{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:19:36Z","timestamp":1789996776789,"version":"4.0.1"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.mce.2020.111116","type":"journal-article","created":{"date-parts":[[2020,12,13]],"date-time":"2020-12-13T10:29:10Z","timestamp":1607855350000},"page":"111116","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":64,"special_numbering":"C","title":["The bile acid TUDCA improves glucose metabolism in streptozotocin-induced Alzheimer's disease mice model"],"prefix":"10.1016","volume":"521","author":[{"given":"Lucas","family":"Zangerolamo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean F.","family":"Vettorazzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8222-0493","authenticated-orcid":false,"given":"Carina","family":"Solon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7641-6649","authenticated-orcid":false,"given":"Gabriela A.","family":"Bronczek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiane F.","family":"Engel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2431-8120","authenticated-orcid":false,"given":"Mirian A.","family":"Kurauti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela M.","family":"Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina S.","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Licio A.","family":"Velloso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio C.","family":"Boschero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Everardo M.","family":"Carneiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena C.L.","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6821","key":"10.1016\/j.mce.2020.111116_bib1","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/35055575","article-title":"Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver","volume":"409","author":"Abel","year":"2001","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.mce.2020.111116_bib2","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/j.1464-5491.1992.tb01813.x","article-title":"The short insulin tolerance test for determination of insulin sensitivity: a comparison with the euglycaemic clamp","volume":"9","author":"Akinmokun","year":"1992","journal-title":"Diabet. Med."},{"issue":"2","key":"10.1016\/j.mce.2020.111116_bib3","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s10339-011-0430-z","article-title":"The novel object recognition memory: neurobiology, test procedure, and its modifications","volume":"13","author":"Antunes","year":"2012","journal-title":"Cognit. Process."},{"issue":"1","key":"10.1016\/j.mce.2020.111116_bib4","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1097\/WAD.0b013e3181a6bed5","article-title":"Diabetes and cognitive systems in older black and white persons","volume":"24","author":"Arvanitakis","year":"2010","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"10.1016\/j.mce.2020.111116_bib5","doi-asserted-by":"crossref","first-page":"204","DOI":"10.3389\/fnins.2015.00204","article-title":"Aberrant insulin signaling in Alzheimer's disease: current knowledge","volume":"9","author":"Bedse","year":"2015","journal-title":"Front. Neurosci."},{"issue":"4\u20135","key":"10.1016\/j.mce.2020.111116_bib6","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.brainresbull.2009.07.006","article-title":"Role of the JNK-interacting protein 1\/islet brain 1 in cell degeneration in Alzheimer disease and diabetes","volume":"80","author":"Beeler","year":"2009","journal-title":"Brain Res. Bull."},{"issue":"3","key":"10.1016\/j.mce.2020.111116_bib7","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/S2213-8587(13)70088-3","article-title":"Dementia and cognitive decline in type 2 diabetes and prediabetic stages: towards targeted interventions","volume":"2","author":"Biessels","year":"2014","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"2 Pt 1","key":"10.1016\/j.mce.2020.111116_bib8","first-page":"E336","article-title":"Oxotremorine-m potentiation of glucose-induced insulin release from rat islets involves M3 muscarinic receptors","volume":"268","author":"Boschero","year":"1995","journal-title":"Am. J. Physiol."},{"issue":"1","key":"10.1016\/j.mce.2020.111116_bib9","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0168-8227(03)00084-6","article-title":"Cognitive impairment, physical disability and depressive symptoms in older diabetic patients: the Fremantle Cognition in Diabetes Study","volume":"61","author":"Bruce","year":"2003","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"7","key":"10.1016\/j.mce.2020.111116_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0101797","article-title":"Chaperones ameliorate beta cell dysfunction associated with human islet amyloid polypeptide overexpression","volume":"9","author":"Cadavez","year":"2014","journal-title":"PloS One"},{"issue":"Pt B","key":"10.1016\/j.mce.2020.111116_bib11","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.neuropharm.2017.11.037","article-title":"Intranasal insulin in Alzheimer's disease: food for thought","volume":"136","author":"Chapman","year":"2018","journal-title":"Neuropharmacology"},{"issue":"2","key":"10.1016\/j.mce.2020.111116_bib12","doi-asserted-by":"crossref","first-page":"190","DOI":"10.15252\/emmm.201404183","article-title":"Alzheimer-associated A\u03b2 oligomers impact the central nervous system to induce peripheral metabolic deregulation","volume":"7","author":"Clarke","year":"2015","journal-title":"EMBO Mol. Med."},{"issue":"4","key":"10.1016\/j.mce.2020.111116_bib13","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1073\/pnas.0336073100","article-title":"Reduced glucose tolerance is associated with poor memory performance and hippocampal atrophy among normal elderly","volume":"100","author":"Convit","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mce.2020.111116_bib14","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s40035-017-0093-5","article-title":"Role of BACE1 in Alzheimer's synaptic function","volume":"6","author":"Das","year":"2017","journal-title":"Transl. Neurodegener."},{"issue":"1 Suppl. l","key":"10.1016\/j.mce.2020.111116_bib15","first-page":"S26","article-title":"How does brain insulin resistance develop in Alzheimer's disease?","volume":"10","author":"De Felice","year":"2014","journal-title":"Alzheimers Dement"},{"issue":"1","key":"10.1016\/j.mce.2020.111116_bib16","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s40265-016-0674-0","article-title":"Insulin resistance and neurodegeneration: progress towards the development of new therapeutics for alzheimer's disease","volume":"77","author":"de la Monte","year":"2017","journal-title":"Drugs"},{"issue":"4","key":"10.1016\/j.mce.2020.111116_bib17","doi-asserted-by":"crossref","first-page":"412","DOI":"10.2174\/1567205013666160930110551","article-title":"Targeting tumor necrosis factor Alpha for alzheimer's disease","volume":"14","author":"Decourt","year":"2017","journal-title":"Curr. Alzheimer Res."},{"issue":"1","key":"10.1016\/j.mce.2020.111116_bib18","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.neurobiolaging.2014.08.034","article-title":"Amyloid-\u03b2 pathology is attenuated by tauroursodeoxycholic acid treatment in APP\/PS1 mice after disease onset","volume":"36","author":"Dion\u00edsio","year":"2015","journal-title":"Neurobiol. Aging"},{"issue":"1","key":"10.1016\/j.mce.2020.111116_bib19","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/2251-6581-12-60","article-title":"Review of the mechanism of cell death resulting from streptozotocin challenge in experimental animals, its practical use and potential risk to humans","volume":"12","author":"Eleazu","year":"2013","journal-title":"J. Diabetes Metab. Disord."},{"issue":"211","key":"10.1016\/j.mce.2020.111116_bib20","doi-asserted-by":"crossref","first-page":"211ra156","DOI":"10.1126\/scitranslmed.3006534","article-title":"Restoration of the unfolded protein response in pancreatic \u03b2 cells protects mice against type 1 diabetes","volume":"5","author":"Engin","year":"2013","journal-title":"Sci. Transl. Med."},{"issue":"2","key":"10.1016\/j.mce.2020.111116_bib21","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.diabres.2014.04.006","article-title":"Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes","volume":"105","author":"Esser","year":"2014","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"1","key":"10.1016\/j.mce.2020.111116_bib22","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s40478-019-0828-x","article-title":"Microglial motility in Alzheimer's disease and after A\u03b242 immunotherapy: a human post-mortem study","volume":"7","author":"Franco-Bocanegra","year":"2019","journal-title":"Acta Neuropathol Commun"},{"key":"10.1016\/j.mce.2020.111116_bib23","doi-asserted-by":"crossref","DOI":"10.1002\/0471141755.ph0547s70","article-title":"Streptozotocin-induced diabetic models in mice and rats","volume":"70","author":"Furman","year":"2015","journal-title":"Curr Protoc Pharmacol"},{"issue":"4","key":"10.1016\/j.mce.2020.111116_bib24","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","article-title":"Neuroinflammation in Alzheimer's disease","volume":"14","author":"Heneka","year":"2015","journal-title":"Lancet Neurol."},{"issue":"2","key":"10.1016\/j.mce.2020.111116_bib25","doi-asserted-by":"crossref","first-page":"474","DOI":"10.2337\/diabetes.53.2.474","article-title":"Increased risk of type 2 diabetes in Alzheimer disease","volume":"53","author":"Janson","year":"2004","journal-title":"Diabetes"},{"issue":"13","key":"10.1016\/j.mce.2020.111116_bib26","doi-asserted-by":"crossref","first-page":"7569","DOI":"10.1073\/pnas.1332633100","article-title":"Insulin signaling through Akt\/protein kinase B analyzed by small interfering RNA-mediated gene silencing","volume":"100","author":"Jiang","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"10.1016\/j.mce.2020.111116_bib27","doi-asserted-by":"crossref","first-page":"4548","DOI":"10.1007\/s12035-015-9384-y","article-title":"Streptozotocin intracerebroventricular-induced neurotoxicity and brain insulin resistance: a therapeutic intervention for treatment of sporadic alzheimer's disease (sAD)-Like pathology","volume":"53","author":"Kamat","year":"2016","journal-title":"Mol. Neurobiol."},{"issue":"3","key":"10.1016\/j.mce.2020.111116_bib28","doi-asserted-by":"crossref","first-page":"479","DOI":"10.3349\/ymj.2017.58.3.479","article-title":"Metabolism-centric overview of the pathogenesis of alzheimer's disease","volume":"58","author":"Kang","year":"2017","journal-title":"Yonsei Med. J."},{"issue":"2","key":"10.1016\/j.mce.2020.111116_bib29","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1006\/exnr.2001.7755","article-title":"A bile acid protects against motor and cognitive deficits and reduces striatal degeneration in the 3-nitropropionic acid model of Huntington's disease","volume":"171","author":"Keene","year":"2001","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.mce.2020.111116_bib30","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.trci.2018.06.014","article-title":"Inflammation as a central mechanism in Alzheimer's disease","volume":"4","author":"Kinney","year":"2018","journal-title":"Alzheimers Dement (N Y)"},{"issue":"3","key":"10.1016\/j.mce.2020.111116_bib31","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1530\/JOE-15-0483","article-title":"Acute exercise restores insulin clearance in diet-induced obese mice","volume":"229","author":"Kurauti","year":"2016","journal-title":"J. Endocrinol."},{"issue":"4","key":"10.1016\/j.mce.2020.111116_bib32","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.bbrc.2010.06.022","article-title":"Tauroursodeoxycholate (TUDCA), chemical chaperone, enhances function of islets by reducing ER stress","volume":"397","author":"Lee","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mce.2020.111116_bib33","doi-asserted-by":"crossref","first-page":"549","DOI":"10.2147\/CIA.S74042","article-title":"Link between type 2 diabetes and Alzheimer's disease: from epidemiology to mechanism and treatment","volume":"10","author":"Li","year":"2015","journal-title":"Clin. Interv. Aging"},{"key":"10.1016\/j.mce.2020.111116_bib34","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.nbd.2012.09.003","article-title":"Tauroursodeoxycholic acid (TUDCA) supplementation prevents cognitive impairment and amyloid deposition in APP\/PS1 mice","volume":"50","author":"Lo","year":"2013","journal-title":"Neurobiol. Dis."},{"issue":"5708","key":"10.1016\/j.mce.2020.111116_bib35","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1126\/science.1104343","article-title":"Mitochondrial dysfunction and type 2 diabetes","volume":"307","author":"Lowell","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.mce.2020.111116_bib36","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.exger.2016.12.019","article-title":"Glucose tolerance and insulin sensitivity are impaired in APP\/PS1 transgenic mice prior to amyloid plaque pathogenesis and cognitive decline","volume":"88","author":"Macklin","year":"2017","journal-title":"Exp. Gerontol."},{"issue":"2 Suppl. 1","key":"10.1016\/j.mce.2020.111116_bib37","doi-asserted-by":"crossref","first-page":"S144","DOI":"10.1016\/j.dsx.2016.01.021","article-title":"Shared links between type 2 diabetes mellitus and Alzheimer's disease: a review","volume":"10","author":"Mittal","year":"2016","journal-title":"Diabetes Metab Syndr"},{"issue":"10\u201312","key":"10.1016\/j.mce.2020.111116_bib38","first-page":"1271","article-title":"Streptozotocin increases free fatty acids and decreases phospholipids in rat brain","volume":"105","author":"M\u00fcller","year":"1998","journal-title":"J. Neural. Transm."},{"key":"10.1016\/j.mce.2020.111116_bib39","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.vascn.2016.10.007","article-title":"A murine model of type 2 diabetes mellitus developed using a combination of high fat diet and multiple low doses of streptozotocin treatment mimics the metabolic characteristics of type 2 diabetes mellitus in humans","volume":"84","author":"Nath","year":"2017","journal-title":"J. Pharmacol. Toxicol. Methods"},{"issue":"3","key":"10.1016\/j.mce.2020.111116_bib40","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1007\/s12035-012-8256-y","article-title":"TUDCA, a bile acid, attenuates amyloid precursor protein processing and amyloid-\u03b2 deposition in APP\/PS1 mice","volume":"45","author":"Nunes","year":"2012","journal-title":"Mol. Neurobiol."},{"issue":"5790","key":"10.1016\/j.mce.2020.111116_bib41","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1126\/science.1128294","article-title":"Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes","volume":"313","author":"Ozcan","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.mce.2020.111116_bib42","doi-asserted-by":"crossref","first-page":"1805304","DOI":"10.1155\/2016\/1805304","article-title":"Killing me softly: connotations to unfolded protein response and oxidative stress in alzheimer's disease","author":"Paj\u0105k","year":"2016","journal-title":"Oxid Med Cell Longev, 2016"},{"issue":"4","key":"10.1016\/j.mce.2020.111116_bib43","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/glia.20207","article-title":"Astrocyte activation and reactive gliosis","volume":"50","author":"Pekny","year":"2005","journal-title":"Glia"},{"issue":"1","key":"10.1016\/j.mce.2020.111116_bib44","doi-asserted-by":"crossref","DOI":"10.3390\/ph11010012","article-title":"Alpha-secretase ADAM10 regulation: insights into alzheimer's disease treatment","volume":"11","author":"Peron","year":"2018","journal-title":"Pharmaceuticals"},{"issue":"4","key":"10.1016\/j.mce.2020.111116_bib45","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/0736-5748(93)90021-5","article-title":"Action of the diabetogenic drug streptozotocin on glycolytic and glycogenolytic metabolism in adult rat brain cortex and hippocampus","volume":"11","author":"Plaschke","year":"1993","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.mce.2020.111116_bib46","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.pbb.2013.11.035","article-title":"Glial activation and post-synaptic neurotoxicity: the key events in Streptozotocin (ICV) induced memory impairment in rats","volume":"117","author":"Rai","year":"2014","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"8","key":"10.1016\/j.mce.2020.111116_bib47","doi-asserted-by":"crossref","first-page":"6507","DOI":"10.1007\/s12035-016-0169-8","article-title":"Intranasal insulin administration ameliorates streptozotocin (ICV)-Induced insulin receptor dysfunction, neuroinflammation, amyloidogenesis, and memory impairment in rats","volume":"54","author":"Rajasekar","year":"2017","journal-title":"Mol. Neurobiol."},{"issue":"3","key":"10.1016\/j.mce.2020.111116_bib48","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s12640-016-9684-7","article-title":"Intracerebroventricular streptozotocin as a model of alzheimer's disease: neurochemical and behavioral characterization in mice","volume":"31","author":"Ravelli","year":"2017","journal-title":"Neurotox. Res."},{"issue":"11","key":"10.1016\/j.mce.2020.111116_bib49","doi-asserted-by":"crossref","first-page":"3896","DOI":"10.1096\/fj.11-181297","article-title":"Direct evidence of phosphorylated neuronal intermediate filament proteins in neurofibrillary tangles (NFTs): phosphoproteomics of Alzheimer's NFTs","volume":"25","author":"Rudrabhatla","year":"2011","journal-title":"Faseb. J."},{"issue":"72","key":"10.1016\/j.mce.2020.111116_bib50","first-page":"217","article-title":"Central insulin resistance as a trigger for sporadic Alzheimer-like pathology: an experimental approach","volume":"Suppl","author":"Salkovic-Petrisic","year":"2007","journal-title":"J. Neural. Transm."},{"issue":"4","key":"10.1016\/j.mce.2020.111116_bib51","doi-asserted-by":"crossref","first-page":"729","DOI":"10.3233\/JAD-2009-1184","article-title":"Modeling sporadic Alzheimer's disease: the insulin resistant brain state generates multiple long-term morphobiological abnormalities including hyperphosphorylated tau protein and amyloid-beta","volume":"18","author":"Salkovic-Petrisic","year":"2009","journal-title":"J Alzheimers Dis"},{"issue":"2","key":"10.1016\/j.mce.2020.111116_bib52","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1152\/physrev.2001.81.2.741","article-title":"Alzheimer's disease: genes, proteins, and therapy","volume":"81","author":"Selkoe","year":"2001","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.mce.2020.111116_bib53","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.neuint.2017.04.020","article-title":"Bidirectional interactions between diabetes and Alzheimer's disease","volume":"108","author":"Shinohara","year":"2017","journal-title":"Neurochem. Int."},{"issue":"9","key":"10.1016\/j.mce.2020.111116_bib54","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1001\/jamaneurol.2013.284","article-title":"Glucose intolerance, insulin resistance, and pathological features of Alzheimer disease in the Baltimore Longitudinal Study of Aging","volume":"70","author":"Thambisetty","year":"2013","journal-title":"JAMA Neurol"},{"issue":"10","key":"10.1016\/j.mce.2020.111116_bib55","doi-asserted-by":"crossref","first-page":"4273","DOI":"10.1096\/fj.14-268482","article-title":"Age-dependent impairment of glucose tolerance in the 3xTg-AD mouse model of Alzheimer's disease","volume":"29","author":"Vandal","year":"2015","journal-title":"Faseb. J."},{"issue":"12","key":"10.1016\/j.mce.2020.111116_bib56","doi-asserted-by":"crossref","first-page":"4291","DOI":"10.2337\/db14-0375","article-title":"Insulin reverses the high-fat diet-induced increase in brain A\u03b2 and improves memory in an animal model of Alzheimer disease","volume":"63","author":"Vandal","year":"2014","journal-title":"Diabetes"},{"issue":"3","key":"10.1016\/j.mce.2020.111116_bib57","doi-asserted-by":"crossref","first-page":"398","DOI":"10.2337\/diacare.21.3.398","article-title":"Cognitive function in an elderly population with persistent impaired glucose tolerance","volume":"21","author":"Vanhanen","year":"1998","journal-title":"Diabetes Care"},{"issue":"1","key":"10.1016\/j.mce.2020.111116_bib58","doi-asserted-by":"crossref","first-page":"14876","DOI":"10.1038\/s41598-017-13974-0","article-title":"Bile acid TUDCA improves insulin clearance by increasing the expression of insulin-degrading enzyme in the liver of obese mice","volume":"7","author":"Vettorazzi","year":"2017","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.mce.2020.111116_bib59","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.metabol.2015.10.021","article-title":"The bile acid TUDCA increases glucose-induced insulin secretion via the cAMP\/PKA pathway in pancreatic beta cells","volume":"65","author":"Vettorazzi","year":"2016","journal-title":"Metabolism"},{"issue":"1","key":"10.1016\/j.mce.2020.111116_bib60","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.neuron.2004.09.010","article-title":"Deciphering the molecular basis of memory failure in Alzheimer's disease","volume":"44","author":"Walsh","year":"2004","journal-title":"Neuron"},{"issue":"10","key":"10.1016\/j.mce.2020.111116_bib61","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/nrneurol.2017.111","article-title":"A systemic view of Alzheimer disease - insights from amyloid-\u03b2 metabolism beyond the brain","volume":"13","author":"Wang","year":"2017","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.mce.2020.111116_bib62","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.freeradbiomed.2016.04.200","article-title":"Energy metabolism and inflammation in brain aging and Alzheimer's disease","volume":"100","author":"Yin","year":"2016","journal-title":"Free Radic. Biol. Med."},{"issue":"11","key":"10.1016\/j.mce.2020.111116_bib63","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1139\/cjpp-2018-0691","article-title":"ARHGAP21 deficiency impairs hepatic lipid metabolism and improves insulin signaling in lean and obese mice","volume":"97","author":"Zangerolamo","year":"2019","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.mce.2020.111116_bib64","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1756-6606-4-3","article-title":"APP processing in Alzheimer's disease","volume":"4","author":"Zhang","year":"2011","journal-title":"Mol. Brain"},{"issue":"1\u20133","key":"10.1016\/j.mce.2020.111116_bib65","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ejphar.2004.02.045","article-title":"Insulin and the insulin receptor in experimental models of learning and memory","volume":"490","author":"Zhao","year":"2004","journal-title":"Eur. J. Pharmacol."},{"issue":"8","key":"10.1016\/j.mce.2020.111116_bib66","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1038\/78693","article-title":"Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance","volume":"6","author":"Zisman","year":"2000","journal-title":"Nat. Med."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720720304184?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720720304184?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T14:14:15Z","timestamp":1759587255000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720720304184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":66,"alternative-id":["S0303720720304184"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2020.111116","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The bile acid TUDCA improves glucose metabolism in streptozotocin-induced Alzheimer's disease mice model","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2020.111116","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111116"}}