{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T04:27:11Z","timestamp":1783571231605,"version":"3.55.0"},"reference-count":76,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["G0500717"],"award-info":[{"award-number":["G0500717"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["G0801807"],"award-info":[{"award-number":["G0801807"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["G0802782"],"award-info":[{"award-number":["G0802782"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/P011535\/1"],"award-info":[{"award-number":["MR\/P011535\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"name":"MRC Centre for Reproductive Health","award":["MR\/N022556\/1"],"award-info":[{"award-number":["MR\/N022556\/1"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.mce.2020.111042","type":"journal-article","created":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T02:07:02Z","timestamp":1601518022000},"page":"111042","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Aberrant subcutaneous adipogenesis precedes adult metabolic dysfunction in an ovine model of polycystic ovary syndrome (PCOS)"],"prefix":"10.1016","volume":"519","author":[{"given":"Katarzyna J.","family":"Siemienowicz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavien","family":"Coukan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Franks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mick T.","family":"Rae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Colin","family":"Duncan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2020.111042_bib1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.mce.2013.01.013","article-title":"Nonhuman primate models of polycystic ovary syndrome","volume":"373","author":"Abbott","year":"2013","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2020.111042_bib2","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.3390\/ijms18061321","article-title":"Adiponectin, a therapeutic target for obesity, diabetes, and endothelial dysfunction","volume":"18","author":"Achari","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mce.2020.111042_bib3","doi-asserted-by":"crossref","first-page":"e33","DOI":"10.1016\/j.clnesp.2016.03.078","article-title":"The high-molecular weight multimer form of adiponectin is a useful marker of polycystic ovary syndrome in Bahraini Arab women","volume":"13","author":"Al-Awadi","year":"2016","journal-title":"Clin. Nutr. ESPEN"},{"key":"10.1016\/j.mce.2020.111042_bib4","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1210\/jc.2012-3289","article-title":"Visceral fat accumulation during lipid overfeeding is related to subcutaneous adipose tissue characteristics in healthy men","volume":"98","author":"Alligier","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2020.111042_bib5","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/j.1365-2265.2009.03645.x","article-title":"Effects of androgens on adipocyte differentiation and adipose tissue explant metabolism in men and women","volume":"72","author":"Blouin","year":"2010","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.mce.2020.111042_bib6","doi-asserted-by":"crossref","first-page":"4053","DOI":"10.1210\/jc.2004-0303","article-title":"Gender differences of adiponectin levels develop during the progression of puberty and are related to serum androgen levels","volume":"89","author":"B\u00f6ttner","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2020.111042_bib7","doi-asserted-by":"crossref","first-page":"e837","DOI":"10.1161\/CIRCULATIONAHA.111.077602","article-title":"Ectopic fat depots and cardiovascular disease","volume":"124","author":"Britton","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.mce.2020.111042_bib8","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.fertnstert.2014.05.032","article-title":"Insulin resistance and its relationship with high molecule weight adiponectin in adolescents with polycystic ovary syndrome and a maternal history","volume":"102","author":"Cankaya","year":"2014","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.mce.2020.111042_bib9","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1530\/eje.1.01868","article-title":"Evidence for altered adipocyte function in polycystic ovary syndrome","volume":"152","author":"Carmina","year":"2005","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.mce.2020.111042_bib10","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/978-3-319-48382-5_7","article-title":"Adipose tissue function and expandability as determinants of lipotoxicity and the metabolic syndrome","volume":"960","author":"Carobbio","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.mce.2020.111042_bib11","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.steroids.2013.05.001","article-title":"Androgens inhibit adipogenesis during human adipose stem cell commitment to preadipocyte formation","volume":"78","author":"Chazenbalk","year":"2013","journal-title":"Steroids"},{"key":"10.1016\/j.mce.2020.111042_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0080416","article-title":"Adiponectin and its receptors in the ovary: further evidence for a link between obesity and hyperandrogenism in polycystic ovary syndrome","volume":"8","author":"Comim","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.mce.2020.111042_bib13","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/nrm3198","article-title":"Forming functional fat: a growing understanding of adipocyte differentiation","volume":"12","author":"Cristancho","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mce.2020.111042_bib14","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.pep.2008.01.012","article-title":"Differentiation of human pre-adipocytes by recombinant adiponectin","volume":"59","author":"do Carmo Avides","year":"2008","journal-title":"Protein Expr. Purif."},{"key":"10.1016\/j.mce.2020.111042_bib15","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1038\/oby.2006.178","article-title":"Decreased expression of adipogenic genes in obese subjects with type 2 diabetes","volume":"14","author":"Dubois","year":"2006","journal-title":"Obesity"},{"key":"10.1016\/j.mce.2020.111042_bib16","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.steroids.2017.12.009","article-title":"Enlarged adipocytes in subcutaneous adipose tissue associated to hyperandrogenism and visceral adipose tissue volume in women with polycystic ovary syndrome","volume":"130","author":"Echibur\u00fa","year":"2018","journal-title":"Steroids"},{"key":"10.1016\/j.mce.2020.111042_bib17","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1093\/humrep\/del146","article-title":"Adiponectin and resistin in PCOS: a clinical, biochemical and molecular genetic study","volume":"21","author":"Escobar-Morreale","year":"2006","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.mce.2020.111042_bib18","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1210\/jc.2002-021573","article-title":"Mechanisms behind lipolytic catecholamine resistance of subcutaneous fat cells in the polycystic ovarian syndrome","volume":"88","author":"Faulds","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2020.111042_bib19","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1093\/humrep\/der396","article-title":"Consensus on women's health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE\/ASRM-Sponsored 3rd PCOS Consensus Workshop Group","volume":"27","author":"Fauser","year":"2012","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.mce.2020.111042_bib20","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/j.fertnstert.2018.08.042","article-title":"Precocious subcutaneous abdominal stem cell development to adipocytes in normal-weight women with polycystic ovary syndrome","volume":"110","author":"Fisch","year":"2018","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.mce.2020.111042_bib21","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1530\/EJE-11-0565","article-title":"Testosterone therapy decreases subcutaneous fat and adiponectin in aging men","volume":"166","author":"Frederiksen","year":"2012","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.mce.2020.111042_bib22","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1194\/jlr.M400373-JLR200","article-title":"Adiponectin promotes adipocyte differentiation, insulin sensitivity, and lipid accumulation","volume":"46","author":"Fu","year":"2005","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.mce.2020.111042_bib23","doi-asserted-by":"crossref","first-page":"E694","DOI":"10.1152\/ajpendo.00112.2011","article-title":"Dehydroepiandrosterone reduces preadipocyte proliferation via androgen receptor","volume":"302","author":"Fujioka","year":"2012","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2020.111042_bib24","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1194\/jlr.D023788","article-title":"Adiposoft: automated software for the analysis of white adipose tissue cellularity in histological sections","volume":"53","author":"Galarraga","year":"2012","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.mce.2020.111042_bib25","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.mce.2008.08.019","article-title":"Effects of dihydrotestosterone on differentiation and proliferation of human mesenchymal stem cells and preadipocytes","volume":"296","author":"Gupta","year":"2008","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2020.111042_bib26","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1038\/sj.ijo.0802853","article-title":"Failure of fat cell proliferation, mitochondrial function and fat oxidation results in ectopic fat storage, insulin resistance and type II diabetes mellitus","volume":"28","author":"Heilbronn","year":"2004","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.mce.2020.111042_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0024877","article-title":"The in utero programming effect of increased maternal androgens and a direct fetal intervention on liver and metabolic function in adult sheep","volume":"6","author":"Hogg","year":"2011","journal-title":"PloS One"},{"key":"10.1016\/j.mce.2020.111042_bib28","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1210\/en.2011-1607","article-title":"Enhanced thecal androgen production is prenatally programmed in an ovine model of polycystic ovary syndrome","volume":"153","author":"Hogg","year":"2012","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2020.111042_bib29","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1001\/archinternmed.2011.288","article-title":"Polycystic ovary syndrome in the United States: clinical visit rates, characteristics, and associated health care costs","volume":"171","author":"Jason","year":"2011","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.mce.2020.111042_bib30","doi-asserted-by":"crossref","first-page":"2696","DOI":"10.1210\/en.2014-1050","article-title":"Impaired preadipocyte differentiation into adipocytes in subcutaneous abdominal adipose of PCOS-like female rhesus monkeys","volume":"155","author":"Keller","year":"2014","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2020.111042_bib31","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1172\/JCI31021","article-title":"Obesity-associated improvements in metabolic profile through expansion of adipose tissue","volume":"117","author":"Kim","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mce.2020.111042_bib32","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1177\/1358863X16682107","article-title":"Obese adolescents with polycystic ovarian syndrome have elevated cardiovascular disease risk markers","volume":"22","author":"King","year":"2017","journal-title":"Vasc. Med."},{"key":"10.1016\/j.mce.2020.111042_bib33","doi-asserted-by":"crossref","first-page":"28430","DOI":"10.1074\/jbc.M103382200","article-title":"Insulin-induced adipocyte differentiation - activation of CREB rescues adipogenesis from the arrest caused by inhibition of prenylation","volume":"276","author":"Klemm","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2020.111042_bib34","doi-asserted-by":"crossref","first-page":"22883","DOI":"10.1038\/srep22883","article-title":"Epigenetic and transcriptional alterations in human adipose tissue of polycystic ovary syndrome","volume":"6","author":"Kokosar","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mce.2020.111042_bib35","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.diabet.2013.08.002","article-title":"Adipose tissue and adipocyte dysregulation","volume":"40","author":"Lafontan","year":"2014","journal-title":"Diabetes Metab."},{"key":"10.1016\/j.mce.2020.111042_bib36","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.mce.2008.01.007","article-title":"Role of adiponectin in regulating ovarian theca and granulosa cell function","volume":"284","author":"Lagaly","year":"2008","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2020.111042_bib37","doi-asserted-by":"crossref","first-page":"4292","DOI":"10.4238\/2013.February.28.16","article-title":"Association between adipose tissue expression and serum levels of leptin and adiponectin in women with polycystic ovary syndrome","volume":"12","author":"Lecke","year":"2013","journal-title":"Genet. Mol. Res."},{"key":"10.1016\/j.mce.2020.111042_bib38","doi-asserted-by":"crossref","first-page":"197","DOI":"10.4161\/adip.29385","article-title":"Low abdominal subcutaneous preadipocyte adipogenesis is associated with visceral obesity, visceral adipocyte hypertrophy, and a dysmetabolic state","volume":"3","author":"Lessard","year":"2014","journal-title":"Adipocyte"},{"key":"10.1016\/j.mce.2020.111042_bib39","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.mce.2020.111042_bib40","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.3390\/ijms20092358","article-title":"Adipose tissue dysfunction as determinant of obesity-associated metabolic complications","volume":"20","author":"Longo","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mce.2020.111042_bib41","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/obr.12255","article-title":"The role for adipose tissue in weight regain after weight loss","volume":"16","author":"MacLean","year":"2015","journal-title":"Obes. Rev."},{"key":"10.1016\/j.mce.2020.111042_bib42","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.2337\/db11-1753","article-title":"Intrinsic differences in adipocyte precursor cells from different white fat depots","volume":"61","author":"Macotela","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2020.111042_bib43","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ejogrb.2011.12.012","article-title":"Relationship of serum adipocyte-derived proteins with insulin sensitivity and reproductive features in pre-pubertal and pubertal daughters of polycystic ovary syndrome women","volume":"161","author":"Maliqueo","year":"2012","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.mce.2020.111042_bib44","doi-asserted-by":"crossref","first-page":"E304","DOI":"10.1210\/jc.2010-1290","article-title":"Adipose tissue has aberrant morphology and function in PCOS: enlarged adipocytes and low serum adiponectin, but not circulating sex steroids, are strongly associated with insulin resistance","volume":"96","author":"Manneras-Holm","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2020.111042_bib45","doi-asserted-by":"crossref","first-page":"E1134","DOI":"10.1152\/ajpendo.00314.2012","article-title":"Dehydroepiandrosterone exerts antiglucocorticoid action on human preadipocyte proliferation, differentiation, and glucose uptake","volume":"305","author":"McNelis","year":"2013","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2020.111042_bib46","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1757-2215-7-18","article-title":"Association between circulating adiponectin levels and polycystic ovarian syndrome","volume":"7","author":"Mirza","year":"2014","journal-title":"J. Ovarian Res."},{"key":"10.1016\/j.mce.2020.111042_bib47","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.tem.2014.12.003","article-title":"Metabolic risk in PCOS: phenotype and adiposity impact","volume":"26","author":"Moran","year":"2015","journal-title":"Trends Endocrinol. Metabol."},{"key":"10.1016\/j.mce.2020.111042_bib48","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.2337\/diabetes.51.9.2734","article-title":"Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived protein","volume":"51","author":"Nishizawa","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2020.111042_bib49","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.mce.2012.10.005","article-title":"Sheep models of polycystic ovary syndrome phenotype","volume":"373","author":"Padmanabhan","year":"2013","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2020.111042_bib50","doi-asserted-by":"crossref","first-page":"E958","DOI":"10.1152\/ajpendo.00544.2003","article-title":"Subcutaneous abdominal preadipocyte differentiation in vitro inversely correlates with central obesity","volume":"286","author":"Permana","year":"2004","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2020.111042_bib51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0378-3782(83)90028-2","article-title":"Growth and development of human adipose tissue during early gestation","volume":"8","author":"Poissonnet","year":"1983","journal-title":"Early Hum. Dev."},{"key":"10.1016\/j.mce.2020.111042_bib52","doi-asserted-by":"crossref","first-page":"6014","DOI":"10.1210\/jc.2005-1002","article-title":"Central fat excess in polycystic ovary syndrome: relation to low-grade inflammation and insulin resistance","volume":"90","author":"Puder","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2020.111042_bib53","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1177\/1933719117746767","article-title":"Developmental programming: impact of prenatal testosterone excess on steroidal machinery and cell differentiation markers in visceral adipocytes of female sheep","volume":"25","author":"Puttabyatappa","year":"2018","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.mce.2020.111042_bib54","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0056263","article-title":"The pancreas is altered by in utero androgen exposure: implications for clinical conditions such as polycystic ovary syndrome (PCOS)","volume":"8","author":"Rae","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.mce.2020.111042_bib55","doi-asserted-by":"crossref","first-page":"27408","DOI":"10.1038\/srep27408","article-title":"Developmental programming of polycystic ovary syndrome (PCOS): prenatal androgens establish pancreatic islet \u03b1\/\u03b2 cell ratio and subsequent insulin secretion","volume":"6","author":"Ramaswamy","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mce.2020.111042_bib56","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1159\/000346898","article-title":"Relationship of adiponectin with sex hormone levels in adolescents","volume":"79","author":"Riestra","year":"2013","journal-title":"Horm. Res. Paediatr."},{"key":"10.1016\/j.mce.2020.111042_bib57","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.cell.2013.12.012","article-title":"What we talk about when we talk about fat","volume":"156","author":"Rosen","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.mce.2020.111042_bib58","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.fertnstert.2015.05.007","article-title":"Validity of adiponectin-to-leptin and adiponectin-to-resistin ratios as predictors of polycystic ovary syndrome","volume":"104","author":"Sarray","year":"2015","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.mce.2020.111042_bib59","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1093\/humrep\/dep122","article-title":"Omental adipose tissue overexpression of fatty acid transporter CD36 and decreased expression of hormone-sensitive lipase in insulin-resistant women with polycystic ovary syndrome","volume":"24","author":"Seow","year":"2009","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.mce.2020.111042_bib60","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.jsgi.2004.09.003","article-title":"Adiponectin levels in women with polycystic ovary syndrome and severe insulin resistance","volume":"12","author":"Sepilian","year":"2005","journal-title":"J. Soc. Gynecol. Invest."},{"key":"10.1016\/j.mce.2020.111042_bib61","article-title":"Insights into manipulating postprandial energy expenditure to manage weight gain in polycystic ovary syndrome (PCOS)","volume":"101164","author":"Siemienowicz","year":"2020","journal-title":"iScience"},{"key":"10.1016\/j.mce.2020.111042_bib62","doi-asserted-by":"crossref","first-page":"20195","DOI":"10.1038\/s41598-019-56790-4","article-title":"Fetal androgen exposure is a determinant of adult male metabolic health","volume":"9","author":"Siemienowicz","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mce.2020.111042_bib63","doi-asserted-by":"crossref","first-page":"5081","DOI":"10.1210\/en.2003-0741","article-title":"Androgens stimulate myogenic differentiation and inhibit adipogenesis in C3H 10T1\/2 pluripotent cells through an androgen receptor-mediated pathway","volume":"144","author":"Singh","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2020.111042_bib64","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1210\/en.2004-1649","article-title":"Testosterone inhibits adipogenic differentiation in 3T3-L1 cells: nuclear translocation of androgen receptor complex with beta-catenin and T-cell factor 4 may bypass canonical Wnt signaling to down-regulate adipogenic transcription factors","volume":"147","author":"Singh","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2020.111042_bib65","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/nature06902","article-title":"Dynamics of fat cell turnover in humans","volume":"453","author":"Spalding","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.mce.2020.111042_bib66","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1111\/j.1474-9726.2010.00608.x","article-title":"Fat tissue, aging, and cellular senescence","volume":"9","author":"Tchkonia","year":"2010","journal-title":"Aging Cell"},{"key":"10.1016\/j.mce.2020.111042_bib67","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.cmet.2013.03.008","article-title":"Mechanisms and metabolic implications of regional differences among fat depots","volume":"17","author":"Tchkonia","year":"2013","journal-title":"Cell Metabol."},{"key":"10.1016\/j.mce.2020.111042_bib68","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1741-7015-8-41","article-title":"Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan","volume":"8","author":"Teede","year":"2010","journal-title":"BMC Med."},{"key":"10.1016\/j.mce.2020.111042_bib69","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1210\/en.2012-2145","article-title":"Developmental programming: impact of prenatal testosterone excess on insulin sensitivity, adiposity, and free fatty acid profile in postpubertal female sheep","volume":"154","author":"Veiga-Lopez","year":"2013","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2020.111042_bib70","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jsbmb.2012.02.003","article-title":"The expression of sex steroid synthesis and inactivation enzymes in subcutaneous adipose tissue of PCOS patients","volume":"132","author":"Wang","year":"2012","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.mce.2020.111042_bib71","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1172\/JCI200319246","article-title":"Obesity is associated with macrophage accumulation in adipose tissue","volume":"112","author":"Weisberg","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mce.2020.111042_bib72","first-page":"69","article-title":"The development of adipose tissue in sheep foetuses","volume":"4","author":"Wensvoort","year":"1967","journal-title":"Path.Vet"},{"key":"10.1016\/j.mce.2020.111042_bib73","doi-asserted-by":"crossref","first-page":"18073","DOI":"10.1074\/jbc.M414231200","article-title":"Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes","volume":"280","author":"Xu","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2020.111042_bib74","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.bbrc.2004.03.152","article-title":"Evidence of impaired adipogenesis in insulin resistance","volume":"317","author":"Yang","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mce.2020.111042_bib75","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1016\/S0015-0282(03)00265-6","article-title":"Relation of intra-abdominal fat distribution to metabolic disorders in nonobese patients with polycystic ovary syndrome","volume":"79","author":"Yildirim","year":"2003","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.mce.2020.111042_bib76","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1007\/s13679-014-0119-6","article-title":"Androgens, body fat distribution and adipogenesis","volume":"3","author":"Zerradi","year":"2014","journal-title":"Curr. Obes. Rep."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720720303440?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720720303440?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T14:12:09Z","timestamp":1759587129000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720720303440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":76,"alternative-id":["S0303720720303440"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2020.111042","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aberrant subcutaneous adipogenesis precedes adult metabolic dysfunction in an ovine model of polycystic ovary syndrome (PCOS)","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2020.111042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111042"}}