{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:04:47Z","timestamp":1792073087675,"version":"4.4.0"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001771","name":"University of Newcastle","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001771","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"NHMRC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.mce.2021.111193","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T19:27:44Z","timestamp":1613676464000},"page":"111193","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Evidence that extrapancreatic insulin production is involved in the mediation of sperm survival"],"prefix":"10.1016","volume":"526","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9152-156X","authenticated-orcid":false,"given":"R. John","family":"Aitken","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin J.","family":"Curry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Said","family":"Shokri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7274-4151","authenticated-orcid":false,"given":"Dwi Ari","family":"Pujianto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Gavriliouk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zamira","family":"Gibb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Whiting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayley S.","family":"Connaughton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett","family":"Nixon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lois A.","family":"Salamonsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2021.111193_bib1","first-page":"287","article-title":"Not every sperm is sacred; a perspective on male infertility","volume":"24","author":"Aitken","year":"2018","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.mce.2021.111193_bib2","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1093\/molehr\/gat067","article-title":"Sperm capacitation: a distant landscape glimpsed but unexplored","volume":"19","author":"Aitken","year":"2013","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.mce.2021.111193_bib3","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/j.1600-0897.1996.tb00055.x","article-title":"On the use of paramagnetic beads and ferrofluids to assess and eliminate the leukocytic contribution to oxygen radical generation by human sperm suspensions","volume":"35","author":"Aitken","year":"1996","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.mce.2021.111193_bib4","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1095\/biolreprod.112.102020","article-title":"Sperm motility is lost in vitro as a consequence of mitochondrial free radical production and the generation of electrophilic aldehydes but can be significantly rescued by the presence of nucleophilic thiols","volume":"87","author":"Aitken","year":"2012","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2021.111193_bib5","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.bcp.2016.09.015","article-title":"Analysis of the effects of polyphenols on human spermatozoa reveals unexpected impacts on mitochondrial membrane potential, oxidative stress and DNA integrity; implications for assisted reproductive technology","volume":"121","author":"Aitken","year":"2016","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.mce.2021.111193_bib6","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1093\/molehr\/gag086","article-title":"Multiple forms of redox activity in populations of human spermatozoa","volume":"9","author":"Aitken","year":"2003","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.mce.2021.111193_bib7","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s12862-017-0994-z","article-title":"Evolution of the vertebrate insulin receptor substrate (Irs) gene family","volume":"17","author":"Al-Salam","year":"2017","journal-title":"BMC Evol. Biol."},{"key":"10.1016\/j.mce.2021.111193_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mce.2005.09.011","article-title":"Arguments raised by the recent discovery that insulin and leptin are expressed in and secreted by human ejaculated spermatozoa","volume":"245","author":"And\u00f2","year":"2005","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2021.111193_bib9","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1210\/en.2004-1252","article-title":"Autocrine regulation of insulin secretion in human ejaculated spermatozoa","volume":"146","author":"Aquila","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2021.111193_bib10","doi-asserted-by":"crossref","first-page":"2594","DOI":"10.1093\/humrep\/dem243","article-title":"Human sperm express a functional androgen receptor: effects on PI3K\/AKT pathway","volume":"22","author":"Aquila","year":"2007","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.mce.2021.111193_bib11","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/mrd.22145","article-title":"Red wine consumption may affect sperm biology: the effects of different concentrations of the phytoestrogen myricetin on human male gamete function","volume":"80","author":"Aquila","year":"2013","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.mce.2021.111193_bib12","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1210\/jc.2003-031681","article-title":"Estrogen receptor (ER)alpha and ER beta are both expressed in human ejaculated spermatozoa: evidence of their direct interaction with phosphatidylinositol-3-OH kinase\/Akt pathway","volume":"89","author":"Aquila","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2021.111193_bib13","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ydbio.2009.06.022","article-title":"Phosphorylation and consequent stimulation of the tyrosine kinase c-Abl by PKA in mouse spermatozoa; its implications during capacitation","volume":"333","author":"Baker","year":"2009","journal-title":"Dev. Biol."},{"key":"10.1016\/j.mce.2021.111193_bib14","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3109\/19396368.2011.639844","article-title":"Proteomic insights into the maturation and capacitation of mammalian spermatozoa","volume":"58","author":"Baker","year":"2012","journal-title":"Syst. Biol. Reprod. Med."},{"key":"10.1016\/j.mce.2021.111193_bib15","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1002\/prca.200601013","article-title":"Identification of gene products present in Triton X-100 soluble and insoluble fractions of human spermatozoa lysates using LC-MS\/MS analysis","volume":"1","author":"Baker","year":"2007","journal-title":"Proteonomics Clin. Appl."},{"key":"10.1016\/j.mce.2021.111193_bib16","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1021\/pr1007224","article-title":"Use of titanium dioxide to find phosphopeptide and total protein changes during epididymal sperm maturation","volume":"10","author":"Baker","year":"2011","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.mce.2021.111193_bib17","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1172\/JCI115819","article-title":"Alternatively spliced variants of the insulin receptor protein. Expression in normal and diabetic human tissues","volume":"89","author":"Benecke","year":"1992","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mce.2021.111193_bib18","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1007\/s00125-002-0945-z","article-title":"Absence of functional insulin receptor substrate-3 (IRS-3) gene in humans","volume":"45","author":"Bj\u00f6rnholm","year":"2002","journal-title":"Diabetologia"},{"key":"10.1016\/j.mce.2021.111193_bib19","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1071\/BI9540552","article-title":"Fertilization of the mouse egg and the effect of delayed coitus and of hot-shock treatment","volume":"7","author":"Braden","year":"1954","journal-title":"Aust. J. Biol. Sci."},{"key":"10.1016\/j.mce.2021.111193_bib20","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.mce.2009.06.009","article-title":"Role and regulation of PI3K in sperm capacitation and the acrosome reaction","volume":"314","author":"Breitbart","year":"2010","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2021.111193_bib21","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/nrendo.2016.116","article-title":"Fertile ground: human endometrial programming and lessons in health and disease","volume":"12","author":"Evans","year":"2016","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.mce.2021.111193_bib22","first-page":"787","article-title":"Peroxiredoxin 6 regulates the phosphoinositide 3-kinase\/AKT pathway to maintain human sperm viability","volume":"25","author":"Fernandez","year":"2019","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.mce.2021.111193_bib23","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1093\/biolre\/ioy063","article-title":"Idiopathic infertility in women is associated with distinct changes in proliferative phase uterine fluid proteins","volume":"98","author":"Fitzgerald","year":"2018","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2021.111193_bib24","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1439-0272.1992.tb02605.x","article-title":"Progesterone induces capacitation in human spermatozoa","volume":"24","author":"Foresta","year":"1992","journal-title":"Andrologia"},{"key":"10.1016\/j.mce.2021.111193_bib25","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3109\/01485019108987634","article-title":"Semen characteristics and diabetes mellitus: significance of insulin in male infertility","volume":"26","author":"Garc\u00eda-D\u00edez","year":"1991","journal-title":"Arch. Androl."},{"key":"10.1016\/j.mce.2021.111193_bib26","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1101\/gad.367606","article-title":"Mammalian sperm translate nuclear-encoded proteins by mitochondrial-type ribosomes","volume":"20","author":"Gur","year":"2006","journal-title":"Genes Dev."},{"key":"10.1016\/j.mce.2021.111193_bib27","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/BF02618171","article-title":"Hormonal growth control of cells in culture","volume":"14","author":"Hayashi","year":"1978","journal-title":"In Vitro"},{"key":"10.1016\/j.mce.2021.111193_bib28","doi-asserted-by":"crossref","DOI":"10.1111\/and.12928","article-title":"Expression and localisation of RXFP3 in human spermatozoa and impact of INSL7 on sperm functions","volume":"50","author":"Heidari","year":"2018","journal-title":"Andrologia"},{"key":"10.1016\/j.mce.2021.111193_bib29","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1095\/biolreprod59.2.330","article-title":"Identification of insulin-like growth factor I in bovine seminal plasma and its receptor on spermatozoa: influence on sperm motility","volume":"59","author":"Henricks","year":"1998","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2021.111193_bib30","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.anireprosci.2014.01.012","article-title":"Genome-wide association study for poor sperm motility in Holstein-Friesian bulls","volume":"146","author":"Hering","year":"2014","journal-title":"Anim. Reprod. Sci."},{"issue":"Suppl. 2","key":"10.1016\/j.mce.2021.111193_bib31","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/j.1439-0531.2011.01862.x","article-title":"Mechanisms of sperm storage in the female reproductive tract: an interspecies comparison","volume":"46","author":"Holt","year":"2011","journal-title":"Reprod. Domest. Anim."},{"key":"10.1016\/j.mce.2021.111193_bib32","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1042\/BJ20110114","article-title":"Phosphoinositide 3-kinase signalling pathway involvement in a truncated apoptotic cascade associated with motility loss and oxidative DNA damage in human spermatozoa","volume":"436","author":"Koppers","year":"2011","journal-title":"Biochem. J."},{"key":"10.1016\/j.mce.2021.111193_bib33","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1111\/j.1745-7262.2008.00421.x","article-title":"Insulin and leptin enhance human sperm motility, acrosome reaction and nitric oxide production","volume":"10","author":"Lampiao","year":"2008","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.mce.2021.111193_bib34","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1095\/biolreprod67.2.648","article-title":"Insulin-like growth factor-I and insulin-like growth factor binding protein-2 and -5 in equine seminal plasma: association with sperm characteristics and fertility","volume":"67","author":"Macpherson","year":"2002","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2021.111193_bib35","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1017\/S0967199412000500","article-title":"Effect of insulin-like growth factor I on functional parameters of ram cooled-stored spermatozoa","volume":"22","author":"Makarevich","year":"2014","journal-title":"Zygote"},{"key":"10.1016\/j.mce.2021.111193_bib36","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/BF01213434","article-title":"In vivo survival of spermatozoa in the human fallopian tube for 25 days: a case report","volume":"10","author":"Mansour","year":"1993","journal-title":"J. Assist. Reprod. Genet."},{"key":"10.1016\/j.mce.2021.111193_bib37","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1093\/biolre\/ioz008","article-title":"Investigation into the presence and functional significance of proinsulin C-peptide in the female germline","volume":"100","author":"Martin","year":"2019","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2021.111193_bib38","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1017\/S1751731112002285","article-title":"Effect of the addition of IGF-I and vitamin E to stored boar semen","volume":"7","author":"Mendez","year":"2013","journal-title":"Animal"},{"key":"10.1016\/j.mce.2021.111193_bib39","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/jez.1058","article-title":"Isolation and purification of the IGF-I protein complex from rabbit seminal plasma: effects on sperm motility and viability","volume":"290","author":"Minelli","year":"2001","journal-title":"J. Exp. Zool."},{"key":"10.1016\/j.mce.2021.111193_bib40","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.freeradbiomed.2005.10.055","article-title":"Reactive oxygen species modulate independent protein phosphorylation pathways during human sperm capacitation","volume":"40","author":"O'Flaherty","year":"2006","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mce.2021.111193_bib41","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s00232-006-0009-2","article-title":"Role of cholesterol, DOTAP, and DPPC in prostasome\/spermatozoa interaction and fusion","volume":"211","author":"Palmerini","year":"2006","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.mce.2021.111193_bib42","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.theriogenology.2015.05.007","article-title":"Insulin like growth factor I improves yak (Bos grunniens) spermatozoa motility and the oocyte cleavage rate by modulating the expression of Bax and Bcl-2","volume":"84","author":"Pan","year":"2015","journal-title":"Theriogenology"},{"key":"10.1016\/j.mce.2021.111193_bib43","doi-asserted-by":"crossref","first-page":"486","DOI":"10.2337\/diab.33.5.486","article-title":"C-peptide as a measure of the secretion and hepatic extraction of insulin. Pitfalls and limitations","volume":"33","author":"Polonsky","year":"1984","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2021.111193_bib44","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1210\/en.2009-0964","article-title":"Prolactin exerts a prosurvival effect on human spermatozoa via mechanisms that involve the stimulation of Akt phosphorylation and suppression of caspase activation and capacitation","volume":"151","author":"Pujianto","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2021.111193_bib45","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqaa031","article-title":"Human sperm express the receptor for Glucagon-like Peptide-1 (GLP-1), which affects sperm function and metabolism","volume":"161","author":"Rago","year":"2020","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2021.111193_bib46","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1073\/pnas.77.1.285","article-title":"Insulin receptor synthesis and turnover in differentiating 3T3-L1 preadipocytes","volume":"77","author":"Reed","year":"1980","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.mce.2021.111193_bib47","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0050851","article-title":"The molecular chaperone HSPA2 plays a key role in regulating the expression of sperm surface receptors that mediate sperm-egg recognition","volume":"7","author":"Redgrove","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.mce.2021.111193_bib48","doi-asserted-by":"crossref","first-page":"106130","DOI":"10.1016\/j.anireprosci.2019.106130","article-title":"Addition of insulin-like growth factor I (IGF-I) and reduced glutathione (GSH) to cryopreserved boar semen","volume":"208","author":"Resende","year":"2019","journal-title":"Anim. Reprod. Sci."},{"key":"10.1016\/j.mce.2021.111193_bib49","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.mce.2013.04.005","article-title":"Progesterone utilizes the PI3K-AKT pathway in human spermatozoa to regulate motility and hyperactivation but not acrosome reaction","volume":"374","author":"Sagare-Patil","year":"2013","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2021.111193_bib50","doi-asserted-by":"crossref","first-page":"4931","DOI":"10.1210\/endo.138.11.5518","article-title":"Cloning, tissue expression, and chromosomal localization of the mouse IRS-3 gene","volume":"138","author":"Sciacchitano","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2021.111193_bib51","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.cryobiol.2016.05.012","article-title":"IGF1 stabilizes sperm membrane proteins to reduce cryoinjury and maintain post-thaw sperm motility in buffalo (Bubalus bubalis) spermatozoa","volume":"73","author":"Selvaraju","year":"2016","journal-title":"Cryobiology"},{"key":"10.1016\/j.mce.2021.111193_bib52","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1292\/jvms.14-0049","article-title":"IGF-I improves mitochondrial membrane potential during hypothermic storage of canine spermatozoa","volume":"76","author":"Shin","year":"2014","journal-title":"J. Vet. Med. Sci."},{"key":"10.1016\/j.mce.2021.111193_bib53","doi-asserted-by":"crossref","DOI":"10.1111\/and.13715","article-title":"Expression of RXFP2 receptor on human spermatozoa and the anti-apoptotic and antioxidant effects of insulin-like factor 3","volume":"52","author":"Shokri","year":"2020","journal-title":"Andrologia"},{"key":"10.1016\/j.mce.2021.111193_bib54","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/1471-2202-8-84","article-title":"Mitochondrial respiratory chain is involved in insulin-stimulated hydrogen peroxide production and plays an integral role in insulin receptor autophosphorylation in neurons","volume":"8","author":"Storozhevykh","year":"2007","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.mce.2021.111193_bib55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bcmd.2005.03.005","article-title":"Role of exosomes in sperm maturation during the transit along the male reproductive tract","volume":"35","author":"Sullivan","year":"2005","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.mce.2021.111193_bib56","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1002\/mrd.20222","article-title":"Involvement of the pentose phosphate pathway and redox regulation in fertilization in the mouse","volume":"70","author":"Urner","year":"2005","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.mce.2021.111193_bib57","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1530\/REP-19-0274","article-title":"Role of Angiotensin-(1-7) via MAS receptor in human sperm motility and acrosome reaction","volume":"159","author":"Valdivia","year":"2020","journal-title":"Reproduction"},{"key":"10.1016\/j.mce.2021.111193_bib58","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1530\/REP-06-0302","article-title":"Circulating hormones and estrous stage predict cellular and stromal remodeling in murine uterus","volume":"133","author":"Wood","year":"2007","journal-title":"Reproduction"},{"key":"10.1016\/j.mce.2021.111193_bib59","series-title":"WHO Laboratory Manual for the Examination and Processing of Human Semen","author":"World Health Organization","year":"2010"}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030372072100037X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030372072100037X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T14:16:36Z","timestamp":1759587396000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030372072100037X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":59,"alternative-id":["S030372072100037X"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2021.111193","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evidence that extrapancreatic insulin production is involved in the mediation of sperm survival","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2021.111193","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111193"}}