{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:42:09Z","timestamp":1792226529820,"version":"4.4.0"},"reference-count":137,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.mce.2024.112270","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T01:42:25Z","timestamp":1715650945000},"page":"112270","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["The role of nitric oxide and neuroendocrine system in pain generation"],"prefix":"10.1016","volume":"591","author":[{"given":"Aayush","family":"Gupta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja","family":"Vejapi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8028-1495","authenticated-orcid":false,"given":"Nebojsa Nick","family":"Knezevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2024.112270_bib1","doi-asserted-by":"crossref","first-page":"S60","DOI":"10.1016\/j.pain.2007.02.006","article-title":"Cross-sex hormone administration changes pain in transsexual women and men","volume":"132","author":"Aloisi","year":"2007","journal-title":"Pain"},{"key":"10.1016\/j.mce.2024.112270_bib3","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jsbmb.2017.05.010","article-title":"Effects of sex steroids on the pattern of methylation and expression of the promoter region of estrogen and androgen receptors in people with gender dysphoria under cross-sex hormone treatment","volume":"172","author":"Aranda","year":"2017","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.mce.2024.112270_bib5","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.3390\/ijms24031866","article-title":"The role of sex hormones in pain-related conditions","volume":"24","author":"Athnaiel","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mce.2024.112270_bib6","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1016\/j.mayocp.2022.06.036","article-title":"Effect of the renin-angiotensin system inhibitors on inflammatory markers: a systematic review and meta-analysis of randomized controlled trials","volume":"97","author":"Awad","year":"2022","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.mce.2024.112270_bib7","doi-asserted-by":"crossref","first-page":"165","DOI":"10.4155\/tde.14.95","article-title":"Pain management via local anesthetics and responsive hydrogels","volume":"6","author":"Bagshaw","year":"2015","journal-title":"Ther. Deliv."},{"key":"10.1016\/j.mce.2024.112270_bib8","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1053\/eujp.2001.0236","article-title":"Sensory changes during the ovulatory phase of the menstrual cycle in healthy women","volume":"5","author":"Bajaj","year":"2001","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.mce.2024.112270_bib9","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1177\/1470320313503694","article-title":"Renin\u2013angiotensin system in pain: existing in a double life?","volume":"15","author":"Bali","year":"2014","journal-title":"J. Renin-Angiotensin-Aldosterone Syst. JRAAS"},{"key":"10.1016\/j.mce.2024.112270_bib10","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1097\/AJP.0000000000000153","article-title":"Natural variation in testosterone is associated with hypoalgesia in healthy women","volume":"31","author":"Bartley","year":"2015","journal-title":"Clin. J. Pain"},{"key":"10.1016\/j.mce.2024.112270_bib11","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.yfrne.2017.05.001","article-title":"Checks and balances: the glucocorticoid receptor and NF\u0138B in good times and bad","volume":"46","author":"Bekhbat","year":"2017","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.mce.2024.112270_bib12","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1111\/j.1460-9568.2006.04742.x","article-title":"Nitric oxide regulation of calcitonin gene\u2010related peptide gene expression in rat trigeminal ganglia neurons","volume":"23","author":"Bellamy","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.mce.2024.112270_bib13","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S0885-3924(99)00120-7","article-title":"Update on the neurophysiology of pain transmission and modulation","volume":"19","author":"Bennett","year":"2000","journal-title":"J. Pain Symptom Manag."},{"key":"10.1016\/j.mce.2024.112270_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.114147","article-title":"Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: a current perspective","volume":"180","author":"Bindu","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.mce.2024.112270_bib15","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S1043-2760(02)00004-8","article-title":"Pain in the brain: are hormones to blame?","volume":"14","author":"Blackburn-Munro","year":"2003","journal-title":"Trends Endocrinol. Metabol."},{"key":"10.1016\/j.mce.2024.112270_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s40122-020-00217-w","article-title":"Not all pain is created equal: basic definitions and diagnostic work-up","volume":"9","author":"Bonezzi","year":"2020","journal-title":"Pain Ther"},{"key":"10.1016\/j.mce.2024.112270_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.721813","article-title":"Expression of sex hormone receptor and immune response genes in peripheral blood mononuclear cells during the menstrual cycle","volume":"12","author":"Brundin","year":"2021","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.mce.2024.112270_bib18","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1152\/jn.1995.74.5.1870","article-title":"Variation in serotonergic inhibition of calcium channel currents in four types of rat sensory neurons differentiated by membrane properties","volume":"74","author":"Cardenas","year":"1995","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.mce.2024.112270_bib19","first-page":"1596","article-title":"Ion channels involved in substance P-mediated nociception and antinociception","volume":"20","author":"Chang","year":"2019","journal-title":"Indian J. Manag. Sci."},{"key":"10.1016\/j.mce.2024.112270_bib20","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.arcmed.2019.01.004","article-title":"Valproic acid induced neurotoxicological manifestations and its mitigation by melatonin in rat brain synaptosomes","volume":"49","author":"Chaudhary","year":"2018","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.mce.2024.112270_bib21","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1074\/jbc.273.2.749","article-title":"Involvement of p38 mitogen-activated protein kinase signaling pathway in the rapid induction of the 78-kDa glucose-regulated protein in 9L rat brain tumor cells","volume":"273","author":"Chen","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2024.112270_bib22","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1152\/jn.2002.87.6.2851","article-title":"Cyclooxygenase-2 regulates prostaglandin E 2 signaling in hippocampal long-term synaptic plasticity","volume":"87","author":"Chen","year":"2002","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.mce.2024.112270_bib23","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1089\/ars.2007.1959","article-title":"Nitric oxide in the vasculature: where does it come from and where does it go? A quantitative perspective","volume":"10","author":"Chen","year":"2008","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.mce.2024.112270_bib24","first-page":"1963","volume":"vol. 12","author":"Chen","year":"2016"},{"key":"10.1016\/j.mce.2024.112270_bib25","first-page":"313","volume":"vol. 15","author":"Chen","year":"2016"},{"key":"10.1016\/j.mce.2024.112270_bib26","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s13293-021-00364-5","article-title":"Estrogen receptors in pain modulation: cellular signaling","volume":"12","author":"Chen","year":"2021","journal-title":"Biol. Sex Differ."},{"key":"10.1016\/j.mce.2024.112270_bib27","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.neuchi.2015.03.002","article-title":"Melatonin: physiological effects in humans","volume":"61","author":"Claustrat","year":"2015","journal-title":"Neurochirurgie"},{"key":"10.1016\/j.mce.2024.112270_bib28","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/j.1532-2149.2013.00376.x","article-title":"Progesterone reduces the expression of spinal cyclooxygenase-2 and inducible nitric oxide synthase and prevents allodynia in a rat model of central neuropathic pain","volume":"18","author":"Coronel","year":"2014","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.mce.2024.112270_bib29","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.niox.2011.06.004","article-title":"Pain and analgesia: the dual effect of nitric oxide in the nociceptive system","volume":"25","author":"Cury","year":"2011","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.mce.2024.112270_bib30","first-page":"3","article-title":"Androgen receptor structure, function and biology: from bench to bedside","volume":"37","author":"Davey","year":"2016","journal-title":"Clin. Biochem. Rev."},{"key":"10.1016\/j.mce.2024.112270_bib31","series-title":"The Pituitary and Testis: Clinical and Experimental Studies","first-page":"12","article-title":"Control of FSH and LH secretion","author":"de Kretser","year":"1983"},{"key":"10.1016\/j.mce.2024.112270_bib32","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s10194-018-0922-7","article-title":"Male and female sex hormones in primary headaches","volume":"19","author":"Delaruelle","year":"2018","journal-title":"J. Headache Pain"},{"key":"10.1016\/j.mce.2024.112270_bib33","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0014-2999(90)90446-D","article-title":"Peripheral analgesia and activation of the nitric oxide-cyclic GMP pathway","volume":"186","author":"Duarte","year":"1990","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.mce.2024.112270_bib34","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/j.1600-079X.2010.00796.x","article-title":"Melatonin reduces hyperalgesia associated with inflammation","volume":"49","author":"Esposito","year":"2010","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.mce.2024.112270_bib35","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1097\/FBP.0000000000000579","article-title":"The antinociceptive mechanisms of melatonin: role of l-arginine\/nitric oxide\/cyclic GMP\/KATP channel signaling pathway","volume":"31","author":"Fakhri","year":"2020","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.mce.2024.112270_bib36","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1093\/ckj\/sfv011","article-title":"Calcitonin, the forgotten hormone: does it deserve to be forgotten?","volume":"8","author":"Felsenfeld","year":"2015","journal-title":"Clinical Kidney Journal"},{"key":"10.1016\/j.mce.2024.112270_bib38","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1152\/physrev.00045.2019","article-title":"Neuropathic pain: from mechanisms to treatment","volume":"101","author":"Finnerup","year":"2021","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.mce.2024.112270_bib39","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3389\/neuro.01.024.2009","article-title":"Pain modulation by nitric oxide in the spinal cord","volume":"3","author":"Freire","year":"2009","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.mce.2024.112270_bib40","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0024-3205(00)00953-X","article-title":"Testosterone inhibits expression of inducible nitric oxide synthase in murine macrophages","volume":"68","author":"Friedl","year":"2000","journal-title":"Life Sci."},{"key":"10.1016\/j.mce.2024.112270_bib41","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0006-8993(99)02448-8","article-title":"Capsaicin-evoked release of immunoreactive calcitonin gene-related peptide from the spinal cord is mediated by nitric oxide but not by cyclic GMP","volume":"861","author":"Garry","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.mce.2024.112270_bib42","series-title":"Nonsteroidal Anti-inflammatory Drugs (NSAIDs)","author":"Ghlichloo","year":"2024"},{"key":"10.1016\/j.mce.2024.112270_bib43","series-title":"Encyclopedia of Biological Chemistry","first-page":"270","article-title":"Calcitonin receptor","author":"Girgis","year":"2013"},{"key":"10.1016\/j.mce.2024.112270_bib45","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1210\/er.2017-00025","article-title":"A reappraisal of testosterone's binding in circulation: physiological and clinical implications","volume":"38","author":"Goldman","year":"2017","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.mce.2024.112270_bib46","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1111\/j.1526-4610.2011.01908.x","article-title":"Mechanisms of pain modulation by sex hormones in migraine","volume":"51","author":"Gupta","year":"2011","journal-title":"Headache J. Head Face Pain"},{"key":"10.1016\/j.mce.2024.112270_bib47","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.2522\/ptj.20130597","article-title":"Chronic stress, cortisol dysfunction, and pain: a psychoneuroendocrine rationale for stress management in pain rehabilitation","volume":"94","author":"Hannibal","year":"2014","journal-title":"Phys. Ther."},{"key":"10.1016\/j.mce.2024.112270_bib48","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/bcpt.13453","article-title":"Renin\u2010angiotensin system blockade modulates both the peripheral and central components of neuropathic pain in rats: role of calcitonin gene\u2013related peptide, substance P and nitric oxide","volume":"127","author":"Hegazy","year":"2020","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.mce.2024.112270_bib49","doi-asserted-by":"crossref","first-page":"11184","DOI":"10.1523\/JNEUROSCI.6159-10.2011","article-title":"CNGA3: a target of spinal nitric oxide\/cGMP signaling and modulator of inflammatory pain hypersensitivity","volume":"31","author":"Heine","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mce.2024.112270_bib50","doi-asserted-by":"crossref","DOI":"10.1177\/17448069211035217","article-title":"Circulating sex steroids and bladder pain sensitivity in dysmenorrhea","volume":"17","author":"Hellman","year":"2021","journal-title":"Mol. Pain"},{"key":"10.1016\/j.mce.2024.112270_bib51","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.yhbeh.2017.10.011","article-title":"Sex differences and estradiol involvement in hyperalgesia and allodynia in an experimental model of fibromyalgia","volume":"97","author":"Hernandez-Leon","year":"2018","journal-title":"Horm. Behav."},{"key":"10.1016\/j.mce.2024.112270_bib52","doi-asserted-by":"crossref","DOI":"10.1186\/1744-8069-7-25","article-title":"Peripheral effects of morphine and expression of \u03bc-opioid receptors in the dorsal root ganglia during neuropathic pain: nitric oxide signaling","volume":"7","author":"Hervera","year":"2011","journal-title":"Mol. Pain"},{"key":"10.1016\/j.mce.2024.112270_bib53","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.euroneuro.2012.04.013","article-title":"Testosterone in the brain: neuroimaging findings and the potential role for neuropsychopharmacology","volume":"23","author":"H\u00f6fer","year":"2013","journal-title":"Eur. Neuropsychopharmacol"},{"key":"10.1016\/j.mce.2024.112270_bib54","doi-asserted-by":"crossref","DOI":"10.1177\/17448069211069255","article-title":"Sigma-1 receptors and progesterone metabolizing enzymes in nociceptive sensory neurons of the female rat trigeminal ganglia: a neural substrate for the antinociceptive actions of progesterone","volume":"18","author":"Hornung","year":"2022","journal-title":"Mol. Pain"},{"key":"10.1016\/j.mce.2024.112270_bib55","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.sxmr.2019.02.005","article-title":"Testosterone deficiency and endothelial dysfunction: nitric oxide, asymmetric dimethylarginine, and endothelial progenitor cells","volume":"7","author":"Hotta","year":"2019","journal-title":"Sexual Med. Rev."},{"key":"10.1016\/j.mce.2024.112270_bib56","first-page":"563","article-title":"Activation of cGMP-PKG signaling pathway contributes to neuronal hyperexcitability and hyperalgesia after in vivo prolonged compression or in vitro acute dissociation of dorsal root ganglion in rats","volume":"64","author":"Huang","year":"2012","journal-title":"Sheng Li Xue Bao"},{"key":"10.1016\/j.mce.2024.112270_bib57","doi-asserted-by":"crossref","DOI":"10.1177\/1744806917720316","article-title":"Mechanisms of the analgesic effect of calcitonin on chronic pain by alteration of receptor or channel expression","volume":"13","author":"Ito","year":"2017","journal-title":"Mol. Pain"},{"key":"10.1016\/j.mce.2024.112270_bib58","doi-asserted-by":"crossref","DOI":"10.1186\/1744-8069-9-2","article-title":"Non-pain-related CRF1 activation in the amygdala facilitates synaptic transmission and pain responses","volume":"9","author":"Ji","year":"2013","journal-title":"Mol. Pain"},{"key":"10.1016\/j.mce.2024.112270_bib59","doi-asserted-by":"crossref","DOI":"10.1111\/apha.13066","article-title":"The stressed brain of humans and rodents","volume":"223","author":"Jo\u00ebls","year":"2018","journal-title":"Acta Physiol."},{"key":"10.1016\/j.mce.2024.112270_bib60","doi-asserted-by":"crossref","first-page":"C328","DOI":"10.1152\/ajpcell.00383.2010","article-title":"Antagonist action of progesterone at \u03c3-receptors in the modulation of voltage-gated sodium channels","volume":"300","author":"Johannessen","year":"2011","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.mce.2024.112270_bib61","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.3390\/cells12081178","article-title":"Glucocorticoid hormones as modulators of the kynurenine pathway in chronic pain conditions","volume":"12","author":"Jovanovic","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.mce.2024.112270_bib62","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1111\/j.1476-5381.1994.tb13108.x","article-title":"Effect of topical administration of l \u2010arginine on formalin\u2010induced nociception in the mouse: a dual role of peripherally formed NO in pain modulation","volume":"112","author":"Kawabata","year":"1994","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.mce.2024.112270_bib63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0168-0102(96)81278-8","article-title":"Roles of steroid hormones and their receptors in structural organization in the nervous system","volume":"24","author":"Kawata","year":"1995","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.mce.2024.112270_bib64","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1111\/1440-1681.12915","article-title":"Salmon calcitonin ameliorates migraine pain through modulation of CGRP release and dural mast cell degranulation in rats","volume":"45","author":"Kilinc","year":"2018","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.mce.2024.112270_bib65","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.niox.2011.07.002","article-title":"The role of nitric oxide in prostaglandin biology; update","volume":"25","author":"Kim","year":"2011","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.mce.2024.112270_bib66","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s00011-007-6088-4","article-title":"Nitric oxide and pro-inflammatory cytokines correlate with pain intensity in chronic pain patients","volume":"56","author":"Koch","year":"2007","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.mce.2024.112270_bib67","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s10194-023-01569-2","article-title":"Shared and independent roles of CGRP and PACAP in migraine pathophysiology","volume":"24","author":"Kuburas","year":"2023","journal-title":"J. Headache Pain"},{"key":"10.1016\/j.mce.2024.112270_bib68","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s10194-023-01644-8","article-title":"Mode and site of action of therapies targeting CGRP signaling","volume":"24","author":"Labastida-Ram\u00edrez","year":"2023","journal-title":"J. Headache Pain"},{"key":"10.1016\/j.mce.2024.112270_bib69","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0304-3940(96)12702-6","article-title":"Induction of spinal cord neuronal nitric oxide synthase (NOS) after formalin injection in the rat hind paw","volume":"210","author":"Lam","year":"1996","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.mce.2024.112270_bib70","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/0306-4522(85)90265-9","article-title":"Distribution of calcitonin gene-related peptide in the rat peripheral nervous system with reference to its coexistence with substance P","volume":"15","author":"Lee","year":"1985","journal-title":"Neuroscience"},{"key":"10.1016\/j.mce.2024.112270_bib71","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1533-2500.2004.04002.x","article-title":"NO pain: potential roles of nitric oxide in neuropathic pain","volume":"4","author":"Levy","year":"2004","journal-title":"Pain Pract."},{"key":"10.1016\/j.mce.2024.112270_bib72","doi-asserted-by":"crossref","first-page":"996","DOI":"10.4103\/1673-5374.355748","article-title":"Targeting the nitric oxide\/cGMP signaling pathway to treat chronic pain","volume":"18","author":"Li","year":"2023","journal-title":"Neural Regen Res."},{"key":"10.1016\/j.mce.2024.112270_bib73","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1146\/annurev-pharmtox-010814-124742","article-title":"MT 1 and MT 2 melatonin receptors: a therapeutic perspective","volume":"56","author":"Liu","year":"2016","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.mce.2024.112270_bib74","doi-asserted-by":"crossref","DOI":"10.1186\/1744-8069-7-101","article-title":"Rapid S-nitrosylation of actin by NO-generating donors and in inflammatory pain model mice","volume":"7","author":"Lu","year":"2011","journal-title":"Mol. Pain"},{"key":"10.1016\/j.mce.2024.112270_bib75","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1001283","article-title":"Presynaptically localized cyclic GMP-dependent protein kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity","volume":"10","author":"Luo","year":"2012","journal-title":"PLoS Biol."},{"key":"10.1016\/j.mce.2024.112270_bib76","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1007\/s10753-021-01615-8","article-title":"Regulatory role of nitric oxide in cutaneous inflammation","volume":"45","author":"Man","year":"2022","journal-title":"Inflammation"},{"key":"10.1016\/j.mce.2024.112270_bib77","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s00540-018-2579-4","article-title":"Roles of inflammation, neurogenic inflammation, and neuroinflammation in pain","volume":"33","author":"Matsuda","year":"2019","journal-title":"J. Anesth."},{"key":"10.1016\/j.mce.2024.112270_bib78","doi-asserted-by":"crossref","first-page":"285","DOI":"10.2217\/pmt-2015-0002","article-title":"Pain and sex hormones: a review of current understanding","volume":"6","author":"Maurer","year":"2016","journal-title":"Pain Manag."},{"key":"10.1016\/j.mce.2024.112270_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2021.111320","article-title":"Role of sex hormones in modulating breast and ovarian cancer associated pain","volume":"533","author":"McHann","year":"2021","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.mce.2024.112270_bib80","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1016\/0028-3908(94)90051-5","article-title":"The possible role of glia in nociceptive processing and hyperalgesia in the spinal cord of the rat","volume":"33","author":"Meller","year":"1994","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.mce.2024.112270_bib81","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1159\/000338400","article-title":"Membrane estrogen receptor regulation of hypothalamic function","volume":"96","author":"Micevych","year":"2012","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.mce.2024.112270_bib82","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/j.1526-4610.1988.hed2803196.x","article-title":"Effectiveness of salmon calcitonin nasal spray preparation in migraine treatment","volume":"28","author":"Micieli","year":"1988","journal-title":"Headache"},{"key":"10.1016\/j.mce.2024.112270_bib83","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1007\/BF02280990","article-title":"Failure of L-NAME to cause inhibition of nitric oxide synthesis: role of inducible nitric oxide synthase","volume":"45","author":"Miller","year":"1996","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.mce.2024.112270_bib84","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/1440-1681.12862","article-title":"Synergistic effect of spexin and progesterone on pain sensitivity attenuation in ovariectomized rats","volume":"45","author":"Moazen","year":"2018","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.mce.2024.112270_bib85","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1038\/nrn3360","article-title":"Sex differences in pain and pain inhibition: multiple explanations of a controversial phenomenon","volume":"13","author":"Mogil","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.mce.2024.112270_bib86","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1111\/acem.12529","article-title":"Gender differences in acute and chronic pain in the emergency department: results of the 2014 academic emergency medicine consensus conference pain section","volume":"21","author":"Musey","year":"2014","journal-title":"Acad. Emerg. Med."},{"key":"10.1016\/j.mce.2024.112270_bib87","doi-asserted-by":"crossref","first-page":"755","DOI":"10.3390\/biology12050755","article-title":"Angiotensin-related peptides and their role in pain regulation","volume":"12","author":"Nemoto","year":"2023","journal-title":"Biology"},{"key":"10.1016\/j.mce.2024.112270_bib88","first-page":"141","article-title":"Estrogen induces nitric oxide production via nitric oxide synthase activation in endothelial cells","volume":"vol. 120","author":"Nevzati","year":"2015"},{"key":"10.1016\/j.mce.2024.112270_bib89","doi-asserted-by":"crossref","first-page":"17","DOI":"10.2165\/00003495-200363010-00002","article-title":"Responsible prescribing of opioids for the management of chronic pain","volume":"63","author":"Nicholson","year":"2003","journal-title":"Drugs"},{"key":"10.1016\/j.mce.2024.112270_bib90","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1186\/s13075-015-0875-z","article-title":"A low cortisol response to stress is associated with musculoskeletal pain combined with increased pain sensitivity in young adults: a longitudinal cohort study","volume":"17","author":"Paananen","year":"2015","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.mce.2024.112270_bib91","doi-asserted-by":"crossref","first-page":"E899","DOI":"10.1152\/ajpendo.00527.2014","article-title":"Progesterone increases nitric oxide synthesis in human vascular endothelial cells through activation of membrane progesterone receptor-\u03b1","volume":"308","author":"Pang","year":"2015","journal-title":"Am. J. Physiol. Endocrinol. Metabol."},{"key":"10.1016\/j.mce.2024.112270_bib92","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1046\/j.1464-410x.1999.00913.x","article-title":"Effects of androgens on the expression of nitric oxide synthase mRNAs in rat corpus cavernosum","volume":"83","author":"Park","year":"1999","journal-title":"BJU Int."},{"key":"10.1016\/j.mce.2024.112270_bib93","doi-asserted-by":"crossref","first-page":"9044","DOI":"10.1073\/pnas.0502968102","article-title":"Substance P inhibits progesterone conversion to neuroactive metabolites in spinal sensory circuit: a potential component of nociception","volume":"102","author":"Patte-Mensah","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mce.2024.112270_bib94","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1097\/j.pain.0000000000001440","article-title":"Distinct functions of soluble guanylyl cyclase isoforms NO-GC1 and NO-GC2 in inflammatory and neuropathic pain processing","volume":"160","author":"Petersen","year":"2019","journal-title":"Pain"},{"key":"10.1016\/j.mce.2024.112270_bib95","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/ddr.21177","article-title":"Anti-inflammatory activities of melatonin derivatives in lipopolysaccharide-stimulated RAW 264.7 cells and antinociceptive effects in mice","volume":"75","author":"Phiphatwatcharaded","year":"2014","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.mce.2024.112270_bib96","doi-asserted-by":"crossref","DOI":"10.1016\/j.yfrne.2021.100926","article-title":"On the role of sex steroids in biological functions by classical and non-classical pathways. An update","volume":"62","author":"Pillerov\u00e1","year":"2021","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.mce.2024.112270_bib97","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1530\/JME-15-0184","article-title":"Estrogen-dependent up-regulation of TRPA1 and TRPV1 receptor proteins in the rat endometrium","volume":"56","author":"Poh\u00f3czky","year":"2016","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.mce.2024.112270_bib98","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1161\/01.CIR.98.8.800","article-title":"Evidence that macrophages in atherosclerotic lesions contain angiotensin II","volume":"98","author":"Potter","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.mce.2024.112270_bib99","first-page":"575","volume":"vol. 37","author":"Poza","year":"2022"},{"key":"10.1016\/j.mce.2024.112270_bib100","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0014-2999(02)01413-9","article-title":"Dual effect of local application of nitric oxide donors in a model of incision pain in rats","volume":"441","author":"Prado","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.mce.2024.112270_bib101","series-title":"Conn's Translational Neuroscience","first-page":"517","article-title":"Somatosensation and pain","author":"Prescott","year":"2017"},{"key":"10.1016\/j.mce.2024.112270_bib102","doi-asserted-by":"crossref","first-page":"925","DOI":"10.4103\/1673-5374.250567","article-title":"The hypothalamic-spinal dopaminergic system: a target for pain modulation","volume":"14","author":"Puopolo","year":"2019","journal-title":"Neural Regen Res."},{"key":"10.1016\/j.mce.2024.112270_bib104","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1097\/j.pain.0000000000001939","article-title":"The revised International Association for the Study of Pain definition of pain: concepts, challenges, and compromises","volume":"161","author":"Raja","year":"2020","journal-title":"Pain"},{"key":"10.1016\/j.mce.2024.112270_bib105","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/sj.bjp.0704755","article-title":"Dual effect of nitric oxide in articular inflammatory pain in zymosan\u2010induced arthritis in rats","volume":"136","author":"Rocha","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.mce.2024.112270_bib106","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcn.2020.103497","article-title":"Effects of selective inhibition of nNOS and iNOS on neuropathic pain in rats","volume":"105","author":"Rocha","year":"2020","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.mce.2024.112270_bib107","series-title":"Androgen Action. CRE 5","author":"Roy","year":"1995"},{"key":"10.1016\/j.mce.2024.112270_bib108","doi-asserted-by":"crossref","first-page":"R473","DOI":"10.1152\/ajpregu.00355.2012","article-title":"Reciprocal regulation of the nitric oxide and cyclooxygenase pathway in pathophysiology: relevance and clinical implications","volume":"304","author":"Salvemini","year":"2013","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.mce.2024.112270_bib109","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.expneurol.2010.03.006","article-title":"Estrogen effects on pain sensitivity and neuropeptide expression in rat sensory neurons","volume":"224","author":"Sarajari","year":"2010","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.mce.2024.112270_bib111","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1523\/JNEUROSCI.5037-07.2008","article-title":"Cysteine-rich protein 2, a novel downstream effector of cGMP\/cGMP-Dependent protein kinase I-mediated persistent inflammatory pain","volume":"28","author":"Schmidtko","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mce.2024.112270_bib112","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s10194-017-0741-2","article-title":"Calcitonin gene-related peptide and pain: a systematic review","volume":"18","author":"Schou","year":"2017","journal-title":"J. Headache Pain"},{"key":"10.1016\/j.mce.2024.112270_bib113","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1186\/s12974-020-01864-8","article-title":"Neuronal aldosterone elicits a distinct genomic response in pain signaling molecules contributing to inflammatory pain","volume":"17","author":"Shaqura","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.mce.2024.112270_bib114","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.3390\/molecules26092431","article-title":"Prospects for the personalized multimodal therapy approach to pain management via action on NO and NOS","volume":"26","author":"Shnayder","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.mce.2024.112270_bib115","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1177\/2047487313481755","article-title":"A supraphysiological dose of testosterone induces nitric oxide production and oxidative stress","volume":"21","author":"Skogastierna","year":"2014","journal-title":"Eur. J. Prev. Cardiol."},{"key":"10.1016\/j.mce.2024.112270_bib116","first-page":"129","article-title":"Membrane estrogen receptors - is it an alternative way of estrogen action?","volume":"64","author":"Soltysik","year":"2013","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.mce.2024.112270_bib117","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0006-8993(01)01995-3","article-title":"The dual effect of a nitric oxide donor in nociception","volume":"897","author":"Sousa","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.mce.2024.112270_bib118","doi-asserted-by":"crossref","first-page":"3758","DOI":"10.4049\/jimmunol.163.7.3758","article-title":"Estradiol coupling to human monocyte nitric oxide release is dependent on intracellular calcium transients: evidence for an estrogen surface receptor","volume":"163","author":"Stefano","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.mce.2024.112270_bib119","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1186\/s12967-019-2030-0","article-title":"Transitioning from acute to chronic pain: a simulation study of trajectories of low back pain","volume":"17","author":"Su","year":"2019","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.mce.2024.112270_bib120","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1038\/sj.bjp.0705107","article-title":"Local anaesthetics have different mechanisms and sites of action at the recombinant N\u2010methyl\u2010D\u2010aspartate (NMDA) receptors","volume":"138","author":"Sugimoto","year":"2003","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.mce.2024.112270_bib121","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.ejphar.2013.02.014","article-title":"Local anesthetics inhibit nitric oxide production and l-arginine uptake in cultured bovine aortic endothelial cells","volume":"704","author":"Takaishi","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.mce.2024.112270_bib122","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.neuropharm.2008.12.003","article-title":"Pharmacological assessments of nitric oxide synthase isoforms and downstream diversity of NO signaling in the maintenance of thermal and mechanical hypersensitivity after peripheral nerve injury in mice","volume":"56","author":"Tanabe","year":"2009","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.mce.2024.112270_bib124","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S0304-3940(02)00938-2","article-title":"Dual effects of spinally delivered 8-bromo-cyclic guanosine monophosphate (8-bromo-cGMP) in formalin-induced nociception in rats","volume":"332","author":"Tegeder","year":"2002","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.mce.2024.112270_bib125","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s40122-013-0015-x","article-title":"The physiologic effects of pain on the endocrine system","volume":"2","author":"Tennant","year":"2013","journal-title":"Pain Ther"},{"key":"10.1016\/j.mce.2024.112270_bib126","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1097\/00000542-200410000-00025","article-title":"Contribution of interaction between nitric oxide and cyclooxygenases to the production of prostaglandins in carrageenan-induced inflammation","volume":"101","author":"Toriyabe","year":"2004","journal-title":"Anesthesiology"},{"key":"10.1016\/j.mce.2024.112270_bib127","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.jss.2021.08.040","article-title":"Relationship between decreased cortisol and development of chronic pain in traumatically injured","volume":"270","author":"Trevino","year":"2022","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.mce.2024.112270_bib128","article-title":"Ovarian steroids regulate neuropeptides in the trigeminal ganglion","volume":"39","author":"V","year":"2005","journal-title":"Neuropeptides"},{"key":"10.1016\/j.mce.2024.112270_bib129","doi-asserted-by":"crossref","DOI":"10.3389\/fnhum.2013.00313","article-title":"Neural traces of stress: cortisol related sustained enhancement of amygdala-hippocampal functional connectivity","volume":"7","author":"Vaisvaser","year":"2013","journal-title":"Front. Hum. Neurosci."},{"key":"10.1016\/j.mce.2024.112270_bib130","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0304-3959(98)00117-1","article-title":"Prevalence of chronic benign pain disorder among adults: a review of the literature","volume":"77","author":"Verhaak","year":"1998","journal-title":"Pain"},{"key":"10.1016\/j.mce.2024.112270_bib131","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1177\/204946370800200206","article-title":"Hormones and their interaction with the pain experience","volume":"2","author":"Vincent","year":"2008","journal-title":"Reviews in Pain"},{"key":"10.1016\/j.mce.2024.112270_bib132","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1038\/sj.bjp.0705181","article-title":"Opposite nociceptive effects of the arginine\/NO\/cGMP pathway stimulation in dermal and subcutaneous tissues","volume":"138","author":"Vivancos","year":"2003","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.mce.2024.112270_bib133","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1096\/fasebj.11.11.9285487","article-title":"Cyclooxygenase-2: an essential regulator of NO-mediated apoptosis","volume":"11","author":"Von Knethen","year":"1997","journal-title":"Faseb. J."},{"key":"10.1016\/j.mce.2024.112270_bib134","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1080\/14728222.2020.1724285","article-title":"Calcitonin gene-related peptide (CGRP): role in migraine pathophysiology and therapeutic targeting","volume":"24","author":"Wattiez","year":"2020","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.mce.2024.112270_bib135","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.intimp.2015.05.016","article-title":"Treatment of pain in fibromyalgia patients with testosterone gel: pharmacokinetics and clinical response","volume":"27","author":"White","year":"2015","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.mce.2024.112270_bib136","doi-asserted-by":"crossref","first-page":"655","DOI":"10.4187\/respcare.06314","article-title":"Clinical pharmacology of corticosteroids","volume":"63","author":"Williams","year":"2018","journal-title":"Respir. Care"},{"key":"10.1016\/j.mce.2024.112270_bib137","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ejphar.2015.11.005","article-title":"Progesterone modulates the LPS-induced nitric oxide production by a progesterone-receptor independent mechanism","volume":"769","author":"Wolfson","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.mce.2024.112270_bib138","doi-asserted-by":"crossref","first-page":"4550","DOI":"10.1210\/en.2004-0327","article-title":"Estrogen induces nitric oxide production via activation of constitutive nitric oxide synthases in human neuroblastoma cells","volume":"145","author":"Xia","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2024.112270_bib139","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1080\/01616412.2017.1315864","article-title":"A review of sleep disorders and melatonin","volume":"39","author":"Xie","year":"2017","journal-title":"Neurol. Res."},{"key":"10.1016\/j.mce.2024.112270_bib140","doi-asserted-by":"crossref","first-page":"331","DOI":"10.2147\/JPR.S228577","article-title":"Role of melatonin in the regulation of pain","volume":"13","author":"Xie","year":"2020","journal-title":"JPR"},{"key":"10.1016\/j.mce.2024.112270_bib141","article-title":"Characterization, neurosteroid binding and brain distribution of human membrane progesterone receptors \u03b4 and {epsilon} (mPR\u03b4 and mPR{epsilon}) and mPR\u03b4 involvement in neurosteroid inhibition of apoptosis","volume":"154","author":"Y","year":"2013","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2024.112270_bib142","first-page":"3130","article-title":"Chronic pain: structural and functional changes in brain structures and associated negative affective states","volume":"20","author":"Yang","year":"2019","journal-title":"Indian J. Manag. Sci."},{"key":"10.1016\/j.mce.2024.112270_bib143","doi-asserted-by":"crossref","first-page":"15319","DOI":"10.1074\/jbc.M212520200","article-title":"Non-steroidal anti-inflammatory drugs inhibit nitric oxide-induced apoptosis and dedifferentiation of articular chondrocytes independent of cyclooxygenase activity","volume":"278","author":"Yoon","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2024.112270_bib144","doi-asserted-by":"crossref","first-page":"3190","DOI":"10.1111\/bph.14116","article-title":"New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation","volume":"175","author":"Zisapel","year":"2018","journal-title":"Br. J. Pharmacol."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720724001266?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720724001266?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T01:28:20Z","timestamp":1718242100000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720724001266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":137,"alternative-id":["S0303720724001266"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2024.112270","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of nitric oxide and neuroendocrine system in pain generation","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2024.112270","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"112270"}}