{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:42:47Z","timestamp":1790844167524,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473205"],"award-info":[{"award-number":["81473205"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673433"],"award-info":[{"award-number":["81673433"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010218","name":"Department of Science and Technology","doi-asserted-by":"publisher","award":["2015B020232009"],"award-info":[{"award-number":["2015B020232009"]}],"id":[{"id":"10.13039\/501100010218","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010218","name":"Department of Science and Technology","doi-asserted-by":"publisher","award":["2014B020210003"],"award-info":[{"award-number":["2014B020210003"]}],"id":[{"id":"10.13039\/501100010218","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010218","name":"Department of Science and Technology","doi-asserted-by":"publisher","award":["2013B090700010"],"award-info":[{"award-number":["2013B090700010"]}],"id":[{"id":"10.13039\/501100010218","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Major Project of Platform Construction Education Department of Guangdong Province","award":["2014GKPT002"],"award-info":[{"award-number":["2014GKPT002"]}]},{"name":"Guangzhou Science and Technology Program Project","award":["201604020121"],"award-info":[{"award-number":["201604020121"]}]},{"name":"111 Project of China","award":["B16047"],"award-info":[{"award-number":["B16047"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.mce.2018.05.009","type":"journal-article","created":{"date-parts":[[2018,5,10]],"date-time":"2018-05-10T04:53:16Z","timestamp":1525927996000},"page":"1-14","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"special_numbering":"C","title":["JMJD3 inhibition protects against isoproterenol-induced cardiac hypertrophy by suppressing \u03b2-MHC expression"],"prefix":"10.1016","volume":"477","author":[{"given":"Zhen","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5766-2775","authenticated-orcid":false,"given":"Jing","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panxia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiteng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiantao","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5433-0302","authenticated-orcid":false,"given":"Peiqing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2018.05.009_bib1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.gde.2007.12.003","article-title":"The emerging functions of histone demethylases","volume":"18","author":"Agger","year":"2008","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.mce.2018.05.009_bib2","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.1242\/dev.049395","article-title":"H3K27me3 regulates BMP activity in developing spinal cord","volume":"137","author":"Akizu","year":"2010","journal-title":"Development (Cambridge, England)"},{"key":"10.1016\/j.mce.2018.05.009_bib3","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1038\/onc.2010.579","article-title":"The H3K27me3 demethylase, KDM6B, is induced by Epstein-Barr virus and over-expressed in Hodgkin's Lymphoma","volume":"30","author":"Anderton","year":"2011","journal-title":"Oncogene"},{"key":"10.1016\/j.mce.2018.05.009_bib4","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1038\/nature04048","article-title":"Reversing histone methylation","volume":"436","author":"Bannister","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.mce.2018.05.009_bib5","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/cr.2011.22","article-title":"Regulation of chromatin by histone modifications","volume":"21","author":"Bannister","year":"2011","journal-title":"Cell Res."},{"key":"10.1016\/j.mce.2018.05.009_bib6","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.cell.2007.05.009","article-title":"High-resolution profiling of histone methylations in the human genome","volume":"129","author":"Barski","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.mce.2018.05.009_bib7","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1097\/FJC.0000000000000466","article-title":"The cardioprotective effect of dexmedetomidine in rats is dose-dependent and mediated by BKCa channels","volume":"69","author":"Behmenburg","year":"2017","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.mce.2018.05.009_bib8","doi-asserted-by":"crossref","first-page":"976","DOI":"10.4161\/epi.21615","article-title":"Mechanisms of histone H3 lysine 27 trimethylation remodeling during early mammalian development","volume":"7","author":"Bogliotti","year":"2012","journal-title":"Epigenetics"},{"key":"10.1016\/j.mce.2018.05.009_bib9","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.biocel.2015.07.006","article-title":"JMJD3 as an epigenetic regulator in development and disease","volume":"67","author":"Burchfield","year":"2015","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.mce.2018.05.009_bib10","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/j.celrep.2012.09.013","article-title":"The H3K27 demethylase JMJD3 is required for maintenance of the embryonic respiratory neuronal network, neonatal breathing, and survival","volume":"2","author":"Burgold","year":"2012","journal-title":"Cell Rep."},{"key":"10.1016\/j.mce.2018.05.009_bib11","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1101\/gad.1652908","article-title":"Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease","volume":"22","author":"Cloos","year":"2008","journal-title":"Gene Dev."},{"key":"10.1016\/j.mce.2018.05.009_bib12","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/hdy.2010.54","article-title":"Epigenetics and gene expression","volume":"105","author":"Gibney","year":"2010","journal-title":"Heredity"},{"key":"10.1016\/j.mce.2018.05.009_bib13","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1177\/0748233714552687","article-title":"The regulatory role of nickel on H3K27 demethylase JMJD3 in kidney cancer cells","volume":"32","author":"Guo","year":"2016","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.mce.2018.05.009_bib14","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.ejphar.2015.05.056","article-title":"Kaempferol protects cardiomyocytes against anoxia\/reoxygenation injury via mitochondrial Epathway mediated by SIRT1","volume":"761","author":"Guo","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.mce.2018.05.009_bib15","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/aps.2017.58","article-title":"G3BP2 is involved in isoproterenol-induced cardiac hypertrophy through activating the NF-kappaB signaling pathway","volume":"39","author":"Hong","year":"2018","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.mce.2018.05.009_bib16","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.bcp.2017.02.016","article-title":"Protein kinase CK2alpha catalytic subunit ameliorates diabetic renal inflammatory fibrosis via NF-kappaB signaling pathway","volume":"132","author":"Huang","year":"2017","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.mce.2018.05.009_bib17","first-page":"715","article-title":"JmjC-domain-containing proteins and histone demethylation. Nature reviews","volume":"7","author":"Klose","year":"2006","journal-title":"Genetics"},{"key":"10.1016\/j.mce.2018.05.009_bib18","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2007.02.005","article-title":"Chromatin modifications and their function","volume":"128","author":"Kouzarides","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.mce.2018.05.009_bib19","doi-asserted-by":"crossref","first-page":"17466","DOI":"10.1074\/jbc.M210804200","article-title":"Analysis of myosin heavy chain functionality in the heart","volume":"278","author":"Krenz","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2018.05.009_bib20","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/nature11262","article-title":"A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response","volume":"488","author":"Kruidenier","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.mce.2018.05.009_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004524","article-title":"Stage-dependent and locus-specific role of histone demethylase Jumonji D3 (JMJD3) in the embryonic stages of lung development","volume":"10","author":"Li","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.mce.2018.05.009_bib22","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.bcp.2017.10.010","article-title":"Endogenous hydrogen sulfide regulates histone demethylase JMJD3-mediated inflammatory response in LPS-stimulated macrophages and in a mouse model of LPS-induced septic shock","volume":"149","author":"Liu","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.mce.2018.05.009_bib23","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.trsl.2016.03.002","article-title":"SIRT6 suppresses isoproterenol-induced cardiac hypertrophy through activation of autophagy","volume":"172","author":"Lu","year":"2016","journal-title":"Transl. Res."},{"key":"10.1016\/j.mce.2018.05.009_bib24","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1111\/j.1476-5381.2010.00750.x","article-title":"Renin-angiotensin-aldosterone system blockade for cardiovascular diseases: current status","volume":"160","author":"Ma","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.mce.2018.05.009_bib25","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1093\/eurheartj\/ehn156","article-title":"Diabetes, left ventricular systolic dysfunction, and chronic heart failure","volume":"29","author":"MacDonald","year":"2008","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.mce.2018.05.009_bib26","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/cvr\/cvu122","article-title":"Chromatin modifications remodel cardiac gene expression","volume":"103","author":"Mathiyalagan","year":"2014","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.mce.2018.05.009_bib27","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.cardiores.2006.11.036","article-title":"Derepression of pathological cardiac genes by members of the CaM kinase superfamily","volume":"73","author":"McKinsey","year":"2007","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.mce.2018.05.009_bib28","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1475-2840-13-43","article-title":"Effect of vildagliptin, a dipeptidyl peptidase 4 inhibitor, on cardiac hypertrophy induced by chronic beta-adrenergic stimulation in rats","volume":"13","author":"Miyoshi","year":"2014","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.mce.2018.05.009_bib29","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.bcp.2015.10.004","article-title":"Nicorandil enhances the efficacy of mesenchymal stem cell therapy in isoproterenol-induced heart failure in rats","volume":"98","author":"Mohamed","year":"2015","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.mce.2018.05.009_bib30","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1161\/01.CIR.87.5.1451","article-title":"Regulation of myosin heavy chain genes in the heart","volume":"87","author":"Morkin","year":"1993","journal-title":"Circulation"},{"key":"10.1016\/j.mce.2018.05.009_bib31","doi-asserted-by":"crossref","first-page":"62131","DOI":"10.18632\/oncotarget.19100","article-title":"Inhibitor of H3K27 demethylase JMJD3\/UTX GSK-J4 is a potential therapeutic option for castration resistant prostate cancer","volume":"8","author":"Morozov","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.mce.2018.05.009_bib32","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1172\/JCI114351","article-title":"Molecular basis of cardiac performance. Plasticity of the myocardium generated through protein isoform switches","volume":"84","author":"Nadal-Ginard","year":"1989","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mce.2018.05.009_bib33","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1161\/CIRCRESAHA.113.302035","article-title":"Jmjd3 controls mesodermal and cardiovascular differentiation of embryonic stem cells","volume":"113","author":"Ohtani","year":"2013","journal-title":"Circ. Res."},{"key":"10.1016\/j.mce.2018.05.009_bib34","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s10741-007-9007-4","article-title":"Cardiac hypertrophy induced by sustained beta-adrenoreceptor activation: pathophysiological aspects","volume":"12","author":"Osadchii","year":"2007","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.mce.2018.05.009_bib35","doi-asserted-by":"crossref","first-page":"20164","DOI":"10.1073\/pnas.1315155110","article-title":"Genome-wide analysis of histone marks identifying an epigenetic signature of promoters and enhancers underlying cardiac hypertrophy","volume":"110","author":"Papait","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mce.2018.05.009_bib36","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/35020506","article-title":"Regulation of chromatin structure by site-specific histone H3 methyltransferases","volume":"406","author":"Rea","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.mce.2018.05.009_bib37","first-page":"6607","article-title":"GSKJ4, a selective jumonji H3K27 demethylase inhibitor, effectively targets ovarian cancer stem cells","volume":"35","author":"Sakaki","year":"2015","journal-title":"Anticancer Res."},{"key":"10.1016\/j.mce.2018.05.009_bib38","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1007\/s00109-014-1182-x","article-title":"Histone demethylase Jumonji D3 (JMJD3\/KDM6B) at the nexus of epigenetic regulation of inflammation and the aging process","volume":"92","author":"Salminen","year":"2014","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.mce.2018.05.009_bib39","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.bcp.2010.03.024","article-title":"Carbonylation of myosin heavy chains in rat heart during diabetes","volume":"80","author":"Shao","year":"2010","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.mce.2018.05.009_bib40","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1186\/1471-2407-12-470","article-title":"Expression and significance of histone H3K27 demethylases in renal cell carcinoma","volume":"12","author":"Shen","year":"2012","journal-title":"BMC Canc."},{"key":"10.1016\/j.mce.2018.05.009_bib41","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1161\/01.RES.82.10.1029","article-title":"Comparison of unitary displacements and forces between 2 cardiac myosin isoforms by the optical trap technique: molecular basis for cardiac adaptation","volume":"82","author":"Sugiura","year":"1998","journal-title":"Circ. Res."},{"key":"10.1016\/j.mce.2018.05.009_bib42","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1172\/JCI88353","article-title":"The H3K9 dimethyltransferases EHMT1\/2 protect against pathological cardiac hypertrophy","volume":"127","author":"Thienpont","year":"2017","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mce.2018.05.009_bib43","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/cr.2007.83","article-title":"JMJD3 is a histone H3K27 demethylase","volume":"17","author":"Xiang","year":"2007","journal-title":"Cell Res."},{"key":"10.1016\/j.mce.2018.05.009_bib44","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1093\/carcin\/bgu136","article-title":"Loss of histone demethylase KDM6B enhances aggressiveness of pancreatic cancer through downregulation of C\/EBPalpha","volume":"35","author":"Yamamoto","year":"2014","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.mce.2018.05.009_bib45","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.yexcr.2017.08.024","article-title":"GSKJ4, an H3K27me3 demethylase inhibitor, effectively suppresses the breast cancer stem cells","volume":"359","author":"Yan","year":"2017","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.mce.2018.05.009_bib46","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.bbamcr.2016.01.006","article-title":"Histone demethylase Jmjd3 regulates osteoblast apoptosis through targeting anti-apoptotic protein Bcl-2 and pro-apoptotic protein Bim","volume":"1863","author":"Yang","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mce.2018.05.009_bib47","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1002\/jbmr.464","article-title":"Epigenetic regulation of osteoclast differentiation: possible involvement of Jmjd3 in the histone demethylation of Nfatc1","volume":"26","author":"Yasui","year":"2011","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.mce.2018.05.009_bib48","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1093\/jmcb\/mjv003","article-title":"JMJD3 promotes chondrocyte proliferation and hypertrophy during endochondral bone formation in mice","volume":"7","author":"Zhang","year":"2015","journal-title":"J. Mol. Cell Biol."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720718301576?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720718301576?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,20]],"date-time":"2018-09-20T23:26:06Z","timestamp":1537485966000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720718301576"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":48,"alternative-id":["S0303720718301576"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2018.05.009","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"JMJD3 inhibition protects against isoproterenol-induced cardiac hypertrophy by suppressing \u03b2-MHC expression","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2018.05.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}