{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:49:38Z","timestamp":1789951778546,"version":"4.0.1"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1016\/j.mce.2017.02.019","type":"journal-article","created":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T11:51:57Z","timestamp":1487159517000},"page":"66-70","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["JAK\/STAT pathway directed therapy of T-cell leukemia\/lymphoma: Inspired by functional and structural genomics"],"prefix":"10.1016","volume":"451","author":[{"given":"Thomas A.","family":"Waldmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.mce.2017.02.019_bib1","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1073\/pnas.95.5.2452","article-title":"Human T cell lymphotropic virus type I Tax protein trans-activates interleukin 15 gene transcription through an NF-kappa B site","volume":"95","author":"Azimi","year":"1998","journal-title":"Pro Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.mce.2017.02.019_bib2","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/leu.2013.271","article-title":"Recurrent JAK1 and JAK3 somatic mutations in T-cell prolymphocytic leukemia","volume":"28","author":"Bellanger","year":"2014","journal-title":"Leukemia"},{"issue":"4","key":"10.1016\/j.mce.2017.02.019_bib3","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/gcc.22141","article-title":"Recurrent mutation of JAK3 in T-cell prolymphocytic leukemia","volume":"53","author":"Bergmann","year":"2014","journal-title":"Genes Chromosomes Cancer"},{"issue":"2","key":"10.1016\/j.mce.2017.02.019_bib4","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/leu.2013.157","article-title":"JAK3 deregulation by activating mutations confers invasive growth advantage in extranodal nasal-type natural killer cell lymphoma","volume":"28","author":"Bouchekioua","year":"2014","journal-title":"Leukemia"},{"issue":"10","key":"10.1016\/j.mce.2017.02.019_bib5","doi-asserted-by":"crossref","first-page":"5163","DOI":"10.1182\/blood-2007-09-113654","article-title":"Induction of the IL-9 gene by HTLV-1 Tax stimulates the spontaneous proliferation of primary adult T-cell leukemia cells by a paracrine mechanism","volume":"111","author":"Chen","year":"2008","journal-title":"Blood"},{"issue":"26","key":"10.1016\/j.mce.2017.02.019_bib6","doi-asserted-by":"crossref","first-page":"5948","DOI":"10.1182\/blood-2010-04-277418","article-title":"Autocrine\/paracrine cytokine stimulation of leukemic cell proliferation in smoldering and chronic adult T-cell leukemia","volume":"116","author":"Chen","year":"2010","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.mce.2017.02.019_bib7","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nm1249","article-title":"Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target","volume":"11","author":"Chiarle","year":"2005","journal-title":"Nat. Med."},{"issue":"9","key":"10.1016\/j.mce.2017.02.019_bib8","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1038\/ng.3356","article-title":"Genomic landscape of cutaneous T cell lymphoma","volume":"47","author":"Choi","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mce.2017.02.019_bib9","article-title":"Ruxolitinib for adult T-cell leukemia","author":"Conlon","year":"2017","journal-title":"Clin. Study Rec."},{"issue":"9","key":"10.1016\/j.mce.2017.02.019_bib10","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1038\/leu.2009.91","article-title":"STAT3 transcription factor is constitutively activated and is oncogenic in nasal-type NK\/T-cell lymphoma","volume":"23","author":"Coppo","year":"2009","journal-title":"Leukemia"},{"issue":"4","key":"10.1016\/j.mce.2017.02.019_bib11","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.ccell.2015.03.006","article-title":"Convergent mutations and kinase fusions lead to oncogenic STAT3 activation in anaplastic large cell lymphoma","volume":"27","author":"Crescenzo","year":"2015","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/j.mce.2017.02.019_bib12","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1182\/blood.V92.1.252.413k08_252_258","article-title":"Interleukin-15 is an autocrine\/paracrine viability factor for cutaneous T-cell lymphoma cells","volume":"92","author":"D\u00f6bbeling","year":"1998","journal-title":"Blood"},{"issue":"14","key":"10.1016\/j.mce.2017.02.019_bib13","doi-asserted-by":"crossref","first-page":"3911","DOI":"10.1182\/blood-2010-12-319467","article-title":"FERM domain mutations induce gain of function in JAK3 in adult T-cell leukemia\/lymphoma","volume":"118","author":"Elliott","year":"2011","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.mce.2017.02.019_bib14","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/sj.leu.2402093","article-title":"Constitutive STAT3-activation in Sezary syndrome: tyrphostin AG490 inhibits STAT3-activation, interleukin-2 receptor expression and growth of leukemic Sezary cells","volume":"15","author":"Eriksen","year":"2001","journal-title":"Leukemia"},{"issue":"3","key":"10.1016\/j.mce.2017.02.019_bib15","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.chembiol.2011.01.012","article-title":"Jak1 has a dominant role over Jak3 in signal transduction through gamma c-containing cytokine receptors","volume":"18","author":"Haan","year":"2011","journal-title":"Chem Biol."},{"issue":"11","key":"10.1016\/j.mce.2017.02.019_bib16","doi-asserted-by":"crossref","first-page":"6773","DOI":"10.1074\/jbc.M807531200","article-title":"Acute lymphoblastic leukemia-associated JAK1 mutants activate the janus kinase\/STAT pathway via Interleukin-9 receptor alpha homodimers","volume":"284","author":"Hornakova","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"issue":"11","key":"10.1016\/j.mce.2017.02.019_bib17","doi-asserted-by":"crossref","first-page":"3102","DOI":"10.1016\/j.ajpath.2015.07.021","article-title":"IL-21-driven neoplasms in SJL mice mimic some key features of human angioimmunoblastic T-cell lymphoma","volume":"185","author":"Jain","year":"2015","journal-title":"Am. J. Pathol."},{"issue":"6","key":"10.1016\/j.mce.2017.02.019_bib18","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1182\/blood-2010-09-305425","article-title":"CP-690,550, a therapeutic agent, inhibits cytokine-mediated Jak3 activation and proliferation of T cells from patients with ATL and HAM\/TSP","volume":"117","author":"Ju","year":"2011","journal-title":"Blood"},{"issue":"11","key":"10.1016\/j.mce.2017.02.019_bib19","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1038\/ng.3415","article-title":"Integrated molecular analysis of adult T cell leukemia\/lymphoma","volume":"47","author":"Kataoka","year":"2015","journal-title":"Nat. Genet."},{"issue":"10","key":"10.1016\/j.mce.2017.02.019_bib20","first-page":"3692","article-title":"Differential expression and clinical significance of tyrosine-phosphorylated STAT3 in ALK(+) and ALK(-) anaplastic large cell lymphoma","volume":"9","author":"Khoury","year":"2003","journal-title":"Clin. Cancer Res."},{"issue":"9","key":"10.1016\/j.mce.2017.02.019_bib21","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1182\/blood-2014-03-559542","article-title":"Integrated genomic sequencing reveals mutational landscape of T-cell prolymphocytic leukemia","volume":"124","author":"Kiel","year":"2014","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.mce.2017.02.019_bib22","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1158\/2159-8290.CD-12-0028","article-title":"Janus kinase 3-activating mutations identified in natural\/killer\/T-cell lymphoma","volume":"2","author":"Koo","year":"2012","journal-title":"Cancer Discov."},{"issue":"20","key":"10.1016\/j.mce.2017.02.019_bib23","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1056\/NEJMoa1114885","article-title":"Somatic STAT3 mutations in large granular lymphocytic leukemia","volume":"366","author":"Koskela","year":"2012","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.mce.2017.02.019_bib24","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms7025","article-title":"Activating mutations of STAT5B and STAT3 in lymphomas derived from gamma delta-T or NK cells","volume":"6 vol","author":"K\u00fcc\u00fck","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mce.2017.02.019_bib25","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1146\/annurev.immunol.16.1.293","article-title":"JAKS AND STATS: biological implications","volume":"16","author":"Leonard","year":"1998","journal-title":"Annu. Rev. Immunol."},{"issue":"52","key":"10.1016\/j.mce.2017.02.019_bib26","doi-asserted-by":"crossref","first-page":"18962","DOI":"10.1073\/pnas.0509714102","article-title":"Expression of a homodimeric type I cytokine receptor is required for JAK2V617F-mediated transformation","volume":"102","author":"Lu","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5220","key":"10.1016\/j.mce.2017.02.019_bib27","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1126\/science.7604283","article-title":"Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I","volume":"269","author":"Migone","year":"1995","journal-title":"Science"},{"issue":"11","key":"10.1016\/j.mce.2017.02.019_bib28","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1038\/leu.2014.200","article-title":"Frequent STAT5B mutations in gamma delta hepatosplenic T-cell lymphomas","volume":"28","author":"Nicolae","year":"2014","journal-title":"Leukemia"},{"issue":"6","key":"10.1016\/j.mce.2017.02.019_bib29","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1023\/A:1027388508570","article-title":"Advances in the understanding of cytokine signal transduction: the role of Jaks and STATs in immunoregulation and the pathogenesis of immunodeficiency","volume":"17","author":"O'Shea","year":"1997","journal-title":"J.\u00a0Clin. Immunol."},{"issue":"9","key":"10.1016\/j.mce.2017.02.019_bib30","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1182\/blood-2013-10-531509","article-title":"A\u00a0targeted mutational landscape of angioimmunoblastic T-cell lymphoma","volume":"123","author":"Odejide","year":"2014","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.mce.2017.02.019_bib31","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/nri2580","article-title":"New insights into the regulation of T cells by gamma(c) family cytokines","volume":"9","author":"Rochman","year":"2009","journal-title":"Nat. Rev. Immunol."},{"issue":"49","key":"10.1016\/j.mce.2017.02.019_bib32","doi-asserted-by":"crossref","first-page":"47954","DOI":"10.1074\/jbc.M205156200","article-title":"The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction","volume":"277","author":"Saharinen","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"issue":"6","key":"10.1016\/j.mce.2017.02.019_bib33","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1084\/jem.201105802011512c","article-title":"Gain-of-function mutations in interleukin-7 receptor-alpha (IL7R) in childhood acute lymphoblastic leukemias","volume":"208","author":"Shochat","year":"2011","journal-title":"J.\u00a0Expl Med."},{"issue":"5","key":"10.1016\/j.mce.2017.02.019_bib34","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nchembio.2056","article-title":"Essential biphasic role for JAK3 catalytic activity in IL-2 receptor signaling","volume":"12","author":"Smith","year":"2016","journal-title":"Nat. Chem. Bio"},{"issue":"13","key":"10.1016\/j.mce.2017.02.019_bib35","doi-asserted-by":"crossref","first-page":"5218","DOI":"10.1073\/pnas.87.13.5218","article-title":"Transactivation of interleukin-2 and its receptor induces immune activation in human T-cell lymphotropic virus type I-associated myelopathy: pathogenic implications and a rationale for immunotherapy","volume":"87","author":"Tendler","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"8","key":"10.1016\/j.mce.2017.02.019_bib36","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/nri1901","article-title":"The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design","volume":"6","author":"Waldmann","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.mce.2017.02.019_bib37","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1146\/annurev-immunol-110416-120628","article-title":"Disorders of the JAK\/STAT pathway in T cell lymphoma pathogenesis: implications for immunotherapy","volume":"35","author":"Waldmann","year":"2017","journal-title":"Annu. Rev. Immunol."},{"issue":"10","key":"10.1016\/j.mce.2017.02.019_bib38","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/ng.924","article-title":"Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia","volume":"43","author":"Zenatti","year":"2011","journal-title":"Nat. Genet."},{"issue":"17","key":"10.1016\/j.mce.2017.02.019_bib39","doi-asserted-by":"crossref","first-page":"9148","DOI":"10.1073\/pnas.93.17.9148","article-title":"Activation of Jak\/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome","volume":"93","author":"Zhang","year":"1996","journal-title":"Pro Natl. Acad. Sci. U. S. A."},{"issue":"7380","key":"10.1016\/j.mce.2017.02.019_bib40","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/nature10725","article-title":"The genetic basis of early T-cell precursor acute lymphoblastic leukaemia","volume":"481","author":"Zhang","year":"2012","journal-title":"Nature"},{"issue":"40","key":"10.1016\/j.mce.2017.02.019_bib41","doi-asserted-by":"crossref","first-page":"12480","DOI":"10.1073\/pnas.1516208112","article-title":"Selective targeting of JAK\/STAT signaling is potentiated by Bcl-xL blockade in IL-2-dependent adult T-cell leukemia","volume":"112","author":"Zhang","year":"2015","journal-title":"Pro Natl. Acad. Sci. U. S. A."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720717301065?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720717301065?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,2]],"date-time":"2020-10-02T09:00:40Z","timestamp":1601629240000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720717301065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":41,"alternative-id":["S0303720717301065"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2017.02.019","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2017,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"JAK\/STAT pathway directed therapy of T-cell leukemia\/lymphoma: Inspired by functional and structural genomics","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2017.02.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Ireland Ltd.","name":"copyright","label":"Copyright"}]}}