{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:20:25Z","timestamp":1777868425322,"version":"3.51.4"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T00:00:00Z","timestamp":1603065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000090","name":"Congressionally Directed Medical Research Programs","doi-asserted-by":"publisher","award":["602115HP.3720.001"],"award-info":[{"award-number":["602115HP.3720.001"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000090","name":"Congressionally Directed Medical Research Programs","doi-asserted-by":"publisher","award":["81XWH-17-2-0019"],"award-info":[{"award-number":["81XWH-17-2-0019"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000090","name":"Congressionally Directed Medical Research Programs","doi-asserted-by":"publisher","award":["A1515"],"award-info":[{"award-number":["A1515"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.mce.2020.111036","type":"journal-article","created":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T02:41:35Z","timestamp":1600137695000},"page":"111036","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Characterization of the cortisol response to traumatic hemorrhage and intra-abdominal contamination models in Cynomologus Macaques"],"prefix":"10.1016","volume":"518","author":[{"given":"Rex E.","family":"Atwood","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana M.","family":"Golden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen A.","family":"Kaba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew J.","family":"Bradley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.mce.2020.111036_bib1","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1111\/j.1365-2265.2004.02023.x","article-title":"Neuroendocrine dysfunction in the acute phase of traumatic brain injury","volume":"60","author":"Agha","year":"2004","journal-title":"Clin. Endocrinol."},{"issue":"12","key":"10.1016\/j.mce.2020.111036_bib2","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1097\/CCM.0000000000002737","article-title":"Guidelines for the diagnosis and management of critical illness-related corticosteroid insufficiency (CIRCI) in critically ill patients (Part I): society of critical care medicine (SCCM) and European society of intensive care medicine (ESICM) 2017","volume":"45","author":"Annane","year":"2017","journal-title":"Crit. Care Med."},{"issue":"4","key":"10.1016\/j.mce.2020.111036_bib3","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1097\/00005373-198704000-00007","article-title":"Relationships among plasma cortisol, adrenocorticotrophin, and severity of injury in recently injured patients","volume":"27","author":"Barton","year":"1987","journal-title":"J. Trauma"},{"issue":"Suppl. 1","key":"10.1016\/j.mce.2020.111036_bib4","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/SHK.0000000000000322","article-title":"An evolving uncontrolled hemorrhage model using cynomolgus macaques","volume":"44","author":"Bograd","year":"2015","journal-title":"Shock"},{"key":"10.1016\/j.mce.2020.111036_bib5","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s12950-017-0170-7","article-title":"Host responses to concurrent combined injuries in non-human primates","volume":"14","author":"Bradley","year":"2017","journal-title":"J. Inflamm."},{"issue":"4","key":"10.1016\/j.mce.2020.111036_bib6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0214312","article-title":"Cortisol and adrenal androgens as independent predictors of mortality in septic patients","volume":"14","author":"De Castro","year":"2019","journal-title":"PloS One"},{"issue":"2","key":"10.1016\/j.mce.2020.111036_bib7","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1210\/endo-114-2-477","article-title":"Cortisol decreases bone formation by inhibiting periosteal cell proliferation","volume":"114","author":"Chyun","year":"1984","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2020.111036_bib8","series-title":"Glucocorticoid Receptors, Their Mechanisms of Action, and Glucocorticoid Resistance. Endocrinology: Adult and Pediatric","author":"Cidlowski","year":"2016"},{"issue":"3","key":"10.1016\/j.mce.2020.111036_bib9","doi-asserted-by":"crossref","first-page":"dgz302","DOI":"10.1210\/clinem\/dgz302","article-title":"Mapping the steroid response to major trauma from injury to recovery: a prospective cohort study","volume":"105","author":"Foster","year":"2020","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.mce.2020.111036_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ajp.22526","article-title":"Responses to the Human Intruder Test are related to hair cortisol phenotype and sex in resus macaques (Macaca mulatta)","volume":"79","author":"Hamel","year":"2017","journal-title":"Am. J. Primatol."},{"issue":"4","key":"10.1016\/j.mce.2020.111036_bib11","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1136\/emj.13.4.243","article-title":"Stress hormones in accident patients studied before admission to hospital","volume":"13","author":"Hetz","year":"1996","journal-title":"Emerg. Med. J."},{"issue":"6","key":"10.1016\/j.mce.2020.111036_bib12","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1042\/cs1010739","article-title":"Cortisol increases gluconeogenesis in humans: its role in the metabolic syndrome","volume":"101","author":"Khani","year":"2001","journal-title":"Clin. Sci."},{"issue":"4","key":"10.1016\/j.mce.2020.111036_bib13","first-page":"435","article-title":"Molecular control of immune\/inflammatory responses: interactions between nuclear factor-kappa B and steroid receptor-signaling pathways","volume":"20","author":"McKay","year":"1999","journal-title":"Endocr. Rev."},{"issue":"1","key":"10.1016\/j.mce.2020.111036_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0190190","article-title":"Assessment of stress responses in rhesus macaques (Macaca mulatta) to daily routine procedures in system neuroscience based on salivary cortisol concentrations","volume":"13","author":"Pfefferle","year":"2018","journal-title":"PloS One"},{"key":"10.1016\/j.mce.2020.111036_bib15","series-title":"Characterization of serum levels of testosterone and corticosterone in a blast and amputation rat model of heterotopic ossification. Molecular and cellular endocrinology","first-page":"110799","author":"Qin","year":"2020"},{"issue":"6","key":"10.1016\/j.mce.2020.111036_bib16","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1177\/000313480607200619","article-title":"Adrenal insufficiency in hemorrhagic shock","volume":"72","author":"Rushing","year":"2006","journal-title":"Am. Surg."},{"issue":"5","key":"10.1016\/j.mce.2020.111036_bib17","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1097\/01.sla.0000216759.36819.1b","article-title":"Effects of hemorrhagic shock on adrenal response in a rat model","volume":"243","author":"Rushing","year":"2006","journal-title":"Ann. Surg."},{"issue":"2","key":"10.1016\/j.mce.2020.111036_bib18","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1172\/JCI111227","article-title":"Increased proteolysis. An effect of increases in plasma cortisol within the physiologic range","volume":"73","author":"Simmons","year":"1984","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.mce.2020.111036_bib19","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1097\/TA.0b013e31827e2aaf","article-title":"Hyperacute adrenal insufficiency after hemorrhagic shock exists and is associated with poor outcomes","volume":"74","author":"Stein","year":"2013","journal-title":"The journal of trauma and acute care surgery"},{"key":"10.1016\/j.mce.2020.111036_bib20","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12950-018-0187-6","article-title":"The impact of septic stimuli on the systemic inflammatory response and physiologic insult in a preclinical non-human primate model of polytraumatic injury","volume":"15","author":"Vicente","year":"2018","journal-title":"J. Inflamm."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720720303385?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720720303385?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T11:55:30Z","timestamp":1777550130000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720720303385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":20,"alternative-id":["S0303720720303385"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2020.111036","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of the cortisol response to traumatic hemorrhage and intra-abdominal contamination models in Cynomologus Macaques","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2020.111036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"111036"}}