{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T15:28:50Z","timestamp":1767972530870,"version":"3.49.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570612"],"award-info":[{"award-number":["81570612"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370826"],"award-info":[{"award-number":["81370826"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Clinical Medical Research Center Program of Jiangsu Province","award":["BL2014080"],"award-info":[{"award-number":["BL2014080"]}]},{"DOI":"10.13039\/501100012154","name":"Scientific Innovation Research of College Graduates in Jiangsu Province","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012154","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","award":["KYLX16_0297"],"award-info":[{"award-number":["KYLX16_0297"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","award":["KYLX15_0180"],"award-info":[{"award-number":["KYLX15_0180"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.mce.2018.01.001","type":"journal-article","created":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T14:13:25Z","timestamp":1515593605000},"page":"44-52","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Vitamin D suppresses macrophage infiltration by down-regulation of TREM-1 in diabetic nephropathy rats"],"prefix":"10.1016","volume":"473","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3295-7379","authenticated-orcid":false,"given":"Yu","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinfeng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuteng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoliang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.mce.2018.01.001_bib1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1189\/jlb.0312145","article-title":"TREM-1: intracellular signaling pathways and interaction with pattern recognition receptors","volume":"93","author":"Arts","year":"2013","journal-title":"J.\u00a0Leukoc. Biol."},{"issue":"41","key":"10.1016\/j.mce.2018.01.001_bib2","doi-asserted-by":"crossref","first-page":"6209","DOI":"10.2174\/1381612822666160826110539","article-title":"Therapeutic potential of targeting TREM-1 in inflammatory diseases and cancer","volume":"22","author":"Bosco","year":"2016","journal-title":"Curr. Pharmaceut. Des."},{"issue":"6832","key":"10.1016\/j.mce.2018.01.001_bib3","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1038\/35074114","article-title":"TREM-1 amplifies inflammation and is a crucial mediator of septic shock","volume":"410","author":"Bouchon","year":"2001","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.mce.2018.01.001_bib4","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.semnephrol.2016.08.001","article-title":"Developing treatments for chronic kidney disease in the 21st century","volume":"36","author":"Breyer","year":"2016","journal-title":"Semin. Nephrol."},{"issue":"7","key":"10.1016\/j.mce.2018.01.001_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0068640","article-title":"TLR-2\/TLR-4 TREM-1 signaling pathway is dispensable in inflammatory myeloid cells during sterile kidney injury","volume":"8","author":"Campanholle","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.mce.2018.01.001_bib6","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.yexmp.2007.11.004","article-title":"Regulation of TREM expression in hepatic macrophages and endothelial cells during acute endotoxemia","volume":"84","author":"Chen","year":"2008","journal-title":"Exp. Mol. Pathol."},{"issue":"3","key":"10.1016\/j.mce.2018.01.001_bib7","doi-asserted-by":"crossref","first-page":"393","DOI":"10.4239\/wjd.v5.i3.393","article-title":"Diabetic nephropathy and inflammation","volume":"5","author":"Duran-Salgado","year":"2014","journal-title":"World J. Diabetes"},{"issue":"4","key":"10.1016\/j.mce.2018.01.001_bib8","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1093\/ndt\/gfv053","article-title":"A\u00a0new chance to beat diabetic kidney disease: innate immunity and MCP-1: a matter of good and bad macrophages?","volume":"30","author":"Gnudi","year":"2015","journal-title":"Nephrol. Dial. Transplant."},{"issue":"9","key":"10.1016\/j.mce.2018.01.001_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0107228","article-title":"Vitamin D deficiency aggravates chronic kidney disease progression after ischemic acute kidney injury","volume":"9","author":"Goncalves","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.mce.2018.01.001_bib10","doi-asserted-by":"crossref","DOI":"10.4061\/2011\/419524","article-title":"Vitamin d receptor activators and clinical outcomes in chronic kidney disease","volume":"2011","author":"Gravellone","year":"2011","journal-title":"Int. J. Nephrol."},{"issue":"4","key":"10.1016\/j.mce.2018.01.001_bib11","doi-asserted-by":"crossref","first-page":"994","DOI":"10.2337\/db16-1199","article-title":"Developmental role of macrophage Cannabinoid-1 receptor signaling in Type-2 diabetes","volume":"66","author":"Jourdan","year":"2017","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.mce.2018.01.001_bib12","doi-asserted-by":"crossref","first-page":"R78","DOI":"10.1186\/bcr2927","article-title":"Dietary fat increases solid tumor growth and metastasis of 4T1 murine mammary carcinoma cells and mortality in obesity-resistant BALB\/c mice","volume":"13","author":"Kim","year":"2011","journal-title":"Breast Cancer Res."},{"issue":"1\u20132","key":"10.1016\/j.mce.2018.01.001_bib13","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.imlet.2013.08.012","article-title":"Regulation of TREM-1 expression by 1,25-dihydroxyvitamin D3 in human monocytes\/macrophages","volume":"154","author":"Kim","year":"2013","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.mce.2018.01.001_bib14","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2147\/IJNRD.S40172","article-title":"Diabetic nephropathy - complications and treatment","volume":"7","author":"Lim","year":"2014","journal-title":"Int. J. Nephrol. Renovascular Dis."},{"issue":"8","key":"10.1016\/j.mce.2018.01.001_bib15","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1007\/s00125-009-1399-3","article-title":"Antibody blockade of c-fms suppresses the progression of inflammation and injury in early diabetic nephropathy in obese db\/db mice","volume":"52","author":"Lim","year":"2009","journal-title":"Diabetologia"},{"key":"10.1016\/j.mce.2018.01.001_bib16","doi-asserted-by":"crossref","first-page":"146154","DOI":"10.1155\/2012\/146154","article-title":"Inflammation in diabetic nephropathy","volume":"2012","author":"Lim","year":"2012","journal-title":"Mediat. Inflamm."},{"issue":"2","key":"10.1016\/j.mce.2018.01.001_bib17","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.diabres.2014.04.020","article-title":"Expression and cellular distribution of TLR4, MyD88, and NF-kappaB in diabetic renal tubulointerstitial fibrosis, in\u00a0vitro and in\u00a0vivo","volume":"105","author":"Liu","year":"2014","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"6","key":"10.1016\/j.mce.2018.01.001_bib18","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1038\/ki.2014.205","article-title":"TREM-1 regulates macrophage polarization in ureteral obstruction","volume":"86","author":"Lo","year":"2014","journal-title":"Kidney Int."},{"issue":"2","key":"10.1016\/j.mce.2018.01.001_bib19","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/path.4133","article-title":"Macrophage plasticity and polarization in tissue repair and remodelling","volume":"229","author":"Mantovani","year":"2013","journal-title":"J.\u00a0Pathol."},{"issue":"2","key":"10.1016\/j.mce.2018.01.001_bib20","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.4049\/jimmunol.178.2.1144","article-title":"Lipopolysaccharide-induced up-regulation of triggering receptor expressed on myeloid cells-1 expression on macrophages is regulated by endogenous prostaglandin E2","volume":"178","author":"Murakami","year":"2007","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.mce.2018.01.001_bib21","first-page":"47","article-title":"Novel attributions of TREMs in immunity","volume":"20","author":"Pandupuspitasari","year":"2016","journal-title":"Curr. Issues Mol. Biol."},{"key":"10.1016\/j.mce.2018.01.001_bib22","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.phrs.2016.11.004","article-title":"Roles of the NLRP3 inflammasome in the pathogenesis of diabetic nephropathy","volume":"114","author":"Qiu","year":"2016","journal-title":"Pharmacol. Res."},{"issue":"Pt A","key":"10.1016\/j.mce.2018.01.001_bib23","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.jsbmb.2013.10.016","article-title":"25(OH) vitamin D suppresses macrophage adhesion and migration by downregulation of ER stress and scavenger receptor A1 in type 2 diabetes","volume":"144","author":"Riek","year":"2014","journal-title":"J.\u00a0Steroid Biochem. Mol. Biol."},{"issue":"6","key":"10.1016\/j.mce.2018.01.001_bib24","doi-asserted-by":"crossref","first-page":"F647","DOI":"10.1152\/ajprenal.00090.2011","article-title":"Beyond proteinuria: VDR activation reduces renal inflammation in experimental diabetic nephropathy","volume":"302","author":"Sanchez-Nino","year":"2012","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"7","key":"10.1016\/j.mce.2018.01.001_bib25","first-page":"3224","article-title":"Signifcant association of TREM-1 with HMGB1, TLRs and RAGE in the pathogenesis of insulin resistance in obese diabetic populations","volume":"9","author":"Saravanan","year":"2017","journal-title":"Am. J. Transl. Res."},{"issue":"3","key":"10.1016\/j.mce.2018.01.001_bib26","doi-asserted-by":"crossref","first-page":"466","DOI":"10.2337\/diabetes.49.3.466","article-title":"Early glomerular macrophage recruitment in streptozotocin-induced diabetic rats","volume":"49","author":"Sassy-Prigent","year":"2000","journal-title":"Diabetes"},{"issue":"12","key":"10.1016\/j.mce.2018.01.001_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0082498","article-title":"Role of TREM1-DAP12 in renal inflammation during obstructive nephropathy","volume":"8","author":"Tammaro","year":"2013","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.mce.2018.01.001_bib28","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.semnephrol.2010.03.007","article-title":"Macrophages and diabetic nephropathy","volume":"30","author":"Tesch","year":"2010","journal-title":"Semin. Nephrol."},{"issue":"9752","key":"10.1016\/j.mce.2018.01.001_bib29","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/S0140-6736(10)61304-9","article-title":"Into the light? Diabetic nephropathy and vitamin D","volume":"376","author":"Thomas","year":"2010","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.mce.2018.01.001_bib30","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1002\/eji.200425932","article-title":"KARAP\/DAP12\/TYROBP: three names and a multiplicity of biological functions","volume":"35","author":"Tomasello","year":"2005","journal-title":"Eur. J. Immunol."},{"issue":"2","key":"10.1016\/j.mce.2018.01.001_bib31","doi-asserted-by":"crossref","first-page":"494","DOI":"10.2337\/db16-0773","article-title":"Macrophage Cyclooxygenase-2 protects against development of diabetic nephropathy","volume":"66","author":"Wang","year":"2017","journal-title":"Diabetes"},{"issue":"7","key":"10.1016\/j.mce.2018.01.001_bib32","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1128\/IAI.00144-11","article-title":"TREM-1 amplifies corneal inflammation after Pseudomonas aeruginosa infection by modulating Toll-like receptor signaling and Th1\/Th2-type immune responses","volume":"79","author":"Wu","year":"2011","journal-title":"Infect. Immun."},{"key":"10.1016\/j.mce.2018.01.001_bib33","article-title":"HIV-related proteins prolong macrophage survival through induction of Triggering receptor expressed on myeloid cells-1","volume":"7","author":"Yuan","year":"2017","journal-title":"Sci. Rep."},{"issue":"21","key":"10.1016\/j.mce.2018.01.001_bib34","doi-asserted-by":"crossref","first-page":"15118","DOI":"10.1074\/jbc.M113.536490","article-title":"Triggering receptor expressed on myeloid cells 1 (TREM-1)-mediated Bcl-2 induction prolongs macrophage survival","volume":"289","author":"Yuan","year":"2014","journal-title":"J.\u00a0Biol. Chem."},{"issue":"6","key":"10.1016\/j.mce.2018.01.001_bib35","doi-asserted-by":"crossref","first-page":"471","DOI":"10.11569\/wcjd.v21.i6.471","article-title":"Effect of TREM-1 expression in intestinal macrophages on their invasion and proliferation of intestinal epithelial cells","volume":"21","author":"Zhang","year":"2013","journal-title":"World Chin. J. Dig."},{"key":"10.1016\/j.mce.2018.01.001_bib36","article-title":"NLRP3 inflammasome expression and signaling in human diabetic wounds and in high glucose induced macrophages","volume":"2017","author":"Zhang","year":"2017","journal-title":"J.\u00a0Diabetes. Res."},{"issue":"1\u20132","key":"10.1016\/j.mce.2018.01.001_bib37","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s11010-014-2242-9","article-title":"The novel role of TRPC6 in vitamin D ameliorating podocyte injury in STZ-induced diabetic rats","volume":"399","author":"Zhang","year":"2015","journal-title":"Mol. Cell. Biochem."},{"issue":"12","key":"10.1016\/j.mce.2018.01.001_bib38","doi-asserted-by":"crossref","first-page":"4939","DOI":"10.1210\/en.2014-1020","article-title":"Vitamin D prevents podocyte injury via regulation of macrophage M1\/M2 phenotype in diabetic nephropathy rats","volume":"155","author":"Zhang","year":"2014","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.mce.2018.01.001_bib39","first-page":"33","article-title":"Fasting capillary blood glucose: an appropriate measurement in screening for diabetes and pre-diabetes in low-resource rural settings","volume":"36","author":"Zhao","year":"2013","journal-title":"J.\u00a0Endocrinol. Invest."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720718300017?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720718300017?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T14:05:40Z","timestamp":1759586740000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720718300017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":39,"alternative-id":["S0303720718300017"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2018.01.001","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vitamin D suppresses macrophage infiltration by down-regulation of TREM-1 in diabetic nephropathy rats","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2018.01.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}