{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:41:05Z","timestamp":1788543665581,"version":"build-2803163510"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T00:00:00Z","timestamp":1640908800000},"content-version":"vor","delay-in-days":305,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.mce.2020.111141","type":"journal-article","created":{"date-parts":[[2020,12,24]],"date-time":"2020-12-24T18:49:52Z","timestamp":1608835792000},"page":"111141","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Early life nicotine exposure alters mRNA and microRNA expressions related to thyroid function and lipid metabolism in liver and BAT of adult wistar rats"],"prefix":"10.1016","volume":"523","author":[{"given":"Thamara Cherem","family":"Peixoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Egberto","family":"Gaspar de Moura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Torres","family":"Quitete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"La\u00eds Ang\u00e9lica","family":"Simino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana Souza","family":"Torsoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcio Alberto","family":"Torsoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4629-8343","authenticated-orcid":false,"given":"Alex Christian","family":"Manhaes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia Cristina","family":"Lisboa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.mce.2020.111141_bib1","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1017\/S2040174419000151","article-title":"Environmental monitoring and the developmental origins of health and disease","volume":"10","author":"Almeida","year":"2019","journal-title":"Journal of developmental origins of health and disease"},{"issue":"10","key":"10.1016\/j.mce.2020.111141_bib2","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1016\/j.biocel.2011.05.016","article-title":"Type 2 deiodinase at the crossroads of thyroid hormone action","volume":"43","author":"Arrojo E Drigo","year":"2011","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"1","key":"10.1016\/j.mce.2020.111141_bib3","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1093\/toxsci\/kfy083","article-title":"Maternal nicotine exposure leads to augmented expression of the antioxidant adipose tissue triglyceride lipase long-term in the white adipose of female rat offspring","volume":"164","author":"Barra","year":"2018","journal-title":"Toxicol. Sci.: an official journal of the Society of Toxicology"},{"key":"10.1016\/j.mce.2020.111141_bib4","doi-asserted-by":"crossref","first-page":"113781","DOI":"10.1016\/j.envpol.2019.113781","article-title":"Programming of hepatic lipid metabolism in a rat model of postnatal nicotine exposure - sex-related differences","volume":"258","author":"Bertasso","year":"2020","journal-title":"Environ. Pollut."},{"issue":"9","key":"10.1016\/j.mce.2020.111141_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0024541","article-title":"MiR-224 targets the 3'UTR of type 1 5'-iodothyronine deiodinase possibly contributing to tissue hypothyroidism in renal cancer","volume":"6","author":"Boguslawska","year":"2011","journal-title":"PloS One"},{"issue":"1\u20132","key":"10.1016\/j.mce.2020.111141_bib6","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.mce.2014.01.006","article-title":"Regulatory feedback loop between T3 and microRNAs in renal cancer","volume":"384","author":"Boguslawska","year":"2014","journal-title":"Mol. Cell. Endocrinol."},{"issue":"12","key":"10.1016\/j.mce.2020.111141_bib7","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1016\/j.metabol.2010.04.003","article-title":"Hepatic and very low-density lipoprotein fatty acids in obese offspring of overfed dams","volume":"59","author":"Bouanane","year":"2010","journal-title":"Metab., Clin. Exp."},{"issue":"6","key":"10.1016\/j.mce.2020.111141_bib8","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1210\/jc.2003-030398","article-title":"Hypothyroidism and atherosclerosis","volume":"88","author":"Cappola","year":"2003","journal-title":"J. Clin. Endocrinol. Metabol."},{"issue":"9","key":"10.1016\/j.mce.2020.111141_bib9","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.2337\/db15-1423","article-title":"\u03b2-Lapachone prevents diet-induced obesity by increasing energy expenditure and stimulating the browning of white adipose tissue via downregulation of miR-382 expression","volume":"65","author":"Choi","year":"2016","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.mce.2020.111141_bib10","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1530\/JOE-12-0204","article-title":"Iodothyronine deiodinase structure and function: from ascidians to humans","volume":"215","author":"Darras","year":"2012","journal-title":"J. Endocrinol."},{"issue":"2","key":"10.1016\/j.mce.2020.111141_bib11","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.cmet.2006.01.005","article-title":"miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting","volume":"3","author":"Esau","year":"2006","journal-title":"Cell Metabol."},{"issue":"5","key":"10.1016\/j.mce.2020.111141_bib12","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1080\/01913123.2016.1223243","article-title":"Prenatal and lactation nicotine exposure affects morphology and function of brown adipose tissue in male rat offspring","volume":"40","author":"Fan","year":"2016","journal-title":"Ultrastruct. Pathol."},{"key":"10.1016\/j.mce.2020.111141_bib13","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.mce.2016.12.017","article-title":"MicroRNAs in thyroid development, function and tumorigenesis","volume":"456","author":"Fuziwara","year":"2017","journal-title":"Mol. Cell. Endocrinol."},{"issue":"2","key":"10.1016\/j.mce.2020.111141_bib14","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1378\/chest.15-1858","article-title":"Impact of tobacco smoke and nicotine exposure on lung development","volume":"149","author":"Gibbs","year":"2016","journal-title":"Chest"},{"issue":"1","key":"10.1016\/j.mce.2020.111141_bib15","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1017\/S2040174409990171","article-title":"A conceptual framework for the developmental origins of health and disease","volume":"1","author":"Gluckman","year":"2010","journal-title":"Journal of developmental origins of health and disease"},{"issue":"11","key":"10.1016\/j.mce.2020.111141_bib16","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/j.dld.2018.08.012","article-title":"Association of non-alcoholic fatty liver disease with thyroid function: a systematic review and meta-analysis","volume":"50","author":"Guo","year":"2018","journal-title":"Dig Liver Dis. v."},{"issue":"1","key":"10.1016\/j.mce.2020.111141_bib17","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1210\/en.2012-1559","article-title":"Human stearoyl-CoA desaturase 1 (SCD-1) gene expression is negatively regulated by thyroid hormone without direct binding of thyroid hormone receptor to the gene promoter","volume":"154","author":"Hashimoto","year":"2013","journal-title":"Endocrinology"},{"issue":"8","key":"10.1016\/j.mce.2020.111141_bib18","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1158\/0008-5472.CAN-12-2218","article-title":"Thyroid hormone regulation of miR-21 enhances migration and invasion of hepatoma","volume":"73","author":"Huang","year":"2013","journal-title":"Canc. Res."},{"issue":"6","key":"10.1016\/j.mce.2020.111141_bib19","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1194\/jlr.M004812","article-title":"MicroRNA-370 controls the expression of microRNA-122 and Cpt1alpha and affects lipid metabolism","volume":"51","author":"Iliopoulos","year":"2010","journal-title":"J. Lipid Res."},{"issue":"10","key":"10.1016\/j.mce.2020.111141_bib20","doi-asserted-by":"crossref","first-page":"7964","DOI":"10.1074\/jbc.M211062200","article-title":"A thyroid hormone response unit formed between the promoter and first intron of the carnitine palmitoyltransferase-Ialpha gene mediates the liver-specific induction by thyroid hormone","volume":"278","author":"Jackson-Hayes","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.mce.2020.111141_bib21","doi-asserted-by":"crossref","first-page":"E546","DOI":"10.1210\/jc.2010-1594","article-title":"Thyroid hormone receptor beta (THRB) is a major target gene for microRNAs deregulated in papillary thyroid carcinoma (PTC)","volume":"96","author":"Jazdzewski","year":"2011","journal-title":"J. Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.mce.2020.111141_bib22","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1741-7015-11-27","article-title":"Multigenerational epigenetic effects of nicotine on lung function","volume":"11","author":"Leslie","year":"2013","journal-title":"BMC Med."},{"issue":"3","key":"10.1016\/j.mce.2020.111141_bib23","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.jhep.2010.12.023","article-title":"Positive regulation of hepatic miR-122 expression by HNF4\u03b1","volume":"55","author":"Li","year":"2011","journal-title":"J. Hepatol."},{"key":"10.1016\/j.mce.2020.111141_bib24","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0079-6123(08)60502-6","article-title":"Prenatal adverse effects of nicotine on the developing brain","volume":"73","author":"Lichtensteiger","year":"1988","journal-title":"Prog. Brain Res."},{"issue":"3","key":"10.1016\/j.mce.2020.111141_bib25","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1530\/JOE-14-0473","article-title":"Effects of maternal nicotine exposure on thyroid hormone metabolism and function in adult rat progeny","volume":"224","author":"Lisboa","year":"2015","journal-title":"J. Endocrinol."},{"issue":"4","key":"10.1016\/j.mce.2020.111141_bib26","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"4","key":"10.1016\/j.mce.2020.111141_bib27","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.jaci.2017.08.034","article-title":"MicroRNA","volume":"141","author":"Lu","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"issue":"3","key":"10.1016\/j.mce.2020.111141_bib28","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1530\/JOE-10-0481","article-title":"Deiodinases: the balance of thyroid hormone: type 1 iodothyronine deiodinase in human physiology and disease","volume":"209","author":"Maia","year":"2011","journal-title":"J. Endocrinol."},{"issue":"7","key":"10.1016\/j.mce.2020.111141_bib29","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1038\/nn.4330","article-title":"Epigenetics, behavior and early nicotine","volume":"19","author":"Maldonado","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.mce.2020.111141_bib30","doi-asserted-by":"crossref","first-page":"111623","DOI":"10.1016\/j.fct.2020.111623","article-title":"Tobacco smoking during breastfeeding increases the risk of developing metabolic syndrome in adulthood: lessons from experimental models","volume":"144","author":"Miranda","year":"2020","journal-title":"Food Chem. Toxicol.: an international journal published for the British Industrial Biological Research Association"},{"key":"10.1016\/j.mce.2020.111141_bib31","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-72725-w","article-title":"Thyroid redox imbalance in adult Wistar rats that were exposed to nicotine during breastfeeding","author":"Miranda","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mce.2020.111141_bib32","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/bs.acr.2017.06.003","article-title":"MicroRNAs and epigenetics","volume":"135","author":"Moutinho","year":"2017","journal-title":"Adv. Canc. Res."},{"key":"10.1016\/j.mce.2020.111141_bib33","doi-asserted-by":"crossref","first-page":"113973","DOI":"10.1016\/j.bcp.2020.113973","article-title":"The role of epigenetics in the development of obesity","volume":"177","author":"Obri","year":"2020","journal-title":"Biochem. Pharmacol."},{"issue":"3","key":"10.1016\/j.mce.2020.111141_bib34","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1677\/JOE-09-0020","article-title":"Short- and long-term effects of maternal nicotine exposure during lactation on body adiposity, lipid profile, and thyroid function of rat offspring","volume":"202","author":"Oliveira","year":"2009","journal-title":"J. Endocrinol."},{"issue":"2","key":"10.1016\/j.mce.2020.111141_bib35","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1677\/JOE-09-0430","article-title":"Nicotine exposure affects mother's and pup's nutritional, biochemical, and hormonal profiles during lactation in rats","volume":"205","author":"Oliveira","year":"2010","journal-title":"J. Endocrinol."},{"issue":"3","key":"10.1016\/j.mce.2020.111141_bib36","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1002\/j.2040-4603.2016.tb00708.x","article-title":"Hypothalamus-pituitary-thyroid Axis","volume":"6","author":"Ortiga-Carvalho","year":"2016","journal-title":"Comprehensive Physiology"},{"key":"10.1016\/j.mce.2020.111141_bib37","doi-asserted-by":"crossref","first-page":"111328","DOI":"10.1016\/j.fct.2020.111328","article-title":"Nicotine exposure during breastfeeding reduces sympathetic activity in brown adipose tissue and increases in white adipose tissue in adult rats: sex-related differences","volume":"140","author":"Peixoto","year":"2020","journal-title":"Food Chem. Toxicol."},{"issue":"10","key":"10.1016\/j.mce.2020.111141_bib38","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1055\/s-0031-1285909","article-title":"Developmental plasticity in adrenal function and leptin production primed by nicotine exposure during lactation: gender differences in rats","volume":"43","author":"Pinheiro","year":"2011","journal-title":"Horm. Metab. Res."},{"issue":"4","key":"10.1016\/j.mce.2020.111141_bib39","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1007\/s12035-019-01843-y","article-title":"Pre-exposure to nicotine with nocturnal abstinence induces epigenetic changes that potentiate nicotine preference","volume":"57","author":"Pisera-Fuster","year":"2020","journal-title":"Mol. Neurobiol."},{"issue":"6 Pt 2","key":"10.1016\/j.mce.2020.111141_bib40","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S1262-3636(08)74599-3","article-title":"The role of the lipogenic pathway in the development of hepatic steatosis","volume":"34","author":"Postic","year":"2008","journal-title":"Diabetes Metabol."},{"key":"10.1016\/j.mce.2020.111141_bib41","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41420-018-0076-z","article-title":"Modulation of liver steatosis by miR-21\/PPAR\u03b1","volume":"4","author":"Rodrigues","year":"2018","journal-title":"Cell death discovery"},{"issue":"7","key":"10.1016\/j.mce.2020.111141_bib42","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1089\/thy.2017.0369","article-title":"Thyroid hormone receptors regulate the expression of microRNAs with key roles in skin homeostasis","volume":"28","author":"Ruiz-Llorente","year":"2018","journal-title":"Thyroid: official journal of the American Thyroid Association"},{"issue":"10","key":"10.1016\/j.mce.2020.111141_bib43","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1111\/j.1742-4658.2011.08089.x","article-title":"MicroRNAs and epigenetics","volume":"278","author":"Sato","year":"2011","journal-title":"FEBS J."},{"key":"10.1016\/j.mce.2020.111141_bib44","doi-asserted-by":"crossref","first-page":"125774","DOI":"10.1016\/j.chemosphere.2019.125774","article-title":"Rno-miR-224-5p contributes to 2,2',4,4'-tetrabromodiphenyl ether-induced low triiodothyronine in rats by targeting deiodinases","volume":"246","author":"Wang","year":"2020","journal-title":"Chemosphere"},{"issue":"7","key":"10.1016\/j.mce.2020.111141_bib45","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1177\/1087057110374991","article-title":"Identification of MicroRNAs that control lipid droplet formation and growth in hepatocytes via high-content screening","volume":"15","author":"Whittaker","year":"2010","journal-title":"J. Biomol. Screen"},{"issue":"1","key":"10.1016\/j.mce.2020.111141_bib46","doi-asserted-by":"crossref","first-page":"54","DOI":"10.5603\/EP.2017.0007","article-title":"Thyroid dysfunction in obese and overweight children","volume":"68","author":"Witkowska-S\u0119dek","year":"2017","journal-title":"Endokrynol. Pol."},{"key":"10.1016\/j.mce.2020.111141_bib47","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/bs.apha.2018.02.003","article-title":"Epigenetics and MicroRNAs in pharmacogenetics","volume":"83","author":"Zanger","year":"2018","journal-title":"Adv. Pharmacol."},{"issue":"5","key":"10.1016\/j.mce.2020.111141_bib48","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1097\/MED.0b013e32833d6d46","article-title":"New insights into regulation of lipid metabolism by thyroid hormone","volume":"17","author":"Zhu","year":"2010","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720720304433?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720720304433?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T14:12:41Z","timestamp":1759587161000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720720304433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":48,"alternative-id":["S0303720720304433"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2020.111141","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early life nicotine exposure alters mRNA and microRNA expressions related to thyroid function and lipid metabolism in liver and BAT of adult wistar rats","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2020.111141","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"111141"}}