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Rep."},{"key":"10.1016\/j.mce.2020.110869_bib227","doi-asserted-by":"crossref","first-page":"359","DOI":"10.15252\/emmm.201404846","article-title":"scp>FAT FLUX<\/scp>\u00a0: enzymes, regulators, and pathophysiology of intracellular lipolysis","volume":"7","author":"Zechner","year":"2015","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.mce.2020.110869_bib228","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nrm.2017.76","article-title":"Cytosolic lipolysis and lipophagy: two sides of the same coin","volume":"18","author":"Zechner","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mce.2020.110869_bib229","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0305-0491(90)90178-V","article-title":"Comparative studies on lipogenic enzyme activities in brown adipose tissue and liver of the rat during starvation-refeeeding transition and cold exposure","volume":"97","author":"\u017belewski","year":"1990","journal-title":"Comp. 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