{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:24:26Z","timestamp":1787318666029,"version":"build-2736575974"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T00:00:00Z","timestamp":1644364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.mce.2022.111594","type":"journal-article","created":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T20:40:47Z","timestamp":1644352847000},"page":"111594","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["SDHB and SDHD silenced pheochromocytoma spheroids respond differently to tumour microenvironment and their aggressiveness is inhibited by impairing stroma metabolism"],"prefix":"10.1016","volume":"547","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4992-2252","authenticated-orcid":false,"given":"Serena","family":"Martinelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Riverso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Mello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Amore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Parri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Simeone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Mannelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Maggi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3826-2714","authenticated-orcid":false,"given":"Elena","family":"Rapizzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2022.111594_bib1","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1136\/jmedgenet-2017-105127","article-title":"Tumour risks and genotype\u2013phenotype correlations associated with germline variants in succinate dehydrogenase subunit genes SDHB, SDHC and SDHD","volume":"55","author":"Andrews","year":"2018","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.mce.2022.111594_bib2","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0006-8993(72)90375-7","article-title":"Comparative studies on the effect of the nerve growth factor on sympathetic ganglia and adrenal medulla in newborn rats","volume":"44","author":"Angeletti","year":"1972","journal-title":"Brain Res."},{"key":"10.1016\/j.mce.2022.111594_bib3","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1086\/321282","article-title":"Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma","volume":"69","author":"Astuti","year":"2001","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.mce.2022.111594_bib4","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1126\/science.287.5454.848","article-title":"Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma","volume":"287","author":"Baysal","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.mce.2022.111594_bib5","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1158\/0008-5472.CAN-17-2463","article-title":"Germline mutations in the mitochondrial 2-Oxoglutarate\/malate carrier SLC25A11 gene confer a predisposition to metastatic paragangliomas","volume":"78","author":"Buffet","year":"2018","journal-title":"Cancer Res."},{"key":"10.1016\/j.mce.2022.111594_bib6","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1093\/hmg\/ddq206","article-title":"SDHA is a tumor suppressor gene causing paraganglioma","volume":"19","author":"Burnichon","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mce.2022.111594_bib7","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1038\/s41436-018-0068-7","article-title":"Role of MDH2 pathogenic variant in pheochromocytoma and paraganglioma patients","volume":"20","author":"Calsina","year":"2018","journal-title":"Genet. Med."},{"key":"10.1016\/j.mce.2022.111594_bib60","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201911466","article-title":"A paracrine activin A-mDia2 axis promotes squamous carcinogenesis via fibroblast reprogramming","volume":"12","author":"Cangkrama","year":"2020","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.mce.2022.111594_bib8","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1093\/hmg\/ddt639","article-title":"Germline mutations in FH confer predisposition to malignant pheochromocytomas and paragangliomas","volume":"23","author":"Castro-Vega","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mce.2022.111594_bib9","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/s41573-018-0004-1","article-title":"Turning foes to friends: targeting cancer-associated fibroblasts","volume":"18","author":"Chen","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.mce.2022.111594_bib10","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/ng.861","article-title":"Exome sequencing identifies MAX mutations as a cause of hereditary pheochromocytoma","author":"Comino-M\u00e9ndez","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mce.2022.111594_bib11","doi-asserted-by":"crossref","first-page":"E1266","DOI":"10.1210\/jc.2012-4257","article-title":"Somatic mutations in H-RAS in sporadic pheochromocytoma and paraganglioma identified by exome sequencing","volume":"98","author":"Crona","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2022.111594_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1158\/2159-8290.CD-20-1211","article-title":"Metabolic codependencies in the tumor microenvironment","volume":"11","author":"Dey","year":"2021","journal-title":"Cancer Discov."},{"key":"10.1016\/j.mce.2022.111594_bib13","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1002\/path.1461","article-title":"SDHD mutations in head and neck paragangliomas result in destabilization of complex II in the mitochondrial respiratory chain with loss of enzymatic activity and abnormal mitochondrial morphology","volume":"201","author":"Douwes Dekker","year":"2003","journal-title":"J. Pathol."},{"key":"10.1016\/j.mce.2022.111594_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/ERC-17-0306","article-title":"TERT structural rearrangements in metastatic pheochromocytomas","volume":"25","author":"Dwight","year":"2018","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.mce.2022.111594_bib15","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1530\/ERC-17-0212","article-title":"The microenvironment induces collective migration in SDHB-silenced mouse pheochromocytoma spheroids","volume":"24","author":"D'Antongiovanni","year":"2017","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.mce.2022.111594_bib16","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/cge.13553","article-title":"Clinical implications of the oncometabolite succinate in SDHx-mutation carriers","volume":"97","author":"Eijkelenkamp","year":"2020","journal-title":"Clin. Genet."},{"key":"10.1016\/j.mce.2022.111594_bib17","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ccr.2009.12.041","article-title":"Cancer-associated fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF-kappaB-dependent manner","volume":"17","author":"Erez","year":"2010","journal-title":"Cancer Cell"},{"key":"10.1016\/j.mce.2022.111594_bib18","doi-asserted-by":"crossref","first-page":"96","DOI":"10.3892\/etm.2020.9528","article-title":"An overview of the tumor microenvironment, from cells to complex networks","volume":"21","author":"Farc","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.mce.2022.111594_bib19","doi-asserted-by":"crossref","DOI":"10.1103\/PhysRevE.77.031911","article-title":"Probabilistic approach to a proliferation and migration dichotomy in the tumor cell invasion","volume":"77","author":"Fedotov","year":"2008","journal-title":"Phys. Rev. E - Stat. Nonlinear Soft Matter Phys."},{"key":"10.1016\/j.mce.2022.111594_bib20","doi-asserted-by":"crossref","first-page":"5130","DOI":"10.1158\/0008-5472.CAN-12-1949","article-title":"Reciprocal metabolic reprogramming through lactate shuttle coordinately influences tumor-stroma interplay","volume":"72","author":"Fiaschi","year":"2012","journal-title":"Cancer Res."},{"key":"10.1016\/j.mce.2022.111594_bib21","doi-asserted-by":"crossref","first-page":"6140","DOI":"10.1038\/ncomms7140","article-title":"Whole-exome sequencing identifies somatic ATRX mutations in pheochromocytomas and paragangliomas","volume":"6","author":"Fishbein","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mce.2022.111594_bib22","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1210\/jc.2009-2170","article-title":"Isocitrate dehydrogenase mutations are rare in pheochromocytomas and paragangliomas","volume":"95","author":"Gaal","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2022.111594_bib23","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/s41591-020-01195-4","article-title":"Targeting metastatic cancer","volume":"27","author":"Ganesh","year":"2021","journal-title":"Nat. Med."},{"key":"10.1016\/j.mce.2022.111594_bib24","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1200\/JCO.2003.05.063","article-title":"Cost of migration: invasion of malignant gliomas and implications for treatment","volume":"21","author":"Giese","year":"2003","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.mce.2022.111594_bib25","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1073\/pnas.73.7.2424","article-title":"Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor","volume":"73","author":"Greene","year":"1976","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mce.2022.111594_bib26","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.3324\/haematol.2018.196097","article-title":"Multiple faces of succinate beyond metabolism in blood","volume":"103","author":"Grimolizzi","year":"2018","journal-title":"Haematologica"},{"key":"10.1016\/j.mce.2022.111594_bib27","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3389\/fonc.2017.00068","article-title":"Metabolic cooperation and competition in the tumor microenvironment: implications for therapy","volume":"7","author":"Gupta","year":"2017","journal-title":"Front. Oncol."},{"key":"10.1016\/j.mce.2022.111594_bib28","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.ccr.2012.02.022","article-title":"Accessories to the crime: functions of cells recruited to the tumor microenvironment","volume":"21","author":"Hanahan","year":"2012","journal-title":"Cancer Cell"},{"key":"10.1016\/j.mce.2022.111594_bib29","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1126\/science.1175689","article-title":"SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma","volume":"325","author":"Hao","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.mce.2022.111594_bib30","first-page":"2125","article-title":"Collective cell movement in primary melanoma explants plasticity of cell-cell interaction, \u03b21-integrin function, and migration strategies","volume":"62","author":"Hegerfeldt","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.mce.2022.111594_bib31","doi-asserted-by":"crossref","first-page":"20009","DOI":"10.1073\/pnas.1013805107","article-title":"Autocrine TGF-\u03b2 and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblast","volume":"107","author":"Kojima","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mce.2022.111594_bib32","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12920-019-0483-x","article-title":"Mutational load in carotid body tumor","volume":"2","author":"Kudryavtseva","year":"2019","journal-title":"BMC Med. Genom."},{"key":"10.1016\/j.mce.2022.111594_bib33","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1056\/NEJMoa0806277","article-title":"PHD2 mutation and congenital erythrocytosis with paraganglioma","volume":"359","author":"Ladroue","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mce.2022.111594_bib34","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1126\/science.8493574","article-title":"Identification of the von Hippel-Lindau disease tumor suppressor gene","volume":"260","author":"Latif","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.mce.2022.111594_bib35","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.ccr.2013.04.018","article-title":"SDH mutations establish a hypermethylator phenotype in paraganglioma","volume":"23","author":"Letouz\u00e9","year":"2013","journal-title":"Cancer Cell"},{"key":"10.1016\/j.mce.2022.111594_bib36","doi-asserted-by":"crossref","first-page":"538","DOI":"10.3390\/cells8060538","article-title":"Nodal facilitates differentiation of fibroblasts to cancer-associated fibroblasts that support tumor growth in melanoma and colorectal cancer","volume":"8","author":"Li","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.mce.2022.111594_bib37","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.4161\/cc.25695","article-title":"Oncogenes induce the cancer-associated fibroblast phenotype: metabolic symbiosis and \u201cfibroblast addiction\u201d are new therapeutic targets for drug discovery","volume":"12","author":"Lisanti","year":"2013","journal-title":"Cell Cycle"},{"key":"10.1016\/j.mce.2022.111594_bib38","article-title":"Profiling of somatic mutations in phaeochromocytoma and paraganglioma by targeted next generation sequencing analysis","volume":"2015","author":"Luchetti","year":"2015","journal-title":"Internet J. Endocrinol."},{"key":"10.1016\/j.mce.2022.111594_bib39","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.4161\/cc.10.15.16585","article-title":"Cancer cells metabolically \u201cfertilize\u201d the tumor microenvironment with hydrogen peroxide, driving the Warburg effect: implications for PET imaging of human tumors","volume":"10","author":"Martinez-Outschoorn","year":"2011","journal-title":"Cell Cycle"},{"key":"10.1016\/j.mce.2022.111594_bib40","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s10585-009-9236-0","article-title":"Characterization of an animal model of aggressive metastatic pheochromocytoma linked to a specific gene signature","volume":"26","author":"Martiniova","year":"2009","journal-title":"Clin. Exp. Metastasis"},{"key":"10.1016\/j.mce.2022.111594_bib41","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.589451","article-title":"Succinate mediates tumorigenic effects via succinate receptor 1: potential for new targeted treatment strategies in succinate dehydrogenase deficient paragangliomas","volume":"12","author":"Matlac","year":"2021","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.mce.2022.111594_bib42","doi-asserted-by":"crossref","first-page":"R451","DOI":"10.1530\/ERC-20-0346","article-title":"Epigenetic and metabolic reprogramming of SDH-deficient paragangliomas","volume":"27","author":"Moog","year":"2020","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.mce.2022.111594_bib43","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s10689-004-0621-1","article-title":"SDHC mutations in hereditary paraganglioma\/pheochromocytoma","volume":"4","author":"M\u00fcller","year":"2005","journal-title":"Fam. Cancer"},{"key":"10.1016\/j.mce.2022.111594_bib67","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/363458a0","article-title":"Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A","volume":"363","author":"Mulligan","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.mce.2022.111594_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.117049","article-title":"Stromal reprogramming: a target for tumor therapy","volume":"239","author":"Najafi","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.mce.2022.111594_bib45","first-page":"5002","article-title":"Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium","volume":"59","author":"Olumi","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/j.mce.2022.111594_bib46","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/ng.533","article-title":"Germline mutations in TMEM127 confer susceptibility to pheochromocytoma","volume":"42","author":"Qin","year":"2010","journal-title":"Nat. Genet."},{"key":"10.1016\/j.mce.2022.111594_bib47","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1530\/ERC-11-0263","article-title":"Mitochondrial function and content in pheochromocytoma\/paraganglioma of succinate dehydrogenase mutation carriers","volume":"19","author":"Rapizzi","year":"2012","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.mce.2022.111594_bib48","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1007\/s12672-014-0172-3","article-title":"Succinate dehydrogenase subunit B mutations modify human neuroblastoma cell metabolism and proliferation","volume":"5","author":"Rapizzi","year":"2014","journal-title":"Horm. Cancer"},{"key":"10.1016\/j.mce.2022.111594_bib49","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1530\/ERC-14-0479","article-title":"Role of microenvironment on neuroblastoma SK-N-AS SDHB-silenced cell metabolism and function","volume":"22","author":"Rapizzi","year":"2015","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.mce.2022.111594_bib50","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1038\/s41436-018-0003-y","article-title":"Gain-offunction mutations in DNMT3A in patients with paraganglioma","volume":"20","author":"Remacha","year":"2018","journal-title":"Genet. Med."},{"key":"10.1016\/j.mce.2022.111594_bib51","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.ajhg.2019.02.017","article-title":"Recurrent germline DLST mutations in individuals with multiple pheochromocytomas and paragangliomas","volume":"104","author":"Remacha","year":"2019","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.mce.2022.111594_bib52","doi-asserted-by":"crossref","first-page":"3903","DOI":"10.1210\/jc.2014-2151","article-title":"Krebs cycle metabolite profiling for identification and stratification of pheochromocytomas\/paragangliomas due to succinate dehydrogenase deficiency","volume":"99","author":"Richter","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2022.111594_bib53","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s00441-018-2907-x","article-title":"Primary fibroblast co-culture stimulates growth and metabolism in Sdhb-impaired mouse pheochromocytoma MTT cells","volume":"374","author":"Richter","year":"2018","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.mce.2022.111594_bib54","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.mce.2022.111594_bib55","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ccr.2004.11.022","article-title":"Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase","volume":"7","author":"Selak","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1016\/j.mce.2022.111594_bib56","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1210\/jc.2006-2315","article-title":"Clinical presentations, biochemical phenotypes, and genotype-phenotype correlations in patients with succinate dehydrogenase subunit B-associated pheochromocytomas and paragangliomas","volume":"92","author":"Timmers","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2022.111594_bib57","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1126\/science.2134734","article-title":"Type-1 neurofibromatosis gene: identification of a large transcript disrupted in three NF1 patients","volume":"249","author":"Wallace","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.mce.2022.111594_bib58","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1085\/jgp.8.6.519","article-title":"The metabolism of tumors in the body","volume":"8","author":"Warburg","year":"1927","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.mce.2022.111594_bib59","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1007\/s00268-017-4320-0","article-title":"Activating FGFR1 mutations in sporadic pheochromocytomas","volume":"42","author":"Welander","year":"2018","journal-title":"World J. Surg."},{"key":"10.1016\/j.mce.2022.111594_bib61","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1038\/ncb1616","article-title":"Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion","volume":"9","author":"Wolf","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.mce.2022.111594_bib62","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.canlet.2016.01.043","article-title":"Tumor microenvironment and therapeutic response","volume":"387","author":"Wu","year":"2017","journal-title":"Cancer Lett."},{"key":"10.1016\/j.mce.2022.111594_bib63","first-page":"5301","article-title":"An emerging tumor invasion mechanism about the collective cell migration","volume":"11","author":"Yang","year":"2019","journal-title":"Am. J. Transl. Res"},{"issue":"16","key":"10.1016\/j.mce.2022.111594_bib64","doi-asserted-by":"crossref","first-page":"7867","DOI":"10.1073\/pnas.1809964116","article-title":"Energetic regulation of coordinated leader\u2013follower dynamics during collective invasion of breast cancer cells","volume":"16","author":"Zhang","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mce.2022.111594_bib65","article-title":"Enhanced invasion of metastatic cancer cells via extracellular matrix interface","volume":"10","author":"Zhu","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.mce.2022.111594_bib66","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1056\/NEJMoa1205119","article-title":"Somatic HIF2A gain-of-function mutations in paraganglioma with polycythemia","volume":"367","author":"Zhuang","year":"2012","journal-title":"N. Engl. J. Med."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720722000417?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720722000417?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T14:19:04Z","timestamp":1759587544000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720722000417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":67,"alternative-id":["S0303720722000417"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2022.111594","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SDHB and SDHD silenced pheochromocytoma spheroids respond differently to tumour microenvironment and their aggressiveness is inhibited by impairing stroma metabolism","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2022.111594","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"111594"}}