{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T05:52:07Z","timestamp":1781157127398,"version":"3.54.1"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.mce.2020.110870","type":"journal-article","created":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T21:33:37Z","timestamp":1590096817000},"page":"110870","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["LncRNA MEG3-210 regulates endometrial stromal cells migration, invasion and apoptosis through p38 MAPK and PKA\/SERCA2 signalling via interaction with Galectin-1 in endometriosis"],"prefix":"10.1016","volume":"513","author":[{"given":"Yang","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ding","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangwei","family":"Fei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.mce.2020.110870_bib2","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/path.4397","article-title":"Targeting galectin-1-induced angiogenesis mitigates the severity of endometriosis","volume":"234","author":"Bast\u00f3n","year":"2014","journal-title":"J. Pathol."},{"issue":"5","key":"10.1016\/j.mce.2020.110870_bib3","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/S0015-0282(02)03370-8","article-title":"Role of endocrine status and cell type in adhesion of human endometrial cells to the peritoneum in nude mice","volume":"78","author":"Beliard","year":"2002","journal-title":"Fertil. Steril."},{"issue":"3","key":"10.1016\/j.mce.2020.110870_bib5","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1056\/NEJMra0804690","article-title":"Endometriosis","volume":"360","author":"Bulun","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mce.2020.110870_bib6","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ceca.2017.07.001","article-title":"SERCA control of cell death and survival","volume":"69","author":"Chemaly","year":"2018","journal-title":"Cell Calcium"},{"issue":"15","key":"10.1016\/j.mce.2020.110870_bib7","doi-asserted-by":"crossref","first-page":"4037","DOI":"10.1158\/1078-0432.CCR-11-3348","article-title":"Galectin-1 promotes lung cancer progression and chemoresistance by upregulating p38 MAPK, ERK, and cyclooxygenase-2","volume":"18","author":"Chung","year":"2012","journal-title":"Clin. Canc. Res."},{"key":"10.1016\/j.mce.2020.110870_bib8","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.gene.2018.06.046","article-title":"Analysis of long non-coding RNA expression profiles using RNA sequencing in ovarian endometriosis","volume":"673","author":"Cui","year":"2018","journal-title":"Gene"},{"issue":"11 Pt B","key":"10.1016\/j.mce.2020.110870_bib9","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1016\/j.bbamcr.2018.08.005","article-title":"Establishing life is a calcium-dependent TRiP: transient receptor potential channels in reproduction","volume":"1865","author":"De Clercq","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.mce.2020.110870_bib10","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/978-1-4939-1050-2_3","article-title":"Tissue processing and hematoxylin and eosin staining","volume":"1180","author":"Feldman","year":"2014","journal-title":"Methods Mol. Biol."},{"issue":"2","key":"10.1016\/j.mce.2020.110870_bib11","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1095\/biolreprod.116.140756","article-title":"A novel homologous model for noninvasive monitoring of endometriosis progression","volume":"96","author":"Ferrero","year":"2017","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2020.110870_bib12","doi-asserted-by":"crossref","first-page":"109129","DOI":"10.1016\/j.biopha.2019.109129","article-title":"Maternally expressed gene 3 (MEG3): a tumor suppressor long non coding RNA","volume":"118","author":"Ghafouri-Fard","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"8","key":"10.1016\/j.mce.2020.110870_bib13","doi-asserted-by":"crossref","first-page":"996","DOI":"10.15252\/emmm.201505245","article-title":"H19 lncRNA alters stromal cell growth via IGF signaling in the endometrium of women with endometriosis","volume":"7","author":"Ghazal","year":"2015","journal-title":"EMBO Mol. Med."},{"issue":"9447","key":"10.1016\/j.mce.2020.110870_bib14","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(04)17403-5","article-title":"Endometriosis","volume":"364","author":"Giudice","year":"2004","journal-title":"Lancet"},{"issue":"16","key":"10.1016\/j.mce.2020.110870_bib16","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.2174\/1389557519666190304120821","article-title":"Human galectin-1 and its inhibitors: privileged target for cancer and HIV","volume":"19","author":"Goud","year":"2019","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.mce.2020.110870_bib18","first-page":"420747","article-title":"Genevestigator v3: a reference expression database for the meta-analysis of transcriptomes","author":"Hruz","year":"2008","journal-title":"Adv. Bioinf."},{"issue":"14","key":"10.1016\/j.mce.2020.110870_bib19","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1161\/CIRCULATIONAHA.117.031231","article-title":"Regulation of blood pressure by targeting CaV1.2-galectin-1 protein interaction","volume":"138","author":"Hu","year":"2018","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.mce.2020.110870_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gkn923","article-title":"Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists","volume":"37","author":"Huang","year":"2009","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"10.1016\/j.mce.2020.110870_bib21","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1093\/humrep\/deh611","article-title":"Nimesulide, a COX-2 inhibitor, does not reduce lesion size or number in a nude mouse model of endometriosis","volume":"20","author":"Hull","year":"2005","journal-title":"Hum. Reprod."},{"issue":"18","key":"10.1016\/j.mce.2020.110870_bib22","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.128846","article-title":"Extracellular vesicles from endometriosis patients are characterized by a unique miRNA-lncRNA signature","volume":"4","author":"Khalaj","year":"2019","journal-title":"JCI Insight"},{"issue":"6","key":"10.1016\/j.mce.2020.110870_bib23","doi-asserted-by":"crossref","first-page":"7037","DOI":"10.1096\/fj.201802252R","article-title":"Long noncoding RNA CDKN2B-AS1 interacts with transcription factor BCL11A to regulate progression of cerebral infarction through mediating MAP4K1 transcription","volume":"33","author":"Lei","year":"2019","journal-title":"Faseb. J."},{"key":"10.1016\/j.mce.2020.110870_bib25","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s13578-019-0346-3","article-title":"LncRNA H19 over-expression inhibited Th17 cell differentiation to relieve endometriosis through miR-342-3p\/IER3 pathway","volume":"9","author":"Liu","year":"2019","journal-title":"Cell Biosci."},{"issue":"24","key":"10.1016\/j.mce.2020.110870_bib26","first-page":"4742","article-title":"The role of galectins in tumor progression, treatment and prognosis of gynecological cancers","volume":"9","author":"Mandika","year":"2018","journal-title":"J. Canc."},{"issue":"5","key":"10.1016\/j.mce.2020.110870_bib27","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1093\/humupd\/dmr013","article-title":"Endometrial alterations in endometriosis: a systematic review of putative biomarkers","volume":"17","author":"May","year":"2011","journal-title":"Hum. Reprod. Update"},{"issue":"3","key":"10.1016\/j.mce.2020.110870_bib28","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1093\/humupd\/dmv060","article-title":"Kinase signalling pathways in endometriosis: potential targets for non-hormonal therapeutics","volume":"22","author":"McKinnon","year":"2016","journal-title":"Hum. Reprod. Update"},{"issue":"1","key":"10.1016\/j.mce.2020.110870_bib29","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.fertnstert.2008.04.056","article-title":"High prevalence of endometriosis in infertile women with normal ovulation and normospermic partners","volume":"92","author":"Meuleman","year":"2009","journal-title":"Fertil. Steril."},{"issue":"11","key":"10.1016\/j.mce.2020.110870_bib30","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1080\/14789450.2017.1388167","article-title":"Protein purification and analysis: next generation Western blotting techniques","volume":"14","author":"Mishra","year":"2017","journal-title":"Expert Rev. Proteomics"},{"issue":"9","key":"10.1016\/j.mce.2020.110870_bib31","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.bbabio.2018.04.005","article-title":"Mitochondrial cAMP-PKA signaling: what do we really know?","volume":"1859","author":"Ould","year":"2018","journal-title":"Biochim. Biophys. Acta Bioenerg."},{"issue":"1","key":"10.1016\/j.mce.2020.110870_bib32","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s13669-017-0187-1","article-title":"Endometriosis: epidemiology, diagnosis and clinical management","volume":"6","author":"Parasar","year":"2017","journal-title":"Curr. Obstetr. Gynecol. Rep."},{"issue":"3","key":"10.1016\/j.mce.2020.110870_bib35","first-page":"642","article-title":"Isolation, characterization, and comparison of human endometrial and endometriosis cells in vitro","volume":"78","author":"Ryan","year":"1994","journal-title":"J. Clin. Endocrinol. Metabol."},{"issue":"11","key":"10.1016\/j.mce.2020.110870_bib36","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1517\/14728222.2015.1090974","article-title":"MAP kinases and the inflammatory signaling cascade as targets for the treatment of endometriosis?","volume":"19","author":"Santulli","year":"2015","journal-title":"Expert Opin. Ther. Targets"},{"issue":"12","key":"10.1016\/j.mce.2020.110870_bib37","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1007\/s10495-017-1426-7","article-title":"LncRNA MEG3 inhibit endometrial carcinoma tumorigenesis and progression through PI3K pathway","volume":"22","author":"Sun","year":"2017","journal-title":"Apoptosis"},{"issue":"3","key":"10.1016\/j.mce.2020.110870_bib40","first-page":"4138","article-title":"LncRNA MEG3 ameliorates respiratory syncytial virus infection by suppressing TLR4 signaling","volume":"17","author":"Tao","year":"2018","journal-title":"Mol. Med. Rep."},{"issue":"2","key":"10.1016\/j.mce.2020.110870_bib41","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S1535-6108(02)00034-X","article-title":"Bcl-2-dependent modulation of Ca(2+) homeostasis and store-operated channels in prostate cancer cells","volume":"1","author":"Vanden","year":"2002","journal-title":"Canc. Cell"},{"issue":"12","key":"10.1016\/j.mce.2020.110870_bib43","doi-asserted-by":"crossref","first-page":"e114229","DOI":"10.1371\/journal.pone.0114229","article-title":"Galectin-1 overexpression in endometriosis and its regulation by neuropeptides (CRH, UCN) indicating its important role in reproduction and inflammation","volume":"9","author":"Vergetaki","year":"2014","journal-title":"PloS One"},{"issue":"6","key":"10.1016\/j.mce.2020.110870_bib44","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1159\/000438579","article-title":"Genome-wide microarray analysis of long non-coding RNAs in eutopic secretory endometrium with endometriosis","volume":"37","author":"Wang","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.mce.2020.110870_bib45","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.phrs.2017.02.004","article-title":"ATF2, a paradigm of the multifaceted regulation of transcription factors in biology and disease","volume":"119","author":"Watson","year":"2017","journal-title":"Pharmacol. Res."},{"issue":"2","key":"10.1016\/j.mce.2020.110870_bib46","doi-asserted-by":"crossref","first-page":"499","DOI":"10.3892\/ijmm.2017.3038","article-title":"Role of PKA in the process of neonatal cardiomyocyte hypertrophy induced by urotensin II","volume":"40","author":"Xu","year":"2017","journal-title":"Int. J. Mol. Med."},{"issue":"9","key":"10.1016\/j.mce.2020.110870_bib48","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1093\/molehr\/gaz040","article-title":"The estrogen-regulated lncRNA H19\/miR-216a-5p axis alters stromal cell invasion and migration via ACTA2 in endometriosis","volume":"25","author":"Xu","year":"2019","journal-title":"Mol. Hum. Reprod."},{"issue":"10","key":"10.1016\/j.mce.2020.110870_bib49","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1038\/s41419-018-1068-x","article-title":"LncRNA-MEG3 inhibits activation of hepatic stellate cells through SMO protein and miR-212","volume":"9","author":"Yu","year":"2018","journal-title":"Cell Death Dis."},{"issue":"11","key":"10.1016\/j.mce.2020.110870_bib50","doi-asserted-by":"crossref","first-page":"E1404","DOI":"10.1210\/jc.2015-2031","article-title":"C-jun NH2-terminal kinase and p38 inhibition suppresses prostaglandin E2-stimulated aromatase and estrogen receptor levels in human endometriosis","volume":"100","author":"Zeng","year":"2015","journal-title":"J. Clin. Endocrinol. Metabol."},{"issue":"D1","key":"10.1016\/j.mce.2020.110870_bib52","doi-asserted-by":"crossref","first-page":"D754","DOI":"10.1093\/nar\/gkx1098","article-title":"Ensembl 2018","volume":"46","author":"Zerbino","year":"2018","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"10.1016\/j.mce.2020.110870_bib55","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1002\/hep.28882","article-title":"Long noncoding RNA MEG3 induces cholestatic liver injury by interaction with PTBP1 to facilitate shp mRNA decay","volume":"65","author":"Zhang","year":"2017","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.mce.2020.110870_bib56","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1210\/en.2009-0657","article-title":"Maternally expressed gene 3 (MEG3) noncoding ribonucleic acid: isoform structure, expression, and functions","volume":"151","author":"Zhang","year":"2010","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.mce.2020.110870_bib57","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/s41419-018-0305-7","article-title":"Long noncoding RNA MEG3 suppresses liver cancer cells growth through inhibiting beta-catenin by activating PKM2 and inactivating PTEN","volume":"9","author":"Zheng","year":"2018","journal-title":"Cell Death Dis."},{"issue":"3","key":"10.1016\/j.mce.2020.110870_bib58","doi-asserted-by":"crossref","first-page":"R45","DOI":"10.1530\/JME-12-0008","article-title":"MEG3 noncoding RNA: a tumor suppressor","volume":"48","author":"Zhou","year":"2012","journal-title":"J. Mol. Endocrinol."},{"issue":"1","key":"10.1016\/j.mce.2020.110870_bib59","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41572-018-0008-5","article-title":"Endometriosis","volume":"4","author":"Zondervan","year":"2018","journal-title":"Nat. Rev. Dis. Prim."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720720301702?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720720301702?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T14:11:10Z","timestamp":1759587070000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720720301702"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":45,"alternative-id":["S0303720720301702"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2020.110870","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"LncRNA MEG3-210 regulates endometrial stromal cells migration, invasion and apoptosis through p38 MAPK and PKA\/SERCA2 signalling via interaction with Galectin-1 in endometriosis","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2020.110870","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110870"}}