{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:47:34Z","timestamp":1792446454657,"version":"4.5.0"},"reference-count":190,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["EIN2019-103294"],"award-info":[{"award-number":["EIN2019-103294"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006541","name":"Comunidad de Madrid Consejer\u00eda de Sanidad","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006541","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010198","name":"Ministerio de Econom\u00eda, Industria y Competitividad, Gobierno de Espa\u00f1a","doi-asserted-by":"publisher","award":["IJC2018-035187-I"],"award-info":[{"award-number":["IJC2018-035187-I"]}],"id":[{"id":"10.13039\/501100010198","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","award":["812699"],"award-info":[{"award-number":["812699"]}],"id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["AC18\/00064"],"award-info":[{"award-number":["AC18\/00064"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PERSTIGAN AC18\/00071"],"award-info":[{"award-number":["PERSTIGAN AC18\/00071"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["ISCIII-RETIC REDinREN RD016\/0009"],"award-info":[{"award-number":["ISCIII-RETIC REDinREN RD016\/0009"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004593","name":"Universidad Autonoma de Madrid","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["ISCIII-RETIC REDinREN RD016\/0009"],"award-info":[{"award-number":["ISCIII-RETIC REDinREN RD016\/0009"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["PI18\/01366"],"award-info":[{"award-number":["PI18\/01366"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["PI19\/00588"],"award-info":[{"award-number":["PI19\/00588"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["PI20\/00140"],"award-info":[{"award-number":["PI20\/00140"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["PI17\/00257"],"award-info":[{"award-number":["PI17\/00257"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["PI17\/00119"],"award-info":[{"award-number":["PI17\/00119"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["DTS18\/00032"],"award-info":[{"award-number":["DTS18\/00032"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["DTS20\/00083"],"award-info":[{"award-number":["DTS20\/00083"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["PI19\/00815"],"award-info":[{"award-number":["PI19\/00815"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.mce.2021.111254","type":"journal-article","created":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T18:14:22Z","timestamp":1617128062000},"page":"111254","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":110,"special_numbering":"C","title":["Renin-angiotensin system and inflammation update"],"prefix":"10.1016","volume":"529","author":[{"given":"Elena","family":"Cantero-Navarro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Fern\u00e1ndez-Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian M.","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Rayego-Mateos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal R.","family":"Rodrigues-Diez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Dolores","family":"S\u00e1nchez-Ni\u00f1o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana B.","family":"Sanz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Ruiz-Ortega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9805-9523","authenticated-orcid":false,"given":"Alberto","family":"Ortiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2021.111254_bib1","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1177\/1535370217697385","article-title":"Lymphangiogenesis: fuel, smoke, or extinguisher of inflammation's fire?","volume":"242","author":"Abouelkheir","year":"2017","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.mce.2021.111254_bib2","article-title":"Renin-angiotensin system and cancer: epidemiology, cell signaling, genetics and epigenetics","volume":"15","author":"Afsar","year":"2020","journal-title":"Clin. Transl. Oncol."},{"key":"10.1016\/j.mce.2021.111254_bib3","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1042\/CS20130412","article-title":"Integrin-linked kinase plays a key role in the regulation of angiotensin II-induced renal inflammation","volume":"127","author":"Alique","year":"2014","journal-title":"Clin. Sci."},{"key":"10.1016\/j.mce.2021.111254_bib4","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1177\/1470320314551564","article-title":"Angiotensin II, via angiotensin receptor type 1\/nuclear factor-\u03baB activation, causes a synergistic effect on interleukin-1-\u03b2-induced inflammatory responses in cultured mesangial cells","volume":"16","author":"Alique","year":"2015","journal-title":"JRAAS - J. Renin Angiotensin Aldosterone Syst."},{"key":"10.1016\/j.mce.2021.111254_bib5","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1161\/01.HYP.33.3.879","article-title":"Renal and metabolic clearance of N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP) during angiotensin-converting enzyme inhibition in humans","volume":"33","author":"Azizi","year":"1999","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2021.111254_bib6","series-title":"Clinical and Experimental Pharmacology and Physiology","first-page":"1066","article-title":"Angiotensin I-converting enzyme and metabolism of the haematological peptide N-acetyl-seryl-aspartyl-lysyl-proline","author":"Azizi","year":"2001"},{"key":"10.1016\/j.mce.2021.111254_bib7","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1172\/JCI118484","article-title":"Acute angiotensin-converting enzyme inhibition increases the plasma level of the natural stem cell regulator N-acetyl-seryl-aspartyl-lysyl-proline","volume":"97","author":"Azizi","year":"1996","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mce.2021.111254_bib8","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1681\/ASN.2016121280","article-title":"Tissue-specific MicroRNA expression patterns in four types of kidney disease","volume":"28","author":"Baker","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"issue":"23","key":"10.1016\/j.mce.2021.111254_bib9","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1056\/NEJMoa2025845","article-title":"Effect of finerenone on chronic kidney disease outcomes in type 2 diabetes","volume":"383","author":"Bakris","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mce.2021.111254_bib10","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/ajh\/hpz139","article-title":"Augmenting renal lymphatic density prevents angiotensin II-induced hypertension in male and female mice","volume":"33","author":"Balasubbramanian","year":"2020","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.mce.2021.111254_bib11","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1146\/annurev-physiol-030212-183811","article-title":"TRPA1: a gatekeeper for inflammation","volume":"75","author":"Bautista","year":"2013","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.mce.2021.111254_bib12","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.chembiol.2020.03.016","article-title":"Ferroptosis and necroptosis in the kidney","volume":"27","author":"Belavgeni","year":"2020","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.mce.2021.111254_bib13","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1002\/ejhf.1424","article-title":"Klotho, fibroblast growth factor-23, and the renin\u2013angiotensin system \u2014 an analysis from the PEACE trial","volume":"21","author":"Bergmark","year":"2019","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.mce.2021.111254_bib14","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.phrs.2017.03.017","article-title":"The interplay between Angiotensin II, TLR4 and hypertension","volume":"120","author":"Biancardi","year":"2017","journal-title":"Pharmacol. Res."},{"issue":"4","key":"10.1016\/j.mce.2021.111254_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0094672","article-title":"Predicting kinase activity in angiotensin receptor phosphoproteomes based on sequence-motifs and interactions","volume":"9","author":"B\u00f8gebo","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.mce.2021.111254_bib16","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.2337\/db16-1318","article-title":"Neprilysin is required for angiotensin-(1-7)\u2019s ability to enhance insulin secretion via its proteolytic activity to generate angiotensin-(1-2)","volume":"66","author":"Brar","year":"2017","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2021.111254_bib17","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1097\/MNH.0000000000000440","article-title":"Role of microRNAs in aldosterone signaling","volume":"27","author":"Butterworth","year":"2018","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"10.1016\/j.mce.2021.111254_bib18","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1093\/ckj\/sfz126","article-title":"The chaos of hypertension guidelines for chronic kidney disease patients","volume":"12","author":"Castillo-Rodriguez","year":"2019","journal-title":"Clin. Kidney J."},{"key":"10.1016\/j.mce.2021.111254_bib19","article-title":"The ACE2\/apelin signaling, microRNAs, and hypertension","author":"Chen","year":"2015","journal-title":"Int. J. Hypertens."},{"key":"10.1016\/j.mce.2021.111254_bib20","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1002\/iub.1190","article-title":"Angiotensin converting enzyme 2: a new important player in the regulation of glycemia","volume":"65","author":"Chhabra","year":"2013","journal-title":"IUBMB Life"},{"key":"10.1016\/j.mce.2021.111254_bib21","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1161\/HYPERTENSIONAHA.117.09374","article-title":"Regulatory T-cell augmentation or interleukin-17 inhibition prevents calcineurin inhibitor-induced hypertension in mice","volume":"70","author":"Chiasson","year":"2017","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2021.111254_bib22","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1093\/ndt\/gfr613","article-title":"High-fat diet-induced renal cell apoptosis and oxidative stress in spontaneously hypertensive rat are ameliorated by fenofibrate through the PPAR\u03b1-FoxO3a-PGC-1\u03b1 pathway","volume":"27","author":"Chung","year":"2012","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.mce.2021.111254_bib23","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1681\/ASN.2016101066","article-title":"Immunologic effects of the renin-angiotensin system","volume":"28","author":"Crowley","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.mce.2021.111254_bib24","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/cvr\/cvu067","article-title":"Central blockade of TLR4 improves cardiac function and attenuates myocardial inflammation in angiotensin II-induced hypertension","volume":"103","author":"Dange","year":"2014","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.mce.2021.111254_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0104020","article-title":"Toll-like receptor 4 upregulation by angiotensin II contributes to hypertension and vascular dysfunction through reactive oxygen species production","volume":"9","author":"De Batista","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.mce.2021.111254_bib26","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1681\/ASN.2018080868","article-title":"Early acute microvascular kidney transplant rejection in the absence of anti-HLA antibodies is associated with preformed IgG antibodies against diverse glomerular endothelial cell antigens","volume":"30","author":"Delville","year":"2019","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.mce.2021.111254_bib27","doi-asserted-by":"crossref","first-page":"172549","DOI":"10.1016\/j.ejphar.2019.172549","article-title":"Klotho inhibits angiotensin II-induced cardiac hypertrophy, fibrosis, and dysfunction in mice through suppression of transforming growth factor-\u03b21 signaling pathway","volume":"859","author":"Ding","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.mce.2021.111254_bib28","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1042\/CS20130333","article-title":"Modulation of the action of insulin by angiotensin-(1-7)","volume":"126","author":"Dominici","year":"2014","journal-title":"Clin. Sci."},{"key":"10.1016\/j.mce.2021.111254_bib29","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1681\/ASN.2013090931","article-title":"Aldosterone regulates MicroRNAs in the cortical collecting duct to alter sodium transport","volume":"25","author":"Edinger","year":"2014","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.mce.2021.111254_bib30","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1681\/ASN.2018030323","article-title":"The absence of the ACE N-domain decreases renal inflammation and facilitates sodium excretion during diabetic kidney disease","volume":"29","author":"Eriguchi","year":"2018","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.mce.2021.111254_bib31","doi-asserted-by":"crossref","first-page":"H1426","DOI":"10.1152\/ajpheart.00772.2018","article-title":"Mitochondrial angiotensin receptors and cardioprotective pathways","volume":"316","author":"Escobales","year":"2019","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.mce.2021.111254_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0005406","article-title":"Angiotensin-(1-7) and the G protein-coupled receptor Mas are key players in renal inflammation","volume":"4","author":"Esteban","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.mce.2021.111254_bib33","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1097\/01.ASN.0000130564.75008.F5","article-title":"Angiotensin II, via AT1 and AT2 receptors and NF-\u03baB pathway, regulates the inflammatory response in unilateral ureteral obstruction","volume":"15","author":"Esteban","year":"2004","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.mce.2021.111254_bib34","series-title":"Kidney International, Supplement. Blackwell Publishing Inc","first-page":"S33","article-title":"Effect of simultaneous blockade of AT1 and AT2 receptors on the NF\u03baB pathway and renal inflammatory response","volume":"vol. 86","author":"Esteban","year":"2003"},{"key":"10.1016\/j.mce.2021.111254_bib35","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1093\/ckj\/sfaa198","article-title":"SGLT2 inhibitors for non-diabetic kidney disease: drugs to treat CKD that also improve glycemia","volume":"13","author":"Fernandez-Fernandez","year":"2020","journal-title":"Clin. Kidney J."},{"key":"10.1016\/j.mce.2021.111254_bib36","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1093\/ndt\/gfx376","article-title":"Albumin downregulates Klotho in tubular cells","volume":"33","author":"Fernandez-Fernandez","year":"2018","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.mce.2021.111254_bib37","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.3390\/jcm9061611","article-title":"Gender, albuminuria and chronic kidney disease progression in treated diabetic kidney disease","volume":"9","author":"Fernandez-Fernandez","year":"2020","journal-title":"J. Clin. Med."},{"issue":"Suppl. 2","key":"10.1016\/j.mce.2021.111254_bib38","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/s12325-019-01180-5","article-title":"Albuminuria downregulation of the anti-aging factor klotho: the missing link potentially explaining the association of pathological albuminuria with premature death","volume":"37","author":"Fern\u00e1ndez-Fern\u00e1ndez","year":"2020","journal-title":"Adv. Ther."},{"key":"10.1016\/j.mce.2021.111254_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ckj\/sfx154","article-title":"Women and renal replacement therapy in Europe: lower incidence, equal access to transplantation, longer survival than men","volume":"11","author":"Fernandez-Prado","year":"2018","journal-title":"Clin. Kidney J."},{"key":"10.1016\/j.mce.2021.111254_bib40","doi-asserted-by":"crossref","first-page":"F1171","DOI":"10.1152\/ajprenal.00233.2010","article-title":"Hyperaldosteronism in klotho-deficient mice","volume":"299","author":"Fischer","year":"2010","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.mce.2021.111254_bib41","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/path.5282","article-title":"PGC-1\u03b1 deficiency causes spontaneous kidney inflammation and increases the severity of nephrotoxic AKI","volume":"249","author":"Fontecha-Barriuso","year":"2019","journal-title":"J. Pathol."},{"key":"10.1016\/j.mce.2021.111254_bib42","doi-asserted-by":"crossref","first-page":"347","DOI":"10.3390\/biom10020347","article-title":"The role of PGC-1\u03b1 and mitochondrial biogenesis in kidney diseases","volume":"10","author":"Fontecha-Barriuso","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.mce.2021.111254_bib43","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1152\/physrev.00038.2017","article-title":"Angiotensin II signal transduction: an update on mechanisms of physiology and pathophysiology","volume":"98","author":"Forrester","year":"2018","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.mce.2021.111254_bib44","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1210\/jc.2018-00004","article-title":"Reduced levels of anti-ageing hormone klotho predict renal function decline in type 2 diabetes","volume":"103","author":"Fountoulakis","year":"2018","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2021.111254_bib45","doi-asserted-by":"crossref","first-page":"F683","DOI":"10.1152\/ajprenal.00417.2019","article-title":"Mitochondrial angiotensin II receptors regulate oxygen consumption in kidney mitochondria from healthy and type 1 diabetic rats","volume":"318","author":"Friederich-Persson","year":"2020","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.mce.2021.111254_bib46","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1161\/HYPERTENSIONAHA.107.097865","article-title":"Angiotensin-converting enzyme C-terminal catalytic domain is the main site of angiotensin I cleavage in vivo","volume":"51","author":"Fuchs","year":"2008","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2021.111254_bib47","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/s41418-017-0012-4","article-title":"Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018","volume":"25","author":"Galluzzi","year":"2018","journal-title":"Cell Death Differ."},{"issue":"Suppl. 1","key":"10.1016\/j.mce.2021.111254_bib48","doi-asserted-by":"crossref","first-page":"i13","DOI":"10.1093\/ndt\/gfz237","article-title":"Sodium-glucose cotransporter 2 inhibition: towards an indication to treat diabetic kidney disease","volume":"5","author":"G\u00f3rriz","year":"2020","journal-title":"Nephrol. Dial. Transplant."},{"issue":"5","key":"10.1016\/j.mce.2021.111254_bib49","doi-asserted-by":"crossref","first-page":"F983","DOI":"10.1152\/ajprenal.00371.2010","article-title":"Nuclear angiotensin-(1-7) receptor is functionally coupled to the formation of nitric oxide","volume":"299","author":"Gwathmey","year":"2010","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.mce.2021.111254_bib50","doi-asserted-by":"crossref","first-page":"H981","DOI":"10.1152\/ajpheart.00320.2016","article-title":"Blood capillary rarefaction and lymphatic capillary neoangiogenesis are key contributors to renal allograft fibrosis in an ACE inhibition rat model","volume":"311","author":"Hamar","year":"2016","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.mce.2021.111254_bib51","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1097\/MNH.0000000000000240","article-title":"Multiple faces of fibroblast growth factor-23","volume":"25","author":"Han","year":"2016","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"10.1016\/j.mce.2021.111254_bib52","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1056\/NEJMoa2024816","article-title":"Dapagliflozin in patients with chronic kidney disease","volume":"383","author":"Heerspink","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mce.2021.111254_bib53","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1111\/bph.13117","article-title":"Toll-like receptor 4 contributes to vascular remodeling and endothelial dysfunction in angiotensin II-induced hypertension","volume":"172","author":"Hernanz","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.mce.2021.111254_bib54","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1093\/ckj\/sfy090","article-title":"The potential for improving cardio-renal outcomes by sodium-glucose co-transporter-2 inhibition in people with chronic kidney disease: a rationale for the EMPA-KIDNEY study","volume":"11","author":"Herrington","year":"2018","journal-title":"Clin. Kidney J."},{"key":"10.1016\/j.mce.2021.111254_bib55","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1042\/CS20060342","article-title":"Angiotensin II signal transduction through the AT1 receptor: novel insights into mechanisms and pathophysiology","volume":"112","author":"Higuchi","year":"2007","journal-title":"Clin. Sci."},{"key":"10.1016\/j.mce.2021.111254_bib56","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ceca.2017.01.014","article-title":"Calcium\u2013NFAT transcriptional signalling in T cell activation and T cell exhaustion","volume":"63","author":"Hogan","year":"2017","journal-title":"Cell Calcium"},{"key":"10.1016\/j.mce.2021.111254_bib57","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1681\/ASN.2014050465","article-title":"Klotho and phosphate are modulators of pathologic uremic cardiac remodeling","volume":"26","author":"Hu","year":"2015","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.mce.2021.111254_bib58","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1097\/01.ASN.0000057544.95569.EC","article-title":"N-acetyl-seryl-aspartyl-lysyl-proline inhibits TGF-\u03b2 mediated plasminogen activator inhibitor-1 expression via inhibition of Smad pathway in human mesangial cells","volume":"14","author":"Kanasaki","year":"2003","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.mce.2021.111254_bib59","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.2215\/CJN.02700313","article-title":"Effect of renin-angiotensin system blockade on soluble Klotho in patients with type 2 diabetes, systolic hypertension, and albuminuria","volume":"8","author":"Karalliedde","year":"2013","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.mce.2021.111254_bib60","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.phrs.2017.05.008","article-title":"AT1 receptor signaling pathways in the cardiovascular system","volume":"25","author":"Kawai","year":"2017","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.mce.2021.111254_bib61","first-page":"4152","article-title":"Salt causes aging-associated hypertension via vascular Wnt5a under Klotho deficiency","volume":"140","author":"Kawarazaki","year":"2020","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mce.2021.111254_bib62","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.yjmcc.2014.06.008","article-title":"Angiotensin II-regulated microRNA 483-3p directly targets multiple components of the renin-angiotensin system","volume":"75","author":"Kemp","year":"2014","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.mce.2021.111254_bib63","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.3390\/ijms21062225","article-title":"Structures of human transglutaminase 2: finding clues for interference in cross-linking mediated activity","volume":"21","author":"Kim","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mce.2021.111254_bib64","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1074\/jbc.M116.753616","article-title":"Ankyrin G expression regulates apical delivery of the epithelial sodium channel (ENaC)","volume":"292","author":"Klemens","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2021.111254_bib65","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1093\/ckj\/sfaa048","article-title":"The ERA-EDTA registry annual report 2017: a summary","volume":"13","author":"Kramer","year":"2020","journal-title":"Clin. Kidney J."},{"key":"10.1016\/j.mce.2021.111254_bib66","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1161\/HYPERTENSIONAHA.115.05645","article-title":"Endogenous MicroRNAs in human microvascular endothelial cells regulate mRNAs encoded by hypertension-related genes","volume":"66","author":"Kriegel","year":"2015","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2021.111254_bib67","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1161\/ATVBAHA.113.301717","article-title":"Peroxisome proliferator-activated receptor \u03b3, coactivator 1\u03b1 deletion induces angiotensin II-associated vascular dysfunction by increasing mitochondrial oxidative stress and vascular inflammation","volume":"33","author":"Kr\u00f6ller-Sch\u00f6n","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.mce.2021.111254_bib68","doi-asserted-by":"crossref","first-page":"F1026","DOI":"10.1152\/ajprenal.00562.2015","article-title":"The anti-inflammatory peptide Ac-SDKP is released from thymosin-\u03b24 by renal meprin-\u03b1 and prolyl oligopeptidase","volume":"310","author":"Kumar","year":"2016","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.mce.2021.111254_bib69","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.phrs.2018.07.006","article-title":"The anti-inflammatory peptide Ac-SDKP: synthesis, role in ACE inhibition, and its therapeutic potential in hypertension and cardiovascular diseases","volume":"134","author":"Kumar","year":"2018","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.mce.2021.111254_bib70","first-page":"1803","article-title":"Aldosterone induces renal fibrosis by promoting HDAC1 expression, deacetylating H3K9 and inhibiting klotho transcription","volume":"19","author":"Lai","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.mce.2021.111254_bib71","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/nm1275","article-title":"Angiotensin II and EGF receptor cross-talk in chronic kidney diseases: a new therapeutic approach","volume":"11","author":"Lautrette","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.mce.2021.111254_bib72","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1016\/j.kint.2018.12.031","article-title":"Interleukin-17A blockade reduces albuminuria and kidney injury in an accelerated model of diabetic nephropathy","volume":"95","author":"Lavoz","year":"2019","journal-title":"Kidney Int."},{"key":"10.1016\/j.mce.2021.111254_bib73","doi-asserted-by":"crossref","first-page":"272","DOI":"10.3390\/jcm9010272","article-title":"Could IL-17a Be a novel therapeutic target in diabetic nephropathy?","volume":"9","author":"Lavoz","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.mce.2021.111254_bib74","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.kint.2019.01.030","article-title":"Non-HLA agonistic anti-angiotensin II type 1 receptor antibodies induce a distinctive phenotype of antibody-mediated rejection in kidney transplant recipients","volume":"96","author":"Lefaucheur","year":"2019","journal-title":"Kidney Int."},{"key":"10.1016\/j.mce.2021.111254_bib75","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1073\/pnas.86.3.779","article-title":"Inhibitor of hematopoietic pluripotent stem cell proliferation: purification and determination of its structure","volume":"86","author":"Lenfant","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mce.2021.111254_bib76","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1161\/HYPERTENSIONAHA.116.08814","article-title":"Evidence for heterodimerization and functional interaction of the angiotensin type 2 receptor and the receptor MAS","volume":"69","author":"Leonhardt","year":"2017","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2021.111254_bib77","first-page":"1","article-title":"Kidney disease: improving global outcomes (KDIGO) CKD work group. KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease","volume":"3","author":"Levin","year":"2013","journal-title":"Kidney Int. Suppl."},{"key":"10.1016\/j.mce.2021.111254_bib78","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.vph.2016.05.005","article-title":"PGC-1\u03b1 ameliorates Angiotensin II-induced eNOS dysfunction in human aortic endothelial cells","volume":"83","author":"Li","year":"2016","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.mce.2021.111254_bib79","doi-asserted-by":"crossref","first-page":"E14","DOI":"10.1161\/HYPERTENSIONAHA.118.12319","article-title":"MicroRNA-31 regulates immunosuppression in Ang II (angiotensin II)-induced hypertension by targeting Ppp6C (protein phosphatase 6c)","volume":"73","author":"Li","year":"2019","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2021.111254_bib80","doi-asserted-by":"crossref","first-page":"F1146","DOI":"10.1152\/ajprenal.00039.2015","article-title":"N-acetyl-seryl-aspartyl-lysyl-proline: mechanisms of renal protection in mouse model of systemic lupus erythematosus","volume":"308","author":"Liao","year":"2015","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"2","key":"10.1016\/j.mce.2021.111254_bib81","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1161\/HYPERTENSIONAHA.109.144568","article-title":"N-Acetyl-Seryl-Aspartyl-Lysyl-Proline attenuates renal injury and dysfunction in hypertensive rats with reduced renal mass council for high blood pressure research","volume":"55","author":"Liao","year":"2010","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2021.111254_bib82","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1177\/1470320313475905","article-title":"Elevated circulating alpha-klotho by angiotensin II receptor blocker losartan is associated with reduction of albuminuria in type 2 diabetic patients","volume":"15","author":"Lim","year":"2014","journal-title":"JRAAS - J. Renin Angiotensin Aldosterone Syst."},{"key":"10.1016\/j.mce.2021.111254_bib83","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1093\/ajh\/hpz018","article-title":"Tissue transglutaminase-mediated AT1 receptor sensitization underlies pro-inflammatory cytokine LIGHT-induced hypertension","volume":"32","author":"Liu","year":"2019","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.mce.2021.111254_bib84","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1002\/jcp.25599","article-title":"A MicroRNA cluster miR-23\u201324\u201327 is upregulated by aldosterone in the distal kidney nephron where it alters sodium transport","volume":"232","author":"Liu","year":"2017","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.mce.2021.111254_bib85","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1161\/CIRCRESAHA.118.312765","article-title":"Enhancing renal lymphatic expansion prevents hypertension in mice","volume":"122","author":"Lopez Gelston","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.mce.2021.111254_bib86","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1038\/s41467-019-10116-0","article-title":"Circulating miR-103a-3p contributes to angiotensin II-induced renal inflammation and fibrosis via a SNRK\/NF-\u03baB\/p65 regulatory axis","volume":"10","author":"Lu","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mce.2021.111254_bib87","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.bbrc.2015.02.096","article-title":"Cross-talk between angiotensin-II and toll-like receptor 4 triggers a synergetic inflammatory response in rat mesangial cells under high glucose conditions","volume":"459","author":"Lv","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mce.2021.111254_bib88","doi-asserted-by":"crossref","first-page":"F623","DOI":"10.1152\/ajprenal.00069.2019","article-title":"Knockout of TRPA1 exacerbates angiotensin II-induced kidney injury","volume":"317","author":"Ma","year":"2019","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.mce.2021.111254_bib89","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1681\/ASN.2011121144","article-title":"MicroRNA-324-3p promotes renal fibrosis and is a target of ACE inhibition","volume":"23","author":"Macconi","year":"2012","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.mce.2021.111254_bib90","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1093\/ajh\/hpy052","article-title":"Renal protective effects of N -Acetyl-Seryl-Aspartyl-Lysyl-Proline (Ac-SDKP) in Obese rats on a high-salt diet","volume":"31","author":"Maheshwari","year":"2018","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.mce.2021.111254_bib91","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.nefro.2017.04.004","article-title":"Targeting of regulated necrosis in kidney disease","volume":"38","author":"Martin-S\u00e1nchez","year":"2018","journal-title":"Nefrologia"},{"key":"10.1016\/j.mce.2021.111254_bib92","doi-asserted-by":"crossref","first-page":"4113","DOI":"10.3390\/ijms21114113","article-title":"Epigenetic modifiers as potential therapeutic targets in diabetic kidney disease","volume":"21","author":"Mart\u00ednez-Moreno","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.mce.2021.111254_bib93","doi-asserted-by":"crossref","first-page":"13742","DOI":"10.1038\/srep13742","article-title":"Structural basis of Ac-SDKP hydrolysis by Angiotensin-I converting enzyme","volume":"25","author":"Masuyer","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mce.2021.111254_bib94","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1056\/NEJMoa1911303","article-title":"Dapagliflozin in patients with heart failure and reduced ejection fraction","volume":"381","author":"McMurray","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mce.2021.111254_bib95","doi-asserted-by":"crossref","first-page":"F385","DOI":"10.1152\/ajprenal.00462.2016","article-title":"IL-17 mediates neutrophil infiltration and renal fibrosis following recovery from ischemia reperfusion: compensatory role of natural killer cells in athymic rats","volume":"312","author":"Mehrotra","year":"2017","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.mce.2021.111254_bib96","doi-asserted-by":"crossref","first-page":"4951","DOI":"10.1172\/JCI126108","article-title":"Calcium channel Orai1 promotes lymphocyte IL-17 expression and progressive kidney injury","volume":"129","author":"Mehrotra","year":"2019","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mce.2021.111254_bib97","first-page":"S64","article-title":"Renin-angiotensin system activation and interstitial inflammation in human diabetic nephropathy","volume":"vol. 86","author":"Mezzano","year":"2003"},{"key":"10.1016\/j.mce.2021.111254_bib98","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1161\/hy09t1.094234","article-title":"Angiotensin II and renal fibrosis","volume":"38","author":"Mezzano","year":"2001","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2021.111254_bib99","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s11906-019-0971-6","article-title":"Adaptive immunity in hypertension","volume":"21","author":"Mikolajczyk","year":"2019","journal-title":"Curr. Hypertens. Rep."},{"key":"10.1016\/j.mce.2021.111254_bib100","doi-asserted-by":"crossref","first-page":"10868","DOI":"10.1002\/jcp.27929","article-title":"Uric acid and angiotensin II additively promote inflammation and oxidative stress in human proximal tubule cells by activation of toll-like receptor 4","volume":"234","author":"Milanesi","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.mce.2021.111254_bib101","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1161\/01.HYP.0000013734.33441.EA","article-title":"In vivo klotho gene transfer ameliorates angiotensin II-induced renal damage","volume":"39","author":"Mitani","year":"2002","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2021.111254_bib102","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/s00438-010-0556-1","article-title":"Many ways to generate microRNA-like small RNAs: non-canonical pathways for microRNA production","volume":"284","author":"Miyoshi","year":"2010","journal-title":"Mol. Genet. Genom."},{"key":"10.1016\/j.mce.2021.111254_bib103","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1681\/ASN.2010101073","article-title":"The inflammatory cytokines TWEAK and TNF\u03b1 reduce renal klotho expression through NF\u03baB","volume":"22","author":"Moreno","year":"2011","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.mce.2021.111254_bib104","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.3389\/fphar.2019.01315","article-title":"Bromodomain and extraterminal proteins as novel epigenetic targets for renal diseases","volume":"10","author":"Morgado-Pascual","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.mce.2021.111254_bib105","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1161\/HYPERTENSIONAHA.114.04366","article-title":"Renin, genes, MicroRNAs, and renal mechanisms involved in hypertension","volume":"65","author":"Morris","year":"2015","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2021.111254_bib106","first-page":"e28","article-title":"Heart disease and stroke statistics-2016 update a report from the American Heart Association","volume":"133","author":"Mozaffarian","year":"2016","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.mce.2021.111254_bib107","article-title":"Effects of N-acetyl-seryl-asparyl-lysyl-proline on blood pressure, renal damage, and mortality in systemic lupus erythematosus","volume":"5","author":"Nakagawa","year":"2017","journal-title":"Phys. Rep."},{"key":"10.1016\/j.mce.2021.111254_bib108","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1161\/HYPERTENSIONAHA.116.07493","article-title":"Interleukin-17A regulates renal sodium transporters and renal injury in angiotensin II-induced hypertension","volume":"68","author":"Norlander","year":"2016","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2021.111254_bib109","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1681\/ASN.2005040385","article-title":"N-acetyl-seryl-asparlyl-lysyl-proline ameliorates the progression of renal dysfunction and fibrosis in WKY rats with established anti-glomerular basement membrane nephritis","volume":"17","author":"Omata","year":"2006","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.mce.2021.111254_bib110","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1042\/CS20190682","article-title":"Interleukin-17A induces vascular remodeling of small arteries and blood pressure elevation","volume":"134","author":"Orejudo","year":"2020","journal-title":"Clin. Sci."},{"key":"10.1016\/j.mce.2021.111254_bib111","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.3389\/fphar.2019.01015","article-title":"Interleukin 17A participates in renal inflammation associated to experimental and human hypertension","volume":"10","author":"Orejudo","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.mce.2021.111254_bib112","first-page":"101527","article-title":"Role of MicroRNAs in renin-angiotensin-aldosterone system-mediated cardiovascular inflammation and remodeling","author":"Pacurari","year":"2015","journal-title":"Int. J. Inflamm."},{"key":"10.1016\/j.mce.2021.111254_bib113","doi-asserted-by":"crossref","first-page":"F333","DOI":"10.1152\/ajprenal.00625.2018","article-title":"Role of ADAM17 in kidney disease","volume":"317","author":"Palau","year":"2019","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.mce.2021.111254_bib114","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.3892\/ijmm.2014.1935","article-title":"Role of microRNA-29b in angiotensin II-induced epithelial-mesenchymal transition in renal tubular epithelial cells","volume":"34","author":"Pan","year":"2014","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.mce.2021.111254_bib115","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1042\/CS20120461","article-title":"Angiotensin-(1-7): beyond the cardio-renal actions","volume":"124","author":"Passos-Silva","year":"2013","journal-title":"Clin. Sci."},{"key":"10.1016\/j.mce.2021.111254_bib116","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1161\/HYPERTENSIONAHA.117.09679","article-title":"Angiotensin II type 2 receptor and receptor mas are colocalized and functionally interdependent in obese zucker rat kidney","volume":"70","author":"Patel","year":"2017","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2021.111254_bib117","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.ekir.2018.12.011","article-title":"Cytokine profiles associated with angiotensin II type 1 receptor antibodies","volume":"4","author":"Pearl","year":"2019","journal-title":"Kidney Int. Rep."},{"key":"10.1016\/j.mce.2021.111254_bib118","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.bbrc.2009.04.126","article-title":"The angiotensin II-AT1 receptor stimulates reactive oxygen species within the cell nucleus","volume":"384","author":"Pendergrass","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mce.2021.111254_bib119","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1161\/01.HYP.0000100423.24330.96","article-title":"Ac-SDKP reverses cardiac fibrosis in rats with renovascular hypertension","volume":"42","author":"Peng","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2021.111254_bib120","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1161\/CIRCULATIONAHA.104.528695","article-title":"Angiotensin-converting enzyme inhibitors: a new mechanism of action","volume":"112","author":"Peng","year":"2005","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.mce.2021.111254_bib121","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/ckj\/sfz142","article-title":"Aliskiren and the dual complement inhibition concept","volume":"13","author":"P\u00e9rez-G\u00f3mez","year":"2019","journal-title":"Clin. Kidney J."},{"key":"10.1016\/j.mce.2021.111254_bib122","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1080\/13543784.2016.1196184","article-title":"Targeting inflammation in diabetic kidney disease: early clinical trials","volume":"25","author":"P\u00e9rez-G\u00f3mez","year":"2016","journal-title":"Expet Opin. Invest. Drugs"},{"issue":"1","key":"10.1016\/j.mce.2021.111254_bib123","doi-asserted-by":"crossref","first-page":"12398","DOI":"10.1038\/s41598-018-30098-1","article-title":"Cardiovascular interactions between fibroblast growth factor-23 and angiotensin II","volume":"8","author":"Pi","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mce.2021.111254_bib124","article-title":"Influence of Angiotensin II on cell viability and apoptosis in rat renal proximal tubular epithelial cells in in vitro studies","volume":"21","author":"Piotrowska","year":"2020","journal-title":"JRAAS - J. Renin Angiotensin Aldosterone Syst."},{"key":"10.1016\/j.mce.2021.111254_bib125","doi-asserted-by":"crossref","first-page":"H415","DOI":"10.1152\/ajpheart.00792.2018","article-title":"Menopause and foxp3 treg cell depletion eliminate female protection against t cell-mediated angiotensin ii hypertension","volume":"317","author":"Pollow","year":"2019","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.mce.2021.111254_bib126","doi-asserted-by":"crossref","first-page":"e352","DOI":"10.1038\/emm.2017.89","article-title":"Bcl3: a regulator of NF-\u03baB inducible by TWEAK in acute kidney injury with anti-inflammatory and antiapoptotic properties in tubular cells","volume":"49","author":"Poveda","year":"2017","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.mce.2021.111254_bib127","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.bbadis.2016.01.006","article-title":"NF\u03baBiz protein downregulation in acute kidney injury: modulation of inflammation and survival in tubular cells","volume":"1862","author":"Poveda","year":"2016","journal-title":"Biochim. Biophys. Acta - Mol. Basis Dis."},{"key":"10.1016\/j.mce.2021.111254_bib128","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1093\/ajh\/hpy148","article-title":"Sex differences in hypertension: where we have been and where we are going","volume":"31","author":"Ram\u00edrez","year":"2018","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.mce.2021.111254_bib129","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1080\/17460441.2020.1690450","article-title":"Design and optimization strategies for the development of new drugs that treat chronic kidney disease","volume":"15","author":"Ramos","year":"2020","journal-title":"Expet Opin. Drug Discov."},{"key":"10.1016\/j.mce.2021.111254_bib130","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1002\/path.4250","article-title":"TWEAK transactivation of the epidermal growth factor receptor mediates renal inflammation","volume":"231","author":"Rayego-Mateos","year":"2013","journal-title":"J. Pathol."},{"key":"10.1016\/j.mce.2021.111254_bib131","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.1161\/01.CIR.103.25.3136","article-title":"Long-term effect of N-acetyl-seryl-aspartyl-lysyl-proline on left ventricular collagen deposition in rats with 2-kidney, 1-clip hypertension","volume":"103","author":"Rhaleb","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.mce.2021.111254_bib132","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1038\/s41374-020-0440-5","article-title":"Angiotensin-converting enzyme 2 influences pancreatic and renal function in diabetic mice","volume":"100","author":"Roca-Ho","year":"2020","journal-title":"Lab. Invest."},{"key":"10.1016\/j.mce.2021.111254_bib133","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1152\/physrev.00031.2016","article-title":"Role of the immune system in hypertension","volume":"97","author":"Rodr\u00edguez-Iturbe","year":"2017","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.mce.2021.111254_bib134","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12913","article-title":"The angiotensin-(1-7)\/Mas receptor axis protects from endothelial cell senescence via klotho and Nrf2 activation","volume":"18","author":"Romero","year":"2019","journal-title":"Aging Cell"},{"key":"10.1016\/j.mce.2021.111254_bib135","doi-asserted-by":"crossref","first-page":"F195","DOI":"10.1152\/ajprenal.00270.2018","article-title":"Renal release of N-acetyl-seryl-aspartyl-lysyl-proline is part of an antifibrotic peptidergic system in the kidney","volume":"316","author":"Romero","year":"2019","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.mce.2021.111254_bib136","doi-asserted-by":"crossref","first-page":"3656","DOI":"10.1074\/jbc.270.8.3656","article-title":"The hemoregulatory peptide N-acetyl-Ser-Asp-Lys-Pro is a natural and specific substrate of the N-terminal active site of human angiotensin- converting enzyme","volume":"270","author":"Rousseau","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2021.111254_bib137","doi-asserted-by":"crossref","first-page":"F1329","DOI":"10.1152\/ajprenal.00487.2016","article-title":"Downregulation of kidney protective factors by inflammation: role of transcription factors and epigenetic mechanisms","volume":"311","author":"Ruiz-Andr\u00e9s","year":"2016","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.mce.2021.111254_bib138","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/ki.2015.332","article-title":"The inflammatory cytokine TWEAK decreases PGC-1\u03b1 expression and mitochondrial function in acute kidney injury","volume":"89","author":"Ruiz-Andr\u00e9s","year":"2016","journal-title":"Kidney Int."},{"key":"10.1016\/j.mce.2021.111254_bib139","first-page":"S21","volume":"vol. 86","author":"Ruiz-Ortega","year":"2003"},{"key":"10.1016\/j.mce.2021.111254_bib140","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1016\/S0002-9440(10)64130-2","article-title":"Systemic infusion of angiotensin II into normal rats activates nuclear factor-\u03baB and AP-1 in the kidney role of AT1 and AT2 receptors","volume":"158","author":"Ruiz-Ortega","year":"2001","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.mce.2021.111254_bib141","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1161\/01.RES.86.12.1266","article-title":"Angiotensin II activates nuclear transcription factor \u03baB through AT1 and AT2 in vascular smooth muscle cells molecular mechanisms","volume":"86","author":"Ruiz-Ortega","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.mce.2021.111254_bib142","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/ndt\/16.suppl_1.27","article-title":"Angiotensin II activates nuclear transcription factor-\u03baB in aorta of normal rats and in vascular smooth muscle cells of AT1 knockout mice","volume":"16","author":"Ruiz-Ortega","year":"2001","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.mce.2021.111254_bib143","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41581-019-0248-y","article-title":"Targeting the progression of chronic kidney disease","volume":"16","author":"Ruiz-Ortega","year":"2020","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.mce.2021.111254_bib144","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/ndt\/gfi265","article-title":"Angiotensin II: a key factor in the inflammatory and fibrotic response in kidney diseases","volume":"21","author":"Ruiz-Ortega","year":"2006","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.mce.2021.111254_bib145","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S0014-5793(03)00894-9","article-title":"Iron chelation and a free radical scavenger suppress angiotensin II-induced downregulation of klotho, an anti-aging gene, in rat","volume":"551","author":"Saito","year":"2003","journal-title":"FEBS Lett."},{"key":"10.1016\/j.mce.2021.111254_bib146","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1093\/ckj\/sfz125","article-title":"Klotho, the elusive kidney-derived anti-ageing factor","volume":"13","author":"S\u00e1nchez-Ni\u00f1o","year":"2019","journal-title":"Clin. Kidney J."},{"key":"10.1016\/j.mce.2021.111254_bib147","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/labinvest.2011.138","article-title":"HSP27\/HSPB1 as an adaptive podocyte antiapoptotic protein activated by high glucose and angiotensin II","volume":"92","author":"S\u00e1nchez-Ni\u00f1o","year":"2012","journal-title":"Lab. Invest."},{"key":"10.1016\/j.mce.2021.111254_bib148","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1113\/EP085149","article-title":"Is immune system-related hypertension associated with ovarian hormone deficiency?","volume":"101","author":"Sandberg","year":"2016","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.mce.2021.111254_bib149","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1080\/14789450.2018.1545577","article-title":"Advances in understanding the role of angiotensin-regulated proteins in kidney diseases","volume":"16","author":"Sanz","year":"2019","journal-title":"Expert Rev. Proteomics"},{"key":"10.1016\/j.mce.2021.111254_bib150","doi-asserted-by":"crossref","first-page":"F82","DOI":"10.1152\/ajprenal.00139.2006","article-title":"Angiotensin metabolism in renal proximal tubules, urine, and serum of sheep: evidence for ACE2-dependent processing of angiotensin II","volume":"292","author":"Shaltout","year":"2007","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.mce.2021.111254_bib151","doi-asserted-by":"crossref","first-page":"116796","DOI":"10.1016\/j.lfs.2019.116796","article-title":"Angiotensin II type 2 receptor and angiotensin-converting enzyme 2 mediate ischemic renal injury in diabetic and non-diabetic rats","volume":"235","author":"Sharma","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.mce.2021.111254_bib152","doi-asserted-by":"crossref","first-page":"838","DOI":"10.2337\/diabetes.54.3.838","article-title":"N-acetyl-seryl-aspartyl-lysyl-proline prevents renal insufficiency and mesangial matrix expansion in diabetic db\/db mice","volume":"54","author":"Shibuya","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2021.111254_bib153","doi-asserted-by":"crossref","first-page":"H1027","DOI":"10.1152\/ajpheart.00697.2018","article-title":"Angiotensin II-induced hypertension and cardiac hypertrophy are differentially mediated by TLR3- and TLR4-dependent pathways","volume":"316","author":"Singh","year":"2019","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.mce.2021.111254_bib154","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1093\/ndt\/gft320","article-title":"ACE2 alterations in kidney disease","volume":"28","author":"Soler","year":"2013","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.mce.2021.111254_bib155","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1111\/jch.13897","article-title":"Lower urinary \u03b1-Klotho is associated with lower angiotensin-(1-7) and higher blood pressure in young adults born preterm with very low birth weight","volume":"22","author":"South","year":"2020","journal-title":"J. Clin. Hypertens."},{"key":"10.1016\/j.mce.2021.111254_bib156","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1681\/ASN.2015080910","article-title":"Inhibition of bromodomain and extraterminal domain family proteins ameliorates experimental renal damage","volume":"28","author":"Suarez-\u00c1lvarez","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.mce.2021.111254_bib157","doi-asserted-by":"crossref","DOI":"10.1111\/apha.13280","article-title":"Anti-fibrotic mechanisms of angiotensin AT2-receptor stimulation","volume":"227","author":"Sumners","year":"2019","journal-title":"Acta Physiol."},{"key":"10.1016\/j.mce.2021.111254_bib158","first-page":"1587594","article-title":"Free fatty acids activate renin-angiotensin system in 3t3-l1 adipocytes through nuclear factor-kappa b pathway","author":"Sun","year":"2016","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.mce.2021.111254_bib159","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1161\/HYPERTENSIONAHA.118.11176","article-title":"Klotho ameliorates medullary fibrosis and pressure natriuresis in hypertensive rat kidneys","volume":"72","author":"Takenaka","year":"2018","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2021.111254_bib160","doi-asserted-by":"crossref","DOI":"10.1111\/apha.13190","article-title":"Klotho protein supplementation reduces blood pressure and renal hypertrophy in db\/db mice, a model of type 2 diabetes","volume":"225","author":"Takenaka","year":"2019","journal-title":"Acta Physiol."},{"key":"10.1016\/j.mce.2021.111254_bib161","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.intimp.2012.07.023","article-title":"Ac-SDKP ameliorates the progression of lupus nephritis in MRL\/lpr mice","volume":"14","author":"Tan","year":"2012","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.mce.2021.111254_bib162","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/sj.ki.5002674","article-title":"Angiotensin converting enzyme inhibitor but not angiotensin receptor blockade or statin ameliorates murine adriamycin nephropathy","volume":"73","author":"Tang","year":"2008","journal-title":"Kidney Int."},{"key":"10.1016\/j.mce.2021.111254_bib163","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1161\/HYPERTENSIONAHA.116.07572","article-title":"G-Protein-Coupled receptor MrgD is a receptor for angiotensin-(1-7) involving adenylyl cyclase, cAMP, and phosphokinase A","volume":"68","author":"Tetzner","year":"2016","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2021.111254_bib164","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.jdiacomp.2015.11.003","article-title":"Elevated baseline glomerular filtration rate (GFR) is independently associated with a more rapid decline in renal function of patients with type 1 diabetes","volume":"30","author":"Thomson","year":"2016","journal-title":"J. Diabet. Complicat."},{"key":"10.1016\/j.mce.2021.111254_bib165","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1042\/BSR20140021","article-title":"Rho protein GTPases and their interactions with NF?B: crossroads of inflammation and matrix biology","volume":"34","author":"Tong","year":"2014","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.mce.2021.111254_bib166","doi-asserted-by":"crossref","first-page":"4003","DOI":"10.1172\/JCI58662","article-title":"PGC-1\u03b1 promotes recovery after acute kidney injury during systemic inflammation in mice","volume":"121","author":"Tran","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mce.2021.111254_bib167","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/nature17184","article-title":"PGC1\u03b1 drives NAD biosynthesis linking oxidative metabolism to renal protection","volume":"531","author":"Tran","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.mce.2021.111254_bib168","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1016\/j.jacc.2014.03.026","article-title":"Fibroblast growth factor-23, cardiovascular prognosis, and benefit of angiotensin-converting enzyme inhibition in stable ischemic heart disease","volume":"63","author":"Udell","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.mce.2021.111254_bib169","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1111\/bph.14687","article-title":"Blockade of myeloid differentiation 2 attenuates diabetic nephropathy by reducing activation of the renin-angiotensin system in mouse kidneys","volume":"176","author":"Wang","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.mce.2021.111254_bib170","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.ajpath.2019.02.004","article-title":"Stimulating type 1 angiotensin receptors on T lymphocytes attenuates renal fibrosis","volume":"189","author":"Wen","year":"2019","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.mce.2021.111254_bib171","doi-asserted-by":"crossref","first-page":"F637","DOI":"10.1152\/ajprenal.00479.2015","article-title":"Evidence for a mitochondrial angiotensin-(1-7) system in the kidney","volume":"310","author":"Wilson","year":"2016","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.mce.2021.111254_bib172","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1046\/j.1523-1755.2002.00365.x","article-title":"Angiotensin II activates nuclear transcription factor-\u03baB through AT1 and AT2 receptors","volume":"61","author":"Wolf","year":"2002","journal-title":"Kidney Int."},{"key":"10.1016\/j.mce.2021.111254_bib173","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1165\/rcmb.2011-0289OC","article-title":"LPS-stimulated cytokine production in Type I cells is modulated by the renin-angiotensin system","volume":"46","author":"Wong","year":"2012","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.mce.2021.111254_bib174","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1161\/HYPERTENSIONAHA.115.05970","article-title":"Renal protective effect of N-Acetyl-Seryl-Aspartyl-Lysyl-Proline in dahl salt-sensitive rats","volume":"66","author":"Worou","year":"2015","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2021.111254_bib175","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1161\/hc4601.099404","article-title":"Roles of angiotensin II type 2 receptor stimulation associated with selective angiotensin II type 1 receptor blockade with valsartan in the improvement of inflammation-induced vascular injury","volume":"104","author":"Wu","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.mce.2021.111254_bib176","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.bbrc.2018.09.013","article-title":"Isoliquiritigenin alleviated the Ang II-induced hypertensive renal injury through suppressing inflammation cytokines and oxidative stress-induced apoptosis via Nrf2 and NF-\u03baB pathways","volume":"506","author":"Xiong","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mce.2021.111254_bib177","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1161\/ATVBAHA.112.301019","article-title":"Peroxisome proliferator-activated receptor \u03b3 coactivator-1\u03b1 is a central negative regulator of vascular senescence","volume":"33","author":"Xiong","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.mce.2021.111254_bib178","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1074\/jbc.M109.065235","article-title":"PGC-1\u03b1serine 570 phosphorylation and GCN5-mediated acetylation by angiotensin II drive catalase down-regulation and vascular hypertrophy","volume":"285","author":"Xiong","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2021.111254_bib179","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1681\/ASN.2016070734","article-title":"Physiology and pathophysiology of the intrarenal renin-angiotensin system: an update","volume":"28","author":"Yang","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.mce.2021.111254_bib180","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1159\/000366169","article-title":"Ramipril lowers plasma FGF-23 in patients with diabetic nephropathy","volume":"40","author":"Yilmaz","year":"2014","journal-title":"Am. J. Nephrol."},{"key":"10.1016\/j.mce.2021.111254_bib181","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1093\/ndt\/gfq537","article-title":"Angiotensin II blockade upregulates the expression of Klotho, the anti-ageing gene, in an experimental model of chronic cyclosporine nephropathy","volume":"26","author":"Yoon","year":"2011","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.mce.2021.111254_bib182","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3390\/molecules25010025","article-title":"Myeloid differentiation protein 2 mediates angiotensin II-induced liver inflammation and fibrosis in mice","volume":"25","author":"Zhang","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.mce.2021.111254_bib183","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20150112","article-title":"PGC-1\u03b1 limits angiotensin II-induced rat vascular smooth muscle cells proliferation via attenuating NOX1-mediated generation of reactive oxygen species","volume":"35","author":"Zhao","year":"2015","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.mce.2021.111254_bib184","doi-asserted-by":"crossref","first-page":"3115","DOI":"10.1074\/jbc.RA119.012144","article-title":"Structure-function relationships of the soluble form of the antiaging protein Klotho have therapeutic implications for managing kidney disease","volume":"295","author":"Zhong","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2021.111254_bib185","doi-asserted-by":"crossref","first-page":"3211","DOI":"10.1016\/j.ajpath.2015.08.004","article-title":"Klotho ameliorates kidney injury and fibrosis and normalizes blood pressure by targeting the renin-angiotensin system","volume":"185","author":"Zhou","year":"2015","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.mce.2021.111254_bib186","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1159\/000316703","article-title":"Role of fosinopril and valsartan on klotho gene expression induced by angiotensin II in rat renal tubular epithelial cells","volume":"33","author":"Zhou","year":"2010","journal-title":"Kidney Blood Press. Res."},{"key":"10.1016\/j.mce.2021.111254_bib187","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1681\/ASN.2015010093","article-title":"Antiaging gene klotho regulates adrenal CYP11B2 expression and aldosterone synthesis","volume":"27","author":"Zhou","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"issue":"3","key":"10.1016\/j.mce.2021.111254_bib188","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0228385","article-title":"Angiotensin II triggers RIPK3-MLKL-mediated necroptosis by activating the Fas\/FasL signaling pathway in renal tubular cells","volume":"15","author":"Zhu","year":"2020","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.mce.2021.111254_bib189","doi-asserted-by":"crossref","first-page":"19450","DOI":"10.1038\/s41598-019-55550-8","article-title":"AT1 and AT2 receptors modulate renal tubular cell necroptosis in angiotensin II-infused renal injury mice","volume":"9","author":"Zhu","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mce.2021.111254_bib190","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1038\/ki.2013.209","article-title":"Thymosin \u03b24 and its degradation product, Ac-SDKP, are novel reparative factors in renal fibrosis","volume":"84","author":"Zuo","year":"2013","journal-title":"Kidney Int."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720721000988?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720721000988?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T13:27:46Z","timestamp":1778506066000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720721000988"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":190,"alternative-id":["S0303720721000988"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2021.111254","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Renin-angiotensin system and inflammation update","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2021.111254","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111254"}}