{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:13:21Z","timestamp":1786994001578,"version":"build-2736575974"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001677","name":"INSERM","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ligue Contre le Cancer Comit\u00e9 de Paris"},{"name":"GEFLUC Paris-Ile-de-France"},{"name":"fondation ARC pour la recherche sur le cancer (ND)Fondation ARC pour la Recherche sur le Cancer"},{"name":"La Soci\u00e9t\u00e9 Fran\u00e7aise d'Endocrinologie (SFE)"},{"name":"Sanofi Aventis and La Fondation pour la Recherche M\u00e9dicale (FRM)"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.mce.2016.11.026","type":"journal-article","created":{"date-parts":[[2016,11,28]],"date-time":"2016-11-28T14:17:06Z","timestamp":1480342626000},"page":"1-11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Modulation of signaling through GPCR-cAMP-PKA pathways by PDE4 depends on stimulus intensity: Possible implications for the pathogenesis of acrodysostosis without hormone resistance"],"prefix":"10.1016","volume":"442","author":[{"given":"Emmanuelle","family":"Motte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Le Stunff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Briet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Dumaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Silve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2016.11.026_bib1","article-title":"Relative quantitation of gene expression","volume":"1\u201336","author":"ABI-PRISM-7700-Sequence-Detection-System","year":"2001","journal-title":"User Bull."},{"issue":"7","key":"10.1016\/j.mce.2016.11.026_bib42","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1111\/j.1742-4658.2009.06926.x","article-title":"Compartmentalized signalling: spatial regulation of cAMP by the action of compartmentalized phosphodiesterases","volume":"276","author":"Baillie","year":"2009","journal-title":"FEBS J."},{"key":"10.1016\/j.mce.2016.11.026_bib2","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/0165-6147(90)90066-H","article-title":"Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors","volume":"11","author":"Beavo","year":"1990","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.mce.2016.11.026_bib3","doi-asserted-by":"crossref","first-page":"12590","DOI":"10.1074\/jbc.M110.203604","article-title":"PDE4D and PDE4B function in distinct subcellular compartments in mouse embryonic fibroblasts","volume":"286","author":"Blackman","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.mce.2016.11.026_bib4","doi-asserted-by":"crossref","first-page":"22430","DOI":"10.1074\/jbc.M803306200","article-title":"Critical role of PDE4D in beta2-adrenoceptor-dependent cAMP signaling in mouse embryonic fibroblasts","volume":"283","author":"Bruss","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.mce.2016.11.026_bib5","doi-asserted-by":"crossref","first-page":"E1414","DOI":"10.1073\/pnas.1419906112","article-title":"Engineered stabilization and structural analysis of the autoinhibited conformation of PDE4","volume":"112","author":"Cedervall","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mce.2016.11.026_bib6","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1085\/jgp.201311083","article-title":"Cyclic AMP compartments and signaling specificity: role of cyclic nucleotide phosphodiesterases","volume":"143","author":"Conti","year":"2014","journal-title":"J.\u00a0Gen. Physiol."},{"key":"10.1016\/j.mce.2016.11.026_bib7","doi-asserted-by":"crossref","first-page":"5797","DOI":"10.1016\/S0021-9258(18)45645-1","article-title":"Purification of the putative hormone-sensitive cyclic AMP phosphodiesterase from rat adipose tissue using a derivative of cilostamide as a novel affinity ligand","volume":"262","author":"Degerman","year":"1987","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.mce.2016.11.026_bib8","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1093\/emboj\/20.8.1921","article-title":"mAKAP assembles a protein kinase A\/PDE4 phosphodiesterase cAMP signaling module","volume":"20","author":"Dodge","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.mce.2016.11.026_bib9","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1161\/01.RES.0000218273.91741.30","article-title":"Compartmentation of cyclic nucleotide signaling in the heart: the role of A-kinase anchoring proteins","volume":"98","author":"Dodge-Kafka","year":"2006","journal-title":"Circ. Res."},{"key":"10.1016\/j.mce.2016.11.026_bib10","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1046\/j.1523-1755.1999.00233.x","article-title":"Cyclic-3',5'-nucleotide phosphodiesterase isozymes in cell biology and pathophysiology of the kidney","volume":"55","author":"Dousa","year":"1999","journal-title":"Kidney Int."},{"key":"10.1016\/j.mce.2016.11.026_bib11","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/978-1-59745-467-4_7","article-title":"Analysis of protein phosphorylation in human neutrophils","volume":"412","author":"El-Benna","year":"2007","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.mce.2016.11.026_bib12","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1021\/bi00303a034","article-title":"Purification and characterization of a human platelet cyclic nucleotide phosphodiesterase","volume":"23","author":"Grant","year":"1984","journal-title":"Biochemistry"},{"key":"10.1016\/j.mce.2016.11.026_bib13","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/S0026-895X(25)10279-4","article-title":"Isolation and characterization of bovine cardiac muscle cGMP-inhibited phosphodiesterase: a receptor for new cardiotonic drugs","volume":"29","author":"Harrison","year":"1986","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.mce.2016.11.026_bib14","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.tibs.2009.09.007","article-title":"Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown","volume":"35","author":"Houslay","year":"2010","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.mce.2016.11.026_bib15","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/ng.3316","article-title":"Hypertension linked to PDE3A activation","volume":"47","author":"Houslay","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mce.2016.11.026_bib16","doi-asserted-by":"crossref","first-page":"10576","DOI":"10.1074\/jbc.M609695200","article-title":"Use of a cAMP BRET sensor to characterize a novel regulation of cAMP by the sphingosine 1-phosphate\/G13 pathway","volume":"282","author":"Jiang","year":"2007","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.mce.2016.11.026_bib17","series-title":"Genetics of Bone Biology and Skeletal Disease","first-page":"441","author":"J\u00fcppner","year":"2012"},{"key":"10.1016\/j.mce.2016.11.026_bib18","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1016\/j.cellsig.2014.07.025","article-title":"Heterozygous mutations in cyclic AMP phosphodiesterase-4D (PDE4D) and protein kinase A (PKA) provide new insights into the molecular pathology of acrodysostosis","volume":"26","author":"Kaname","year":"2014","journal-title":"Cell Signal"},{"key":"10.1016\/j.mce.2016.11.026_bib19","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1165\/ajrcmb.26.6.4743","article-title":"PDE4 inhibitors attenuate fibroblast chemotaxis and contraction of native collagen gels","volume":"26","author":"Kohyama","year":"2002","journal-title":"Am. J. Respir. cell Mol. Biol."},{"key":"10.1016\/j.mce.2016.11.026_bib20","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1136\/jmedgenet-2013-101937","article-title":"Different mutations in PDE4D associated with developmental disorders with mirror phenotypes","volume":"51","author":"Lindstrand","year":"2014","journal-title":"J.\u00a0Med. Genet."},{"key":"10.1016\/j.mce.2016.11.026_bib21","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1056\/NEJMoa1012717","article-title":"Recurrent PRKAR1A mutation in acrodysostosis with hormone resistance","volume":"364","author":"Linglart","year":"2011","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.mce.2016.11.026_bib22","doi-asserted-by":"crossref","first-page":"E2328","DOI":"10.1210\/jc.2012-2326","article-title":"PRKAR1A and PDE4D mutations cause acrodysostosis but two distinct syndromes with or without GPCR-signaling hormone resistance","volume":"97","author":"Linglart","year":"2012","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2016.11.026_bib23","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1159\/000348516","article-title":"GNAS -related loss-of-function disorders and the role of imprinting","volume":"79","author":"Linglart","year":"2013","journal-title":"Hormone Res. Paediatr."},{"key":"10.1016\/j.mce.2016.11.026_bib24","doi-asserted-by":"crossref","first-page":"33178","DOI":"10.1074\/jbc.M414316200","article-title":"RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A\/AKAP79-mediated switching of the beta2-adrenergic receptor to activation of ERK in HEK293B2 cells","volume":"280","author":"Lynch","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.mce.2016.11.026_bib25","first-page":"2189","article-title":"[Acrodysostosis]","volume":"76","author":"Maroteaux","year":"1968","journal-title":"La Presse medicale"},{"key":"10.1016\/j.mce.2016.11.026_bib26","doi-asserted-by":"crossref","first-page":"e24392","DOI":"10.1371\/journal.pone.0024392","article-title":"Cyclic AMP control measured in two compartments in HEK293 cells: phosphodiesterase K(M) is more important than phosphodiesterase localization","volume":"6","author":"Matthiesen","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.mce.2016.11.026_bib27","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.ejcb.2006.01.005","article-title":"Spatial organisation of AKAP18 and PDE4 isoforms in renal collecting duct principal cells","volume":"85","author":"McSorley","year":"2006","journal-title":"Eur. J. cell Biol."},{"key":"10.1016\/j.mce.2016.11.026_bib28","article-title":"PDE4D phosphorylation: a coincidence detector integrating multiple signaling pathways","author":"Mika","year":"2015","journal-title":"Cell Signal"},{"key":"10.1016\/j.mce.2016.11.026_bib29","first-page":"2872","article-title":"Induction of specific phosphodiesterase isoforms by constitutive activation of the cAMP pathway in autonomous thyroid adenomas","volume":"85","author":"Persani","year":"2000","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2016.11.026_bib30","doi-asserted-by":"crossref","first-page":"27816","DOI":"10.1074\/jbc.M115.656553","article-title":"Functional characterization of PRKAR1A mutations reveals a unique molecular mechanism causing Acrodysostosis but multiple mechanisms causing carney complex","volume":"290","author":"Rhayem","year":"2015","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.mce.2016.11.026_bib31","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1001\/archpedi.1971.02100140061002","article-title":"Acrodysostosis. A syndrome of peripheral dysostosis, nasal hypoplasia, and mental retardation","volume":"121","author":"Robinow","year":"1971","journal-title":"Am. J. Dis. Child."},{"key":"10.1016\/j.mce.2016.11.026_bib32","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0014-2999(86)90210-4","article-title":"Stereospecific binding of the antidepressant rolipram to brain protein structures","volume":"127","author":"Schneider","year":"1986","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.mce.2016.11.026_bib33","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/jcp.22037","article-title":"Cytokine-dependent balance of mitogenic effects in primary human lung fibroblasts related to cyclic AMP signaling and phosphodiesterase 4 inhibition","volume":"223","author":"Selige","year":"2010","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.mce.2016.11.026_bib34","doi-asserted-by":"crossref","first-page":"16526","DOI":"10.1074\/jbc.271.28.16526","article-title":"Phosphorylation and activation of a cAMP-specific phosphodiesterase by the cAMP-dependent protein kinase. Involvement of serine 54 in the enzyme activation","volume":"271","author":"Sette","year":"1996","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.mce.2016.11.026_bib35","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1016\/j.cellsig.2014.04.023","article-title":"Mitotic activation of the DISC1-inducible cyclic AMP phosphodiesterase-4D9 (PDE4D9), through multi-site phosphorylation, influences cell cycle progression","volume":"26","author":"Sheppard","year":"2014","journal-title":"Cell Signal"},{"key":"10.1016\/j.mce.2016.11.026_bib36","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/bonekey.2012.225","article-title":"Acrodysostosis syndromes","volume":"1","author":"Silve","year":"2012","journal-title":"BoneKEy Rep."},{"key":"10.1016\/j.mce.2016.11.026_bib37","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1146\/annurev.med.55.091902.103843","article-title":"Inherited diseases involving g proteins and g protein-coupled receptors","volume":"55","author":"Spiegel","year":"2004","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.mce.2016.11.026_bib38","doi-asserted-by":"crossref","first-page":"9140","DOI":"10.1074\/jbc.M805366200","article-title":"The cardiac IKs potassium channel macromolecular complex includes the phosphodiesterase PDE4D3","volume":"284","author":"Terrenoire","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.mce.2016.11.026_bib39","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1083\/jcb.200605050","article-title":"PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases","volume":"175","author":"Terrin","year":"2006","journal-title":"J.\u00a0cell Biol."},{"key":"10.1016\/j.mce.2016.11.026_bib40","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1006\/bbrc.1997.6636","article-title":"Expression, purification, and characterization of human cAMP-specific phosphodiesterase (PDE4) subtypes A, B, C, and D","volume":"234","author":"Wang","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mce.2016.11.026_bib41","doi-asserted-by":"crossref","first-page":"36214","DOI":"10.1074\/jbc.M707263200","article-title":"NHERF1 regulates parathyroid hormone receptor membrane retention without affecting recycling","volume":"282","author":"Wang","year":"2007","journal-title":"J.\u00a0Biol. Chem."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720716304956?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720716304956?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T18:20:49Z","timestamp":1749752449000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720716304956"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":42,"alternative-id":["S0303720716304956"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2016.11.026","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modulation of signaling through GPCR-cAMP-PKA pathways by PDE4 depends on stimulus intensity: Possible implications for the pathogenesis of acrodysostosis without hormone resistance","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2016.11.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}