{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:59:26Z","timestamp":1783126766670,"version":"3.54.6"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570772"],"award-info":[{"award-number":["81570772"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003427","name":"Gout Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003427","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"crossref","award":["2015A030313434"],"award-info":[{"award-number":["2015A030313434"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Scientific Research Foundation","award":["20111568"],"award-info":[{"award-number":["20111568"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.mce.2016.12.025","type":"journal-article","created":{"date-parts":[[2016,12,29]],"date-time":"2016-12-29T23:00:26Z","timestamp":1483052426000},"page":"138-145","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"special_numbering":"C","title":["Metformin ameliorates high uric acid-induced insulin resistance in skeletal muscle cells"],"prefix":"10.1016","volume":"443","author":[{"given":"Huier","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqiu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongneng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaohuan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tengfei","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanling","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfang","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangli","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Hisatome","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5909-5759","authenticated-orcid":false,"given":"Jidong","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2016.12.025_bib1","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.bbrc.2014.04.031","article-title":"Differential AMPK phosphorylation by glucagon and metformin regulates insulin signaling in human hepatic cells","volume":"447","author":"Aw","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mce.2016.12.025_bib2","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1152\/japplphysiol.01101.2013","article-title":"Reduced skeletal muscle AMPK and mitochondrial markers do not promote age-induced insulin resistance","volume":"117","author":"Bujak","year":"2014","journal-title":"J.\u00a0Appl. Physiol."},{"key":"10.1016\/j.mce.2016.12.025_bib3","doi-asserted-by":"crossref","first-page":"3197","DOI":"10.1096\/fj.13-247148","article-title":"Uric acid induces endothelial dysfunction by vascular insulin resistance associated with the impairment of nitric oxide synthesis","volume":"28","author":"Choi","year":"2014","journal-title":"FASEB. J."},{"issue":"297","key":"10.1016\/j.mce.2016.12.025_bib4","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/S0006-291X(02)02343-4","article-title":"Novel human cDNAs homologous to Drosophila Orctand mammalian carnitine transporters","volume":"11","author":"Eraly","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"452","key":"10.1016\/j.mce.2016.12.025_bib5","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.bbrc.2014.08.079","article-title":"A\u00a0polyphenol rescues lipid induced insulin resistance in skeletal muscle cells and adipocytes","volume":"26","author":"Gogoi","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mce.2016.12.025_bib6","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s11010-010-0649-5","article-title":"Over-expression of LYRM1 inhibits glucose transport in rat skeletal muscles via attenuated phosphorylation of PI3K (p85) and Akt","volume":"348","author":"Kou","year":"2011","journal-title":"Mol. Cell Biochem."},{"key":"10.1016\/j.mce.2016.12.025_bib7","doi-asserted-by":"crossref","first-page":"39422","DOI":"10.1074\/jbc.M305371200","article-title":"Akt activity negatively regulates phosphorylation of AMP-activated protein kinase inthe heart","volume":"278","author":"Kovacic","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.mce.2016.12.025_bib8","doi-asserted-by":"crossref","first-page":"E1099","DOI":"10.1152\/ajpendo.00417.2013","article-title":"Two weeks of metformin treatment induces AMPK-dependent enhancement of insulin-stimulated glucose uptake in mouse soleus muscle","volume":"306","author":"Kristensen","year":"2014","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2016.12.025_bib9","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.mam.2012.10.010","article-title":"The SLC22 family with transporters of organic cations, anions and zwitterions","volume":"34","author":"Koepsell","year":"2013","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.mce.2016.12.025_bib10","doi-asserted-by":"crossref","first-page":"10003","DOI":"10.1038\/srep10003","article-title":"The association between serum uric acid levels and the prevalence of vulnerable atherosclerotic carotid plaque: a cross-sectional study","volume":"11","author":"Li","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mce.2016.12.025_bib11","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.ejphar.2011.05.021","article-title":"Protective effects of cortex fraxinicoumarines against oxonate-induced hyperuricemia and renal dysfunction in mice","volume":"666","author":"Li","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.mce.2016.12.025_bib12","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1007\/s10517-007-0335-0","article-title":"Reparative reactions of the skeletal muscles in early aging OXYS rats with toxic metabolic injuries caused by bupivacaine","volume":"144","author":"Nepomnyashchikh","year":"2007","journal-title":"Bull. Exp. Biol. Med."},{"key":"10.1016\/j.mce.2016.12.025_bib14","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1517\/14728222.2015.1005603","article-title":"Targeting the 5'-AMP-activated protein kinase and related metabolic pathways for the treatment of prostate cancer","volume":"19","author":"Popovics","year":"2015","journal-title":"Expert. Opin. Ther. Targets"},{"key":"10.1016\/j.mce.2016.12.025_bib15","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1210\/en.2009-1429","article-title":"Phosphorylation and activation of AMP-activated protein kinase (AMPK) by metformin in the human ovary requires insulin","volume":"152","author":"Pellatt","year":"2011","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2016.12.025_bib16","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s10863-012-9460-1","article-title":"\u03b1-Lipoic acid ameliorates impaired glucose uptake in LYRM1 overexpressing 3T3-L1 adipocytes through the IRS-1\/Akt signaling pathway","volume":"44","author":"Qin","year":"2012","journal-title":"J.\u00a0Bioenerg. Biomembr."},{"key":"10.1016\/j.mce.2016.12.025_bib17","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1172\/JCI42344","article-title":"Uric acid transport and disease","volume":"120","author":"So","year":"2010","journal-title":"J.\u00a0Clin. Invest"},{"key":"10.1016\/j.mce.2016.12.025_bib28","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3109\/13813455.2012.713366","article-title":"Contribution of the serine kinase c-Jun N-terminal kinase (JNK) to oxidant-induced insulin resistance in isolated rat skeletal muscle","volume":"118","author":"Santos","year":"2012","journal-title":"Arch. Physiol. Biochem"},{"key":"10.1016\/j.mce.2016.12.025_bib29","doi-asserted-by":"crossref","first-page":"F1134","DOI":"10.1152\/ajprenal.00104.2008","article-title":"Role of oxidative stress in the renal abnormalities induced by experimental hyperuricemia","volume":"295","author":"S\u00e1nchez-Lozada","year":"2008","journal-title":"Am. J. Physiol. Renal. Physiol"},{"key":"10.1016\/j.mce.2016.12.025_bib30","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.freeradbiomed.2007.10.053","article-title":"Reactive oxygen species produced by NADPH oxidase, xanthine oxidase, and mitochondrial electron transport system mediate heat shock-induced MMP-1 and MMP-9 expression","volume":"44","author":"Shin","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mce.2016.12.025_bib18","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.mce.2015.03.009","article-title":"Dihydromyricetin improves skeletal muscle insulin resistance by inducing autophagy via the AMPK signaling pathway","volume":"409","author":"Shi","year":"2015","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2016.12.025_bib19","doi-asserted-by":"crossref","first-page":"C584","DOI":"10.1152\/ajpcell.00600.2006","article-title":"Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative\/nitrosative stress","volume":"293","author":"Sautin","year":"2007","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.mce.2016.12.025_bib20","doi-asserted-by":"crossref","first-page":"18069","DOI":"10.1074\/jbc.M610101200","article-title":"Energy depletion inhibits phosphatidylinositol 3-kinase\/Akt signaling and induces apoptosis via AMP-activated proteinkinase-dependent phosphorylation of IRS-1 at Ser-794","volume":"282","author":"Tzatsos","year":"2007","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.mce.2016.12.025_bib21","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.3892\/ijmm.2015.2187","article-title":"Metformin attenuates palmitic acid-induced insulin resistance in L6 cells through the AMP-activated protein kinase\/sterol regulatory element-binding protein-1c pathway","volume":"35","author":"Wu","year":"2015","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.mce.2016.12.025_bib22","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1530\/REP-13-0135","article-title":"Metformin inhibits growth of eutopic stromal cells from adenomyotic endometrium via AMPK activation and subsequent inhibition of AKT phosphorylation: a possible role in the treatment of adenomyosis","volume":"146","author":"Xue","year":"2013","journal-title":"Reproduction"},{"key":"10.1016\/j.mce.2016.12.025_bib23","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.atherosclerosis.2011.11.014","article-title":"Uric acid level as a risk marker for metabolic syndrome: a Chinese cohort study","volume":"220","author":"Yang","year":"2012","journal-title":"Atherosclerosis"},{"issue":"447","key":"10.1016\/j.mce.2016.12.025_bib24","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.bbrc.2014.04.080","article-title":"High uric acid directly inhibits insulin signaling and induces insulin resistance","volume":"16","author":"Zhu","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mce.2016.12.025_bib25","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.1002\/art.30520","article-title":"Prevalence of gout and hyperuricemia in the US general population: the national health and nutrition examination survey 2007\u20132008","volume":"63","author":"Zhu","year":"2011","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.mce.2016.12.025_bib26","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.mce.2013.04.027","article-title":"Uric acid induces oxidative stress and growth inhibition by activating adenosine monophosphate-activated protein kinase and extracellular signal-regulated kinase signal pathways in rat pancreatic \u03b2-cells","volume":"375","author":"Zhang","year":"2013","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.mce.2016.12.025_bib27","doi-asserted-by":"crossref","first-page":"e0147737","DOI":"10.1371\/journal.pone.0147737","article-title":"High uric acid induces insulin resistance in cardiomyocytes in\u00a0vitro and in\u00a0vivo","volume":"11","author":"Zhi","year":"2016","journal-title":"PLoS One"}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720716305482?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720716305482?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T10:11:23Z","timestamp":1573639883000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720716305482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":29,"alternative-id":["S0303720716305482"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2016.12.025","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metformin ameliorates high uric acid-induced insulin resistance in skeletal muscle cells","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2016.12.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}