{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:17:46Z","timestamp":1790896666781,"version":"4.1.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T00:00:00Z","timestamp":1659052800000},"content-version":"vor","delay-in-days":331,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.mce.2021.111397","type":"journal-article","created":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T11:54:56Z","timestamp":1626263696000},"page":"111397","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["The gene expression of GPER1 is low in fresh samples of papillary thyroid carcinoma (PTC), and in silico analysis"],"prefix":"10.1016","volume":"535","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3025-4293","authenticated-orcid":false,"given":"Ana Paula Santin","family":"Bertoni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7635-5797","authenticated-orcid":false,"given":"Patr\u00edcia de Araujo","family":"Manfroi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joelson","family":"Tomedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz Maria","family":"Assis-Brasil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9119-0107","authenticated-orcid":false,"given":"Erika Laurini","family":"de Souza Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8300-2073","authenticated-orcid":false,"given":"Tania Weber","family":"Furlanetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2021.111397_bib1","first-page":"93","article-title":"The Eighth Edition AJCC Cancer Staging Manual: continuing to build a bridge from a population-based to a more \u201cpersonalized\u201d approach to cancer staging","volume":"67","author":"Amin","year":"2017","journal-title":"CA A Cancer J. Clin."},{"key":"10.1016\/j.mce.2021.111397_bib2","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1158\/1055-9965.EPI-13-0242","article-title":"The clinical and economic burden of a sustained increase in thyroid cancer incidence","volume":"22","author":"Aschebrook-Kilfoy","year":"2013","journal-title":"Canc. Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.mce.2021.111397_bib3","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.jsbmb.2017.03.021","article-title":"Twenty years of the G protein-coupled estrogen receptor GPER: historical and personal perspectives","volume":"176","author":"Barton","year":"2018","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.mce.2021.111397_bib4","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.mce.2018.08.013","article-title":"Activity of ecto-5'-nucleotidase (NT5E\/CD73) is increased in papillary thyroid carcinoma and its expression is associated with metastatic lymph nodes","volume":"479","author":"Bertoni","year":"2019","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2021.111397_bib5","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.cell.2014.09.050","article-title":"Integrated genomic characterization of papillary thyroid carcinoma","volume":"159","author":"Cancer Genome Atlas Research","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.mce.2021.111397_bib6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0120672","article-title":"Estrogens induce rapid cytoskeleton re-organization in human dermal fibroblasts via the non-classical receptor GPR30","volume":"10","author":"Carnesecchi","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.mce.2021.111397_bib7","doi-asserted-by":"crossref","first-page":"367","DOI":"10.2174\/156800908785133150","article-title":"Regulation of cell growth by estrogen signaling and potential targets in thyroid cancer","volume":"8","author":"Chen","year":"2008","journal-title":"Curr. Cancer Drug Targets"},{"key":"10.1016\/j.mce.2021.111397_bib8","first-page":"892","article-title":"Retrograde transport of the transmembrane estrogen receptor, G-protein-coupled-receptor-30 (GPR30\/GPER) from the plasma membrane towards the nucleus","volume":"76","author":"Cheng","year":"2011","journal-title":"Steroids"},{"key":"10.1016\/j.mce.2021.111397_bib9","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1038\/bjc.2012.302","article-title":"A gene expression signature distinguishes normal tissues of sporadic and radiation-induced papillary thyroid carcinomas","volume":"107","author":"Dom","year":"2012","journal-title":"Br. J. Canc."},{"key":"10.1016\/j.mce.2021.111397_bib10","doi-asserted-by":"crossref","first-page":"2840","DOI":"10.1210\/jc.2006-2707","article-title":"BRAF mutations in papillary thyroid carcinomas inhibit genes involved in iodine metabolism","volume":"92","author":"Durante","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2021.111397_bib11","doi-asserted-by":"crossref","first-page":"3236","DOI":"10.1210\/en.2006-1605","article-title":"Activation of the novel estrogen receptor G protein-coupled receptor 30 (GPR30) at the plasma membrane","volume":"148","author":"Filardo","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2021.111397_bib12","doi-asserted-by":"crossref","first-page":"6359","DOI":"10.1158\/1078-0432.CCR-06-0860","article-title":"Distribution of GPR30, a seven membrane-spanning estrogen receptor, in primary breast cancer and its association with clinicopathologic determinants of tumor progression","volume":"12","author":"Filardo","year":"2006","journal-title":"Clin. Canc. Res."},{"key":"10.1016\/j.mce.2021.111397_bib13","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.bbrc.2006.05.191","article-title":"G protein-coupled receptor 30 is an estrogen receptor in the plasma membrane","volume":"346","author":"Funakoshi","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mce.2021.111397_bib14","doi-asserted-by":"crossref","first-page":"5705","DOI":"10.1210\/endo.140.12.7197","article-title":"Estradiol increases proliferation and down-regulates the sodium\/iodide symporter gene in FRTL-5 cells","volume":"140","author":"Furlanetto","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2021.111397_bib15","first-page":"259","article-title":"Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells","volume":"34","author":"Furlanetto","year":"2001","journal-title":"Braz. J. Med. Biol. Res. = Revista brasileira de pesquisas medicas e biologicas"},{"key":"10.1016\/j.mce.2021.111397_bib16","first-page":"403","article-title":"Characterization of microarray gene expression profiles of early stage thyroid tumours","volume":"4","author":"Gombos","year":"2007","journal-title":"CANCER GENOMICS PROTEOMICS"},{"key":"10.1016\/j.mce.2021.111397_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/thy.2015.0020","article-title":"2015 American thyroid association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American thyroid association guidelines task force on thyroid nodules and differentiated thyroid cancer","volume":"26","author":"Haugen","year":"2016","journal-title":"Thyroid"},{"key":"10.1016\/j.mce.2021.111397_bib18","doi-asserted-by":"crossref","first-page":"19075","DOI":"10.1073\/pnas.0509603102","article-title":"The role of microRNA genes in papillary thyroid carcinoma","volume":"102","author":"He","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mce.2021.111397_bib19","doi-asserted-by":"crossref","first-page":"20567","DOI":"10.1038\/srep20567","article-title":"Transcriptional profiles from paired normal samples offer complementary information on cancer patient survival--evidence from TCGA pan-cancer data","volume":"6","author":"Huang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mce.2021.111397_bib20","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3109\/07357907.2013.789901","article-title":"GPER-1 expression decreases during breast cancer tumorigenesis","volume":"31","author":"Ignatov","year":"2013","journal-title":"Canc. Invest."},{"key":"10.1016\/j.mce.2021.111397_bib21","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2407-12-624","article-title":"Enhanced expression of G-protein coupled estrogen receptor (GPER\/GPR30) in lung cancer","volume":"12","author":"Jala","year":"2012","journal-title":"BMC Canc."},{"key":"10.1016\/j.mce.2021.111397_bib22","doi-asserted-by":"crossref","first-page":"18408","DOI":"10.1038\/s41598-020-75495-7","article-title":"The pseudogene problem and RT-qPCR data normalization; SYMPK: a suitable reference gene for papillary thyroid carcinoma","volume":"10","author":"Javadirad","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mce.2021.111397_bib23","first-page":"209","article-title":"Role of G Protein-Coupled estrogen receptor in cancer","volume":"35","author":"Jung","year":"2019"},{"key":"10.1016\/j.mce.2021.111397_bib24","doi-asserted-by":"crossref","DOI":"10.1038\/s41574-020-00414-9","article-title":"Understanding the ever-changing incidence of thyroid cancer","author":"Kitahara","year":"2020","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.mce.2021.111397_bib25","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1124\/mol.108.046854","article-title":"17-Beta-estradiol inhibits transforming growth factor-beta signaling and function in breast cancer cells via activation of extracellular signal-regulated kinase through the G protein-coupled receptor 30","volume":"74","author":"Kleuser","year":"2008","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.mce.2021.111397_bib26","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1038\/bjc.2012.91","article-title":"Loss of GPER identifies new targets for therapy among a subgroup of ERalpha-positive endometrial cancer patients with poor outcome","volume":"106","author":"Krakstad","year":"2012","journal-title":"Br. J. Canc."},{"key":"10.1016\/j.mce.2021.111397_bib27","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S1028-4559(07)60007-2","article-title":"The interactions between GPR30 and the major biomarkers in infiltrating ductal carcinoma of the breast in an Asian population","volume":"46","author":"Kuo","year":"2007","journal-title":"Taiwan. J. Obstet. Gynecol."},{"key":"10.1016\/j.mce.2021.111397_bib28","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/nature12213","article-title":"Mutational heterogeneity in cancer and the search for new cancer-associated genes","volume":"499","author":"Lawrence","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.mce.2021.111397_bib29","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.tem.2009.06.009","article-title":"Plasma membrane estrogen receptors","volume":"20","author":"Levin","year":"2009","journal-title":"Trends Endocrinol. Metabol."},{"key":"10.1016\/j.mce.2021.111397_bib30","doi-asserted-by":"crossref","first-page":"5415","DOI":"10.1158\/0008-5472.CAN-08-1622","article-title":"Stimulating the GPR30 estrogen receptor with a novel tamoxifen analogue activates SF-1 and promotes endometrial cell proliferation","volume":"69","author":"Lin","year":"2009","journal-title":"Canc. Res."},{"key":"10.1016\/j.mce.2021.111397_bib31","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1095\/biolreprod.110.084160","article-title":"Expression and signaling of G protein-coupled estrogen receptor 1 (GPER) in rat sertoli cells","volume":"83","author":"Lucas","year":"2010","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2021.111397_bib32","doi-asserted-by":"crossref","first-page":"148","DOI":"10.3389\/fendo.2020.00148","article-title":"Does GPER really function as a G protein-coupled estrogen receptor in vivo?","volume":"11","author":"Luo","year":"2020","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.mce.2021.111397_bib33","doi-asserted-by":"crossref","first-page":"27008","DOI":"10.1074\/jbc.M403588200","article-title":"The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells","volume":"279","author":"Maggiolini","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2021.111397_bib34","doi-asserted-by":"crossref","first-page":"117112","DOI":"10.1016\/j.lfs.2019.117112","article-title":"GPER1 in the thyroid: a systematic review","volume":"241","author":"Manfroi","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.mce.2021.111397_bib35","first-page":"1072","article-title":"Estrogen promotes growth of human thyroid tumor cells by different molecular mechanisms","volume":"86","author":"Manole","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2021.111397_bib36","doi-asserted-by":"crossref","first-page":"25946","DOI":"10.18632\/oncotarget.25408","article-title":"Low expression of G protein-coupled oestrogen receptor 1 (GPER) is associated with adverse survival of breast cancer patients","volume":"9","author":"Martin","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.mce.2021.111397_bib37","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.mce.2016.05.010","article-title":"Up-regulation of Hsp27 by ERalpha\/Sp1 facilitates proliferation and confers resistance to apoptosis in human papillary thyroid cancer cells","volume":"431","author":"Mo","year":"2016","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2021.111397_bib38","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1080\/14728222.2017.1350264","article-title":"GPER-1\/GPR30 a novel estrogen receptor sited in the cell membrane: therapeutic coupling to breast cancer","volume":"21","author":"Molina","year":"2017","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.mce.2021.111397_bib39","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.1002\/jcb.25909","article-title":"Extracellular nucleotide hydrolysis in dermal and limbal mesenchymal stem cells: a source of adenosine production","volume":"118","author":"Naasani","year":"2017","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.mce.2021.111397_bib40","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1001\/jamaoncol.2016.0386","article-title":"Nomenclature revision for encapsulated follicular variant of papillary thyroid carcinoma: a paradigm shift to reduce overtreatment of indolent tumors","volume":"2","author":"Nikiforov","year":"2016","journal-title":"JAMA Oncol."},{"key":"10.1016\/j.mce.2021.111397_bib41","doi-asserted-by":"crossref","first-page":"4846","DOI":"10.1210\/en.2008-0269","article-title":"G protein-coupled receptor 30 localizes to the endoplasmic reticulum and is not activated by estradiol","volume":"149","author":"Otto","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2021.111397_bib42","doi-asserted-by":"crossref","first-page":"108493","DOI":"10.1016\/j.steroids.2019.108493","article-title":"ERalpha-targeted endocrine therapy, resistance and the role of GPER","volume":"152","author":"Pepermans","year":"2019","journal-title":"Steroids"},{"key":"10.1016\/j.mce.2021.111397_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/cells10030672","article-title":"G protein-coupled estrogen receptor in cancer and stromal cells: functions and novel therapeutic perspectives","volume":"10","author":"Pepermans","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.mce.2021.111397_bib44","doi-asserted-by":"crossref","first-page":"E497","DOI":"10.1210\/jc.2013-1512","article-title":"Cell cycle deregulation and TP53 and RAS mutations are major events in poorly differentiated and undifferentiated thyroid carcinomas","volume":"99","author":"Pita","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2021.111397_bib45","first-page":"65","article-title":"The cell surface estrogen receptor, G protein- coupled receptor 30 (GPR30), is markedly down regulated during breast tumorigenesis","volume":"1","author":"Poola","year":"2008","journal-title":"Breast Canc."},{"key":"10.1016\/j.mce.2021.111397_bib46","doi-asserted-by":"crossref","first-page":"15241","DOI":"10.1038\/s41598-019-49247-1","article-title":"Validation of reference genes for normalization of relative qRT-PCR studies in papillary thyroid carcinoma","volume":"9","author":"Razavi","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mce.2021.111397_bib47","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1126\/science.1106943","article-title":"A transmembrane intracellular estrogen receptor mediates rapid cell signaling","volume":"307","author":"Revankar","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.mce.2021.111397_bib48","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1677\/ERC-07-0130","article-title":"BRAFV600E mutation, but not RET\/PTC rearrangements, is correlated with a lower expression of both thyroperoxidase and sodium iodide symporter genes in papillary thyroid cancer","volume":"15","author":"Romei","year":"2008","journal-title":"Endocr. Relat. Canc."},{"key":"10.1016\/j.mce.2021.111397_bib49","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1002\/jcb.25369","article-title":"Intracellular distribution and involvement of GPR30 in the actions of E2 on C2C12 cells","volume":"117","author":"Ronda","year":"2016","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.mce.2021.111397_bib50","doi-asserted-by":"crossref","first-page":"591217","DOI":"10.3389\/fendo.2020.591217","article-title":"Therapeutic perspectives on the modulation of G-protein coupled estrogen receptor, GPER, function","volume":"11","author":"Rouhimoghadam","year":"2020","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.mce.2021.111397_bib51","doi-asserted-by":"crossref","first-page":"5842","DOI":"10.1210\/en.2007-0436","article-title":"Expression of G protein-coupled receptor-30, a G protein-coupled membrane estrogen receptor, in oxytocin neurons of the rat paraventricular and supraoptic nuclei","volume":"148","author":"Sakamoto","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2021.111397_bib52","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1124\/mol.110.069500","article-title":"G protein-coupled estrogen receptor 1\/G protein-coupled receptor 30 localizes in the plasma membrane and traffics intracellularly on cytokeratin intermediate filaments","volume":"79","author":"Sanden","year":"2011","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.mce.2021.111397_bib53","first-page":"875125","article-title":"Role of estrogen in thyroid function and growth regulation","author":"Santin","year":"2011","journal-title":"J. Thyroid Res."},{"key":"10.1016\/j.mce.2021.111397_bib54","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.ygyno.2009.05.015","article-title":"GPR30 predicts poor survival for ovarian cancer","volume":"114","author":"Smith","year":"2009","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.mce.2021.111397_bib55","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.ajog.2007.01.004","article-title":"GPR30: a novel indicator of poor survival for endometrial carcinoma","volume":"196","author":"Smith","year":"2007","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.mce.2021.111397_bib56","first-page":"3213","article-title":"High expression of GPER1, EGFR and CXCR1 is associated with lymph node metastasis in papillary thyroid carcinoma","volume":"7","author":"Tang","year":"2014","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.mce.2021.111397_bib57","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1210\/en.2004-1064","article-title":"Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells","volume":"146","author":"Thomas","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2021.111397_bib58","first-page":"3115","article-title":"Downregulation of G Protein-Coupled estrogen receptor (GPER) is associated with reduced prognosis in patients with gastric cancer","volume":"25","author":"Tian","year":"2019","journal-title":"Med. Sci. Mon. Int. Med. J. Exp. Clin. Res."},{"key":"10.1016\/j.mce.2021.111397_bib59","doi-asserted-by":"crossref","first-page":"4490","DOI":"10.1038\/onc.2011.626","article-title":"A general method to derive robust organ-specific gene expression-based differentiation indices: application to thyroid cancer diagnostic","volume":"31","author":"Tom\u00e1s","year":"2012","journal-title":"Oncogene"},{"key":"10.1016\/j.mce.2021.111397_bib60","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nrg3185","article-title":"Insights into the regulation of protein abundance from proteomic and transcriptomic analyses","volume":"13","author":"Vogel","year":"2012","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.mce.2021.111397_bib61","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.biocel.2019.05.002","article-title":"GPER1 influences cellular homeostasis and cytostatic drug resistance via influencing long chain ceramide synthesis in breast cancer cells","volume":"112","author":"Wegner","year":"2019","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.mce.2021.111397_bib62","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1177\/0300060517717625","article-title":"Nuclear G protein-coupled oestrogen receptor (GPR30) predicts poor survival in patients with ovarian cancer","volume":"46","author":"Zhu","year":"2018","journal-title":"J. Int. Med. Res."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720721002410?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720721002410?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T14:20:48Z","timestamp":1759587648000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720721002410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":62,"alternative-id":["S0303720721002410"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2021.111397","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The gene expression of GPER1 is low in fresh samples of papillary thyroid carcinoma (PTC), and in silico analysis","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2021.111397","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"111397"}}