{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T02:49:40Z","timestamp":1792464580369,"version":"4.5.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.mce.2023.111990","type":"journal-article","created":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T13:35:48Z","timestamp":1686836148000},"page":"111990","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Role of omentin-1 in susceptibility to anxiety and depression like behaviors"],"prefix":"10.1016","volume":"574","author":[{"given":"Lianru","family":"Ji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sufang","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiamin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7272-6917","authenticated-orcid":false,"given":"Zhiping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wai Sang","family":"Poon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonggui","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baodong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rikang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2023.111990_bib1","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.bbi.2020.09.017","article-title":"Andrographolide suppresses NLRP3 inflammasome activation in microglia through induction of parkin-mediated mitophagy in in-vitro and in-vivo models of Parkinson disease","volume":"91","author":"Ahmed","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.mce.2023.111990_bib2","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3009759","article-title":"The gut microbiota influences blood-brain barrier permeability in mice","volume":"6","author":"Braniste","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.mce.2023.111990_bib3","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1186\/s12974-021-02349-y","article-title":"p38-TFEB pathways promote microglia activation through inhibiting CMA-mediated NLRP3 degradation in Parkinson's disease","volume":"18","author":"Chen","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.mce.2023.111990_bib4","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1080\/15548627.2020.1719723","article-title":"Microglial autophagy defect causes Parkinson disease-like symptoms by accelerating inflammasome activation in mice","volume":"16","author":"Cheng","year":"2020","journal-title":"Autophagy"},{"key":"10.1016\/j.mce.2023.111990_bib5","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1530\/EJE-11-0375","article-title":"Plasma omentin-1 levels are reduced in non-obese women with normal glucose tolerance and polycystic ovary syndrome","volume":"165","author":"Choi","year":"2011","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.mce.2023.111990_bib6","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.neuropharm.2017.09.009","article-title":"Increasing adult hippocampal neurogenesis in mice after exposure to unpredictable chronic mild stress may counteract some of the effects of stress","volume":"126","author":"Culig","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.mce.2023.111990_bib7","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.2337\/db06-1506","article-title":"Omentin plasma levels and gene expression are decreased in obesity","volume":"56","author":"de Souza Batista","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2023.111990_bib8","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1126\/science.1222941","article-title":"Depression and hippocampal neurogenesis: a road to remission?","volume":"338","author":"Eisch","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.mce.2023.111990_bib9","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.brainresbull.2022.07.009","article-title":"Neuromodulation and hippocampal neurogenesis in depression: a scoping review","volume":"188","author":"Flores","year":"2022","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.mce.2023.111990_bib10","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.brainresbull.2016.12.006","article-title":"Anti-apoptotic and angiogenic effects of intelectin-1 in rat cerebral ischemia","volume":"130","author":"Gu","year":"2017","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.mce.2023.111990_bib11","doi-asserted-by":"crossref","first-page":"383","DOI":"10.3389\/fneur.2019.00383","article-title":"The effects of intelectin-1 on antioxidant and angiogenesis in HUVECs exposed to oxygen glucose deprivation","volume":"10","author":"Gu","year":"2019","journal-title":"Front. Neurol."},{"key":"10.1016\/j.mce.2023.111990_bib12","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1038\/mp.2016.225","article-title":"Role of the adipose PPARgamma-adiponectin axis in susceptibility to stress and depression\/anxiety-related behaviors","volume":"22","author":"Guo","year":"2017","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.mce.2023.111990_bib13","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1080\/15548627.2016.1187366","article-title":"Autophagy promotes ferroptosis by degradation of ferritin","volume":"12","author":"Hou","year":"2016","journal-title":"Autophagy"},{"key":"10.1016\/j.mce.2023.111990_bib14","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.neuropharm.2019.05.013","article-title":"The protective effects of Ghrelin\/GHSR on hippocampal neurogenesis in CUMS mice","volume":"155","author":"Huang","year":"2019","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.mce.2023.111990_bib15","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s12974-019-1492-6","article-title":"Adiponectin suppresses amyloid-beta oligomer (AbetaO)-induced inflammatory response of microglia via AdipoR1-AMPK-NF-kappaB signaling pathway","volume":"16","author":"Jian","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.mce.2023.111990_bib16","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1186\/s12974-017-1013-4","article-title":"Salvianolic acid B protects against lipopolysaccharide-induced behavioral deficits and neuroinflammatory response: involvement of autophagy and NLRP3 inflammasome","volume":"14","author":"Jiang","year":"2017","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.mce.2023.111990_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2020.155083","article-title":"Circulating omentin level, obesity and cancer risk","volume":"130","author":"Kawada","year":"2020","journal-title":"Cytokine"},{"key":"10.1016\/j.mce.2023.111990_bib18","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1002\/bab.2104","article-title":"The interplay of ROS and the PI3K\/Akt pathway in autophagy regulation","volume":"69","author":"Kma","year":"2022","journal-title":"Biotechnol. Appl. Biochem."},{"key":"10.1016\/j.mce.2023.111990_bib19","article-title":"Intelectin1 ameliorates macrophage activation via inhibiting the nuclear factor kappa B pathway","volume":"69,539-546","author":"Kobayashi","year":"2021","journal-title":"Endocrine J."},{"key":"10.1016\/j.mce.2023.111990_bib20","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1080\/15548627.2018.1556946","article-title":"TLR4 (toll-like receptor 4) activation suppresses autophagy through inhibition of FOXO3 and impairs phagocytic capacity of microglia","volume":"15","author":"Lee","year":"2019","journal-title":"Autophagy"},{"key":"10.1016\/j.mce.2023.111990_bib21","doi-asserted-by":"crossref","first-page":"4141","DOI":"10.1080\/15548627.2021.1904495","article-title":"Platelet autophagic machinery involved in thrombosis through a novel linkage of AMPK-MTOR to sphingolipid metabolism","volume":"17","author":"Lee","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.mce.2023.111990_bib22","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.neuroscience.2019.10.025","article-title":"Postnatal lipopolysaccharide exposure impairs adult neurogenesis and causes depression-like behaviors through astrocytes activation triggering GABAA receptor downregulation","volume":"422","author":"Liang","year":"2019","journal-title":"Neuroscience"},{"key":"10.1016\/j.mce.2023.111990_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.757926","article-title":"Omentin-1 modulates macrophage function via integrin receptors alphavbeta3 and alphavbeta5 and reverses plaque vulnerability in animal models of atherosclerosis","volume":"8","author":"Lin","year":"2021","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.mce.2023.111990_bib24","doi-asserted-by":"crossref","first-page":"12248","DOI":"10.1073\/pnas.1202835109","article-title":"Adiponectin is critical in determining susceptibility to depressive behaviors and has antidepressant-like activity","volume":"109","author":"Liu","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mce.2023.111990_bib25","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.brainresbull.2018.09.002","article-title":"Depression and adult neurogenesis: positive effects of the antidepressant fluoxetine and of physical exercise","volume":"143","author":"Micheli","year":"2018","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.mce.2023.111990_bib26","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1038\/oby.2010.351","article-title":"Circulating omentin as a novel biomarker of endothelial dysfunction","volume":"19","author":"Moreno-Navarrete","year":"2011","journal-title":"Obesity"},{"key":"10.1016\/j.mce.2023.111990_bib27","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/1742-2094-10-142","article-title":"Neurovascular unit dysfunction with blood-brain barrier hyperpermeability contributes to major depressive disorder: a review of clinical and experimental evidence","volume":"10","author":"Najjar","year":"2013","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.mce.2023.111990_bib28","article-title":"Neuroprotective effects of omentin-1 against cerebral hypoxia\/reoxygenation injury via activating GAS6\/axl signaling pathway in neuroblastoma cells","volume":"9","author":"Niu","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.mce.2023.111990_bib29","doi-asserted-by":"crossref","first-page":"9335","DOI":"10.1038\/s41598-021-88599-5","article-title":"Diazepam causes sedative rather than anxiolytic effects in C57BL\/6J mice","volume":"11","author":"Padua-Reis","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mce.2023.111990_bib30","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1186\/s12974-022-02543-6","article-title":"Chronic stress-induced depression requires the recruitment of peripheral Th17 cells into the brain","volume":"19","author":"Peng","year":"2022","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.mce.2023.111990_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18030598","article-title":"Autophagy and microglia: novel partners in neurodegeneration and aging","volume":"18","author":"Plaza-Zabala","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mce.2023.111990_bib32","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.265","article-title":"Omentin protects against LPS-induced ARDS through suppressing pulmonary inflammation and promoting endothelial barrier via an Akt\/eNOS-dependent mechanism","volume":"7","author":"Qi","year":"2016","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.mce.2023.111990_bib33","doi-asserted-by":"crossref","first-page":"5434","DOI":"10.7150\/thno.27882","article-title":"Microglial TLR4-dependent autophagy induces ischemic white matter damage via STAT1\/6 pathway","volume":"8","author":"Qin","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.mce.2023.111990_bib34","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.bbi.2020.10.010","article-title":"Impaired autophagy in microglia aggravates dopaminergic neurodegeneration by regulating NLRP3 inflammasome activation in experimental models of Parkinson's disease","volume":"91","author":"Qin","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.mce.2023.111990_bib35","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41413-018-0012-0","article-title":"Omentin-1 prevents inflammation-induced osteoporosis by downregulating the pro-inflammatory cytokines","volume":"6","author":"Rao","year":"2018","journal-title":"Bone Res"},{"key":"10.1016\/j.mce.2023.111990_bib36","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s12943-017-0661-4","article-title":"C10ORF10\/DEPP-mediated ROS accumulation is a critical modulator of FOXO3-induced autophagy","volume":"16","author":"Salcher","year":"2017","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.mce.2023.111990_bib37","article-title":"Increased human intestinal barrier permeability plasma biomarkers zonulin and FABP2 correlated with plasma LPS and altered gut microbiome in anxiety or depression","author":"Stevens","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.mce.2023.111990_bib38","article-title":"Protective effects of melatonin against obesity-induced by leptin resistance","volume":"417","author":"Suriagandhi","year":"2022","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.mce.2023.111990_bib39","doi-asserted-by":"crossref","first-page":"434","DOI":"10.3389\/fpsyt.2018.00434","article-title":"Inhibition of autophagy in microglia alters depressive-like behavior via BDNF pathway in postpartum depression","volume":"9","author":"Tan","year":"2018","journal-title":"Front. Psychiatr."},{"key":"10.1016\/j.mce.2023.111990_bib40","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1186\/s12974-018-1261-y","article-title":"The plasticity of primary microglia and their multifaceted effects on endogenous neural stem cells in vitro and in vivo","volume":"15","author":"Vay","year":"2018","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.mce.2023.111990_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2019.108187","article-title":"Omentin-1 attenuates lipopolysaccharide (LPS)-induced U937 macrophages activation by inhibiting the TLR4\/MyD88\/NF-kappaB signaling","volume":"679","author":"Wang","year":"2020","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.mce.2023.111990_bib42","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.bbrc.2020.01.168","article-title":"FOXO3 protects nucleus pulposus cells against apoptosis under nutrient deficiency via autophagy","volume":"524","author":"Wang","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mce.2023.111990_bib43","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.cell.2020.02.013","article-title":"Repopulating microglia promote brain repair in an IL-6-dependent manner","volume":"180","author":"Willis","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.mce.2023.111990_bib44","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1186\/s12974-019-1591-4","article-title":"NDP-MSH binding melanocortin-1 receptor ameliorates neuroinflammation and BBB disruption through CREB\/Nr4a1\/NF-kappaB pathway after intracerebral hemorrhage in mice","volume":"16","author":"Wu","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.mce.2023.111990_bib45","article-title":"Adiponectin ameliorates GMH-induced brain injury by regulating microglia M1\/M2 polarization via AdipoR1\/APPL1\/AMPK\/PPARgamma signaling pathway in neonatal rats","volume":"13","author":"Xu","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.mce.2023.111990_bib46","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1515\/jpem-2018-0231","article-title":"Serum omentin-1 levels in obese children","volume":"32","author":"Zengi","year":"2019","journal-title":"J. Pediatr. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2023.111990_bib47","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1038\/mp.2016.58","article-title":"Adiponectin regulates contextual fear extinction and intrinsic excitability of dentate gyrus granule neurons through AdipoR2 receptors","volume":"22","author":"Zhang","year":"2017","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.mce.2023.111990_bib48","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.bbi.2017.07.012","article-title":"Salvianolic acid B promotes microglial M2-polarization and rescues neurogenesis in stress-exposed mice","volume":"66","author":"Zhang","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.mce.2023.111990_bib49","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.neuroscience.2019.05.060","article-title":"AdipoRon attenuates neuroinflammation after intracerebral hemorrhage through AdipoR1-AMPK pathway","volume":"412","author":"Zheng","year":"2019","journal-title":"Neuroscience"},{"key":"10.1016\/j.mce.2023.111990_bib50","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.bbrc.2012.07.110","article-title":"Omentin inhibits TNF-alpha-induced expression of adhesion molecules in endothelial cells via ERK\/NF-kappaB pathway","volume":"425","author":"Zhong","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720723001417?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720723001417?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T14:24:05Z","timestamp":1759587845000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720723001417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":50,"alternative-id":["S0303720723001417"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2023.111990","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of omentin-1 in susceptibility to anxiety and depression like behaviors","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2023.111990","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"111990"}}