{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T08:09:02Z","timestamp":1778746142238,"version":"3.51.4"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100011333","name":"Westminster Medical School Research Trust","doi-asserted-by":"publisher","award":["1167073"],"award-info":[{"award-number":["1167073"]}],"id":[{"id":"10.13039\/100011333","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011333","name":"Westminster Medical School Research Trust","doi-asserted-by":"publisher","award":["247808"],"award-info":[{"award-number":["247808"]}],"id":[{"id":"10.13039\/100011333","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011333","name":"Westminster Medical School Research Trust","doi-asserted-by":"publisher","award":["1060508"],"award-info":[{"award-number":["1060508"]}],"id":[{"id":"10.13039\/100011333","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013342","name":"NIHR Imperial Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013342","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003921","name":"Department of Health, Australian Government","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000317","name":"Action Medical Research","doi-asserted-by":"publisher","award":["GN2395"],"award-info":[{"award-number":["GN2395"]}],"id":[{"id":"10.13039\/501100000317","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000317","name":"Action Medical Research","doi-asserted-by":"publisher","award":["208701"],"award-info":[{"award-number":["208701"]}],"id":[{"id":"10.13039\/501100000317","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.mce.2019.110633","type":"journal-article","created":{"date-parts":[[2019,11,2]],"date-time":"2019-11-02T03:46:22Z","timestamp":1572666382000},"page":"110633","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["The impact of progesterone and RU-486 on classic pro-labour proteins & contractility in human myometrial tissues during 24-hour exposure to tension & interleukin-1\u03b2"],"prefix":"10.1016","volume":"500","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4669-7029","authenticated-orcid":false,"given":"Pei F.","family":"Lai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ektoras X.","family":"Georgiou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3675-9978","authenticated-orcid":false,"given":"Rachel M.","family":"Tribe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1096-9918","authenticated-orcid":false,"given":"Mark R.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2019.110633_bib1","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3390\/ijms19051296","article-title":"Connexins: synthesis, post-translational modifications, and trafficking in Health and disease","volume":"19","author":"Aasen","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mce.2019.110633_bib2","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1177\/1933719115597787","article-title":"Agonist-dependent downregulation of progesterone receptors in human cervical stromal fibroblasts","volume":"23","author":"Ackerman","year":"2016","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.mce.2019.110633_bib3","doi-asserted-by":"crossref","first-page":"4434","DOI":"10.1210\/en.2016-1654","article-title":"Human parturition involves phosphorylation of progesterone receptor-A at serine-345 in myometrial cells","volume":"157","author":"Amini","year":"2016","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2019.110633_bib4","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0301-2115(02)00422-0","article-title":"The involvement of progesterone in the onset of human labour","volume":"108","author":"Astle","year":"2003","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.mce.2019.110633_bib5","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1210\/jc.2017-02195","article-title":"Retosiban prevents stretch-induced human myometrial contractility and delays labor in cynomolgus monkeys","volume":"103","author":"Aye","year":"2018","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2019.110633_bib6","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1210\/jcem-46-4-622","article-title":"17Beta-Estradiol and progesterone concentrations in myometrium of pregnancy and their relationships to concentrations in peripheral plasma","volume":"46","author":"Batra","year":"1978","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2019.110633_bib7","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/j.1365-2265.1979.tb03114.x","article-title":"Interrelations between plasma and tissue concentrations of 17-beta-estradiol and progesterone during human pregnancy","volume":"11","author":"Batra","year":"1979","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.mce.2019.110633_bib8","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3109\/07853899309147859","article-title":"Mode of action of RU-486","volume":"25","author":"Bygdeman","year":"1993","journal-title":"Ann. Med."},{"key":"10.1016\/j.mce.2019.110633_bib9","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.neulet.2011.09.016","article-title":"Effects of RU486 in the expression of progesterone receptor isoforms in the hypothalamus and the preoptic area of the rat during postpartum estrus","volume":"504","author":"Carrillo-Martinez","year":"2011","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.mce.2019.110633_bib10","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1093\/molehr\/gau005","article-title":"Increased progesterone receptor A expression in labouring human myometrium is associated with decreased promoter occupancy by the histone demethylase JARID1A","volume":"20","author":"Chai","year":"2014","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.mce.2019.110633_bib11","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1093\/molehr\/gas012","article-title":"Term myometrium is characterized by increased activating epigenetic modifications at the progesterone receptor-A promoter","volume":"18","author":"Chai","year":"2012","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.mce.2019.110633_bib12","first-page":"514","article-title":"Endocrine and paracrine regulation of birth at term and preterm","volume":"21","author":"Challis","year":"2000","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.mce.2019.110633_bib13","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.ejogrb.2006.07.024","article-title":"Changes of nuclear factor kappa B (NF-kappa B), cyclooxygenase-2 (COX-2) and matrix metalloproteinase-9 (MMP-9) in human myometrium before and during term labor","volume":"132","author":"Choi","year":"2007","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.mce.2019.110633_bib14","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/S0002-9378(94)70284-5","article-title":"Expression of the gap junction protein connexin-43 is increased in the human myometrium toward term and with the onset of labor","volume":"170","author":"Chow","year":"1994","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.mce.2019.110633_bib15","first-page":"202","article-title":"Mechanism of action of antiprogestins in the pregnant uterus","volume":"761","author":"Chwalisz","year":"1995","journal-title":"Steroid Recept. Antihormones"},{"key":"10.1016\/j.mce.2019.110633_bib16","doi-asserted-by":"crossref","first-page":"E437","DOI":"10.1210\/jc.2010-1541","article-title":"Effects of medroxyprogesterone acetate on gene expression in myometrial explants from pregnant women","volume":"95","author":"Cordeaux","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2019.110633_bib17","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1136\/bmj.1.4812.687","article-title":"Action of the ovarian hormones on uterine muscle","volume":"1","author":"Corner","year":"1953","journal-title":"Br. Med. J."},{"key":"10.1016\/j.mce.2019.110633_bib18","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ajog.2011.03.014","article-title":"Methodology and pharmacological analysis of effects of uterotonic compounds in human myometrium in vitro","volume":"205","author":"Crankshaw","year":"2011","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.mce.2019.110633_bib19","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/aja.1000980206","article-title":"Progesterone block","volume":"98","author":"Csapo","year":"1956","journal-title":"Am. J. Anat."},{"key":"10.1016\/j.mce.2019.110633_bib20","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.1210\/endo.138.7.5247","article-title":"Effects of RU486 on estrogen, progesterone, oxytocin, and their receptors in the rat uterus during late gestation","volume":"138","author":"Fang","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2019.110633_bib21","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1093\/molehr\/gaw037","article-title":"The study of progesterone action in human myometrial explants","volume":"22","author":"Georgiou","year":"2016","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.mce.2019.110633_bib22","doi-asserted-by":"crossref","first-page":"3102","DOI":"10.1128\/MCB.20.9.3102-3115.2000","article-title":"The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor binding","volume":"20","author":"Giangrande","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.mce.2019.110633_bib23","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1113\/expphysiol.2013.075754","article-title":"Kv7 and Kv11 channels in myometrial regulation symposium report","volume":"99","author":"Greenwood","year":"2014","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.mce.2019.110633_bib24","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/aji.12776","article-title":"Gestational tissue inflammatory biomarkers at term labor: asystematic review of literature","volume":"79","author":"Hadley","year":"2018","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.mce.2019.110633_bib25","first-page":"125","article-title":"Progesterone receptor localization and ioforms in myometrium, decidua, and fetal membranes from rhesus macaques: evidence for functional progesterone withdrawal at parturition","volume":"9","author":"Haluska","year":"2002","journal-title":"J. Soc. Gynecol. Investig."},{"key":"10.1016\/j.mce.2019.110633_bib26","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1540\/jsmr.53.73","article-title":"The expression of genes involved in myometrial contractility changes during ex situ culture of pregnant human uterine smooth muscle tissue","volume":"53","author":"Ilicic","year":"2017","journal-title":"J. Smooth Muscle Res."},{"key":"10.1016\/j.mce.2019.110633_bib27","first-page":"4589214","article-title":"Modulation of progesterone receptor isoform expression in pregnant human myometrium","author":"Ilicic","year":"2017","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.mce.2019.110633_bib28","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1210\/me.2012-1328","article-title":"A new strategy for selective targeting of progesterone receptor with passive antagonists","volume":"27","author":"Khan","year":"2013","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.mce.2019.110633_bib29","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.mce.2017.01.034","article-title":"Advances in the role of oxytocin receptors in human parturition","volume":"449","author":"Kim","year":"2017","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2019.110633_bib30","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1590\/1414-431X20122453","article-title":"Maternal serum progesterone, estradiol and estriol levels in successful dinoprostone-induced labor","volume":"46","author":"Konopka","year":"2013","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.mce.2019.110633_bib31","doi-asserted-by":"crossref","first-page":"6369","DOI":"10.1113\/JP272320","article-title":"Differential impact of acute and prolonged cAMP agonist exposure on protein kinase A activation and human myometrium contractile activity","volume":"594","author":"Lai","year":"2016","journal-title":"J. Physiol. Lond."},{"key":"10.1016\/j.mce.2019.110633_bib32","doi-asserted-by":"crossref","first-page":"E1013","DOI":"10.1210\/jc.2010-2310","article-title":"Uterine stretch and progesterone action","volume":"96","author":"Lei","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2019.110633_bib33","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.gene.2016.02.040","article-title":"Calponin isoforms CNN1, CNN2 and CNN3: regulators for actin cytoskeleton functions in smooth muscle and non-muscle cells","volume":"585","author":"Liu","year":"2016","journal-title":"Gene"},{"key":"10.1016\/j.mce.2019.110633_bib34","doi-asserted-by":"crossref","first-page":"7940","DOI":"10.1073\/pnas.122225699","article-title":"Coactivator\/corepressor ratios modulate PR-mediated transcription by the selective receptor modulator RU486","volume":"99","author":"Liu","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.mce.2019.110633_bib35","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1210\/jc.2009-2136","article-title":"Human labor is associated with reduced decidual cell expression of progesterone, but not glucocorticoid, receptors","volume":"95","author":"Lockwood","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2019.110633_bib36","doi-asserted-by":"crossref","first-page":"423","DOI":"10.3109\/00016349709047823","article-title":"High progesterone is related to effective human labor - study of serum progesterone and 5 alpha-pregnane-3,20-dione in normal and abnormal deliveries","volume":"76","author":"Lofgren","year":"1997","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"10.1016\/j.mce.2019.110633_bib37","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1177\/107155760200900508","article-title":"Expression of Gs alpha, connexin-43, connexin-26, and EP1, 3, and 4 receptors in myometrium of prelabor singleton versus multiple gestations and the effects of mechanical stretch and steroids on Gs alpha","volume":"9","author":"Lyall","year":"2002","journal-title":"J. Soc. Gynecol. Investig."},{"key":"10.1016\/j.mce.2019.110633_bib38","doi-asserted-by":"crossref","first-page":"C1206","DOI":"10.1152\/ajpcell.1998.274.5.C1206","article-title":"Serum deprivation induces a unique hypercontractile phenotype of cultured smooth muscle cells","volume":"274","author":"Ma","year":"1998","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.mce.2019.110633_bib39","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1210\/jc.2003-031037","article-title":"Prostaglandins differentially modulate progesterone receptor-A and -B expression in human myometrial cells: evidence for prostaglandin-induced functional progesterone withdrawal","volume":"89","author":"Madsen","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2019.110633_bib40","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1136\/bmj.300.6719.230","article-title":"Analysis of serial measurements in medical-research","volume":"300","author":"Matthews","year":"1990","journal-title":"Br. Med. J."},{"key":"10.1016\/j.mce.2019.110633_bib41","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1210\/jc.2007-0077","article-title":"Nuclear progesterone receptors in the human pregnancy myometrium: evidence that parturition involves functional progesterone withdrawal mediated by increased expression of progesterone receptor-A","volume":"92","author":"Merlino","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2019.110633_bib42","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1055\/s-2006-956771","article-title":"Myometrial progesterone responsiveness","volume":"25","author":"Mesiano","year":"2007","journal-title":"Semin. Reprod. Med."},{"key":"10.1016\/j.mce.2019.110633_bib43","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.1210\/jcem.87.6.8609","article-title":"Progesterone withdrawal and estrogen activation in human parturition are coordinated by progesterone receptor A expression in the myometrium","volume":"87","author":"Mesiano","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2019.110633_bib44","doi-asserted-by":"crossref","first-page":"R525","DOI":"10.1152\/ajpregu.00153.2009","article-title":"Are animal models relevant to key aspects of human parturition?","volume":"297","author":"Mitchell","year":"2009","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.mce.2019.110633_bib45","doi-asserted-by":"crossref","first-page":"3511","DOI":"10.1210\/en.2015-1378","article-title":"The effect of an oxytocin receptor antagonist (retosiban, GSK221149A) on the response of human myometrial explants to prolonged mechanical stretch","volume":"156","author":"Moraitis","year":"2015","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2019.110633_bib46","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1113\/expphysiol.2013.072876","article-title":"The importance of the smooth muscle cytoskeleton to preterm labour","volume":"99","author":"Morgan","year":"2014","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.mce.2019.110633_bib47","doi-asserted-by":"crossref","first-page":"11565","DOI":"10.1038\/ncomms11565","article-title":"Molecular evidence of functional progesterone withdrawal in human myometrium","volume":"7","author":"Nadeem","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mce.2019.110633_bib48","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/j.1365-2826.2008.01668.x","article-title":"Cytokine networks and the regulation of uterine function in pregnancy and parturition","volume":"20","author":"Orsi","year":"2008","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.mce.2019.110633_bib49","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/molehr\/gag001","article-title":"Leukocyte density and pro-inflammatory cytokine expression in human fetal membranes, decidua, cervix and myometrium before and during labour at term","volume":"9","author":"Osman","year":"2003","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.mce.2019.110633_bib50","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1177\/1933719110371517","article-title":"Progesterone receptor isoform expression in the Guinea pig myometrium from normal and growth restricted pregnancies","volume":"17","author":"Palliser","year":"2010","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.mce.2019.110633_bib51","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/BF00215887","article-title":"Uterine smooth-muscle cells in primary culture - alterations in fine-structure, cytoskeletal organisation and growth-characteristics","volume":"246","author":"Palmberg","year":"1986","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.mce.2019.110633_bib52","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.steroids.2009.05.002","article-title":"Nongenomic uterine relaxing effect of RU 486 (mifepristone) prior to its antiprogesterone activity in the human pregnancy","volume":"74","author":"Perusquia","year":"2009","journal-title":"Steroids"},{"key":"10.1016\/j.mce.2019.110633_bib53","first-page":"158","article-title":"Inflammatory stimuli increase progesterone receptor-A stability and transrepressive activity in myometrial cells","volume":"158","author":"Peters","year":"2017","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2019.110633_bib54","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1093\/molehr\/7.9.875","article-title":"Interactions between progesterone receptor isoforms in myometrial cells in human labour","volume":"7","author":"Pieber","year":"2001","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.mce.2019.110633_bib55","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1067\/mob.2002.121108","article-title":"Connexin 43 expression in normal versus dysfunctional labor","volume":"186","author":"Pierce","year":"2002","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.mce.2019.110633_bib56","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1177\/1933719117725826","article-title":"Interaction between progesterone and interleukin-1 beta in modulating progesterone receptor expression and the inflammatory phenotype in human cervical fibroblasts","volume":"25","author":"Pierce","year":"2018","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.mce.2019.110633_bib57","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.steroids.2006.05.009","article-title":"Determination of conformational changes in the progesterone receptor using ELISA-like assays","volume":"71","author":"Pullen","year":"2006","journal-title":"Steroids"},{"key":"10.1016\/j.mce.2019.110633_bib58","doi-asserted-by":"crossref","first-page":"19572","DOI":"10.1074\/jbc.M109.007872","article-title":"The X-ray structure of RU486 bound to the progesterone receptor in a destabilized agonistic conformation","volume":"284","author":"Raaijmakers","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2019.110633_bib59","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1530\/REP-07-0208","article-title":"Follistatin serum concentrations during full-term labour in women - significant differences between spontaneous and induced labour","volume":"134","author":"Rae","year":"2007","journal-title":"Reproduction"},{"key":"10.1016\/j.mce.2019.110633_bib60","doi-asserted-by":"crossref","first-page":"20828","DOI":"10.1073\/pnas.1008301107","article-title":"miR-200 family and targets, ZEB1 and ZEB2, modulate uterine quiescence and contractility during pregnancy and labor","volume":"107","author":"Renthal","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.mce.2019.110633_bib61","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/S0029-7844(97)00116-6","article-title":"Sex steroid receptors and human parturition","volume":"89","author":"Rezapour","year":"1997","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.mce.2019.110633_bib62","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/0039-128X(96)00035-9","article-title":"Myometrial steroid concentration and oxytocin receptor density in parturient women at term","volume":"61","author":"Rezapour","year":"1996","journal-title":"Steroids"},{"key":"10.1016\/j.mce.2019.110633_bib63","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1471-0528.2006.01120.x","article-title":"The preterm parturition syndrome","volume":"113","author":"Romero","year":"2006","journal-title":"BJOG An Int. J. Obstet. Gynaecol."},{"key":"10.1016\/j.mce.2019.110633_bib64","first-page":"715","article-title":"Progesterone and 20alpha-dihydroprogesterone in human myometrium during pregnancy","author":"Runnebaum","year":"1971","journal-title":"Acta Endocrinol."},{"key":"10.1016\/j.mce.2019.110633_bib65","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1113\/jphysiol.1964.sp007507","article-title":"Length-tension relation in rabbit and human myometrium","volume":"175","author":"Schofield","year":"1964","journal-title":"J. Physiol."},{"key":"10.1016\/j.mce.2019.110633_bib66","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1093\/molehr\/5.9.880","article-title":"Expression of cyclo-oxygenase types-1 and-2 in human myometrium throughout pregnancy","volume":"5","author":"Slater","year":"1999","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.mce.2019.110633_bib67","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1056\/NEJMra061360","article-title":"Mechanisms of disease - parturition","volume":"356","author":"Smith","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mce.2019.110633_bib68","doi-asserted-by":"crossref","first-page":"3517","DOI":"10.1210\/jc.2004-1390","article-title":"The mitogen-activated protein kinase dependent expression of prostaglandin H synthase-2 and interleukin-8 messenger ribonucleic acid by myometrial cells: the differential effect of stretch and interleukin-1 beta","volume":"90","author":"Sooranna","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2019.110633_bib69","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/molehr\/gah021","article-title":"Mechanical stretch activates type 2 cyclooxygenase via activator protein-1 transcription factor in human myometrial cells","volume":"10","author":"Sooranna","year":"2004","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.mce.2019.110633_bib70","first-page":"1705","article-title":"The differential expression of myometrial connexin-43, cyclooxygenase-1 and -2, and G(s)alpha proteins in the upper and lower segments of the human uterus during pregnancy and labor","volume":"84","author":"Sparey","year":"1999","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2019.110633_bib71","doi-asserted-by":"crossref","first-page":"E719","DOI":"10.1210\/jc.2011-3251","article-title":"Progesterone receptor-A and -B have opposite effects on proinflammatory gene expression in human myometrial cells: implications for progesterone actions in human pregnancy and parturition","volume":"97","author":"Tan","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2019.110633_bib72","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1113\/jphysiol.2012.228239","article-title":"Expression of gastrin-releasing peptide is increased by prolonged stretch of human myometrium, and antagonists of its receptor inhibit contractility","volume":"590","author":"Tattersall","year":"2012","journal-title":"J. Physiol. Lond."},{"key":"10.1016\/j.mce.2019.110633_bib73","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1530\/REP-07-0461","article-title":"Pro-labour myometrial gene expression: are preterm labour and term labour the same?","volume":"135","author":"Tattersall","year":"2008","journal-title":"Reproduction"},{"key":"10.1016\/j.mce.2019.110633_bib74","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1210\/jc.2004-0277","article-title":"Mechanical stretch up-regulates the human oxytocin receptor in primary human uterine myocytes","volume":"90","author":"Terzidou","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2019.110633_bib75","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ajog.2011.11.001","article-title":"Pulsatile versus continuous administration of oxytocin for induction and augmentation of labor: two randomized controlled trials","volume":"206","author":"Tribe","year":"2012","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.mce.2019.110633_bib76","doi-asserted-by":"crossref","first-page":"8036","DOI":"10.1021\/bi7004575","article-title":"Amino-terminal domain of TIF2 is involved in competing for corepressor binding to glucocorticoid and progesterone receptors","volume":"46","author":"Wang","year":"2007","journal-title":"Biochemistry"},{"key":"10.1016\/j.mce.2019.110633_bib77","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1371\/journal.pone.0105253","article-title":"Progesterone receptor expression declines in the Guinea pig uterus during functional progesterone withdrawal and in response to prostaglandins","volume":"9","author":"Welsh","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.mce.2019.110633_bib78","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1093\/humupd\/5.4.356","article-title":"Glycosylation of G-protein-coupled receptors for hormones central to normal reproductive functioning: its occurrence and role","volume":"5","author":"Wheatley","year":"1999","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.mce.2019.110633_bib79","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1210\/me.2012-1199","article-title":"The microRNA (miR)-199a\/214 cluster mediates opposing effects of progesterone and estrogen on uterine contractility during pregnancy and labor","volume":"26","author":"Williams","year":"2012","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.mce.2019.110633_bib80","doi-asserted-by":"crossref","first-page":"12195","DOI":"10.1073\/pnas.93.22.12195","article-title":"The extreme C terminus of progesterone receptor contains a transcriptional repressor domain that functions through a putative corepressor","volume":"93","author":"Xu","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.mce.2019.110633_bib81","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.jsgi.2004.05.005","article-title":"Tissue-level bioelectrical signals as the trigger for uterine contractions in human pregnancy","volume":"11","author":"Young","year":"2004","journal-title":"J. Soc. Gynecol. Investig."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720719303351?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720719303351?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T07:14:42Z","timestamp":1778742882000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720719303351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":81,"alternative-id":["S0303720719303351"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2019.110633","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The impact of progesterone and RU-486 on classic pro-labour proteins & contractility in human myometrial tissues during 24-hour exposure to tension & interleukin-1\u03b2","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2019.110633","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110633"}}