{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T19:16:45Z","timestamp":1781983005084,"version":"3.54.5"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.mce.2022.111688","type":"journal-article","created":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T20:25:55Z","timestamp":1653942355000},"page":"111688","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Treatment with spexin mitigates diet-induced hepatic steatosis in vivo and in vitro through activation of galanin receptor 2"],"prefix":"10.1016","volume":"552","author":[{"given":"Mengyuan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyue","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Kan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wancheng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengxian","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuxin","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyu","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenwen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penghua","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2022.111688_bib1","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/1679690","article-title":"Spexin levels are associated with metabolic syndrome components","volume":"2018","author":"Al-Daghri","year":"2018","journal-title":"Dis. Markers"},{"key":"10.1016\/j.mce.2022.111688_bib2","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1038\/labinvest.2011.55","article-title":"Fatty liver is associated with impaired activity of PPAR\u03b3-coactivator 1\u03b1 (PGC1\u03b1) and mitochondrial biogenesis in mice","volume":"91","author":"Aharoni-Simon","year":"2011","journal-title":"Lab. Invest."},{"key":"10.1016\/j.mce.2022.111688_bib3","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.cmet.2013.07.004","article-title":"DNA methylation analysis in nonalcoholic fatty liver disease suggests distinct disease-specific and remodeling signatures after bariatric surgery","volume":"18","author":"Ahrens","year":"2013","journal-title":"Cell Metabol."},{"key":"10.1016\/j.mce.2022.111688_bib4","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1053\/j.gastro.2016.09.017","article-title":"Estrogen signals through peroxisome proliferator-activated receptor-\u03b3 coactivator 1\u03b1 to reduce oxidative damage associated with diet-induced fatty liver disease","volume":"152","author":"Besse-Patin","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.mce.2022.111688_bib5","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1002\/hep.26226","article-title":"Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease","volume":"58","author":"Begriche","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.mce.2022.111688_bib6","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1042\/CS20171221","article-title":"TRAIL reduces impaired glucose tolerance and NAFLD in the high-fat diet fed mouse","volume":"132","author":"Bernardi","year":"2018","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.mce.2022.111688_bib7","doi-asserted-by":"crossref","first-page":"48941","DOI":"10.1074\/jbc.M407120200","article-title":"Impaired tricarboxylic acid cycle activity in mouse livers lacking cytosolic phosphoenolpyruvatecarboxykinase","volume":"279","author":"Burgess","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2022.111688_bib8","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.metabol.2015.12.012","article-title":"The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)","volume":"65","author":"Buzzetti","year":"2016","journal-title":"Metabolism"},{"issue":"1\u20132","key":"10.1016\/j.mce.2022.111688_bib54","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.cell.2013.12.021","article-title":"Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch","volume":"156","author":"Cohen","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.mce.2022.111688_bib9","first-page":"1","article-title":"Effect of spexin on renal dysfunction in experimentally obese rats: potential mitigating mechanisms via galanin receptor-2","author":"El-Saka","year":"2021","journal-title":"Arch. Physiol. Biochem."},{"key":"10.1016\/j.mce.2022.111688_bib10","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.2337\/db08-1571","article-title":"Sensitivity of lipid metabolism and insulin signaling to genetic alterations in hepatic peroxisomeproliferator-activated receptor-gamma coactivator-1alpha expression","volume":"58","author":"Estall","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2022.111688_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.yfrne.2019.100801","article-title":"Galanin peptide family regulation of glucose metabolism","volume":"56","author":"Fang","year":"2020","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.mce.2022.111688_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101509","article-title":"Adipose tissue spexin in physical exercise and age-associated diseases","volume":"73","author":"Fang","year":"2022","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.mce.2022.111688_bib13","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.metabol.2016.01.012","article-title":"Epidemiology and natural history of non-alcoholic fatty liver disease","volume":"65","author":"Fazel","year":"2016","journal-title":"Metabolism"},{"key":"10.1016\/j.mce.2022.111688_bib14","article-title":"Spexin improves adipose tissue inflammation and macrophage recruitment in obese mice","volume":"1865","author":"Gambaro","year":"2020","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.mce.2022.111688_bib15","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.molcel.2011.12.005","article-title":"The cAMP\/PKA pathway rapidly activates SIRT1 to promote fatty acid oxidation independently of changes in NAD(+)","volume":"44","author":"Gerhart-Hines","year":"2011","journal-title":"Mol. Cell."},{"key":"10.1016\/j.mce.2022.111688_bib16","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1055\/s-0036-1597248","article-title":"Regulation of hepatocellular fatty acid uptake in mouse models of fatty liver disease with and without functional leptin signaling: roles of NfKB and SREBP-1C and the effects of spexin","volume":"36","author":"Ge","year":"2016","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.mce.2022.111688_bib17","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.peptides.2015.07.018","article-title":"Spexin peptide is expressed in human endocrine and epithelial tissues and reduced after glucose load in type 2 diabetes","volume":"71","author":"Gu","year":"2015","journal-title":"Peptides"},{"key":"10.1016\/j.mce.2022.111688_bib18","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.7150\/ijbs.31781","article-title":"Spexin alleviates insulin resistance and inhibits hepatic gluconeogenesis via the FoxO1\/PGC-1\u03b1 pathway in high-fat-diet-induced rats and insulin resistant cells","volume":"15","author":"Gu","year":"2019","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.mce.2022.111688_bib19","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/j.metabol.2016.01.001","article-title":"Non-alcoholic fatty liver disease and diabetes","volume":"65","author":"Hazlehurst","year":"2016","journal-title":"Metabolism"},{"key":"10.1016\/j.mce.2022.111688_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2021.101238","article-title":"Metabolic-associated fatty liver disease and lipoprotein metabolism","volume":"50","author":"Heeren","year":"2021","journal-title":"Mol. Metabol."},{"key":"10.1016\/j.mce.2022.111688_bib21","article-title":"Genetic and epigenetic factors determining NAFLD risk","volume":"5","author":"Jonas","year":"2020","journal-title":"Mol. Metabol."},{"key":"10.1016\/j.mce.2022.111688_bib22","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1159\/000493482","article-title":"Decreased spexin levels in patients with type 1 and type 2 diabetes","volume":"27","author":"Karaca","year":"2018","journal-title":"Med. Princ. Pract."},{"key":"10.1016\/j.mce.2022.111688_bib23","doi-asserted-by":"crossref","first-page":"45","DOI":"10.33549\/physiolres.933467","article-title":"Serum levels of spexin and kisspeptin negatively correlate with obesity and insulin resistance in women","volume":"67","author":"Ko\u0142odziejski","year":"2018","journal-title":"Physiol. Res."},{"key":"10.1016\/j.mce.2022.111688_bib24","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/j.bbalip.2018.08.001","article-title":"Spexin: a novel regulator of adipogenesis and fat tissue metabolism","volume":"1863","author":"Kolodziejski","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"issue":"1","key":"10.1016\/j.mce.2022.111688_bib53","doi-asserted-by":"crossref","first-page":"10635","DOI":"10.1038\/s41598-020-67624-z","article-title":"Spexin as an indicator of beneficial effects of exercise in human obesity and diabetes","volume":"10","author":"Khadir","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mce.2022.111688_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2021.111420","article-title":"30-Day spexin treatment of mice with diet-induced obesity (DIO) and type 2 diabetes (T2DM) increases insulin sensitivity, improves liver functions and metabolic status","volume":"536","author":"Kolodziejski","year":"2021","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2022.111688_bib26","doi-asserted-by":"crossref","first-page":"2931","DOI":"10.1210\/jc.2016-1177","article-title":"Decreased circulating levels of spexin in obese children","volume":"101","author":"Kumar","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2022.111688_bib27","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1016\/j.soard.2018.07.007","article-title":"Roux-en-Y gastric bypass surgery in youth with severe obesity: 1-year longitudinal changes in spexin","volume":"14","author":"Kumar","year":"2018","journal-title":"Surg. Obes. Relat. Dis."},{"key":"10.1016\/j.mce.2022.111688_bib28","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00210-019-01708-0","article-title":"Spexin protects cardiomyocytes from hypoxia-induced metabolic and mitochondrial dysfunction","volume":"393","author":"Liu","year":"2020","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"10.1016\/j.mce.2022.111688_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.0030101","article-title":"PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscledysfunction, abnormal weight control and hepatic steatosis","volume":"3","author":"Leone","year":"2005","journal-title":"PLoS Biol."},{"issue":"1","key":"10.1016\/j.mce.2022.111688_bib30","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3390\/genes13010081","article-title":"Spexin promotes the proliferation and differentiation of C2C12 cells in vitro-the effect of exercise on SPX and SPX receptor expression in skeletal muscle in vivo","volume":"13","author":"Leciejewska","year":"2021","journal-title":"Genes"},{"key":"10.1016\/j.mce.2022.111688_bib32","doi-asserted-by":"crossref","first-page":"G868","DOI":"10.1152\/ajpgi.00179.2013","article-title":"Reduced hepatic mitochondrial respiration following acute high-fat diet is prevented by PGC-1\u03b1 overexpression","volume":"305","author":"Morris","year":"2013","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.mce.2022.111688_bib33","doi-asserted-by":"crossref","first-page":"G979","DOI":"10.1152\/ajpgi.00169.2012","article-title":"PGC-1\u03b1 overexpression results in increased hepatic fatty acid oxidation with reducedtriacylglycerol accumulation and secretion","volume":"303","author":"Morris","year":"2012","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.mce.2022.111688_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2020.101049","article-title":"Non-alcoholic fatty liver disease and steatohepatitis: state of the art on effective therapeutics based on the gold standard method for diagnosis","volume":"50","author":"Mahjoubin-Tehran","year":"2021","journal-title":"Mol. Metabol."},{"key":"10.1016\/j.mce.2022.111688_bib35","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/nature13478","article-title":"The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes","volume":"510","author":"Perry","year":"2014","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.mce.2022.111688_bib55","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1152\/physrev.00063.2017","article-title":"Mechanisms of Insulin Action and Insulin Resistance","volume":"98","author":"Petersen","year":"2018","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.mce.2022.111688_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.ygcen.2020.113615","article-title":"Short-term administration of spexin in rats reduces obesity by affecting lipolysis and lipogenesis: an in vivo and in vitro study","volume":"299","author":"Pruszynska-Oszmalek","year":"2020","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.mce.2022.111688_bib37","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nature03354","article-title":"Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1","volume":"434","author":"Rodgers","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.mce.2022.111688_bib38","first-page":"1","article-title":"Spexin alleviates hypertension, hyperuricaemia, dyslipidemia and insulin resistance in high fructose diet induced metabolic syndrome in rats via enhancing PPAR-\u0263 and AMPK and inhibiting IL-6 and TNF-\u03b1","author":"Said","year":"2021","journal-title":"Arch. Physiol. Biochem."},{"key":"10.1016\/j.mce.2022.111688_bib39","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s13340-015-0212-4","article-title":"Glucose area under the curve during oral glucose tolerance test as an index of glucose intolerance","volume":"7","author":"Sakaguchi","year":"2015","journal-title":"Diabetol. Int."},{"key":"10.1016\/j.mce.2022.111688_bib40","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.jhep.2015.08.022","article-title":"Gestational exercise protects adult male offspring from high-fat diet-induced hepatic steatosis","volume":"64","author":"Sheldon","year":"2016","journal-title":"J. Hepatol."},{"key":"10.1016\/j.mce.2022.111688_bib41","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.2337\/diabetes.52.7.1649","article-title":"Mechanisms by which liver-specific PEPCK knockout mice preserve euglycemia during starvation","volume":"52","author":"She","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2022.111688_bib42","doi-asserted-by":"crossref","first-page":"6508","DOI":"10.1128\/MCB.20.17.6508-6517.2000","article-title":"Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energymetabolism","volume":"20","author":"She","year":"2000","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.mce.2022.111688_bib43","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.2337\/db07-0156","article-title":"Genes involved in fatty acid partitioning and binding, lipolysis, monocyte\/macrophage recruitment, and inflammation are overexpressed in the human fatty liver of insulin-resistant subjects","volume":"56","author":"Westerbacka","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2022.111688_bib44","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.681647","article-title":"Mouse spexin: (II) functional role as a satiety factor inhibiting food intake by regulatory actions within the hypothalamus","volume":"12","author":"Wong","year":"2021","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.mce.2022.111688_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2020.110991","article-title":"Palmitate differentially regulates Spexin, and its receptors Galr2 and Galr3, in GnRH neurons through mechanisms involving PKC, MAPKs, and TLR4","volume":"518","author":"Wang","year":"2020","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2022.111688_bib46","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s11695-009-0002-9","article-title":"Adipocyte accumulation of long-chain fatty acids in obesity is multifactorial, resulting from increased fatty acid uptake and decreased activity of genes involved in fat utilization","volume":"20","author":"Walewski","year":"2010","journal-title":"Obes. Surg."},{"key":"10.1016\/j.mce.2022.111688_bib47","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1002\/oby.20725","article-title":"Spexin is a novel human peptide that reduces adipocyte uptake of long chain fatty acids and causes weight loss in rodents with diet-induced obesity","volume":"22","author":"Walewski","year":"2014","journal-title":"Obesity"},{"key":"10.1016\/j.mce.2022.111688_bib48","first-page":"48","article-title":"Baicalin attenuates high fat diet-induced insulin resistance and ectopic fat storage in skeletal muscle, through modulating the protein kinase B\/Glycogen synthase kinase 3 beta pathway","volume":"14","author":"Xi","year":"2016","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.mce.2022.111688_bib49","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.mce.2022.111688_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174731","article-title":"Spexin ameliorates skeletal muscle insulin resistance through activation of GAL2 receptor","volume":"917","author":"Yu","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.mce.2022.111688_bib51","doi-asserted-by":"crossref","first-page":"391","DOI":"10.3389\/fnins.2019.00391","article-title":"Spexin-Based galanin receptor type 2 agonist for comorbid mood disorders and abnormal body weight","volume":"13","author":"Yun","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.mce.2022.111688_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.plabm.2021.e00207","article-title":"Low levels of spexin and adiponectin may predict insulin resistance in patients with non-alcoholic fatty liver","volume":"24","author":"Zhang","year":"2021","journal-title":"Practical Lab. Med."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720722001368?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720722001368?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T14:21:33Z","timestamp":1759587693000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720722001368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":54,"alternative-id":["S0303720722001368"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2022.111688","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Treatment with spexin mitigates diet-induced hepatic steatosis in vivo and in vitro through activation of galanin receptor 2","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2022.111688","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111688"}}