{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T15:28:26Z","timestamp":1775662106073,"version":"3.50.1"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012156","name":"Genesis Research Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.mce.2019.110611","type":"journal-article","created":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T10:26:25Z","timestamp":1570443985000},"page":"110611","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"C","title":["Genome-wide methylation profiling in granulosa lutein cells of women with polycystic ovary syndrome (PCOS)"],"prefix":"10.1016","volume":"500","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9590-287X","authenticated-orcid":false,"given":"E.","family":"Makrinou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.W.","family":"Drong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Christopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Lerner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Chapa-Chorda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Karaderi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Lavery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Hardy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.M.","family":"Lindgren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Franks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2019.110611_bib1","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1093\/humupd\/dmi013","article-title":"Androgen excess fetal programming of female reproduction: a developmental aetiology for polycystic ovary syndrome?","volume":"11","author":"Abbott","year":"2005","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.mce.2019.110611_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1677\/joe.0.1740001","article-title":"Developmental origin of polycystic ovary syndrome - a hypothesis","volume":"174","author":"Abbott","year":"2002","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.mce.2019.110611_bib3","doi-asserted-by":"crossref","first-page":"3459","DOI":"10.1210\/jc.2015-4275","article-title":"Enhanced inflammatory transcriptome in the granulosa cells of women with polycystic ovarian syndrome","volume":"101","author":"Adams","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2019.110611_bib4","doi-asserted-by":"crossref","first-page":"385","DOI":"10.2174\/1389202918666170412112130","article-title":"Aging as an epigenetic phenomenon","volume":"18","author":"Ashapkin","year":"2017","journal-title":"Curr. Genom."},{"key":"10.1016\/j.mce.2019.110611_bib5","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1210\/jc.2003-032046","article-title":"The prevalence and features of the polycystic ovary syndrome in an unselected population","volume":"89","author":"Azziz","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2019.110611_bib6","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1159\/000341682","article-title":"Genetics of polycystic ovary syndrome","volume":"40","author":"Barber","year":"2013","journal-title":"Front. Horm. Res."},{"key":"10.1016\/j.mce.2019.110611_bib7","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1002\/oby.21909","article-title":"The epigenomic analysis of human obesity","volume":"25","author":"Bell","year":"2017","journal-title":"Obesity"},{"key":"10.1016\/j.mce.2019.110611_bib8","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1101\/gr.190629.115","article-title":"The Mendelian disorders of the epigenetic machinery","volume":"25","author":"Bjornsson","year":"2015","journal-title":"Genome Res."},{"key":"10.1016\/j.mce.2019.110611_bib9","doi-asserted-by":"crossref","first-page":"E182","DOI":"10.1210\/jc.2014-2689","article-title":"Further investigation in europeans of susceptibility variants for polycystic ovary syndrome discovered in genome-wide association studies of Chinese individuals","volume":"100","author":"Brower","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2019.110611_bib10","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/ng.732","article-title":"Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3","volume":"43","author":"Chen","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mce.2019.110611_bib11","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1080\/08958378.2017.1392655","article-title":"Perinatal exposure to environmental tobacco smoke is associated with changes in DNA methylation that precede the adult onset of lung disease in a mouse model","volume":"29","author":"Cole","year":"2017","journal-title":"Inhal. Toxicol."},{"key":"10.1016\/j.mce.2019.110611_bib12","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s10815-013-9935-y","article-title":"Gene expression profiling of granulosa cells from PCOS patients following varying doses of human chorionic gonadotropin","volume":"30","author":"Coskun","year":"2013","journal-title":"J. Assist. Reprod. Genet."},{"key":"10.1016\/j.mce.2019.110611_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1007813","article-title":"Large-scale genome-wide meta analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnostic criteria","author":"Day","year":"2018","journal-title":"PLoS Genet."},{"issue":"9","key":"10.1016\/j.mce.2019.110611_bib57","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1038\/ijo.2017.126","article-title":"Metabolic profiling of polycystic ovary syndrome reveals interactions with abdominal obesity","volume":"41","author":"Couto Alves","year":"2017","journal-title":"Int J Obes (Lond)"},{"key":"10.1016\/j.mce.2019.110611_bib14","doi-asserted-by":"crossref","first-page":"8464","DOI":"10.1038\/ncomms9464","article-title":"Causal mechanisms and balancing selection inferred from genetic associations with polycystic ovary syndrome","volume":"6","author":"Day","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mce.2019.110611_bib15","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1210\/er.2011-1034","article-title":"Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications","volume":"33","author":"Diamanti-Kandarakis","year":"2012","journal-title":"Endocr. Rev."},{"issue":"6","key":"10.1016\/j.mce.2019.110611_bib62","first-page":"2984","article-title":"Mutations in mitochondrial tRNA genes may be related to insulin resistance in women with polycystic ovary syndrome.","volume":"Jun 15;9","author":"Ding","year":"2017","journal-title":"Am J Transl Res"},{"key":"10.1016\/j.mce.2019.110611_bib16","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1093\/bioinformatics\/btw691","article-title":"Preprocessing, normalization and integration of the Illumina HumanMethylationEPIC array with minfi","volume":"33","author":"Fortin","year":"2017","journal-title":"Bioinformatics"},{"key":"10.1016\/j.mce.2019.110611_bib17","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1056\/NEJM199509283331307","article-title":"Polycystic ovary syndrome","volume":"333","author":"Franks","year":"1995","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mce.2019.110611_bib18","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.fertnstert.2011.11.029","article-title":"Does PCOS have developmental origins?","volume":"97","author":"Franks","year":"2012","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.mce.2019.110611_bib19","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1093\/humrep\/12.12.2641","article-title":"The genetic basis of polycystic ovary syndrome","volume":"12","author":"Franks","year":"1997","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.mce.2019.110611_bib20","doi-asserted-by":"crossref","first-page":"3396","DOI":"10.1210\/jc.2008-0369","article-title":"Ovarian morphology is a marker of heriTable biochemical traits in sisters with polycystic ovaries","volume":"93","author":"Franks","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.mce.2019.110611_bib61","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.autrev.2007.06.001","article-title":"Functional autoantibodies, a new paradigm in autoimmunity?","volume":"Nov;7","author":"Gleicher","year":"2007","journal-title":"Autoimmun Rev."},{"key":"10.1016\/j.mce.2019.110611_bib21","doi-asserted-by":"crossref","first-page":"7502","DOI":"10.1038\/ncomms8502","article-title":"Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations","volume":"6","author":"Hayes","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mce.2019.110611_bib22","first-page":"869","article-title":"Application of proteomics to the study of polycystic ovary syndrome","volume":"34","author":"Insenser","year":"2011","journal-title":"J. Endocrinol. Investig."},{"key":"10.1016\/j.mce.2019.110611_bib23","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/nrendo.2014.102","article-title":"The management of patients with polycystic ovary syndrome","volume":"10","author":"Jayasena","year":"2014","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.mce.2019.110611_bib24","doi-asserted-by":"crossref","first-page":"D1032","DOI":"10.1093\/nar\/gkv1146","article-title":"PCOSKB: a KnowledgeBase on genes, diseases, ontology terms and biochemical pathways associated with PolyCystic Ovary Syndrome","volume":"44","author":"Joseph","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mce.2019.110611_bib25","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-4939-1804-1_1","article-title":"Cancer epigenetics: an introduction","volume":"1238","author":"Kanwal","year":"2015","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.mce.2019.110611_bib26","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1530\/EJE-12-0891","article-title":"BMP system expression in GCs from polycystic ovary syndrome women and the in vitro effects of BMP4, BMP6, and BMP7 on GC steroidogenesis","volume":"168","author":"Khalaf","year":"2013","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.mce.2019.110611_bib28","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1093\/bioinformatics\/btt703","article-title":"Causal analysis approaches in ingenuity pathway analysis","volume":"30","author":"Kramer","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.mce.2019.110611_bib29","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s13059-015-0600-x","article-title":"A coherent approach for analysis of the Illumina HumanMethylation450 BeadChip improves data quality and performance in epigenome-wide association studies","volume":"16","author":"Lehne","year":"2015","journal-title":"Genome Biol."},{"key":"10.1016\/j.mce.2019.110611_bib30","article-title":"Proteomic profiling for identification of novel biomarkers differentially expressed in human ovaries from polycystic ovary syndrome patients","volume":"11","author":"Li","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.mce.2019.110611_bib32","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1136\/jmedgenet-2011-100727","article-title":"Identification of YAP1 as a novel susceptibility gene for polycystic ovary syndrome","volume":"49","author":"Li","year":"2012","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.mce.2019.110611_bib33","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.mehy.2006.09.076","article-title":"Epigenetic abnormality: a possible mechanism underlying the fetal origin of polycystic ovary syndrome","volume":"70","author":"Li","year":"2008","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.mce.2019.110611_bib34","doi-asserted-by":"crossref","first-page":"E2006","DOI":"10.1210\/jc.2013-2495","article-title":"Cross-ethnic meta-analysis of genetic variants for polycystic ovary syndrome","volume":"98","author":"Louwers","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2019.110611_bib35","doi-asserted-by":"crossref","first-page":"6961","DOI":"10.1038\/s41598-017-07346-x","article-title":"Identification of reference genes for qRT-PCR in granulosa cells of healthy women and polycystic ovarian syndrome patients","volume":"7","author":"Lv","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mce.2019.110611_bib36","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1111\/cen.12068","article-title":"Diabetes and cardiovascular events in women with polycystic ovary syndrome: a 20-year retrospective cohort study","volume":"78","author":"Mani","year":"2013","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.mce.2019.110611_bib37","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1093\/humrep\/dep399","article-title":"The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria","volume":"25","author":"March","year":"2010","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.mce.2019.110611_bib38","doi-asserted-by":"crossref","first-page":"389","DOI":"10.2217\/epi.15.114","article-title":"Validation of a DNA methylation microarray for 850,000 CpG sites of the human genome enriched in enhancer sequences","volume":"8","author":"Moran","year":"2016","journal-title":"Epigenomics"},{"key":"10.1016\/j.mce.2019.110611_bib39","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1054\/bjoc.2001.2163","article-title":"Expression of the Hypermethylated in Cancer gene (HIC-1) is associated with good outcome in human breast cancer","volume":"85","author":"Nicoll","year":"2001","journal-title":"Br. J. Canc."},{"key":"10.1016\/j.mce.2019.110611_bib40","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1007\/s00109-012-0881-4","article-title":"A molecular mechanism underlying ovarian dysfunction of polycystic ovary syndrome: hyperandrogenism induces epigenetic alterations in the granulosa cells","volume":"90","author":"Qu","year":"2012","journal-title":"J. Mol. Med. (Berl.)"},{"key":"10.1016\/j.mce.2019.110611_bib41","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.fertnstert.2003.10.004","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome","volume":"81","author":"Rotterdam EA-SPCWG","year":"2004","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.mce.2019.110611_bib42","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.ajhg.2010.01.014","article-title":"Allelic skewing of DNA methylation is widespread across the genome","volume":"86","author":"Schalkwyk","year":"2010","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.mce.2019.110611_bib43","article-title":"Genome-wide methylated DNA immunoprecipitation analysis of patients with polycystic ovary syndrome","volume":"8","author":"Shen","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.mce.2019.110611_bib44","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1038\/ng.2384","article-title":"Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome","volume":"44","author":"Shi","year":"2012","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mce.2019.110611_bib45","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1101\/gr.104695.109","article-title":"Allele-specific methylation is prevalent and is contributed by CpG-SNPs in the human genome","volume":"20","author":"Shoemaker","year":"2010","journal-title":"Genome Res."},{"key":"10.1016\/j.mce.2019.110611_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2147\/CLEP.S37559","article-title":"Epidemiology, diagnosis, and management of polycystic ovary syndrome","volume":"6","author":"Sirmans","year":"2013","journal-title":"Clin. Epidemiol."},{"key":"10.1016\/j.mce.2019.110611_bib47","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1093\/bioinformatics\/bti270","article-title":"Use of within-array replicate spots for assessing differential expression in microarray experiments","volume":"21","author":"Smyth","year":"2005","journal-title":"Bioinformatics"},{"issue":"2","key":"10.1016\/j.mce.2019.110611_bib59","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1530\/REP-08-0317","article-title":"The hedgehog-patched signaling pathway and function in the mammalian ovary: a novel role for hedgehog proteins in stimulating proliferation and steroidogenesis of theca cells","volume":"Aug;138","author":"Spicer","year":"2009","journal-title":"Reproduction"},{"key":"10.1016\/j.mce.2019.110611_bib48","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s13148-017-0335-5","article-title":"DNA methylation profiling in peripheral lung tissues of smokers and patients with COPD","volume":"9","author":"Sundar","year":"2017","journal-title":"Clin. Epigenet."},{"key":"10.1016\/j.mce.2019.110611_bib49","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s11926-017-0657-5","article-title":"Epigenetic variability in systemic lupus erythematosus: what we learned from genome-wide DNA methylation studies","volume":"19","author":"Teruel","year":"2017","journal-title":"Curr. Rheumatol. Rep."},{"key":"10.1016\/j.mce.2019.110611_bib50","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1210\/jc.2005-1494","article-title":"Heritability of polycystic ovary syndrome in a Dutch twin-family study","volume":"91","author":"Vink","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"5","key":"10.1016\/j.mce.2019.110611_bib60","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.mito.2010.03.002","article-title":"Maternal diabetes and oocyte quality","volume":"Aug;10","author":"Wang","year":"2010","journal-title":"Mitochondrion"},{"key":"10.1016\/j.mce.2019.110611_bib51","doi-asserted-by":"crossref","first-page":"6603","DOI":"10.18632\/oncotarget.2224","article-title":"Genome-wide DNA methylation and gene expression patterns provide insight into polycystic ovary syndrome development","volume":"5","author":"Wang","year":"2014","journal-title":"Oncotarget"},{"issue":"8","key":"10.1016\/j.mce.2019.110611_bib58","doi-asserted-by":"crossref","first-page":"3558","DOI":"10.1210\/en.2005-0311","article-title":"Hedgehog signaling in mouse ovary: Indian hedgehog and desert hedgehog from granulosa cells induce target gene expression in developing theca cells","volume":"Aug;146","author":"Wijgerde","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2019.110611_bib52","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1210\/jc.2005-2757","article-title":"Review: fetal programming of polycystic ovary syndrome by androgen excess: evidence from experimental, clinical, and genetic association studies","volume":"91","author":"Xita","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2019.110611_bib53","doi-asserted-by":"crossref","first-page":"27899","DOI":"10.18632\/oncotarget.8544","article-title":"Comprehensive analysis of genome-wide DNA methylation across human polycystic ovary syndrome ovary granulosa cell","volume":"7","author":"Xu","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.mce.2019.110611_bib56","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1177\/1933719113512536","article-title":"Increased expression of kindlin 2 in luteinized granulosa cells correlates with androgen receptor level in patients with polycystic ovary syndrome having hyperandrogenemia","volume":"21","author":"Yang","year":"2014","journal-title":"Reprod. Sci."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720719303132?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720719303132?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T14:08:23Z","timestamp":1759586903000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720719303132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":58,"alternative-id":["S0303720719303132"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2019.110611","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genome-wide methylation profiling in granulosa lutein cells of women with polycystic ovary syndrome (PCOS)","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2019.110611","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2019 Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110611"}}