{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:13:20Z","timestamp":1786994000584,"version":"build-2736575974"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Ricerca Corrente IRCCS Istituto Ortopedico Galeazzi","award":["L4080"],"award-info":[{"award-number":["L4080"]}]},{"name":"Ricerca Finalizzata GR Familia Project","award":["2011-02351489"],"award-info":[{"award-number":["2011-02351489"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.mce.2017.05.010","type":"journal-article","created":{"date-parts":[[2017,5,10]],"date-time":"2017-05-10T03:32:02Z","timestamp":1494387122000},"page":"60-69","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Alterations of DNA methylation in parathyroid tumors"],"prefix":"10.1016","volume":"469","author":[{"given":"Vito","family":"Guarnieri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia Anna","family":"Muscarella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Verdelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8140-3175","authenticated-orcid":false,"given":"Sabrina","family":"Corbetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2017.05.010_bib1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s13148-016-0197-2","article-title":"5-Hydroxymethylcytosine discriminates between parathyroid adenoma and carcinoma","volume":"8","author":"Barazeghi","year":"2016","journal-title":"Clin. Epigenetics"},{"key":"10.1016\/j.mce.2017.05.010_bib2","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1101\/sqb.2005.70.010","article-title":"Aberrant gene silencing in tumor progression: implications for control of cancer","volume":"70","author":"Baylin","year":"2005","journal-title":"Cold. Spring. Harb. Sympt. Quant. Biol."},{"key":"10.1016\/j.mce.2017.05.010_bib3","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a019505","article-title":"Epigenetic determinants of cancer","volume":"8","author":"Baylin","year":"2016","journal-title":"Cold. Spring. Harb. Perspect. Biol."},{"key":"10.1016\/j.mce.2017.05.010_bib4","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1093\/hmg\/10.7.687","article-title":"Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer","volume":"10","author":"Baylin","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mce.2017.05.010_bib5","doi-asserted-by":"crossref","first-page":"98","DOI":"10.2174\/157488809788167409","article-title":"A\u00a0review of gene expression profiling of human embryonic stem cell lines and their differentiated progeny","volume":"4","author":"Bhattacharya","year":"2009","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"10.1016\/j.mce.2017.05.010_bib6","doi-asserted-by":"crossref","first-page":"E403","DOI":"10.1210\/jc.2012-2789","article-title":"Frequent large germline HRPT2 deletions in a French National cohort of patients with primary hyperparathyroidism","volume":"98","author":"Bricaire","year":"2013","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2017.05.010_bib79","first-page":"2000","article-title":"Reduced parathyroid vitamin D receptor messenger ribonucleic acid levels in primary and secondary hyperparathyroidism","volume":"85","author":"Carling","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2017.05.010_bib7","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/S0039-6060(03)00422-7","article-title":"Intragenic allelic loss and promoter hypermethylation of the RIZ1 tumor suppressor gene in parathyroid tumors and pheochromocytomas","volume":"134","author":"Carling","year":"2003","journal-title":"Surgery"},{"key":"10.1016\/j.mce.2017.05.010_bib8","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/ng1048","article-title":"HRPT2, encoding parafibromin, is mutated in hyperparathyroidism-jaw tumor syndrome","volume":"32","author":"Carpten","year":"2002","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mce.2017.05.010_bib9","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1093\/carcin\/bgs338","article-title":"The calcium-sensing receptor is silenced by genetic and epigenetic mechanisms in unfavorable neuroblastomas and its reactivation induces ERK1\/2-dependent apoptosis","volume":"34","author":"Casal\u00e0","year":"2013","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.mce.2017.05.010_bib10","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1126\/science.276.5311.404","article-title":"Positional cloning of the gene for multiple endocrine neoplasia-type 1","volume":"276","author":"Chandrasekharappa","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.mce.2017.05.010_bib11","doi-asserted-by":"crossref","first-page":"6236","DOI":"10.1093\/nar\/gkv567","article-title":"Afine balance: epigenetic control of cellular quiescence by the tumor suppressor PRDM2\/RIZ at a bivalent domain in the cyclin a gene","volume":"43","author":"Cheedipudi","year":"2015","journal-title":"Nucleic. Acids. Res."},{"key":"10.1016\/j.mce.2017.05.010_bib12","doi-asserted-by":"crossref","first-page":"7553","DOI":"10.1074\/jbc.275.11.7553","article-title":"Cloning and characterization of two promoters for the human calcium-sensing receptor (CaSR) and changes of CaSR expression in parathyroid adenomas","volume":"275","author":"Chikatsu","year":"2000","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.mce.2017.05.010_bib13","doi-asserted-by":"crossref","first-page":"T19","DOI":"10.1530\/ERC-14-0185","article-title":"Histone H2B monoubiquitination: roles to play in human malignancy","volume":"22","author":"Cole","year":"2015","journal-title":"Endor. Relat. Cancer."},{"key":"10.1016\/j.mce.2017.05.010_bib14","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1016\/j.celrep.2016.11.032","article-title":"Deletion of the polycomb-group protein EZH2 leads to compromised self-renewal and differentiation defects in human embryonic stem cells","volume":"17","author":"Collinson","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.mce.2017.05.010_bib15","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1677\/ERC-09-0134","article-title":"Differential expression of microRNAs in human parathyroid carcinomas compared with normal parathyroid tissue","volume":"17","author":"Corbetta","year":"2010","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.mce.2017.05.010_bib16","doi-asserted-by":"crossref","first-page":"E1774","DOI":"10.1210\/jc.2012-1743","article-title":"Identification of somatic mutations in parathyroid tumors using whole-exome sequencing","volume":"97","author":"Cromer","year":"2012","journal-title":"J.Clin. Endocrinol. Metab"},{"key":"10.1016\/j.mce.2017.05.010_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mce.2009.08.020","article-title":"Regulation of vitaminD receptor function in MEN1-related parathyroid adenomas","volume":"313","author":"Dreijerink","year":"2009","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2017.05.010_bib18","first-page":"3481","article-title":"Tumor-specific decreased expression of calcium sensing receptor messenger ribonucleic acid in sporadic primary hyperparathyroidism","volume":"82","author":"Farnebo","year":"1997","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2017.05.010_bib19","first-page":"46,662","article-title":"RNF20 and USP44 regulate stem cell differentiation by modulating H2B monoubiquitylation","author":"Fuchs","year":"2012","journal-title":"Mol. Cell"},{"key":"10.1016\/j.mce.2017.05.010_bib20","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1186\/s12885-015-1267-0","article-title":"Lower PRDM2 expression is associated with dopamine-agonist resistance and tumor recurrence in prolactinomas","volume":"15","author":"Gao","year":"2015","journal-title":"BMC Cancer"},{"key":"10.1016\/j.mce.2017.05.010_bib21","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1016\/S0039-6060(97)90223-3","article-title":"Quantitative analysis of the calcium-sensing receptor messenger RNA in parathyroid adenomas","volume":"122","author":"Garner","year":"1997","journal-title":"Surgery"},{"key":"10.1016\/j.mce.2017.05.010_bib22","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/ki.1997.41","article-title":"Depressed expression of calcium receptor in parathyroid gland tissue of patients with hyperparathyroidism","volume":"51","author":"Gogusev","year":"1997","journal-title":"Kidney Int."},{"key":"10.1016\/j.mce.2017.05.010_bib23","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s13402-012-0100-x","article-title":"CDC73 mutations and parafibromin immunohistochemistry in parathyroid tumors: clinical correlations in a single-centre patient cohort","volume":"35","author":"Guarnieri","year":"2012","journal-title":"Cell. Oncol. (Dordr)"},{"key":"10.1016\/j.mce.2017.05.010_bib24","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1677\/ERC-09-0291","article-title":"CDC73\/HRPT2 CpG island hypermethylation and mutation of 5\u2019-untranslated sequence are uncommon mechanisms of silencing parafibromin in parathyroid tumors","volume":"17","author":"Hahn","year":"2010","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.mce.2017.05.010_bib25","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1093\/hmg\/ddr490","article-title":"The tumor suppressor CDC73 interacts with the ring finger proteins RNF20 and RNF40 and is required for the maintenance of histone 2B monoubiquitination","volume":"21","author":"Hahn","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mce.2017.05.010_bib27","doi-asserted-by":"crossref","first-page":"7405","DOI":"10.1158\/0008-5472.CAN-04-2063","article-title":"Gene expression of parathyroid tumors: molecular subclassification and identification of the potential malignant phenotype","volume":"64","author":"Haven","year":"2004","journal-title":"Cancer. Res."},{"key":"10.1016\/j.mce.2017.05.010_bib28","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/ng0897-375","article-title":"Somatic mutation of the MEN1 gene in parathyroid tumours","volume":"16","author":"Heppner","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mce.2017.05.010_bib29","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1177\/000348940711601210","article-title":"Aberrant methylation of the HRPT2 gene in parathyroid carcinoma","volume":"116","author":"Hewitt","year":"2007","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"10.1016\/j.mce.2017.05.010_bib30","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1159\/000090846","article-title":"Imprinting disruption of the CDKN1C\/KCNQ1OT1 domain: the molecular mechanisms causing Beckwith-Wiedemann syndrome and cancer","volume":"113","author":"Higashimoto","year":"2006","journal-title":"Cytogenet. Genome Res."},{"key":"10.1016\/j.mce.2017.05.010_bib31","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1038\/modpathol.2011.10","article-title":"Epigenetic inactivation of calcium-sensing receptor in colorectal carcinogenesis","volume":"24","author":"Hizaki","year":"2011","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.mce.2017.05.010_bib32","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1242\/dev.070110","article-title":"The Prdm family: expanding roles in stem cells and development","volume":"139","author":"Hohenauer","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.mce.2017.05.010_bib71","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1210\/jc.2005-2095","article-title":"Hypercalcemia of malignancy due to ectopic transactivation of the parathyroid hormone gene","volume":"91","author":"vanHouten","year":"2006","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2017.05.010_bib33","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/nrg.2016.93","article-title":"Targeting the cancer epigenome for therapy","volume":"17","author":"Jones","year":"2016","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.mce.2017.05.010_bib34","doi-asserted-by":"crossref","first-page":"e9472","DOI":"10.1371\/journal.pone.0009472","article-title":"Frequent promoter hypermethylation of the APC and RASSF1A tumour suppressors in parathyroid tumours","volume":"5","author":"Juhlin","year":"2010","journal-title":"PLoS. One"},{"key":"10.1016\/j.mce.2017.05.010_bib35","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/path.4203","article-title":"Complete genomic landscape of a recurring sporadic parathyroid carcinoma","volume":"230","author":"Kasaian","year":"2013","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.mce.2017.05.010_bib80","first-page":"1598","article-title":"Reduced immunostaining for the extracellular Ca2+-sensing receptor in primary and uremic secondary hyperparathyroidism","volume":"81","author":"Kifor","year":"1996","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2017.05.010_bib36","doi-asserted-by":"crossref","first-page":"16714","DOI":"10.1038\/srep16714","article-title":"Linker histone H1.2 establishes chromatin compact and gene silencing through recognition of H3K27me3","volume":"5","author":"Kim","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mce.2017.05.010_bib37","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.bbagrm.2013.08.001","article-title":"Intragenic DNA methylation in transcriptional regulation, normal differentiation and cancer","volume":"1829","author":"Kulis","year":"2013","journal-title":"Biochim. Biophys. Acta."},{"key":"10.1016\/j.mce.2017.05.010_bib38","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1634\/stemcells.2007-1081","article-title":"Comprehensive microRNA profiling reveals a unique human embryonic stem cell signature dominated by a single seed sequence","volume":"26","author":"Laurent","year":"2008","journal-title":"Stem Cells"},{"key":"10.1016\/j.mce.2017.05.010_bib39","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1210\/endo-119-4-1618","article-title":"Tissue and gene specific hypomethylation of the human parathyroid hormone gene: association with parathyroid hormone gene expression in parathyroid glands","volume":"119","author":"Levine","year":"1986","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2017.05.010_bib40","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1002\/jcb.22084","article-title":"Target identification of microRNAs expressed highly in human embryonic stem cells","volume":"106","author":"Li","year":"2009","journal-title":"J.\u00a0Cell. Biochem."},{"key":"10.1016\/j.mce.2017.05.010_bib41","first-page":"2737","article-title":"Regulation and role of post-translational modifications of enhancer of zeste homologue 2 in cancer development","volume":"6","author":"Lu","year":"2016","journal-title":"Am. J. Cancer. Res."},{"key":"10.1016\/j.mce.2017.05.010_bib42","doi-asserted-by":"crossref","first-page":"e39767","DOI":"10.1371\/journal.pone.0039767","article-title":"The negative feddback-loop between the oncomir Mir-24-1 and menin modulates the Men1 tumorigenesis by mimicking the \u201cKnudson's second hit\u201d","volume":"7","author":"Luzi","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.mce.2017.05.010_bib43","doi-asserted-by":"crossref","first-page":"44","DOI":"10.4161\/cbt.10.1.11994","article-title":"DNA methylation-related vitamin D receptor insensitivity in breast cancer","volume":"10","author":"Marik","year":"2010","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.mce.2017.05.010_bib44","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.tibs.2013.05.005","article-title":"Menin: a scaffold protein that controls gene expression and cell signaling","volume":"38","author":"Matkar","year":"2013","journal-title":"Trends. Biochem. Sci."},{"key":"10.1016\/j.mce.2017.05.010_bib45","doi-asserted-by":"crossref","first-page":"710","DOI":"10.4161\/epi.6.6.15773","article-title":"Frequent epigenetics inactivation of KEAP1 gene in non-small cell lung cancer","volume":"6","author":"Muscarella","year":"2011","journal-title":"Epigenetics"},{"key":"10.1016\/j.mce.2017.05.010_bib46","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.15252\/embj.201490649","article-title":"Reprogramming of cell fate: epigenetic memory and the erasure of memories past","volume":"34","author":"Nashun","year":"2015","journal-title":"EMBO. J."},{"key":"10.1016\/j.mce.2017.05.010_bib47","doi-asserted-by":"crossref","first-page":"3450","DOI":"10.1074\/mcp.M116.062240","article-title":"Dynamic protein interactions of the polycomb repressive complex 2 during differentiation of pluripotent cells","volume":"15","author":"Oliviero","year":"2016","journal-title":"Mol. Cell. Proteom."},{"key":"10.1016\/j.mce.2017.05.010_bib48","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1111\/j.1365-2265.2011.04134.x","article-title":"A\u00a0novel deletion of the MEN1 gene in alarge family of multiple endocrine neoplasia type 1 (MEN1) with aggressive phenotype","volume":"75","author":"Raef","year":"2011","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"10.1016\/j.mce.2017.05.010_bib49","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.critrevonc.2015.07.008","article-title":"TET proteins in cancer: current 'state of the art'","volume":"96","author":"Raw\u0142uszko-Wieczorek","year":"2015","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.mce.2017.05.010_bib50","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1479-5876-7-20","article-title":"MicroRNA and gene expression patterns in the differentiation of human embryonic stem cells","volume":"7","author":"Ren","year":"2009","journal-title":"J.\u00a0Transl. Med."},{"key":"10.1016\/j.mce.2017.05.010_bib51","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1517\/14728222.2013.788152","article-title":"Deciphering HIC1 control pathways to reveal new avenues in cancer therapeutics","volume":"17","author":"Rood","year":"2013","journal-title":"Expert. Opin. Ther. Targets"},{"key":"10.1016\/j.mce.2017.05.010_bib52","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1128\/MCB.25.2.612-620.2005","article-title":"The parafibromin tumor suppressor protein is part of a human Paf1 complex","volume":"25","author":"Rozenblatt-Rosen","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.mce.2017.05.010_bib53","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/modpathol.3800577","article-title":"Variability in the expression of polycomb proteins in different normal and tumoral tissues. A pilot study using tissue microarrays","volume":"19","author":"Sanchez-Beato","year":"2006","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.mce.2017.05.010_bib54","doi-asserted-by":"crossref","first-page":"4140","DOI":"10.1200\/JCO.2012.48.5516","article-title":"A\u00a0prognostic DNA methylation signature for stage I non-small-cell lung cancer","volume":"31","author":"Sandoval","year":"2013","journal-title":"J.\u00a0Clin. Oncol."},{"key":"10.1016\/j.mce.2017.05.010_bib55","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s12020-016-0892-y","article-title":"EZH2 and ZFX oncogenes in malignant behaviour of parathyroid neoplasms","volume":"54","author":"Sanpaolo","year":"2016","journal-title":"Endocrine"},{"key":"10.1016\/j.mce.2017.05.010_bib56","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.stem.2010.08.002","article-title":"Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer","volume":"7","author":"Sauvageau","year":"2010","journal-title":"Cell. Stem. Cell."},{"key":"10.1016\/j.mce.2017.05.010_bib57","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1056\/NEJMoa031237","article-title":"Somatic and germ-line mutations of the HRPT2 gene in sporadic parathyroid carcinoma","volume":"349","author":"Shattuck","year":"2003","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.mce.2017.05.010_bib58","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1002\/gcc.20895","article-title":"The DNA methylome of benign and malignant parathyroid tumours","volume":"50","author":"Starker","year":"2011","journal-title":"Genes. Chromosomes. Cancer"},{"key":"10.1016\/j.mce.2017.05.010_bib59","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1101\/gad.870101","article-title":"Tumor formation and inactivation of RIZ1, an Rb-binding member of a nuclear protein-methyltransferase superfamily","volume":"15","author":"Steele-Perkins","year":"2001","journal-title":"Genes. Dev."},{"key":"10.1016\/j.mce.2017.05.010_bib60","doi-asserted-by":"crossref","first-page":"646","DOI":"10.4161\/epi.24823","article-title":"Global and gene-specific promoter methylation analysis in primary hyperparathyroidism","volume":"8","author":"Sulaiman","year":"2013","journal-title":"Epigenetics"},{"key":"10.1016\/j.mce.2017.05.010_bib26","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1046\/j.1365-2265.2000.01081.x","article-title":"Reduced vitamin D receptor expression in parathyroid adenomas: implications for pathogenesis","volume":"53","author":"Sudhaker, Rao","year":"2000","journal-title":"Clin. Endocrinol. (Oxf)"},{"key":"10.1016\/j.mce.2017.05.010_bib61","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1186\/1476-4598-9-294","article-title":"Aberrant WNT\/\u03b2-catenin signaling in parathyroid carcinoma","volume":"9","author":"Svedlund","year":"2010","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.mce.2017.05.010_bib62","doi-asserted-by":"crossref","first-page":"E1307","DOI":"10.1210\/jc.2011-3136","article-title":"Hypermethylated in cancer 1 (HIC1), a tumor suppressor gene epigenetically deregulated in hyperparathyroid tumors by histone H3 lysine modification","volume":"97","author":"Svedlund","year":"2012","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2017.05.010_bib63","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1530\/ERC-13-0497","article-title":"The histone methyltransferase EZH2, an oncogene common to benign and malignant parathyroid tumors","volume":"21","author":"Svedlund","year":"2014","journal-title":"Endocr. Relat. Cancer."},{"key":"10.1016\/j.mce.2017.05.010_bib64","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1126\/science.1170116","article-title":"Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1","volume":"324","author":"Tahiliani","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.mce.2017.05.010_bib65","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1210\/jc.2006-2010","article-title":"Hypermethylation of adenosine triphosphate-binding cassette transporter genes in primary hyperparathyroidism and its effect on sestamibi imaging","volume":"92","author":"Takeuchi","year":"2007","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2017.05.010_bib66","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1053\/j.gastro.2011.04.023","article-title":"microRNAs and the MYC network: a major piece in the puzzle of liver cancer","volume":"140","author":"Toffanin","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.mce.2017.05.010_bib67","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s13577-016-0143-9","article-title":"Hypermethylation of the CaSR and VDR genes in the parathyroid glands in chronic kidney disease rats with high-phosphate diet","volume":"29","author":"Uchiyama","year":"2016","journal-title":"Hum. Cell."},{"key":"10.1016\/j.mce.2017.05.010_bib68","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1530\/JME-11-0189","article-title":"The microRNA cluster C19MC is deregulated in parathyroid tumours","volume":"49","author":"Vaira","year":"2012","journal-title":"J.Mol. Endocrinol."},{"key":"10.1016\/j.mce.2017.05.010_bib69","article-title":"MicroRNAs in parathyroid physiopathology","author":"Vaira","year":"2016","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.mce.2017.05.010_bib70","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.cell.2004.08.005","article-title":"Stem cells and cancer; the polycomb connection","volume":"118","author":"Valk-Lingbeek","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.mce.2017.05.010_bib72","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1530\/EJE-13-0085","article-title":"Simultaneous expression analysis of vitamin D receptor, calcium-sensing receptor, cyclin D1, and PTH in symptomatic primary hyperparathyroidism in Asian Indians","volume":"169","author":"Varshney","year":"2013","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.mce.2017.05.010_bib73","doi-asserted-by":"crossref","first-page":"E1631","DOI":"10.1210\/jc.2013-1699","article-title":"Methylation status of the CpG islands in vitamin D and calcium-sensing receptor gene promoters does not explain the reduced gene expressions in parathyroid adenomas","volume":"98","author":"Varshney","year":"2013","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2017.05.010_bib74","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1136\/jmg.2003.016725","article-title":"Genetic testing in familial isolated hyperparathyroidism: unexpected results and their implications","volume":"41","author":"Warner","year":"2004","journal-title":"J.\u00a0Med. Genet."},{"key":"10.1016\/j.mce.2017.05.010_bib75","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1093\/nar\/gkp991","article-title":"The tumor suppressor, parafibromin, mediates histone H3 K9 methylation for cyclin D1 repression","volume":"38","author":"Yang","year":"2010","journal-title":"Nucleic. Acid. Res."},{"key":"10.1016\/j.mce.2017.05.010_bib76","doi-asserted-by":"crossref","first-page":"e583","DOI":"10.1038\/cddis.2013.98","article-title":"Menin mediates epigenetic regulation via histone H3 lysine 9 methylation","volume":"4","author":"Yang","year":"2013","journal-title":"Cell. Death. Dis."},{"key":"10.1016\/j.mce.2017.05.010_bib77","doi-asserted-by":"crossref","first-page":"12633","DOI":"10.18632\/oncotarget.7279","article-title":"Loss of MEN1 activates DNMT1 implicating DNA hypermethylation as a driver of MEN1 tumorigenesis","volume":"7","author":"Yuan","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.mce.2017.05.010_bib78","first-page":"535401","article-title":"2014 FBP1 is an interacting partner of menin","author":"Zaman","year":"2014","journal-title":"Int. J. Endocrinol."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720717302587?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720717302587?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T02:05:30Z","timestamp":1602036330000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720717302587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":80,"alternative-id":["S0303720717302587"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2017.05.010","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alterations of DNA methylation in parathyroid tumors","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2017.05.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}