{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T05:39:19Z","timestamp":1769837959594,"version":"3.49.0"},"reference-count":141,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,12,7]],"date-time":"2020-12-07T00:00:00Z","timestamp":1607299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003061","name":"Department of Obstetrics and Gynecology of the Erasmus Medical Center, Rotterdam, The Netherlands","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003061","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.mce.2020.111118","type":"journal-article","created":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T06:03:48Z","timestamp":1608185028000},"page":"111118","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Prorenin periconceptionally and in pregnancy: Does it have a physiological role?"],"prefix":"10.1016","volume":"522","author":[{"given":"Rosalieke E.","family":"Wiegel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frauke","family":"von Versen-H\u00f6ynck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00e9gine P.M.","family":"Steegers-Theunissen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric A.P.","family":"Steegers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.H. Jan","family":"Danser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2020.111118_bib1","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1210\/jcem-55-5-902","article-title":"Human chorionic cells in primary culture: a model for renin biosynthesis","volume":"55","author":"Acker","year":"1982","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2020.111118_bib2","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1021\/mp300609c","article-title":"Receptor-mediated endocytosis across human placenta: emphasis on megalin","volume":"10","author":"Akour","year":"2013","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.mce.2020.111118_bib3","doi-asserted-by":"crossref","first-page":"3157","DOI":"10.1093\/humrep\/dei184","article-title":"A prospective, longitudinal study of the renin-angiotensin system, prostacyclin and thromboxane in the first trimester of normal human pregnancy: association with birthweight","volume":"20","author":"Al Kadi","year":"2005","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.mce.2020.111118_bib4","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1095\/biolreprod31.5.1015","article-title":"Origin of different cell types in the bovine corpus luteum as characterized by specific monoclonal antibodies","volume":"31","author":"Alila","year":"1984","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2020.111118_bib5","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1161\/HYPERTENSIONAHA.107.103861","article-title":"Activation of local chorionic villi angiotensin II levels but not angiotensin (1-7) in preeclampsia","volume":"51","author":"Anton","year":"2008","journal-title":"Hypertension (Dallas, Tex : 1979)"},{"key":"10.1016\/j.mce.2020.111118_bib6","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1093\/oxfordjournals.humrep.a019045","article-title":"Serum relaxin and the major endometrial secretory proteins in in-vitro fertilization and down-regulated hormone-supported and natural cycle frozen embryo transfer","volume":"11","author":"Arthur","year":"1996","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.mce.2020.111118_bib7","first-page":"394","article-title":"Renal function in human pregnancy. II. Effects of venous pooling on renal hemodynamics and water, electrolyte, and aldosterone excretion during gestation","volume":"54","author":"Assali","year":"1959","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.mce.2020.111118_bib8","doi-asserted-by":"crossref","first-page":"2742","DOI":"10.1210\/endo-126-5-2742","article-title":"Regulation of 11 beta-hydroxysteroid dehydrogenase activity in the baboon placenta by estrogen","volume":"126","author":"Baggia","year":"1990","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2020.111118_bib9","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1161\/HYPERTENSIONAHA.113.02893","article-title":"Multiple ascending dose study with the new renin inhibitor VTP-27999: nephrocentric consequences of too much renin inhibition","volume":"63","author":"Balcarek","year":"2014","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2020.111118_bib10","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/j.1365-2796.2007.01809.x","article-title":"The origins of the developmental origins theory","volume":"261","author":"Barker","year":"2007","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.mce.2020.111118_bib11","doi-asserted-by":"crossref","first-page":"i1753","DOI":"10.1136\/bmj.i1753","article-title":"Clinical risk factors for pre-eclampsia determined in early pregnancy: systematic review and meta-analysis of large cohort studies","volume":"353","author":"Bartsch","year":"2016","journal-title":"BMJ"},{"key":"10.1016\/j.mce.2020.111118_bib12","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1161\/HYPERTENSIONAHA.111.180737","article-title":"Renin- and prorenin-induced effects in rat vascular smooth muscle cells overexpressing the human (pro)renin receptor: does (pro)renin-(pro)renin receptor interaction actually occur?","volume":"58","author":"Batenburg","year":"2011","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2020.111118_bib13","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1681\/ASN.V11112056","article-title":"Rats transgenic for human renin and human angiotensinogen as a model for gestational hypertension","volume":"11","author":"Bohlender","year":"2000","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.mce.2020.111118_bib14","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/0002-9378(86)90148-1","article-title":"Uteroplacental unit as a source of elevated circulating prorenin levels in normal pregnancy","volume":"155","author":"Brar","year":"1986","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.mce.2020.111118_bib15","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0002-9378(87)80173-4","article-title":"Increased fetoplacental active renin production in pregnancy-induced hypertension","volume":"157","author":"Brar","year":"1987","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.mce.2020.111118_bib16","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1210\/endo.133.6.8243273","article-title":"Effects of tumor necrosis factor-alpha on luteinizing hormone-stimulated prorenin production by bovine ovarian thecal cells in vitro","volume":"133","author":"Brunswig-Spickenheier","year":"1993","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2020.111118_bib17","first-page":"669","article-title":"Local regulatory factors in regulation of ovarian function: role of prorenin-renin-angiotensin-system","volume":"41","author":"Brunswig-Spickenheier","year":"2003","journal-title":"Indian J. Exp. Biol."},{"key":"10.1016\/j.mce.2020.111118_bib18","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1210\/jcem-56-3-557","article-title":"Increased inactive renin in diabetes mellitus without evidence of nephropathy","volume":"56","author":"Bryer-Ash","year":"1983","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2020.111118_bib19","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S1472-6483(10)62060-3","article-title":"Oxygen, early embryonic metabolism and free radical-mediated embryopathies","volume":"6","author":"Burton","year":"2003","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.mce.2020.111118_bib20","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1373\/clinchem.2008.118000","article-title":"Activity assays and immunoassays for plasma renin and prorenin: information provided and precautions necessary for accurate measurement","volume":"55","author":"Campbell","year":"2009","journal-title":"Clin. Chem."},{"key":"10.1016\/j.mce.2020.111118_bib21","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/0002-9378(89)90902-2","article-title":"Cardiovascular changes in early phase of pregnancy","volume":"161","author":"Capeless","year":"1989","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.mce.2020.111118_bib22","first-page":"615","article-title":"Endothelins stimulate the synthesis and release of prorenin from human decidual cells","volume":"76","author":"Chao","year":"1993","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2020.111118_bib23","doi-asserted-by":"crossref","first-page":"E842","DOI":"10.1152\/ajpendo.1994.267.6.E842","article-title":"Endothelin-1 modulates renin and prolactin release from human decidua by different mechanisms","volume":"267","author":"Chao","year":"1994","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2020.111118_bib24","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1046\/j.1523-1755.1998.00217.x","article-title":"Temporal relationships between hormonal and hemodynamic changes in early human pregnancy","volume":"54","author":"Chapman","year":"1998","journal-title":"Kidney Int."},{"key":"10.1016\/j.mce.2020.111118_bib25","doi-asserted-by":"crossref","first-page":"F1121","DOI":"10.1152\/ajprenal.00042.2014","article-title":"The renal circulation in normal pregnancy and preeclampsia: is there a place for relaxin?","volume":"306","author":"Conrad","year":"2014","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.mce.2020.111118_bib26","doi-asserted-by":"crossref","first-page":"E677","DOI":"10.1152\/ajpendo.00225.2019","article-title":"Potential influence of the corpus luteum on circulating reproductive and volume regulatory hormones, angiogenic and immunoregulatory factors in pregnant women","volume":"317","author":"Conrad","year":"2019","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2020.111118_bib27","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1161\/HYPERTENSIONAHA.119.13015","article-title":"Maternal cardiovascular dysregulation during early pregnancy after in vitro fertilization cycles in the absence of a corpus luteum","volume":"74","author":"Conrad","year":"2019","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2020.111118_bib28","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1093\/oxfordjournals.humrep.a137113","article-title":"Follicular fluid renin concentration and IVF outcome","volume":"5","author":"Cornwallis","year":"1990","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.mce.2020.111118_bib29","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.pharmthera.2006.12.001","article-title":"ACE phenotyping as a first step toward personalized medicine for ACE inhibitors. Why does ACE genotyping not predict the therapeutic efficacy of ACE inhibition?","volume":"113","author":"Danser","year":"2007","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.mce.2020.111118_bib30","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1097\/00004872-199816060-00017","article-title":"Determinants of interindividual variation of renin and prorenin concentrations: evidence for a sexual dimorphism of (pro)renin levels in humans","volume":"16","author":"Danser","year":"1998","journal-title":"J. Hypertens."},{"key":"10.1016\/j.mce.2020.111118_bib31","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1161\/01.CIR.96.1.220","article-title":"Prorenin, renin, angiotensinogen, and angiotensin-converting enzyme in normal and failing human hearts. Evidence for renin binding","volume":"96","author":"Danser","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.mce.2020.111118_bib32","doi-asserted-by":"crossref","first-page":"d1949-78","DOI":"10.2741\/davis1","article-title":"The corpus luteum: an ovarian structure with maternal instincts and suicidal tendencies","volume":"7","author":"Davis","year":"2002","journal-title":"Front. Biosci."},{"key":"10.1016\/j.mce.2020.111118_bib33","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/0002-9378(58)90808-1","article-title":"Renal glomerulotubular mechanisms during normal pregnancy. I. Glomerular filtration rate, renal plasma flow, and creatinine clearance","volume":"75","author":"De Alvarez","year":"1958","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.mce.2020.111118_bib34","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1097\/01.AOG.0000298622.22494.0c","article-title":"Maternal cardiac output between 11 and 13 weeks of gestation in the prediction of preeclampsia and small for gestational age","volume":"111","author":"De Paco","year":"2008","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.mce.2020.111118_bib35","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1210\/jcem-65-2-349","article-title":"Source of plasma prorenin in early and late pregnancy: observations in a patient with primary ovarian failure","volume":"65","author":"Derkx","year":"1987","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2020.111118_bib36","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.fertnstert.2008.07.1745","article-title":"The human corpus luteum: life cycle and function in natural cycles","volume":"92","author":"Devoto","year":"2009","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.mce.2020.111118_bib37","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1073\/pnas.85.6.1957","article-title":"Human ovarian theca cells are a source of renin","volume":"85","author":"Do","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mce.2020.111118_bib38","first-page":"1027","article-title":"Human chorionic gonadotropin stimulates placental prorenin secretion: evidence for autocrine\/paracrine regulation","volume":"81","author":"Downing","year":"1996","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2020.111118_bib39","first-page":"41","article-title":"Beta-adrenoceptor activation stimulates, and phosphodiesterase inhibition potentiates, placental prorenin synthesis and release","volume":"78","author":"Downing","year":"1994","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2020.111118_bib40","doi-asserted-by":"crossref","first-page":"7588","DOI":"10.1073\/pnas.87.19.7588","article-title":"Regulation of human renin expression in chorion cell primary cultures","volume":"87","author":"Duncan","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mce.2020.111118_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1471-0528.1981.tb00929.x","article-title":"Serial changes in renal haemodynamics during normal human pregnancy","volume":"88","author":"Dunlop","year":"1981","journal-title":"Br. J. Obstet. Gynaecol."},{"key":"10.1016\/j.mce.2020.111118_bib42","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/0029-7844(94)00417-C","article-title":"Maternal volume homeostasis in early pregnancy in relation to fetal growth restriction","volume":"85","author":"Duvekot","year":"1995","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.mce.2020.111118_bib43","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1016\/j.fertnstert.2007.10.026","article-title":"Review of the role of the plasminogen activator system and vascular endothelial growth factor in subfertility","volume":"90","author":"Ebisch","year":"2008","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.mce.2020.111118_bib44","first-page":"141","article-title":"Neovascularization produced by angiotensin II","volume":"105","author":"Fernandez","year":"1985","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.mce.2020.111118_bib45","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1210\/jcem-71-4-1008","article-title":"High plasma prorenin in diabetes mellitus and its correlation with some complications","volume":"71","author":"Franken","year":"1990","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2020.111118_bib46","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0090-6980(74)80001-8","article-title":"The effect of angiotensin-II intravenous infusion on plasma renin activity and prostaglandins A, E, and F levels in the uterine vein of the pregnant monkey","volume":"6","author":"Franklin","year":"1974","journal-title":"Prostaglandins"},{"key":"10.1016\/j.mce.2020.111118_bib47","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/ki.1980.133","article-title":"Control of vascular responsiveness during human pregnancy","volume":"18","author":"Gant","year":"1980","journal-title":"Kidney Int."},{"key":"10.1016\/j.mce.2020.111118_bib48","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.ajog.2019.03.010","article-title":"Neonatal and maternal outcome after frozen embryo transfer: increased risks in programmed cycles","volume":"221","author":"Ginstrom Ernstad","year":"2019","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.mce.2020.111118_bib49","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0002-9378(85)90309-6","article-title":"Prostaglandin production and stimulation by angiotensin II in the isolated perfused human placental cotyledon","volume":"151","author":"Glance","year":"1985","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.mce.2020.111118_bib50","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1126\/science.3529392","article-title":"Prorenin in high concentrations in human ovarian follicular fluid","volume":"233","author":"Glorioso","year":"1986","journal-title":"Science (New York, N Y )"},{"key":"10.1016\/j.mce.2020.111118_bib51","doi-asserted-by":"crossref","first-page":"2928","DOI":"10.1172\/JCI99417","article-title":"RNA interference therapeutics targeting angiotensinogen ameliorate preeclamptic phenotype in rodent models","volume":"130","author":"Haase","year":"2020","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mce.2020.111118_bib52","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0002-9378(96)70399-X","article-title":"The effect of ovulation induction on the concentration of maternal serum relaxin in twin pregnancies","volume":"174","author":"Haning","year":"1996","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.mce.2020.111118_bib53","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1093\/humrep\/deh803","article-title":"Progestogens stimulate prostacyclin production by human endothelial cells","volume":"20","author":"Hermenegildo","year":"2005","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.mce.2020.111118_bib54","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1161\/01.HYP.0000257797.49289.71","article-title":"Dysregulation of the circulating and tissue-based renin-angiotensin system in preeclampsia","volume":"49","author":"Herse","year":"2007","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2020.111118_bib55","first-page":"906","article-title":"Highest concentrations of prorenin and human chorionic gonadotropin in gestational sacs during early human pregnancy","volume":"75","author":"Itskovitz","year":"1992","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2020.111118_bib56","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1210\/jcem-72-1-165","article-title":"Relationship of follicular fluid prorenin to oocyte maturation, steroid levels, and outcome of in vitro fertilization","volume":"72","author":"Itskovitz","year":"1991","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2020.111118_bib57","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1097\/00006254-198709000-00003","article-title":"Ovarian prorenin-renin-angiotensin system","volume":"42","author":"Itskovitz","year":"1987","journal-title":"Obstet. Gynecol. Surv."},{"key":"10.1016\/j.mce.2020.111118_bib58","doi-asserted-by":"crossref","first-page":"7285","DOI":"10.1073\/pnas.84.20.7285","article-title":"Plasma prorenin response to human chorionic gonadotropin in ovarian-hyperstimulated women: correlation with the number of ovarian follicles and steroid hormone concentrations","volume":"84","author":"Itskovitz","year":"1987","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mce.2020.111118_bib59","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1161\/01.HYP.17.6.1115","article-title":"Subtype 2 angiotensin receptors mediate prostaglandin synthesis in human astrocytes","volume":"17","author":"Jaiswal","year":"1991","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2020.111118_bib60","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1093\/humupd\/dml016","article-title":"Placental-related diseases of pregnancy: involvement of oxidative stress and implications in human evolution","volume":"12","author":"Jauniaux","year":"2006","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.mce.2020.111118_bib61","first-page":"195","article-title":"Tumor necrosis factor-\u03b1 and interleukin-1\u03b2 inhibit the synthesis and release of renin from human decidual cells","volume":"80","author":"Jikihara","year":"1995","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2020.111118_bib62","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1095\/biolreprod54.6.1311","article-title":"Interferon-\u03b3 inhibits the synthesis and release of renin from human decidual cells","volume":"54","author":"Jikihara","year":"1996","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2020.111118_bib63","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1046\/j.1365-2265.1996.703525.x","article-title":"Determination of renin, angiotensin converting enzyme and angiotensin II levels in human placenta, chorion and amnion from women with pregnancy induced hypertension","volume":"44","author":"Kalenga","year":"1996","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.mce.2020.111118_bib64","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.lfs.2013.12.007","article-title":"Pigment-Epithelium Derived Factor (PEDF) and the human ovary: a role in the generation of ROS in granulosa cells","volume":"97","author":"Kampfer","year":"2014","journal-title":"Life Sci."},{"key":"10.1016\/j.mce.2020.111118_bib65","doi-asserted-by":"crossref","first-page":"3660","DOI":"10.1210\/endo.130.6.1597163","article-title":"Regulation of hepatic angiotensinogen synthesis and secretion by steroid hormones","volume":"130","author":"Klett","year":"1992","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2020.111118_bib66","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1093\/eurheartj\/ehp012","article-title":"The impact of left ventricular assist device-induced left ventricular unloading on the myocardial renin\u2013angiotensin\u2013aldosterone system: therapeutic consequences?","volume":"30","author":"Klotz","year":"2009","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.mce.2020.111118_bib67","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/S0022-3565(25)23795-8","article-title":"Angiotensin II (AT1) vascular binding sites in human placentae from normal-term, preeclamptic and growth retarded pregnancies","volume":"271","author":"Knock","year":"1994","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.mce.2020.111118_bib68","first-page":"E25","article-title":"Biological roles of angiotensin II via its type 2 receptor during rat follicle atresia","volume":"276","author":"Kotani","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.mce.2020.111118_bib69","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1093\/oxfordjournals.humrep.a019539","article-title":"Supraphysiological serum relaxin concentration during pregnancy achieved by in-vitro fertilization is strongly correlated to the number of growing follicles in the treatment cycle","volume":"11","author":"Kristiansson","year":"1996","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.mce.2020.111118_bib70","doi-asserted-by":"crossref","first-page":"654","DOI":"10.3109\/00365516609049049","article-title":"Plasma creatinine in normal pregnancy","volume":"18","author":"Kuhlback","year":"1966","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"10.1016\/j.mce.2020.111118_bib71","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1210\/jcem-18-11-1237","article-title":"Inhibition of the sodium-retaining influence of aldosterone by progesterone","volume":"18","author":"Landau","year":"1958","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2020.111118_bib72","doi-asserted-by":"crossref","first-page":"E876","DOI":"10.1152\/ajpendo.1991.260.6.E876","article-title":"Prorenin secretion from human placenta perfused in vitro","volume":"260","author":"Lenz","year":"1991","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2020.111118_bib73","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1210\/jcem-69-1-31","article-title":"Tissue levels of active and total renin, angiotensinogen, human chorionic gonadotropin, estradiol, and progesterone in human placentas from different methods of delivery","volume":"69","author":"Lenz","year":"1989","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2020.111118_bib74","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1172\/JCI119881","article-title":"Cellular localization of AT1 receptor mRNA and protein in normal placenta and its reduced expression in intrauterine growth restriction. Angiotensin II stimulates the release of vasorelaxants","volume":"101","author":"Li","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mce.2020.111118_bib75","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/0002-9378(87)90336-X","article-title":"The ovarian renin-angiotensin system: renin-like activity and angiotensin II\/III immunoreactivity in gonadotropin-stimulated and unstimulated human follicular fluid","volume":"156","author":"Lightman","year":"1987","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.mce.2020.111118_bib76","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1161\/CIRCRESAHA.115.306799","article-title":"Identification of the (pro)renin receptor as a novel regulator of low-density lipoprotein metabolism","volume":"118","author":"Lu","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.mce.2020.111118_bib77","doi-asserted-by":"crossref","DOI":"10.1186\/s12958-015-0127-8","article-title":"Decidualisation of human endometrial stromal cells is associated with increased expression and secretion of prorenin","volume":"13","author":"Lumbers","year":"2015","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.mce.2020.111118_bib78","first-page":"H188","article-title":"Uterine prostaglandin production in ovine pregnancy: effects of angiotensin II and indomethacin","volume":"263","author":"Magness","year":"1992","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.mce.2020.111118_bib79","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1097\/HJH.0b013e3283588189","article-title":"Maternal cardiovascular changes from pre-pregnancy to very early pregnancy","volume":"30","author":"Mahendru","year":"2012","journal-title":"J. Hypertens."},{"key":"10.1016\/j.mce.2020.111118_bib80","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1097\/HJH.0000000000001174","article-title":"Do prorenin-synthesizing cells release active, open prorenin?","volume":"35","author":"Martini","year":"2017","journal-title":"J. Hypertens."},{"key":"10.1016\/j.mce.2020.111118_bib81","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1210\/jcem-49-6-851","article-title":"The microenvironment of the human antral follicle: interrelationships among the steroid levels in antral fluid, the population of granulosa cells, and the status of the oocyte in vivo and in vitro","volume":"49","author":"McNatty","year":"1979","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2020.111118_bib82","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1161\/HYPERTENSIONAHA.119.13429","article-title":"Estrogen receptor-beta mediates estradiol-induced pregnancy-specific uterine ertery endothelial cell angiotensin type-2 receptor expression","volume":"74","author":"Mishra","year":"2019","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2020.111118_bib83","first-page":"88","article-title":"The ovarian renin angiotensin system: recent advances and their relationship to assisted reproductive technologies","volume":"3","author":"Morris","year":"1993","journal-title":"Assist Reprod. Rev."},{"key":"10.1016\/j.mce.2020.111118_bib84","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0029-7844(98)00091-X","article-title":"Elevated maternal serum relaxin concentrations throughout pregnancy in singleton gestations after superovulation","volume":"92","author":"Mushayandebvu","year":"1998","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.mce.2020.111118_bib85","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1126\/science.245.4920.871","article-title":"Angiotensin II: does it have a direct obligate role in ovulation?","volume":"245","author":"Naftolin","year":"1989","journal-title":"Science"},{"key":"10.1016\/j.mce.2020.111118_bib86","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/S0002-9378(88)80186-8","article-title":"Effects of pregnancy and hormone treatments on pressor response to angiotensin II in conscious rats","volume":"159","author":"Nakamura","year":"1988","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.mce.2020.111118_bib87","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1172\/JCI0214276","article-title":"Pivotal role of the renin\/prorenin receptor in angiotensin II production and cellular responses to renin","volume":"109","author":"Nguyen","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mce.2020.111118_bib88","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1172\/JCI100707","article-title":"Kidney Function during Normal Pregnancy I. The increased urea clearance of normal pregnancy","volume":"14","author":"Nice","year":"1935","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mce.2020.111118_bib89","first-page":"453","article-title":"Renin activation in normal and hypertensive human pregnancy","volume":"6","author":"Nicholson","year":"1987","journal-title":"Pregnancy Hypertens."},{"key":"10.1016\/j.mce.2020.111118_bib90","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/S0015-0282(16)60612-X","article-title":"Ovarian renin production in vitro and in vivo: characterization and clinical correlation","volume":"51","author":"Paulson","year":"1989","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.mce.2020.111118_bib91","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1126\/science.3381087","article-title":"Blockage of ovulation by an angiotensin antagonist","volume":"240","author":"Pellicer","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.mce.2020.111118_bib92","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/S0002-9378(12)90920-5","article-title":"The angiotensin II antagonist saralasin inhibits ovulation in the perfused rat ovary","volume":"168","author":"Peterson","year":"1993","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.mce.2020.111118_bib93","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1210\/jcem-67-6-1211","article-title":"Isolation and characterization of renin-producing human chorionic cells in culture","volume":"67","author":"Pinet","year":"1988","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2020.111118_bib94","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/978-1-4899-0952-7_31","article-title":"Regulation of utero-placental prorenin","volume":"377","author":"Poisner","year":"1995","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.mce.2020.111118_bib95","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0143-4004(05)80418-7","article-title":"Prorenin secretion from villous placenta: regulation by cyclic AMP and angiotensin","volume":"15","author":"Poisner","year":"1994","journal-title":"Placenta"},{"key":"10.1016\/j.mce.2020.111118_bib96","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1210\/jcem-70-6-1765","article-title":"Relaxin stimulates the synthesis and release of prorenin from human decidual cells: evidence for autocrine\/paracrine regulation","volume":"70","author":"Poisner","year":"1990","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2020.111118_bib97","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0143-4004(91)90007-3","article-title":"Cyclic AMP as a second messenger for prorenin release from human decidual cells","volume":"12","author":"Poisner","year":"1991","journal-title":"Placenta"},{"key":"10.1016\/j.mce.2020.111118_bib98","doi-asserted-by":"crossref","first-page":"347","DOI":"10.3109\/10641959609009595","article-title":"Total renin in preeclamptic placenta","volume":"15","author":"Poranen","year":"2009","journal-title":"Hypertens. Pregnancy"},{"key":"10.1016\/j.mce.2020.111118_bib99","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.preghy.2020.07.008","article-title":"Circulating pregnancy hormone relaxin as a first trimester biomarker for preeclampsia","volume":"22","author":"Post Uiterweer","year":"2020","journal-title":"Pregnancy Hypertens."},{"key":"10.1016\/j.mce.2020.111118_bib100","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1177\/1933719114561555","article-title":"Effects of fetal sex on expression of the (pro)renin receptor and genes influenced by its interaction with prorenin in human amnion","volume":"22","author":"Pringle","year":"2015","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.mce.2020.111118_bib101","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.placenta.2011.09.020","article-title":"The expression and localization of the human placental prorenin\/renin- angiotensin system throughout pregnancy: roles in trophoblast invasion and angiogenesis?","volume":"32","author":"Pringle","year":"2011","journal-title":"Placenta"},{"key":"10.1016\/j.mce.2020.111118_bib102","doi-asserted-by":"crossref","DOI":"10.1177\/2042018820920560","article-title":"The role of the renin\u2013angiotensin system in regulating endometrial neovascularization during the peri-implantation period: literature review and preliminary data","volume":"11","author":"Qi","year":"2020","journal-title":"Ther. Adv. Endocrinol. Metabol."},{"key":"10.1016\/j.mce.2020.111118_bib103","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1161\/CIRCRESAHA.117.312422","article-title":"(Pro)renin receptor inhibition reprograms hepatic lipid metabolism and protects mice from diet-induced obesity and hepatosteatosis","volume":"122","author":"Ren","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.mce.2020.111118_bib104","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1007\/s00125-011-2087-7","article-title":"A high concentration of prorenin in early pregnancy is associated with development of pre-eclampsia in women with type 1 diabetes","volume":"54","author":"Ringholm","year":"2011","journal-title":"Diabetologia"},{"key":"10.1016\/j.mce.2020.111118_bib105","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1161\/HYPERTENSIONAHA.109.130898","article-title":"Influence of the menstrual cycle, pregnancy, and preeclampsia on arterial stiffness","volume":"53","author":"Robb","year":"2009","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2020.111118_bib106","first-page":"F338","article-title":"Altered glomerular permselectivity to neutral dextrans and heteroporous membrane modeling in human pregnancy","volume":"270","author":"Roberts","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.mce.2020.111118_bib107","first-page":"H1060","article-title":"Serial study of factors influencing changes in cardiac output during human pregnancy","volume":"256","author":"Robson","year":"1989","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.mce.2020.111118_bib108","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1016\/j.fertnstert.2007.09.022","article-title":"Corpus luteum across the first trimester: size and laterality as observed by ultrasound","volume":"90","author":"Rowan","year":"2008","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.mce.2020.111118_bib109","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1161\/01.HYP.0000200042.64517.19","article-title":"Time course of maternal plasma volume and hormonal changes in women with preeclampsia or fetal growth restriction","volume":"47","author":"Salas","year":"2006","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2020.111118_bib110","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3109\/10641959809072239","article-title":"Plasma volume, renal function, and hormonal levels in pregnant women with idiopathic fetal growth restriction or preeclampsia","volume":"17","author":"Salas","year":"1998","journal-title":"Hypertens. Pregnancy"},{"key":"10.1016\/j.mce.2020.111118_bib111","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1097\/HJH.0b013e3282f6a671","article-title":"Newly developed renin and prorenin assays and the clinical evaluation of renin inhibitors","volume":"26","author":"Schalekamp","year":"2008","journal-title":"J. Hypertens."},{"key":"10.1016\/j.mce.2020.111118_bib112","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1097\/HJH.0b013e32835d6d11","article-title":"How does the angiotensin II type 1 receptor 'trump' the type 2 receptor in blood pressure control?","volume":"31","author":"Schalekamp","year":"2013","journal-title":"J. Hypertens."},{"key":"10.1016\/j.mce.2020.111118_bib113","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1046\/j.0960-7692.2001.00596.x","article-title":"Uterine artery Doppler and placental volume in the first trimester in the prediction of pregnancy complications","volume":"18","author":"Schuchter","year":"2001","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"10.1016\/j.mce.2020.111118_bib114","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/0895-7061(96)00092-1","article-title":"Specific prorenin\/renin binding (ProBP) identification and characterization of a novel membrane site","volume":"9","author":"Sealey","year":"1996","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.mce.2020.111118_bib115","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/0002-9378(85)90464-8","article-title":"Plasma prorenin in first-trimester pregnancy: relationship to changes in human chorionic gonadotropin","volume":"153","author":"Sealey","year":"1985","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.mce.2020.111118_bib116","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1093\/ajh\/4.12.972","article-title":"The greater renin system. Its prorenin-directed vasodilator limb. Relevance to diabetes mellitus, pregnancy, and hypertension","volume":"4","author":"Sealey","year":"1991","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.mce.2020.111118_bib117","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1210\/jcem-68-6-1073","article-title":"Periovulatory follicular fluid hormone levels in spontaneous human cycles","volume":"68","author":"Seibel","year":"1989","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2020.111118_bib118","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/0002-9378(91)90603-O","article-title":"Effect of progesterone on renin secretion in endometrial stromal, chorionic trophoblast, and mesenchymal monolayer cultures","volume":"164","author":"Shah","year":"1991","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.mce.2020.111118_bib119","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1172\/JCI114121","article-title":"Human decidua is a major source of renin","volume":"83","author":"Shaw","year":"1989","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mce.2020.111118_bib120","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1093\/humrep\/dem109","article-title":"Drospirenone increases endothelial nitric oxide synthesis via a combined action on progesterone and mineralocorticoid receptors","volume":"22","author":"Simoncini","year":"2007","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.mce.2020.111118_bib121","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1172\/JCI103769","article-title":"Serial studies of renal function during pregnancy and the puerperium in normal women","volume":"37","author":"Sims","year":"1958","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mce.2020.111118_bib122","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.placenta.2004.01.013","article-title":"Raised prorenin and renin concentrations in pre-eclamptic placentae when measured after acid activation","volume":"25","author":"Singh","year":"2004","journal-title":"Placenta"},{"key":"10.1016\/j.mce.2020.111118_bib123","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1042\/CS20171550","article-title":"Fetal programming and the angiotensin-(1-7) axis: a review of the experimental and clinical data","volume":"133","author":"South","year":"2019","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.mce.2020.111118_bib124","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1046\/j.1523-1755.2001.00943.x","article-title":"Preeclampsia and maladaptation to pregnancy: a role for atrial natriuretic peptide?","volume":"60","author":"Spaanderman","year":"2001","journal-title":"Kidney Int."},{"key":"10.1016\/j.mce.2020.111118_bib125","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1093\/humupd\/dmt041","article-title":"The periconceptional period, reproduction and long-term health of offspring: the importance of one-carbon metabolism","volume":"19","author":"Steegers-Theunissen","year":"2013","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.mce.2020.111118_bib126","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0021-9258(19)40185-3","article-title":"Angiotensin II inhibits luteinizing hormone-stimulated cholesterol side chain cleavage expression and stimulates basic fibroblast growth factor expression in bovine luteal cells in primary culture","volume":"265","author":"Stirling","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2020.111118_bib127","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1161\/HYPERTENSIONAHA.120.14845","article-title":"Megalin: a novel endocytic receptor for prorenin and renin","volume":"75","author":"Sun","year":"2020","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2020.111118_bib128","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1126\/science.274.5289.995","article-title":"Hypertension induced in pregnant mice by placental renin and maternal angiotensinogen","volume":"274","author":"Takimoto","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.mce.2020.111118_bib129","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1161\/HYPERTENSIONAHA.119.12703","article-title":"Strong and sustained antihypertensive effect of small interfering RNA targeting liver angiotensinogen","volume":"73","author":"Uijl","year":"2019","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2020.111118_bib130","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/uog.1095","article-title":"Abnormal maternal cardiac function precedes the clinical manifestation of fetal growth restriction","volume":"24","author":"Vasapollo","year":"2004","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"10.1016\/j.mce.2020.111118_bib131","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1161\/HYPERTENSIONAHA.115.05267","article-title":"Association studies suggest a key role for endothelin-1 in the pathogenesis of preeclampsia and the accompanying renin-angiotensin-aldosterone system suppression","volume":"65","author":"Verdonk","year":"2015","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2020.111118_bib132","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1042\/CS20130455","article-title":"The renin-angiotensin-aldosterone system in pre-eclampsia: the delicate balance between good and bad","volume":"126","author":"Verdonk","year":"2014","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.mce.2020.111118_bib133","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1161\/HYPERTENSIONAHA.118.12043","article-title":"Increased preeclampsia risk and reduced aortic compliance with in vitro fertilization cycles in the absence of a corpus luteum","volume":"73","author":"von Versen-H\u00f6ynck","year":"2019","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2020.111118_bib134","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.placenta.2012.12.018","article-title":"The effects of cyclic AMP, sex steroids and global hypomethylation on the expression of genes controlling the activity of the renin-angiotensin system in placental cell lines","volume":"34","author":"Wang","year":"2013","journal-title":"Placenta"},{"key":"10.1016\/j.mce.2020.111118_bib135","first-page":"821","article-title":"Elevated first-trimester serum relaxin concentrations in pregnant women following ovarian stimulation predict prematurity risk and preterm delivery","volume":"82","author":"Weiss","year":"1993","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.mce.2020.111118_bib136","first-page":"557","article-title":"Progesterone and estrogen secretion by puerperal human ovaries","volume":"46","author":"Weiss","year":"1975","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.mce.2020.111118_bib137","doi-asserted-by":"crossref","first-page":"3505","DOI":"10.1210\/clinem\/dgaa582","article-title":"Determinants of maternal renin-angiotensin-aldosterone-system activation in early pregnancy: insights from 2 cohorts","volume":"105","author":"Wiegel","year":"2020","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2020.111118_bib138","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1210\/jcem-40-1-108","article-title":"Relationship between plasma renin, renin-substrate, angiotensin II, aldosterone and electrolytes in normal pregnancy","volume":"40","author":"Wier","year":"1975","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2020.111118_bib139","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1006\/frne.1997.0152","article-title":"The ovarian renin-angiotensin system in reproductive physiology","volume":"18","author":"Yoshimura","year":"1997","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.mce.2020.111118_bib140","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1210\/endo.137.4.8625890","article-title":"Angiotensin II induces ovulation and oocyte maturation in rabbit ovaries via the AT2 receptor subtype","volume":"137","author":"Yoshimura","year":"1996","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2020.111118_bib141","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0014-5793(92)80701-H","article-title":"Angiotensin II directly induces follicle rupture and oocyte maturation in the rabbit","volume":"307","author":"Yoshimura","year":"1992","journal-title":"FEBS Lett."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720720304202?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720720304202?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T14:13:45Z","timestamp":1759587225000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720720304202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":141,"alternative-id":["S0303720720304202"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2020.111118","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prorenin periconceptionally and in pregnancy: Does it have a physiological role?","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2020.111118","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"111118"}}