asserted-by":"crossref","first-page":"e67192","DOI":"10.1371\/journal.pone.0067192","article-title":"Renin-angiotensin system blockers protect pancreatic islets against diet-induced obesity and insulin resistance in mice","volume":"8","author":"Frantz","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.mce.2016.10.021_bib17","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1530\/JME-10-0157","article-title":"Upregulation of beta-cell genes and improved function in rodent islets following chronic glucokinase activation","volume":"47","author":"Gill","year":"2011","journal-title":"J.\u00a0Mol. Endocrinol."},{"key":"10.1016\/j.mce.2016.10.021_bib18","doi-asserted-by":"crossref","first-page":"25440","DOI":"10.1074\/jbc.M113.486852","article-title":"Peroxisome proliferator-activated receptor gamma (PPARgamma) and its target genes are downstream effectors of FoxO1 protein in islet beta-cells: mechanism of beta-cell compensation and failure","volume":"288","author":"Gupta","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.mce.2016.10.021_bib19","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.atherosclerosis.2015.04.812","article-title":"Regulation of white adipogenesis and its relation to ectopic fat accumulation and cardiovascular risk","volume":"241","author":"Gustafson","year":"2015","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.mce.2016.10.021_bib20","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1161\/HYPERTENSIONAHA.109.143958","article-title":"Telmisartan prevents weight gain and obesity through activation of peroxisome proliferator-activated receptor-delta-dependent pathways","volume":"55","author":"He","year":"2010","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2016.10.021_bib21","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3892\/ijmm.2015.2207","article-title":"Endogenous GLP-1 as a key self-defense molecule against lipotoxicity in pancreatic islets","volume":"36","author":"Huang","year":"2015","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.mce.2016.10.021_bib22","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.bbrc.2015.03.153","article-title":"Islet beta-cell failure in type 2 diabetes\u2013Within the network of toxic lipids","volume":"460","author":"Janikiewicz","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mce.2016.10.021_bib23","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1172\/JCI200316537","article-title":"Increased islet apoptosis in Pdx1+\/- mice","volume":"111","author":"Johnson","year":"2003","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.mce.2016.10.021_bib24","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/nrendo.2013.157","article-title":"The role of FOXO1 in beta-cell failure and type 2 diabetes mellitus","volume":"9","author":"Kitamura","year":"2013","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.mce.2016.10.021_bib25","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1210\/endo.143.6.8859","article-title":"Comparison of insulin secretory function in two mouse models with different susceptibility to beta-cell failure","volume":"143","author":"Kooptiwut","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2016.10.021_bib26","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2337\/diab.16.1.35","article-title":"Method for the isolation of intact islets of Langerhans from the rat pancreas","volume":"16","author":"Lacy","year":"1967","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2016.10.021_bib27","doi-asserted-by":"crossref","first-page":"12189","DOI":"10.1074\/jbc.R114.557314","article-title":"A\u00a0fresh view of glycolysis and glucokinase regulation: history and current status","volume":"289","author":"Lenzen","year":"2014","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.mce.2016.10.021_bib29","doi-asserted-by":"crossref","first-page":"482","DOI":"10.2337\/diabetes.54.2.482","article-title":"beta-Cell Pdx1 expression is essential for the glucoregulatory, proliferative, and cytoprotective actions of glucagon-like peptide-1","volume":"54","author":"Li","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2016.10.021_bib30","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1590\/S0001-37652003000400006","article-title":"Stereological tools in biomedical research","volume":"75","author":"Mandarim-de-Lacerda","year":"2003","journal-title":"An. Acad. Bras. Cienc."},{"key":"10.1016\/j.mce.2016.10.021_bib31","doi-asserted-by":"crossref","first-page":"S48","DOI":"10.1016\/j.cgh.2009.07.038","article-title":"Roles of pancreatic stellate cells in pancreatic inflammation and fibrosis","volume":"7","author":"Masamune","year":"2009","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.mce.2016.10.021_bib32","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"10.1016\/j.mce.2016.10.021_bib33","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1007\/s00125-014-3304-y","article-title":"Islet amyloid formation is an important determinant for inducing islet inflammation in high-fat-fed human IAPP transgenic mice","volume":"57","author":"Meier","year":"2014","journal-title":"Diabetologia"},{"key":"10.1016\/j.mce.2016.10.021_bib34","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1111\/bph.12510","article-title":"Chronic blockade of angiotensin AT(1) receptors improves cardinal symptoms of metabolic syndrome in diet-induced obesity in rats","volume":"171","author":"Muller-Fielitz","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.mce.2016.10.021_bib35","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1210\/en.2011-0183","article-title":"Improved insulin sensitivity after long-term treatment with AT1 blockers is not associated with PPARgamma target gene regulation","volume":"153","author":"Muller-Fielitz","year":"2012","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2016.10.021_bib36","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/jdi.12294","article-title":"Present status of clinical deployment of glucokinase activators","volume":"6","author":"Nakamura","year":"2015","journal-title":"J.\u00a0Diabetes Investig."},{"key":"10.1016\/j.mce.2016.10.021_bib37","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.mce.2008.12.011","article-title":"Angiotensin II and the development of insulin resistance: implications for diabetes","volume":"302","author":"Olivares-Reyes","year":"2009","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.mce.2016.10.021_bib38","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1113\/expphysiol.2014.081596","article-title":"Enhanced pan-peroxisome proliferator-activated receptor gene and protein expression in adipose tissue of diet-induced obese mice treated with telmisartan","volume":"99","author":"Penna-de-Carvalho","year":"2014","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.mce.2016.10.021_bib39","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1093\/jn\/123.11.1939","article-title":"AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet","volume":"123","author":"Reeves","year":"1993","journal-title":"J.\u00a0Nutr."},{"key":"10.1016\/j.mce.2016.10.021_bib40","doi-asserted-by":"crossref","first-page":"4154","DOI":"10.2337\/db13-0071","article-title":"Vascular endothelial growth factor-a and islet vascularization are necessary in developing, but not adult, pancreatic islets","volume":"62","author":"Reinert","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2016.10.021_bib41","doi-asserted-by":"crossref","first-page":"19090","DOI":"10.1073\/pnas.0904849106","article-title":"Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress","volume":"106","author":"Sachdeva","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"66 Suppl.\u00a0l","key":"10.1016\/j.mce.2016.10.021_bib42","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1159\/000375143","article-title":"The global burden of obesity and the challenges of prevention","volume":"2","author":"Seidell","year":"2015","journal-title":"Ann. Nutr. Metab."},{"key":"10.1016\/j.mce.2016.10.021_bib43","doi-asserted-by":"crossref","first-page":"E1281","DOI":"10.1152\/ajpendo.00286.2013","article-title":"Angiotensin type 2 receptor in pancreatic islets of adult rats: a novel insulinotropic mediator","volume":"305","author":"Shao","year":"2013","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2016.10.021_bib44","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1042\/CS20100061","article-title":"Comparative effects of telmisartan, sitagliptin and metformin alone or in combination on obesity, insulin resistance, and liver and pancreas remodelling in C57BL\/6 mice fed on a very high-fat diet","volume":"119","author":"Souza-Mello","year":"2010","journal-title":"Clin. Sci. Lond."},{"key":"10.1016\/j.mce.2016.10.021_bib45","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1097\/MPA.0b013e3182153922","article-title":"Pancreatic ultrastructural enhancement due to telmisartan plus sitagliptin treatment in diet-induced obese C57BL\/6 mice","volume":"40","author":"Souza-Mello","year":"2011","journal-title":"Pancreas"},{"key":"10.1016\/j.mce.2016.10.021_bib46","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s11892-015-0635-0","article-title":"Transcriptional regulation of the pancreatic islet: implications for islet function","volume":"15","author":"Stitzel","year":"2015","journal-title":"Curr. Diab. Rep."},{"key":"10.1016\/j.mce.2016.10.021_bib47","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s00125-014-3451-1","article-title":"GLUT2, glucose sensing and glucose homeostasis","volume":"58","author":"Thorens","year":"2015","journal-title":"Diabetologia"},{"key":"10.1016\/j.mce.2016.10.021_bib48","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1097\/MCO.0b013e32833aa1ef","article-title":"Pancreatic steatosis in humans: cause or marker of lipotoxicity?","volume":"13","author":"van Raalte","year":"2010","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"10.1016\/j.mce.2016.10.021_bib49","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1111\/bph.13461","article-title":"The brain renin-angiotensin system plays a crucial role in regulating body weight in diet-induced rat obesity","volume":"173","author":"Winkler","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.mce.2016.10.021_bib50","first-page":"H941","article-title":"Use of tibial length to quantify cardiac hypertrophy: application in the aging rat","volume":"243","author":"Yin","year":"1982","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.mce.2016.10.021_bib51","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.metabol.2011.06.007","article-title":"Prophylactic treatment with telmisartan induces tissue-specific gene modulation favoring normal glucose homeostasis in Cohen-Rosenthal diabetic hypertensive rats","volume":"61","author":"Younis","year":"2012","journal-title":"Metabolism"},{"key":"10.1016\/j.mce.2016.10.021_bib52","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.intimp.2014.06.039","article-title":"Anti-diabetic effect of mulberry leaf polysaccharide by inhibiting pancreatic islet cell apoptosis and ameliorating insulin secretory capacity in diabetic rats","volume":"22","author":"Zhang","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.mce.2016.10.021_bib53","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1097\/MPA.0000000000000505","article-title":"Combination of telmisartan and linagliptin preserves pancreatic islet cell function and morphology in db\/db mice","volume":"45","author":"Zhao","year":"2016","journal-title":"Pancreas"}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720716304324?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720716304324?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T00:48:54Z","timestamp":1657500534000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720716304324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":52,"alternative-id":["S0303720716304324"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2016.10.021","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differential effects of angiotensin receptor blockers on pancreatic islet remodelling and glucose homeostasis in diet-induced obese mice","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2016.10.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}