{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T05:16:58Z","timestamp":1793078218412,"version":"4.5.0"},"reference-count":86,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.mce.2020.110950","type":"journal-article","created":{"date-parts":[[2020,7,26]],"date-time":"2020-07-26T17:59:24Z","timestamp":1595786364000},"page":"110950","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Developmental programming: Prenatal testosterone excess disrupts pancreatic islet developmental trajectory in female sheep"],"prefix":"10.1016","volume":"518","author":[{"given":"Ian J.","family":"Jackson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muraly","family":"Puttabyatappa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meha","family":"Muralidharan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almudena","family":"Veiga-Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigid","family":"Gregg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Limesand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasantha","family":"Padmanabhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2020.110950_bib1","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1210\/en.2011-2074","article-title":"Developmental programming: prenatal and postnatal contribution of androgens and insulin in the reprogramming of estradiol positive feedback disruptions in prenatal testosterone-treated sheep","volume":"153","author":"Abi Salloum","year":"2012","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2020.110950_bib2","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1210\/en.2014-2006","article-title":"Developmental programming: exposure to testosterone excess disrupts steroidal and metabolic environment in pregnant sheep","volume":"156","author":"Abi Salloum","year":"2015","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2020.110950_bib3","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/d41586-019-00857-9","article-title":"Scientists rise up against statistical significance","volume":"567","author":"Amrhein","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.mce.2020.110950_bib4","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/0018-506X(85)90042-X","article-title":"Organizational and activational effects of sex steroids on brain and behavior: a reanalysis","volume":"19","author":"Arnold","year":"1985","journal-title":"Horm. Behav."},{"key":"10.1016\/j.mce.2020.110950_bib5","doi-asserted-by":"crossref","first-page":"575","DOI":"10.2147\/VHRM.S1991","article-title":"Fibrosis in diabetes complications: pathogenic mechanisms and circulating and urinary markers","volume":"4","author":"Ban","year":"2008","journal-title":"Vasc. Health Risk Manag."},{"key":"10.1016\/j.mce.2020.110950_bib6","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1007\/s00125-015-3544-5","article-title":"Pancreatic adipose tissue infiltration, parenchymal steatosis and beta cell function in humans","volume":"58","author":"Begovatz","year":"2015","journal-title":"Diabetologia"},{"issue":"Suppl. 1","key":"10.1016\/j.mce.2020.110950_bib7","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.2337\/diabetes.50.2007.S30","article-title":"Endocrine pancreas plasticity under physiological and pathological conditions","volume":"50","author":"Bernard-Kargar","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2020.110950_bib8","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1172\/JCI420","article-title":"Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation","volume":"101","author":"Bollheimer","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mce.2020.110950_bib9","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/0026-0495(80)90014-1","article-title":"Experimental diets affect pancreatic insulin and glucagon differently in male and female mice","volume":"29","author":"Bonnevie-Nielsen","year":"1980","journal-title":"Metabolism"},{"key":"10.1016\/j.mce.2020.110950_bib10","doi-asserted-by":"crossref","first-page":"6218","DOI":"10.1210\/jc.2004-0918","article-title":"Insulin resistance and impaired insulin secretion in prenatally androgenized male rhesus monkeys","volume":"89","author":"Bruns","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2020.110950_bib11","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1146\/annurev-animal-020518-115154","article-title":"Prenatal steroids and metabolic dysfunction: lessons from sheep","volume":"7","author":"Cardoso","year":"2019","journal-title":"Annu. Rev. Anim. Biosci."},{"key":"10.1016\/j.mce.2020.110950_bib12","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1159\/000381830","article-title":"Steroidogenic versus metabolic programming of reproductive neuroendocrine, ovarian and metabolic dysfunctions","volume":"102","author":"Cardoso","year":"2015","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.mce.2020.110950_bib13","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1210\/en.2015-1565","article-title":"Developmental programming: impact of gestational steroid and metabolic milieus on adiposity and insulin sensitivity in prenatal testosterone-treated female sheep","volume":"157","author":"Cardoso","year":"2016","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2020.110950_bib14","doi-asserted-by":"crossref","first-page":"4641","DOI":"10.1210\/en.2016-1613","article-title":"Developmental programming: insulin sensitizer prevents the GnRH-stimulated LH hypersecretion in a sheep model of PCOS","volume":"157","author":"Cardoso","year":"2016","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2020.110950_bib15","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1172\/JCI114219","article-title":"Effects of hypoglycemia and prolonged fasting on insulin and glucagon gene expression. Studies with in situ hybridization","volume":"84","author":"Chen","year":"1989","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mce.2020.110950_bib16","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.molmet.2017.06.019","article-title":"Human beta cell mass and function in diabetes: recent advances in knowledge and technologies to understand disease pathogenesis","volume":"6","author":"Chen","year":"2017","journal-title":"Mol. Metab."},{"key":"10.1016\/j.mce.2020.110950_bib17","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/nature13633","article-title":"Diabetes recovery by age-dependent conversion of pancreatic delta-cells into insulin producers","volume":"514","author":"Chera","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.mce.2020.110950_bib18","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/978-1-4939-7113-8_22","article-title":"Collagen quantification in tissue specimens","volume":"1627","author":"Coentro","year":"2017","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.mce.2020.110950_bib19","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1037\/0033-2909.112.1.155","article-title":"A power primer","volume":"112","author":"Cohen","year":"1992","journal-title":"Psychol. Bull."},{"key":"10.1016\/j.mce.2020.110950_bib20","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1677\/JOE-09-0072","article-title":"One process for pancreatic beta-cell coalescence into islets involves an epithelial-mesenchymal transition","volume":"203","author":"Cole","year":"2009","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.mce.2020.110950_bib21","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1080\/09513590.2017.1342240","article-title":"PCOS and diabetes mellitus: from insulin resistance to altered beta pancreatic function, a link in evolution","volume":"33","author":"Condorelli","year":"2017","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.mce.2020.110950_bib22","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.tem.2014.03.013","article-title":"Revealing transcription factors during human pancreatic beta cell development","volume":"25","author":"Conrad","year":"2014","journal-title":"Trends Endocrinol. Metabol."},{"key":"10.1016\/j.mce.2020.110950_bib23","first-page":"315","article-title":"Pancreatic beta-cells dysfunction in polycystic ovary syndrome","volume":"50","author":"Diamanti-Kandarakis","year":"2008","journal-title":"Panminerva Med."},{"key":"10.1016\/j.mce.2020.110950_bib24","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1055\/s-0034-1371087","article-title":"Intrauterine environment and polycystic ovary syndrome","volume":"32","author":"Dumesic","year":"2014","journal-title":"Semin. Reprod. Med."},{"issue":"Suppl. 1","key":"10.1016\/j.mce.2020.110950_bib25","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1016\/j.fertnstert.2006.04.011","article-title":"Insulin resistance in women with polycystic ovary syndrome","volume":"86","author":"Dunaif","year":"2006","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.mce.2020.110950_bib26","first-page":"1206","article-title":"Timing of prenatal androgen excess determines differential impairment in insulin secretion and action in adult female rhesus monkeys","volume":"85","author":"Eisner","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2020.110950_bib27","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/978-3-319-48382-5_8","article-title":"What is lipotoxicity?","volume":"960","author":"Engin","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"issue":"Suppl. 2","key":"10.1016\/j.mce.2020.110950_bib28","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/dom.13380","article-title":"Pancreatic islet of Langerhans' cytoarchitecture and ultrastructure in normal glucose tolerance and in type 2 diabetes mellitus","volume":"20","author":"Folli","year":"2018","journal-title":"Diabetes Obes. Metabol."},{"key":"10.1016\/j.mce.2020.110950_bib29","first-page":"83","article-title":"Sexual differentiation of the neuroendocrine control of gonadotrophin secretion: concepts derived from sheep models","volume":"59","author":"Foster","year":"2002","journal-title":"Reprod. Suppl."},{"key":"10.1016\/j.mce.2020.110950_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molmet.2019.05.001","article-title":"What role do fat cells play in pancreatic tissue?","volume":"25","author":"Gerst","year":"2019","journal-title":"Mol. Metab."},{"key":"10.1016\/j.mce.2020.110950_bib31","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.siny.2004.03.001","article-title":"Maternal constraint of fetal growth and its consequences","volume":"9","author":"Gluckman","year":"2004","journal-title":"Semin. Fetal Neonatal Med."},{"key":"10.1016\/j.mce.2020.110950_bib32","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1079\/PHN2001145","article-title":"Fetal programming and adult health","volume":"4","author":"Godfrey","year":"2001","journal-title":"Publ. Health Nutr."},{"key":"10.1016\/j.mce.2020.110950_bib33","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1210\/jc.2004-1006","article-title":"beta-Cell function: a key pathological determinant in polycystic ovary syndrome","volume":"90","author":"Goodarzi","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"Suppl. 3","key":"10.1016\/j.mce.2020.110950_bib34","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1093\/ansci\/61.Supplement_3.38","article-title":"Sexual dimorphisms of the brain","volume":"61","author":"Gorski","year":"1985","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.mce.2020.110950_bib35","doi-asserted-by":"crossref","first-page":"13992","DOI":"10.1073\/pnas.0906471106","article-title":"Pancreatic islet amyloidosis, beta-cell apoptosis, and alpha-cell proliferation are determinants of islet remodeling in type-2 diabetic baboons","volume":"106","author":"Guardado-Mendoza","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mce.2020.110950_bib36","doi-asserted-by":"crossref","first-page":"E274","DOI":"10.1152\/ajpendo.00211.2017","article-title":"Androgen signaling expands beta-cell mass in male rats and beta-cell androgen receptor is degraded under high-glucose conditions","volume":"314","author":"Harada","year":"2018","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2020.110950_bib37","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s00109-020-01887-x","article-title":"Paracrine signaling in islet function and survival","volume":"98","author":"Hartig","year":"2020","journal-title":"J. Mol. Med. (Berl.)"},{"key":"10.1016\/j.mce.2020.110950_bib38","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1002\/dmrr.1073","article-title":"Pancreatic fat is negatively associated with insulin secretion in individuals with impaired fasting glucose and\/or impaired glucose tolerance: a nuclear magnetic resonance study","volume":"26","author":"Heni","year":"2010","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.1016\/j.mce.2020.110950_bib39","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0306-4530(83)90055-0","article-title":"Genetic and hormonal factors in sex differentiation of the brain","volume":"8","author":"Jost","year":"1983","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.mce.2020.110950_bib40","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/BF01002772","article-title":"Picrosirius staining plus polarization microscopy, a specific method for collagen detection in tissue sections","volume":"11","author":"Junqueira","year":"1979","journal-title":"Histochem. J."},{"key":"10.1016\/j.mce.2020.110950_bib41","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1172\/JCI29189","article-title":"Insulin resistance and pancreatic beta cell failure","volume":"116","author":"Kasuga","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mce.2020.110950_bib42","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1210\/en.2019-00386","article-title":"Prenatal testosterone excess disrupts placental function in a sheep model of polycystic ovary syndrome","volume":"160","author":"Kelley","year":"2019","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2020.110950_bib43","doi-asserted-by":"crossref","first-page":"6022","DOI":"10.2741\/3133","article-title":"Loss of beta-cells with fibrotic islet destruction in type 2 diabetes mellitus","volume":"13","author":"Kim","year":"2008","journal-title":"Front. Biosci."},{"key":"10.1016\/j.mce.2020.110950_bib44","doi-asserted-by":"crossref","first-page":"E1438","DOI":"10.1210\/jc.2013-1210","article-title":"Hyperinsulinemia stimulates angiogenesis of human fetoplacental endothelial cells: a possible role of insulin in placental hypervascularization in diabetes mellitus","volume":"98","author":"Lassance","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2020.110950_bib45","doi-asserted-by":"crossref","first-page":"R1297","DOI":"10.1152\/ajpregu.00494.2004","article-title":"Diminished beta-cell replication contributes to reduced beta-cell mass in fetal sheep with intrauterine growth restriction","volume":"288","author":"Limesand","year":"2005","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.mce.2020.110950_bib46","doi-asserted-by":"crossref","first-page":"847","DOI":"10.4239\/wjd.v5.i6.847","article-title":"Transdifferentiation of pancreatic alpha-cells into insulin-secreting cells: from experimental models to underlying mechanisms","volume":"5","author":"Lu","year":"2014","journal-title":"World J. Diabetes"},{"key":"10.1016\/j.mce.2020.110950_bib47","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1095\/biolreprod.115.136283","article-title":"Developmental programming: prenatal testosterone excess and insulin signaling disruptions in female sheep","volume":"94","author":"Lu","year":"2016","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2020.110950_bib48","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1210\/en.2003-0478","article-title":"Fetal programming: prenatal testosterone excess leads to fetal growth retardation and postnatal catch-up growth in sheep","volume":"145","author":"Manikkam","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2020.110950_bib49","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1056\/NEJM199008023230505","article-title":"Transplacental passage of insulin in pregnant women with insulin-dependent diabetes mellitus. Its role in fetal macrosomia","volume":"323","author":"Menon","year":"1990","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mce.2020.110950_bib50","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1095\/biolreprod.115.133157","article-title":"Prenatal testosterone exposure leads to gonadal hormone-dependent hyperinsulinemia and gonadal hormone-independent glucose intolerance in adult male rat offspring","volume":"94","author":"More","year":"2016","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2020.110950_bib51","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1111\/j.1469-185X.2007.00027.x","article-title":"Effect size, confidence interval and statistical significance: a practical guide for biologists","volume":"82","author":"Nakagawa","year":"2007","journal-title":"Biol. Rev. Camb. Phil. Soc."},{"key":"10.1016\/j.mce.2020.110950_bib52","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.cmet.2016.03.015","article-title":"Extranuclear actions of the androgen receptor enhance glucose-stimulated insulin secretion in the male","volume":"23","author":"Navarro","year":"2016","journal-title":"Cell Metabol."},{"key":"10.1016\/j.mce.2020.110950_bib53","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.98607","article-title":"Androgen excess in pancreatic beta cells and neurons predisposes female mice to type 2 diabetes","volume":"3","author":"Navarro","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.mce.2020.110950_bib54","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0106527","article-title":"Abnormal infant islet morphology precedes insulin resistance in PCOS-like monkeys","volume":"9","author":"Nicol","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.mce.2020.110950_bib55","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.metabol.2017.12.005","article-title":"Circulating triacylglycerols but not pancreatic fat associate with insulin secretion in healthy humans","volume":"81","author":"Nowotny","year":"2018","journal-title":"Metabolism"},{"key":"10.1016\/j.mce.2020.110950_bib56","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1530\/REP-08-0491","article-title":"Developmental programming: prenatal androgen excess disrupts ovarian steroid receptor balance","volume":"137","author":"Ortega","year":"2009","journal-title":"Reproduction"},{"key":"10.1016\/j.mce.2020.110950_bib57","doi-asserted-by":"crossref","first-page":"3199","DOI":"10.2527\/jas.2014-7637","article-title":"Reproduction Symposium: developmental programming of reproductive and metabolic health","volume":"92","author":"Padmanabhan","year":"2014","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.mce.2020.110950_bib58","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.mce.2005.11.016","article-title":"Prenatal testosterone excess programs reproductive and metabolic dysfunction in the female","volume":"246","author":"Padmanabhan","year":"2006","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2020.110950_bib59","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1210\/en.2009-1015","article-title":"Developmental programming: impact of prenatal testosterone excess and postnatal weight gain on insulin sensitivity index and transfer of traits to offspring of overweight females","volume":"151","author":"Padmanabhan","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2020.110950_bib60","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.1210\/en.2015-1235","article-title":"Developmental programming: prenatal and postnatal androgen antagonist and insulin sensitizer interventions prevent advancement of puberty and improve LH surge dynamics in prenatal testosterone-treated sheep","volume":"156","author":"Padmanabhan","year":"2015","journal-title":"Endocrinology"},{"issue":"Suppl. 2","key":"10.1016\/j.mce.2020.110950_bib61","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1038\/sj.ijo.0801273","article-title":"Dynamics of insulin secretion in obesity and diabetes","volume":"24","author":"Polonsky","year":"2000","journal-title":"Int. J. Obes. Relat. Metab. Disord."},{"key":"10.1016\/j.mce.2020.110950_bib62","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1172\/JCI29103","article-title":"Islet beta cell failure in type 2 diabetes","volume":"116","author":"Prentki","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mce.2020.110950_bib63","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/978-3-319-70178-3_25","article-title":"Prenatal testosterone programming of insulin resistance in the female sheep","volume":"1043","author":"Puttabyatappa","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.mce.2020.110950_bib64","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1210\/en.2017-00460","article-title":"Developmental programming: impact of gestational steroid and metabolic milieus on mediators of insulin sensitivity in prenatal testosterone-treated female sheep","volume":"158","author":"Puttabyatappa","year":"2017","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2020.110950_bib65","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0056263","article-title":"The pancreas is altered by in utero androgen exposure: implications for clinical conditions such as polycystic ovary syndrome (PCOS)","volume":"8","author":"Rae","year":"2013","journal-title":"PloS One"},{"issue":"Suppl. 4","key":"10.1016\/j.mce.2020.110950_bib66","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1463-1326.2008.00969.x","article-title":"Pancreatic beta-cell mass in European subjects with type 2 diabetes","volume":"10","author":"Rahier","year":"2008","journal-title":"Diabetes Obes. Metabol."},{"key":"10.1016\/j.mce.2020.110950_bib67","doi-asserted-by":"crossref","first-page":"27408","DOI":"10.1038\/srep27408","article-title":"Developmental programming of polycystic ovary syndrome (PCOS): prenatal androgens establish pancreatic islet alpha\/beta cell ratio and subsequent insulin secretion","volume":"6","author":"Ramaswamy","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mce.2020.110950_bib68","doi-asserted-by":"crossref","first-page":"E801","DOI":"10.1152\/ajpendo.00107.2005","article-title":"Postnatal developmental consequences of altered insulin sensitivity in female sheep treated prenatally with testosterone","volume":"289","author":"Recabarren","year":"2005","journal-title":"Am. J. Physiol. Endocrinol. Metabol."},{"key":"10.1016\/j.mce.2020.110950_bib69","doi-asserted-by":"crossref","first-page":"550","DOI":"10.2337\/dbi19-0002","article-title":"The local paracrine actions of the pancreatic alpha-cell","volume":"69","author":"Rodriguez-Diaz","year":"2020","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2020.110950_bib70","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/s41574-018-0020-6","article-title":"The somatostatin-secreting pancreatic delta-cell in health and disease","volume":"14","author":"Rorsman","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.mce.2020.110950_bib71","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1093\/humrep\/17.10.2573","article-title":"Maternal serum androgens in pregnant women with polycystic ovarian syndrome: possible implications in prenatal androgenization","volume":"17","author":"Sir-Petermann","year":"2002","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.mce.2020.110950_bib72","doi-asserted-by":"crossref","first-page":"4637","DOI":"10.1210\/jc.2007-1036","article-title":"Early metabolic derangements in daughters of women with polycystic ovary syndrome","volume":"92","author":"Sir-Petermann","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2020.110950_bib73","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1210\/jc.2008-2836","article-title":"Metabolic and reproductive features before and during puberty in daughters of women with polycystic ovary syndrome","volume":"94","author":"Sir-Petermann","year":"2009","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2020.110950_bib74","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/nrgastro.2011.4","article-title":"The clinical significance of pancreatic steatosis","volume":"8","author":"Smits","year":"2011","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.mce.2020.110950_bib75","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3389\/fphys.2016.00119","article-title":"Insulin is a key modulator of fetoplacental endothelium metabolic disturbances in gestational diabetes mellitus","volume":"7","author":"Sobrevia","year":"2016","journal-title":"Front. Physiol."},{"key":"10.1016\/j.mce.2020.110950_bib76","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1055\/s-2007-979040","article-title":"Adaptation of islets of Langerhans to pregnancy: beta-cell growth, enhanced insulin secretion and the role of lactogenic hormones","volume":"29","author":"Sorenson","year":"1997","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.mce.2020.110950_bib77","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1097\/MPA.0000000000000771","article-title":"Pancreatic fat is associated with metabolic syndrome and visceral fat but not beta-cell function or body mass index in pediatric obesity","volume":"46","author":"Staaf","year":"2017","journal-title":"Pancreas"},{"key":"10.1016\/j.mce.2020.110950_bib78","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.celrep.2018.10.018","article-title":"Insulin secretion depends on intra-islet glucagon signaling","volume":"25","author":"Svendsen","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.mce.2020.110950_bib79","doi-asserted-by":"crossref","first-page":"4056","DOI":"10.1210\/en.2018-00781","article-title":"Prenatal androgenization of ewes as a model of hirsutism in polycystic ovary syndrome","volume":"159","author":"Tonellotto Dos Santos","year":"2018","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2020.110950_bib80","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1095\/biolreprod.107.065904","article-title":"Developmental programming: deficits in reproductive hormone dynamics and ovulatory outcomes in prenatal, testosterone-treated sheep","volume":"78","author":"Veiga-Lopez","year":"2008","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2020.110950_bib81","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1210\/en.2012-2145","article-title":"Developmental programming: impact of prenatal testosterone excess on insulin sensitivity, adiposity, and free fatty acid profile in postpubertal female sheep","volume":"154","author":"Veiga-Lopez","year":"2013","journal-title":"Endocrinology"},{"issue":"149","key":"10.1016\/j.mce.2020.110950_bib82","first-page":"1","article-title":"Rodent models for human polycystic ovary syndrome","volume":"86","author":"Walters","year":"2012","journal-title":"Biol. Reprod."},{"issue":"Suppl. 3","key":"10.1016\/j.mce.2020.110950_bib83","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.2337\/diabetes.53.suppl_3.S16","article-title":"Five stages of evolving beta-cell dysfunction during progression to diabetes","volume":"53","author":"Weir","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2020.110950_bib84","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1172\/JCI30862","article-title":"A dominant role for glucose in beta cell compensation of insulin resistance","volume":"117","author":"Weir","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mce.2020.110950_bib85","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1242\/dev.117911","article-title":"Glucagon is essential for alpha cell transdifferentiation and beta cell neogenesis","volume":"142","author":"Ye","year":"2015","journal-title":"Development"},{"issue":"Suppl. 1","key":"10.1016\/j.mce.2020.110950_bib86","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.dsx.2016.08.005","article-title":"Role of pancreatic duct cell in beta cell neogenesis: a mini review study","volume":"11","author":"Zare","year":"2017","journal-title":"Diabetes Metab. Syndr."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720720302501?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720720302501?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T14:26:27Z","timestamp":1759587987000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720720302501"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":86,"alternative-id":["S0303720720302501"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2020.110950","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Developmental programming: Prenatal testosterone excess disrupts pancreatic islet developmental trajectory in female sheep","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2020.110950","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110950"}}