{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:37:21Z","timestamp":1777595841811,"version":"3.51.4"},"reference-count":85,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T00:00:00Z","timestamp":1565308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012067","name":"Babraham Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012067","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.mce.2019.110537","type":"journal-article","created":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T11:28:12Z","timestamp":1565350092000},"page":"110537","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Aldosterone, STX and amyloid-\u03b21-42 peptides modulate GPER (GPR30) signalling in an embryonic mouse hippocampal cell line (mHippoE-18)"],"prefix":"10.1016","volume":"496","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9635-502X","authenticated-orcid":false,"given":"Peter D.","family":"Evans","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2019.110537_bib1","doi-asserted-by":"crossref","first-page":"6438","DOI":"10.1074\/jbc.M112.412478","article-title":"Post-synaptic density- 95 (PSD-95) binding capacity of G-protein-coupled receptor 30 (GPR30), an estrogen receptor that can be identified in hippocampal dendritic spines","volume":"288","author":"Akama","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2019.110537_bib2","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.neuropharm.2016.07.003","article-title":"Emerging roles for the novel estrogen-sensing receptor GPER1 in the CNS","volume":"113","author":"Alexander","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.mce.2019.110537_bib3","doi-asserted-by":"crossref","first-page":"435","DOI":"10.3109\/10799893.2015.1122042","article-title":"Rapid effects of aldosterone in primary cultures of cardiomyocytes \u2013 do they suggest the existence of a membrane-bound receptor?","volume":"36","author":"Araujo","year":"2016","journal-title":"J. Recept. Signal Transduct."},{"key":"10.1016\/j.mce.2019.110537_bib4","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1210\/ME.2014-1410","article-title":"Role of nongenomic signaling pathways activated by aldosterone during cardiac reperfusion injury","volume":"29","author":"Ashton","year":"2015","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.mce.2019.110537_bib5","doi-asserted-by":"crossref","first-page":"11406","DOI":"10.1073\/pnas.1936664100","article-title":"\u03b2-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors","volume":"100","author":"Azzi","year":"2003","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.mce.2019.110537_bib6","article-title":"Rescue of cyclic AMP mediated long term potentiation impairment in the hippocampus of Mecp2 knockout (Mecp2-\/y) mice by rolipram","author":"Balakishnan","year":"2016","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.mce.2019.110537_bib7","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.tem.2015.05.005","article-title":"Nicolaus Copernicus and the rapid vascular responses to aldosterone","volume":"26","author":"Barton","year":"2015","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.mce.2019.110537_bib8","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.jsbmb.2017.03.021","article-title":"Twenty years of the G protein-coupled estrogen receptor GPER: historical and personal perspectives","volume":"176","author":"Barton","year":"2018","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.mce.2019.110537_bib9","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1093\/cvr\/cvs016","article-title":"Angiotensin II-aldosterone interaction in human coronary microarteries involves GPR30, EGFR, and endothelial NO synthase","volume":"94","author":"Batenburg","year":"2012","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.mce.2019.110537_bib10","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/jnc.12158","article-title":"A comparison of the signalling properties of two tyramine receptors from Drosophila","volume":"125","author":"Bayliss","year":"2013","journal-title":"J. Neurochem."},{"key":"10.1016\/j.mce.2019.110537_bib11","doi-asserted-by":"crossref","first-page":"22117","DOI":"10.1074\/jbc.M114.566893","article-title":"G protein-coupled receptor 30 (GPR30) forms a plasma membrane complex with membrane-associated guanylate kinases (MAGUKs) and protein kinase A-anchoring protein 5 (AKAP5) that constitutively inhibits cAMP production","volume":"289","author":"Broselid","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2019.110537_bib12","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s10158-010-0111-0","article-title":"Amphioxus expresses both vertebrate-type and invertebrate- type dopamine D1 receptors","volume":"10","author":"Burman","year":"2010","journal-title":"Invertebr. Neurosci."},{"key":"10.1016\/j.mce.2019.110537_bib13","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1471-4159.2009.06295.x","article-title":"Identification and characterization of a novel Amphioxus dopamine D1-like receptor","volume":"111","author":"Burman","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.mce.2019.110537_bib14","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.3233\/JAD-170543","article-title":"Oxidative stress, amyloid-\u03b2 peptide, and altered key molecular pathways in the pathogenesis and progression of Alzheimer's disease","volume":"62","author":"Butterfield","year":"2018","journal-title":"J. Alzheimer's Dis."},{"key":"10.1016\/j.mce.2019.110537_bib15","doi-asserted-by":"crossref","first-page":"22441","DOI":"10.1074\/jbc.M111.224071","article-title":"Down-modulation of the G protein-coupled estrogen receptor, GPER, from the cell surface occurs via a trans-Golgi-proteasome pathway","volume":"286","author":"Cheng","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2019.110537_bib16","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.mce.2013.11.005","article-title":"Anatomical location and redistribution of G protein-coupled estrogen receptor-1 during the estrus cycle in mouse kidney and specific binding to estrogens but not aldosterone","volume":"382","author":"Cheng","year":"2014","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2019.110537_bib17","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1111\/j.1471-4159.1993.tb09836.x","article-title":"NMDA receptor activation increases cyclic AMP in area CA1 of the hippocampus via calcium\/calmodulin stimulation of adenylyl cyclase","volume":"61","author":"Chetkovich","year":"1993","journal-title":"J. Neurochem."},{"key":"10.1016\/j.mce.2019.110537_bib18","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.ygcen.2013.10.015","article-title":"GPCR-mediated rapid, non-genomic actions of steroids: comparisons between DmDopEcR and GPER1 (GPR30)","volume":"195","author":"Evans","year":"2014","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.mce.2019.110537_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0152138","article-title":"Characterisation of signalling by the endogenous GPER1 (GPR30) receptor in an embryonic mouse hippocampal cell line (mHippoE-18)","volume":"11","author":"Evans","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.mce.2019.110537_bib20","series-title":"Agonist-specific Coupling of G-Protein Coupled Receptors to Second Messenger Systems. Current Neurochemical and Pharmacological Aspects of Biogenic Amines: Their Function, Oxidative Deamination and Inhibition","first-page":"259","volume":"vol. 106","author":"Evans","year":"1995"},{"key":"10.1016\/j.mce.2019.110537_bib21","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1096\/fj.15-275552","article-title":"Aldosterone mediates metastatic spread of renal cancer via the G protein-coupled estrogen receptor (GPER)","volume":"30","author":"Feldman","year":"2016","journal-title":"FASEB J."},{"key":"10.1016\/j.mce.2019.110537_bib22","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1152\/physiol.00010.2004","article-title":"Why calcium-stimulated adenylyl cyclases?","volume":"19","author":"Ferguson","year":"2004","journal-title":"Physiology"},{"key":"10.1016\/j.mce.2019.110537_bib23","doi-asserted-by":"crossref","first-page":"2952","DOI":"10.1210\/en.2012-1061","article-title":"G-protein-coupled estrogen receptor-1 GPER-1: its mechanism of action and role in female reproductive cancer, renal and vascular physiology","volume":"153","author":"Filardo","year":"2012","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2019.110537_bib24","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1210\/mend.14.10.0532","article-title":"Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF","volume":"14","author":"Filardo","year":"2000","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.mce.2019.110537_bib25","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.neuroscience.2010.06.076","article-title":"Estrogen receptor alpha and G-protein coupled receptor 30 mediate the neuroprotective effects of 17\u03b2-estradiol in novel murine hippocampal cell models","volume":"170","author":"Gingerich","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.mce.2019.110537_bib26","doi-asserted-by":"crossref","first-page":"391","DOI":"10.3233\/JAD-150756","article-title":"STX, a novel membrane estrogen receptor ligand, protects against A\u03b2 toxicity","volume":"51","author":"Gray","year":"2016","journal-title":"J. Alzheimer's Dis."},{"key":"10.1016\/j.mce.2019.110537_bib27","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1161\/HYPERTENSIONAHA.110.161653","article-title":"GPR30 expression is required for the mineralocorticoid receptor independent rapid vascular effects of aldosterone","volume":"57","author":"Gros","year":"2011","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2019.110537_bib28","doi-asserted-by":"crossref","first-page":"C532","DOI":"10.1152\/ajpcell.00203.2012","article-title":"Aldosterone mediates its rapid effects in vascular endothelial cells through GPER activation","volume":"304","author":"Gros","year":"2013","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.mce.2019.110537_bib29","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nrm2101","article-title":"Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide","volume":"8","author":"Haass","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mce.2019.110537_bib30","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jsbmb.2017.04.012","article-title":"GPER1\/GPR30 in the brain: crosstalk with classical estrogen receptors and implications for behaviour","volume":"176","author":"Hadjimarkou","year":"2018","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.mce.2019.110537_bib31","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s13024-016-0110-7","article-title":"Synaptophysin depletion and intraneuronal A\u03b2 in organotypic hippocampal slice cultures from huAPP transgenic mice","volume":"11","author":"Harwell","year":"2016","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.mce.2019.110537_bib32","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s10741-016-9591-2","article-title":"Genomic and rapid effects of aldosterone: what we know and do not know thus far","volume":"22","author":"Hermidorff","year":"2017","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.mce.2019.110537_bib33","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1023\/A:1023684503883","article-title":"Forskolin as a tool for examining adenylyl cyclase expression, regulation, and G protein signaling","volume":"23","author":"Insel","year":"2003","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.mce.2019.110537_bib34","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/nature12000","article-title":"Conformational biosensors reveal GPCR signalling from endosomes","volume":"495","author":"Irannejad","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.mce.2019.110537_bib35","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1210\/me.2014-1397","article-title":"Neural signalling of estradiol in the hypothalamus","volume":"29","author":"Kelly","year":"2015","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.mce.2019.110537_bib36","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/S0165-6147(00)89032-X","article-title":"Agonist-receptor efficacy II: agonist-trafficking of receptor signals","volume":"16","author":"Kenakin","year":"1995","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.mce.2019.110537_bib37","doi-asserted-by":"crossref","first-page":"17386","DOI":"10.1016\/S0021-9258(17)32449-3","article-title":"Evidence that production and release of amyloid \u03b2-protein involves the endocytic pathway","volume":"269","author":"Koo","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2019.110537_bib38","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1038\/nature07761","article-title":"Cellular prion protein mediates impairment of synaptic plasticity by amyloid-\u03b2 oligomers","volume":"457","author":"Laur\u00e9n","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.mce.2019.110537_bib39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0008642","article-title":"Acute administration of non-classical estrogen receptor agonists attenuates ischemia-induced hippocampal neuron loss in middle-aged female rats","volume":"5","author":"Lebesgue","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.mce.2019.110537_bib40","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1530\/JME-13-0021","article-title":"G-protein-coupled receptor 30 interacts with receptor activity-modifying protein 3 and confers sex-dependent cardioprotection","volume":"51","author":"Lenhart","year":"2013","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.mce.2019.110537_bib41","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.neuron.2009.05.012","article-title":"Soluble oligomers of amyloid beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake","volume":"62","author":"Li","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.mce.2019.110537_bib42","doi-asserted-by":"crossref","first-page":"5415","DOI":"10.1158\/0008-5472.CAN-08-1622","article-title":"Stimulating the GPR30 estrogen receptor with a novel tamoxifen analogue activates SF-1 and promotes endometrial cell proliferation","volume":"69","author":"Lin","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.mce.2019.110537_bib43","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.steroids.2013.10.017","article-title":"Vasodilation by GPER in mesenteric arteries involves both endothelial nitric oxide and smooth muscle cAMP signaling","volume":"81","author":"Lindsey","year":"2014","journal-title":"Steroids"},{"key":"10.1016\/j.mce.2019.110537_bib44","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/S0002-9440(10)65184-X","article-title":"Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease","volume":"155","author":"Lue","year":"1999","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.mce.2019.110537_bib45","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1080\/07391102.2014.994102","article-title":"Deciphering the GPER\/GPR30-agonist and antagonists interactions using molecular modeling studies, molecular dynamics, and docking simulations","volume":"33","author":"M\u00e9ndez-Luna","year":"2015","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.mce.2019.110537_bib46","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jsbmb.2016.01.001","article-title":"Understanding the molecular basis of agonist\/antagonist mechanism of GPER1\/GPR30 through structural and energetic analyses","volume":"158","author":"M\u00e9ndez-Luna","year":"2016","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.mce.2019.110537_bib47","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/0091-3057(94)90352-2","article-title":"A simple procedure for assaying cAMP","volume":"48","author":"Munirathinam","year":"1994","journal-title":"Pharmacol., Biochem. Behav."},{"key":"10.1016\/j.mce.2019.110537_bib48","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3233\/JAD-2009-1045","article-title":"A\u03b2-dependent inhibition of LTP in different intracortical circuits of the visual cortex: the role of RAGE","volume":"17","author":"Origlia","year":"2009","journal-title":"J. Alzheimer's Dis."},{"key":"10.1016\/j.mce.2019.110537_bib49","doi-asserted-by":"crossref","first-page":"3410","DOI":"10.1210\/en.2007-1663","article-title":"Estrogen signaling characteristics of Atlantic croaker GPR30 and evidence it is involved in maintenance of oocyte meiotic arrest","volume":"149","author":"Pang","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2019.110537_bib50","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aam8661","article-title":"Activation of CaMKIV by soluble amyloid-\u03b21-42 impedes trafficking of axonal vesicles and impairs activity-dependent synaptogenesis","volume":"10","author":"Park","year":"2017","journal-title":"Sci. Signal."},{"key":"10.1016\/j.mce.2019.110537_bib51","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1124\/pr.114.009712","article-title":"International Union of Basic and Clinical Pharmacology. XCVII. G protein-coupled estrogen receptor and its pharmacological modulators","volume":"67","author":"Prossnitz","year":"2015","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.mce.2019.110537_bib52","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/nrendo.2011.122","article-title":"The G-protein-coupled estrogen receptor GPER in health and disease","volume":"7","author":"Prossnitz","year":"2011","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.mce.2019.110537_bib53","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jsbmb.2015.06.014","article-title":"What have we learned about GPCR function in physiology and disease from knockout mice?","volume":"153","author":"Prossnitz","year":"2015","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.mce.2019.110537_bib54","doi-asserted-by":"crossref","first-page":"6887","DOI":"10.1523\/JNEUROSCI.5291-04.2005","article-title":"Amyloid- \u03b2 peptide inhibits activation of the nitric oxide\/cGMP\/cAMP-responsive element-binding protein pathway during hippocampal synaptic plasticity","volume":"25","author":"Puzzo","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mce.2019.110537_bib55","doi-asserted-by":"crossref","first-page":"9529","DOI":"10.1523\/JNEUROSCI.23-29-09529.2003","article-title":"Rapid signaling of estrogen in hypothalamic neurons involves a novel G-protein-coupled estrogen receptor that activates protein kinase C","volume":"23","author":"Qiu","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mce.2019.110537_bib56","doi-asserted-by":"crossref","first-page":"5649","DOI":"10.1523\/JNEUROSCI.0327-06.2006","article-title":"A G-protein-coupled estrogen receptor is involved in hypothalamic control of energy homeostasis","volume":"26","author":"Qiu","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mce.2019.110537_bib57","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.steroids.2007.11.008","article-title":"Modulation of hypothalamic neuronal activity through a novel G-protein coupled estrogen membrane receptor","volume":"73","author":"Qiu","year":"2008","journal-title":"Steroids"},{"key":"10.1016\/j.mce.2019.110537_bib58","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/nrn.2017.10","article-title":"Operation and plasticity of hippocampal CA3 circuits: implications for memory encoding","volume":"18","author":"Rebola","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.mce.2019.110537_bib59","doi-asserted-by":"crossref","first-page":"F427","DOI":"10.1152\/ajprenal.00072.2014","article-title":"Aldosterone sensitizes connecting tubule glomerular feedback via the aldosterone receptor GPR30","volume":"307","author":"Ren","year":"2014","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"10.1016\/j.mce.2019.110537_bib60","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1126\/science.1106943","article-title":"A transmembrane intracellular estrogen receptor mediates rapid cell signaling","volume":"307","author":"Revankar","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.mce.2019.110537_bib61","doi-asserted-by":"crossref","first-page":"94","DOI":"10.18632\/oncotarget.6475","article-title":"GPER is involved in the stimulatory effects of aldosterone in breast cancer cells and breast tumor-derived endothelial cells","volume":"7","author":"Rigiracciolo","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.mce.2019.110537_bib62","doi-asserted-by":"crossref","first-page":"30436","DOI":"10.1074\/jbc.271.48.30436","article-title":"Transient activation of cyclic AMP-dependent protein kinase during hippocampal long-term potentiation","volume":"271","author":"Robertson","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2019.110537_bib63","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.1365-2826.2009.01846.x","article-title":"Cross-talk between membrane-initiated and nuclear-initiated oestrogen signalling in the hypothalamus","volume":"21","author":"Roepke","year":"2009","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.mce.2019.110537_bib64","doi-asserted-by":"crossref","first-page":"T107","DOI":"10.1530\/JOE-16-0659","article-title":"Nongenomic effects via the mineralocorticoid receptor","volume":"234","author":"Ruhs","year":"2017","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.mce.2019.110537_bib65","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.mce.2013.03.018","article-title":"G protein-coupled estrogen receptor is required for the neuritogenic mechanism of 17\u03b2-estradiol in developing hippocampal neurons","volume":"372","author":"Ruiz-Palmero","year":"2013","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2019.110537_bib66","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1111\/jne.12071","article-title":"GPER 1 \u2013 trials and tribulations of a membrane oestrogen receptor","volume":"25","author":"Srivastava","year":"2013","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.mce.2019.110537_bib67","doi-asserted-by":"crossref","first-page":"6145","DOI":"10.1523\/JNEUROSCI.1005-05.2005","article-title":"Rapid, non-genomic responses to ecdysteroids and catecholamines mediated by a novel Drosophila G-protein coupled receptor","volume":"25","author":"Srivastava","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mce.2019.110537_bib68","doi-asserted-by":"crossref","first-page":"3912","DOI":"10.1523\/JNEUROSCI.6256-09.2010","article-title":"Diurnal in vivo and rapid in vitro effects of estradiol on voltage-gated calcium channels in gonadotropin-releasing hormone neurons","volume":"30","author":"Sun","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mce.2019.110537_bib69","doi-asserted-by":"crossref","first-page":"E2518","DOI":"10.1073\/pnas.1306832110","article-title":"A\u03b2 induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss","volume":"110","author":"Talantova","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mce.2019.110537_bib70","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.mce.2014.01.024","article-title":"GPR30 mediates estrogen rapid signalling and neuroprotection","volume":"387","author":"Tang","year":"2014","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2019.110537_bib71","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.yfrne.2012.08.001","article-title":"Neuroestrogen, rapid action of estradiol and GnRH neurons","volume":"33","author":"Terasawa","year":"2012","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.mce.2019.110537_bib72","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1210\/en.2004-1064","article-title":"Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells","volume":"146","author":"Thomas","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2019.110537_bib73","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1210\/en.2003-1462","article-title":"Minireview: a plethora of estrogen receptors in the brain: where will it end?","volume":"145","author":"Toran-Allerand","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2019.110537_bib74","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.tips.2014.04.007","article-title":"Biased ligands at G-protein-coupled receptors: promise and progress","volume":"35","author":"Violin","year":"2014","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.mce.2019.110537_bib75","doi-asserted-by":"crossref","first-page":"13217","DOI":"10.1073\/pnas.172504199","article-title":"Amyloid \u03b2-peptide inhibition of the PKA\/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signalling","volume":"99","author":"Vitolo","year":"2002","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.mce.2019.110537_bib76","doi-asserted-by":"crossref","first-page":"10831","DOI":"10.1021\/bi001048s","article-title":"The oligomerization of amyloid \u03b2-protein begins intracellularly in cells derived from human brain","volume":"39","author":"Walsh","year":"2000","journal-title":"Biochemistry"},{"key":"10.1016\/j.mce.2019.110537_bib77","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1523\/JNEUROSCI.4391-04.2005","article-title":"Certain inhibitors of synthetic amyloid \u03b2-peptide (A\u03b2) fibrillogenesis block oligomerization of natural A\u03b2 and thereby rescue long-term potentiation","volume":"25","author":"Walsh","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mce.2019.110537_bib78","doi-asserted-by":"crossref","first-page":"31852","DOI":"10.1074\/jbc.M111.244335","article-title":"Amyloid \u03b2 peptide1-42 induces internalization and degradation of \u03b22 adrenergic receptors in prefrontal cortical neurons","volume":"286","author":"Wang","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2019.110537_bib79","doi-asserted-by":"crossref","first-page":"3511","DOI":"10.1096\/fj.10-156661","article-title":"Binding of amyloid \u03b2 peptide to \u03b22 adrenergic receptor induces PKA-dependent AMPA receptor hyperactivity","volume":"24","author":"Wang","year":"2010","journal-title":"FASEB J."},{"key":"10.1016\/j.mce.2019.110537_bib80","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jsbmb.2017.01.016","article-title":"Rapid actions of aldosterone revisited: receptors in the limelight","volume":"176","author":"Wehling","year":"2017","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.mce.2019.110537_bib81","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1016\/0006-291X(91)92081-T","article-title":"High affinity aldosterone binding to plasma membrane rich fractions from mononuclear leucocytes: is there a membrane receptor for mineralocorticoids?","volume":"181","author":"Wehling","year":"1991","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mce.2019.110537_bib82","doi-asserted-by":"crossref","DOI":"10.1161\/HYPERTENSIONAHA.111.170977","article-title":"Is GPR30 the membrane aldosterone receptor postulated 20 years ago?","volume":"57","author":"Wendler","year":"2011","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2019.110537_bib83","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1210\/ME.2015-1065","article-title":"Spatial programming of G protein-coupled receptor activity: decoding signaling in health and disease","volume":"29","author":"West","year":"2015","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.mce.2019.110537_bib84","doi-asserted-by":"crossref","first-page":"16657","DOI":"10.1073\/pnas.0707936104","article-title":"A unique mechanism of \u03b2-blocker action: carvedilol stimulates \u03b2-arrestin signaling","volume":"104","author":"Wisler","year":"2007","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.mce.2019.110537_bib85","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1101\/lm.027128.112","article-title":"Role of signal transduction crosstalk between adenylyl cyclase and MAP kinase in hippocampus-dependent memory","volume":"19","author":"Xia","year":"2012","journal-title":"Learn. Mem."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720719302394?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720719302394?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T14:08:53Z","timestamp":1759586933000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720719302394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":85,"alternative-id":["S0303720719302394"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2019.110537","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aldosterone, STX and amyloid-\u03b21-42 peptides modulate GPER (GPR30) signalling in an embryonic mouse hippocampal cell line (mHippoE-18)","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2019.110537","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Author. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"110537"}}